Ulcer disease

This study tests an experimental drug called X842 in people with severe erosive esophagitis caused by GERD (chronic acid reflux). Participants have either severe esophagus damage (grades C or D) or milder damage that hasn't healed after 8 weeks of standard treatment. The trial co…

This study tested a new drug called BLI5100 in 1250 adults with erosive esophagitis, a condition where stomach acid damages the esophagus. Participants took either BLI5100 or a standard PPI (proton pump inhibitor) daily for up to 8 weeks to see if it healed the damage, then for 2…

This study tested whether giving pantoprazole (a stomach acid reducer) to critically ill ICU patients prevents stress ulcers and reduces death. Over 3,300 adults at high risk were randomly assigned to receive pantoprazole or a placebo daily while in the ICU. Researchers tracked d…

This study tested whether sildenafil (the drug in Viagra) can help heal painful finger ulcers in people with scleroderma, a disease that damages blood vessels. 84 participants took either sildenafil or a placebo three times daily for 90 days. The main goal was to see if the ulcer…

This study tested whether adding a special amniotic membrane containing riboflavin and moxifloxacin to standard PACK-CXL therapy helps heal infected corneal ulcers faster. 32 adults with moderate-to-severe ulcers took part. The goal was to see if the membrane improves corneal hea…

This study tested two types of special mattresses—the Fluid Immersion Simulation (FIS) system and the Air Fluidized Bed (AFB)—to see which helps heal surgically closed pressure ulcers (bedsores) better. Eighty adults with stage III or IV bedsores were randomly assigned to one mat…

This study tested whether adding placental tissue grafts to standard wound care helps close diabetic foot and venous leg ulcers faster. 292 adults with nonhealing ulcers received either standard care alone or standard care plus a graft. The main goal was to see if more ulcers clo…

This study tested a pharmacist-driven protocol to stop stomach ulcer prevention drugs in ICU patients when they are no longer needed. The goal was to reduce unnecessary medication and side effects without increasing the risk of stomach bleeding. The trial included 120 adult ICU p…

This study compared two types of gastric bypass surgery for obesity to see which one leads to fewer problems like acid reflux and stomach ulcers. Two hundred adults with a BMI between 30 and 50 took part. The goal was to find out which surgical method is safer and more effective …

This completed Phase 3 study tested the drug D961H (esomeprazole) in 50 Japanese children to see if it can prevent reflux esophagitis from coming back and stop stomach or duodenal ulcers from recurring in kids taking NSAIDs or low-dose aspirin. Children took the drug for up to 52…

This study tested whether adding a light-activated dye (rose bengal) to standard antibiotic or antifungal eye drops could improve vision in people with severe corneal infections. About 330 adults in India and Brazil with fungal or amoeba infections received either standard drops …

This study tested two different 14-day drug combinations to treat Helicobacter pylori, a bacteria that causes stomach inflammation and ulcers. Over 750 adults were randomly assigned to either a triple therapy (omeprazole, amoxicillin, clarithromycin) or a quadruple therapy (omepr…

This study tested whether adding a special collagen-based skin substitute to standard negative pressure wound therapy (NPWT) helps deep wounds heal faster than NPWT alone. It involved 104 adults with full-thickness wounds (at least 4 weeks old) that were not healing well. The mai…

This study tested a borate-based bioactive glass wound matrix (Mirragen) plus standard care against standard care alone for diabetic foot ulcers. 148 adults with diabetes and a foot ulcer were enrolled. The main goal was to see if the glass dressing helped more wounds close compl…

This phase 2 pilot study tested a topical ointment called MEBO on venous leg ulcers. Only 5 people took part, and they were randomly assigned to get either MEBO or standard compression bandages. The main goal was to see if the ulcer healed completely within 8 weeks. Because the s…

This study tested two doses of a daily pill called ozanimod in 198 Japanese adults with moderate to severe ulcerative colitis. The goal was to see if it could reduce symptoms and inflammation better than a placebo. The trial also checked long-term safety. Ozanimod works by calmin…

This study tested whether adding an injection of the antifungal drug voriconazole into the eye could improve treatment for fungal corneal ulcers. 70 people with moderate to severe infections received either standard antifungal drops alone or drops plus three injections over 10 da…

This study checked the safety of taking BLI5100 daily for up to 12 months in 400 adults with gastroesophageal reflux disease (GERD). Participants had either non-erosive reflux disease or healed erosive esophagitis. The main goal was to track any side effects. This is a disease co…

This study tested two different drug combinations in 782 people with H. pylori infection that was resistant to the antibiotic clarithromycin. One group received a triple therapy with a proton pump inhibitor, amoxicillin, and metronidazole, while the other received a quadruple the…

This small study tested ustekinumab, a drug that calms the immune system, in 16 adults with Behçet disease. The goal was to see if it could reduce mouth ulcers and eye inflammation. The trial is complete, but because it's early and small, we don't yet know if the drug will become…

This study tests a new, less invasive way to measure stomach acid using a small wireless capsule (SmartPill) that patients swallow. It compares the capsule's accuracy to the standard method, which involves a tube placed through the nose into the stomach. The study includes health…

This study tested a smartphone app called SeeWound 2 that uses artificial intelligence to measure the size, depth, and tissue makeup of hard-to-heal wounds. Instead of using a probe to touch the wound, the app takes a picture and calculates the measurements digitally. The study i…

This phase 3 trial tested whether ulinastatin, a drug that blocks certain enzymes, can reduce severe mouth sores caused by chemoradiotherapy in 179 patients with advanced nasopharyngeal cancer. Patients received either standard care or ulinastatin alongside their cancer treatment…

This study tested whether a tiny eye insert called DEXTENZA, placed after cataract surgery, works better than standard eye drops alone for reducing pain and swelling. Fifty adults having cataract surgery took part. The insert slowly releases medicine over time, aiming to improve …

This early-stage study tested the safety of eye drops made from stem cell secretions in 9 adults with chronic corneal surface disease that did not improve with standard treatments. The drops were given in increasing doses to find the safest amount. Researchers checked for side ef…

This study tested whether a special medical glue (isobutyl cyanoacrylate) can heal traumatic mouth ulcers in children better than standard treatments. Thirty children were split into three groups: one got the glue applied once, another got a chlorhexidine gel twice daily, and the…

This study looked at how well a special dressing called Aquacel WSF Ribbon works for healing foot ulcers and other wounds in everyday medical practice. Researchers reviewed the medical records of 214 people who used this dressing. The main goal was to see how long it took for wou…

This study aimed to create a better nursing plan for mouth sores caused by cancer treatments like chemo and radiation. Researchers worked with 54 cancer patients to test a new care routine based on the best available evidence. The goal was to reduce mouth soreness and improve dai…

This study looked at whether a special interactive dressing (UrgoStart Plus) used with compression bandages can help heal venous leg ulcers faster than standard dressings. Sixty adults with chronic leg ulcers were treated for up to 12 weeks. The goal was to see if the new dressin…

This study tested two treatments for painful mouth sores caused by radiation therapy: MEBO ointment and Tantum Verde mouthwash. 36 adults with moderate to severe sores were randomly assigned to one treatment for two weeks. Researchers measured soreness and healing at the start, a…

This study investigates whether gut microorganisms and their byproducts play a role in triggering severe flare-ups of ulcerative colitis. Researchers will compare patients hospitalized with severe colitis to those with milder symptoms, analyzing stool and blood samples over three…

This study followed 190 adults who had or were about to have a stem cell transplant from a donor. Researchers tracked changes in the mouth, like dryness or sores, to learn more about chronic graft-versus-host disease (cGVHD). Participants provided saliva, mouth swabs, and had den…

This completed study examined whether differences in the IL-7 receptor gene are linked to the risk of developing ulcerative colitis and how well patients respond to the drug vedolizumab. Researchers enrolled 898 people, including those with UC and healthy controls, and analyzed t…

This study looked at why people with sickle cell disease often get hard-to-heal leg ulcers. Researchers measured blood flow, nerve function, and blood markers in 70 patients with and without ulcers. The goal was to better understand what causes these wounds, not to test a new tre…

This study compared a generic vonoprazan 20 mg tablet to the brand-name Voquezna in 28 healthy adults. Participants took a single dose of each under fasting conditions to see if the generic releases the same amount of drug into the bloodstream. The goal was to check bioequivalenc…

This early-stage study tested two different tablet versions of a drug for gastric ulcers in 46 healthy adults. Participants received a single dose of each formulation on separate occasions to compare how the drug moves through the body and to check for side effects. The goal is t…