Eye injection shows promise against fungal ulcers

NCT ID NCT02731638

Completed Disease control Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding an injection of the antifungal drug voriconazole into the eye could improve treatment for fungal corneal ulcers. 70 people with moderate to severe infections received either standard antifungal drops alone or drops plus three injections over 10 days. The goal was to see if the injection helped clear the fungus faster.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: voriconazole injection plus natamycin drops
What this could lead to: If successful, this approach could become a standard treatment for fungal eye infections, reducing the need for more invasive procedures.
What could go wrong: This is a single, completed trial with 70 participants. The results may not apply to all types of fungal infections or to patients with more severe disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

corneal disorder corneal ulcer fungal keratitis keratitis ulcer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORNEAL ULCER FUNGAL KERATITIS

Contacts and locations

Locations

Aravind Eye Hospitals

Pondicherry, Tamil Nadu, India
Francis I. Proctor Foundation at UCSF

San Francisco, California, 94143, United States

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