Battle of the bacteria: which drug combo wins against resistant h. pylori?
NCT ID NCT03431688
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested two different drug combinations in 782 people with H. pylori infection that was resistant to the antibiotic clarithromycin. One group received a triple therapy with a proton pump inhibitor, amoxicillin, and metronidazole, while the other received a quadruple therapy with a proton pump inhibitor, bismuth, metronidazole, and tetracycline. The goal was to see which combination better eradicated the bacteria.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- metronidazole-based triple therapy (PPI, amoxicillin, metronidazole) and bismuth-based quadruple therapy (PPI, bismuth, metronidazole, tetracycline)
- What this could lead to
- If successful, this could identify a more effective treatment for people with drug-resistant H. pylori, reducing infection and related complications.
- What could go wrong
- This is a completed trial, but results may not apply to all populations. Drug resistance patterns vary, and side effects from the medications can occur.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Kangdong Sacred Heart Hospital
Seoul, 134-701, South Korea
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