Pneumonia

This Phase 3 trial tests updated versions of the BNT162b2 COVID-19 vaccine in adults and children aged 5 and older. Participants include those aged 5 to 64 with medical conditions that raise their risk of severe COVID-19, as well as everyone aged 65 and older. The study compares …

This study tests whether a pneumococcal vaccine (Pneumosil) can produce a strong immune response in children aged 6-59 months who are hospitalised with severe acute malnutrition. Half the children will receive the pneumococcal vaccine, and the other half will receive a typhoid va…

This study tests whether a pharmacist-led electronic consultation can improve lung health for people with HIV who smoke or use certain medications that raise pneumonia risk. Pharmacists will review records and suggest changes like smoking cessation aids, vaccines, or stopping unn…

This study follows over 2,000 elderly patients hospitalized with community-acquired pneumonia to see whether adding traditional Chinese medicine (TCM) to standard care improves recovery. Researchers will compare patients who receive TCM with those who do not, tracking hospital st…

This study tests whether adding probiotic nasal spray and oral probiotics to standard pneumonia treatment helps children aged 6 to 36 months recover faster. 330 children will be split into three groups: one getting a placebo, one getting probiotic nasal spray only, and one gettin…

This study tests whether a machine-learning system called iAST® can improve how doctors choose antibiotics for patients with pneumonia, urinary tract infections, or sepsis. The AI predicts which antibiotics are likely to work before standard lab results are available. Researchers…

This study follows over 500 hospitalized adults with drug-resistant bacterial pneumonia to see whether those who receive systemic traditional Chinese medicine (such as herbal decoctions or injections) have fewer lower respiratory tract infections in the six months after leaving t…

This trial tests whether an AI system can help doctors choose better ventilator settings for children (ages 1 month to 18 years) in the pediatric ICU who need a breathing machine. Half of the children will receive standard care, while the other half will have their ventilator adj…

This study looks at whether a lower dose of the antibiotic TMP-SMX works as well as the standard dose for treating a serious lung infection called Pneumocystis pneumonia (PCP) in people who do not have HIV. The standard dose often causes side effects in more than half of patients…

This study tests whether a 3-day course of amoxicillin works as well as a 5-day course for children aged 3 months to 5 years with uncomplicated pneumonia. The goal is to see if shorter treatment can reduce side effects, lower costs, and fight antibiotic resistance. About 250 chil…

This early-phase trial will test a combination of a Chinese herbal formula (Yiqi Huoxue Jiedu) and bacteriophages (viruses that target bacteria) in 250 people with severe pneumonia caused by drug-resistant bacteria. The goal is to see if this combo can clear the infection faster …

This study looks at whether adding a mix of nutritional supplements (spirulina, bifidobacterium, fish oil, grape seed, blueberry, and ganoderma spore oil) to standard steroid treatment can help people with severe lung inflammation caused by cancer immunotherapy. About 60 adults w…

This Phase 2 trial tests whether NRICM102, a Traditional Chinese Medicine, can help adults with community-acquired pneumonia reach clinical stability faster when added to standard antibiotic therapy. About 150 hospitalized participants will take either NRICM102 or a placebo for 7…

This study looks at whether giving lower doses of two blood thinners (argatroban and enoxaparin) to adults on ECMO (a machine that helps the heart and lungs) is safe and works well. The goal is to reduce bleeding and clotting problems. About 200 people with pneumonia or heart fai…

This study looks at whether the timing of a lung washing procedure (bronchoalveolar lavage) helps children with severe pneumonia recover faster. About 3,168 children will receive standard care plus the procedure at different times. Researchers will track how quickly they need les…

This large trial in China will test two additional treatments for people with severe pneumonia who need a breathing machine. One group will have their bed tilted head-down for at least 12 hours a day. Another group will receive a traditional Chinese herbal formula. The goal is to…

This study looks at which second-choice treatment works best for a serious lung infection called PCP when the usual antibiotic cannot be used due to allergies, side effects, or failure. About 416 adults with weakened immune systems (from HIV, transplants, cancer, or other causes)…

This study tests whether giving steroids based on a patient's immune status can reduce deaths in severe pneumonia with respiratory failure. About 500 ICU patients will receive methylprednisolone, with doses adjusted according to their inflammatory profile. The goal is to find out…

This early-phase trial tests a Chinese herbal formula (Yiqi Huoxue Jiedu) combined with bacteriophages—viruses that target specific bacteria—in 240 people with severe pneumonia caused by drug-resistant germs. The goal is to see if the combination clears the infection faster and l…

This study looks at how long steroids should be given to adults with severe Pneumocystis pneumonia (PCP), a serious lung infection common in people with weakened immune systems. About 416 participants who improve within 10 days will either stop steroids early or continue for 21 d…

This study tests whether adding black seed oil (Nigella sativa) to standard asthma medication can improve asthma control and lung function in children aged 6–18 with moderate persistent asthma. Ninety children will receive either a low or high dose of black seed oil capsules or a…

This early-stage trial tests a drug called OPT101 in 26 adults hospitalized with pneumonia and sepsis. The drug is designed to reduce harmful inflammation. The main goal is to check safety and how the body processes the drug, not yet to prove it works.

This study tests whether taking a low-dose aspirin (100 mg) every day for 90 days can reduce deaths and heart-related complications in people aged 75 and older who are hospitalized with pneumonia. Researchers will compare aspirin against a placebo in 600 participants across multi…

This trial tests whether low or moderate doses of the steroid methylprednisolone can reduce deaths in patients with severe community-acquired pneumonia. It will enroll 1500 ICU patients with pneumonia caused by adenovirus or Pneumocystis jirovecii. The study uses an adaptive desi…

This study tests whether an AI-powered digital stethoscope can help health workers more accurately diagnose pneumonia in children aged 2 months to 5 years. 350 children with cough or breathing difficulty will be randomly assigned to standard care or care plus the AI stethoscope. …

This study will collect cough sounds, breath sounds, and symptom questionnaires from 1,400 children with respiratory symptoms like cough or fever. Researchers will use this data to build a computer model that can help diagnose conditions like asthma and pneumonia. The goal is to …

This study looks at whether using a bronchoscopy (a camera in the airways) together with a CT scan can more accurately identify the germs causing severe pneumonia than a CT scan alone. Researchers will review data from 400 patients to compare the two methods. The goal is to help …

This study tests an AI system that helps doctors navigate a bronchoscope (a thin tube with a camera) into the lungs of patients with severe pneumonia. The AI provides real-time visual cues and voice prompts to guide the doctor to the right spot and describe what they see. About 1…

This trial tests whether training nursing home staff to provide better oral hygiene can reduce pneumonia in residents aged 60 and older. Participants will use special toothpastes and mouthwashes, including stannous fluoride and chlorhexidine options. The study measures how many r…

This large trial will study whether flu and pneumonia vaccines can reduce serious flare-ups and medical costs in people aged 45-80 with COPD. About 7,000 participants will be split into four groups: flu vaccine, pneumonia vaccine, both, or no vaccine. Researchers will track lung …

This study tests whether using two automated devices together—one that drains fluids from above the breathing tube and another that monitors the tube's cuff pressure—can reduce the amount of fluid entering the lungs of critically ill patients on ventilators. The goal is to preven…

This study tests whether using a high-flow nasal cannula (a device that delivers warm, moist oxygen at high speeds) for 24 hours after major abdominal surgery can prevent lung complications like pneumonia or collapsed lungs. Researchers will compare this to standard oxygen therap…

This study tests if giving a nebulized antibiotic (colistimethate sodium) can prevent pneumonia in children who are on breathing machines. About 400 children aged 1 month to 14 years will receive either the drug or a placebo twice daily for up to 7 days. The goal is to see if the…

This study compares two doses of the antibiotic ceftriaxone for adults hospitalized with pneumonia (but not in the ICU). The goal is to see if a 1-gram daily dose works just as well as a 2-gram daily dose while causing fewer side effects. About 430 participants will be followed t…

This study tests a mobile mindfulness program called Lift for people who survived a serious illness in the ICU and now struggle with depression, anxiety, or stress. About 450 adults will use either the Lift app or a health education app for 6 months. The goal is to see if the min…

This study tests whether a ketogenic diet (low carb, high fat) is better than a standard diet at preserving muscle function in older adults hospitalized with pneumonia. Researchers will enroll 30 patients aged 55 and older and measure handgrip strength and diet adherence. The goa…

This study looks at whether changing body position and doing special breathing exercises can help prevent lung issues like pneumonia after heart surgery. About 124 adults having planned heart surgery will be split into four groups: one getting usual care, one doing only breathing…

This study tests a child-friendly breathing exercise program for children aged 6-18 recovering from severe pneumonia. The program is designed to be fun and engaging, aiming to improve recovery and make caregivers happier with the care. Researchers will compare kids who do the exe…

This study tests four different nebulized solutions (various salt concentrations and distilled water) to see which works best for clearing mucus from the airways of pneumonia patients. Eighty adults with pneumonia who need help coughing up phlegm will receive the treatment four t…

This study looks at whether a special oxygen device (high-flow nasal cannula) can prevent dangerously low oxygen levels in children aged 1 to 6 years who are sedated for a lung exam called bronchoscopy. About 430 children will be randomly assigned to receive either the high-flow …

This study looks at two ways to sedate children aged 5-10 who are on breathing machines for pneumonia. One method gives sedation continuously, the other pauses it daily. Researchers will measure comfort levels to see which approach works better. The goal is to improve care and re…

This study looks at whether giving Coenzyme Q10, a natural substance found in the body, along with standard antibiotics can help children hospitalized with pneumonia recover more quickly. About 120 children aged 2 months to 18 years will take part. The goal is to see if it speeds…

This study looks at whether a personalized exercise program, started in the hospital and continued at home with video supervision, can help older adults recover after being hospitalized for pneumonia or a urinary tract infection. The goal is to see if this approach is safe, impro…

This study tests whether pursed-lip breathing exercises, done twice daily with a toy, can improve breathing and readiness for hospital discharge in 66 children aged 3-4 with pneumonia. Researchers will measure changes in heart rate, breathing rate, and oxygen levels before and af…

This study follows adults hospitalized with a lower respiratory tract infection, such as pneumonia or bronchitis, to measure how their quality of life changes over one year. Researchers use a standard questionnaire to track physical, mental, and social well-being at several point…

This study looks at whether taking a combination of GLP-1 receptor agonists and SGLT2 inhibitors before being hospitalized with pneumonia improves early outcomes in adults with type 2 diabetes. Researchers analyzed health records from over 70,000 patients, comparing those on both…

This pilot study tests whether using pleuropulmonary ultrasound in the emergency department can help doctors prescribe antibiotics sooner for suspected pneumonia. Fifteen adults with respiratory symptoms will receive an ultrasound in addition to standard care. The main goal is to…

This study looks at 200 people with pneumonia to find out how many actually have an infection caused by Chlamydia pneumoniae, a type of bacteria. Researchers will use PCR tests to check for the germ and compare results with standard care. The goal is to see if this infection is o…

This study tests whether a team-based care strategy for bubble continuous positive airway pressure (bCPAP) is feasible for children with severe pneumonia in Pakistan. Researchers will enroll 95 children and their caregivers to see if a larger trial is possible. The focus is on wh…

This study looks back at the medical records of 500 adults hospitalized with pneumonia to learn more about the disease. Researchers want to understand what factors affect patient outcomes, such as age, other health conditions, and lab results. The goal is to improve how pneumonia…

This study will follow about 2,700 adults with pneumonia to track their recovery and understand why some become severely ill. Researchers will collect health data and samples to find patterns that predict worsening. The goal is to improve how doctors assess risk and make treatmen…

This observational study will enroll 50 children in intensive care with suspected pneumonia. Researchers will use a new technology called metagenomics to detect all bugs in the lung, and also measure how the body's cells and proteins respond. The goal is to see if this combined a…

This study looks at whether a special genetic test (tNGS) can help doctors treat hospitalized adults with pneumonia that isn't responding to first antibiotics. About 524 participants will be randomly assigned to get the test or standard care. The main goal is to see if the test s…

This study looks at whether patients who get a breathing tube in an emergency are more likely to develop pneumonia than those who get one in a planned setting. Researchers will review medical records of 600 adults intubated in 2024. The goal is to understand the risk and improve …

This study will follow 2,000 people—children under 5 and adults aged 16-60—in 30 villages in rural India to track how often they get serious lung infections from RSV, flu, COVID-19, and other viruses. Researchers will visit homes weekly and test samples to measure how many cases …

This study will use bedside ultrasound to look at the diaphragm and other breathing muscles in 150 ICU patients with pneumonia who are on a breathing machine. The goal is to see if muscle measurements can help predict whether a patient will successfully come off the machine or fa…

This study checks if a Turkish version of the Respiratory Distress Observation Scale (RDOS) accurately measures breathing distress in critically ill patients who cannot speak. Researchers will compare RDOS scores with end-tidal carbon dioxide levels, an objective breathing measur…

This study looks at how the immune system works in people with lung diseases like asthma, COPD, pneumonia, and tuberculosis. Researchers will take a single blood sample from 100 adults to study immune cell changes during inflammation and infection. Participants won't receive dire…

This study tests a mobile app called ALRITE that helps health workers in Uganda diagnose and manage breathing illnesses in young children. The app guides them through patient information and gives treatment recommendations. Researchers will see if using the app improves how often…

This study will observe up to 4,000 children under 5 years old who test positive for RSV and visit emergency departments in Turkey. Researchers will track how many children need to be admitted to the hospital or intensive care, and what treatments they receive. The goal is to bet…

This observational study will track over 2,500 adults hospitalized with severe community-acquired pneumonia across dozens of countries. Researchers will collect data from medical records to see how closely hospitals follow international treatment guidelines and what factors lead …

This study will follow 67 children hospitalized with pneumonia to find out which early signs—like breathing rate, oxygen levels, or blood tests—best predict a severe case. The goal is to help doctors spot high-risk children sooner and tailor their care. No new treatments are bein…

This study looks for proteins in the blood that could signal transfusion-related acute lung injury (TRALI), a rare but dangerous complication in ICU patients. Researchers will compare blood samples from 210 people, including ICU patients with and without lung injury, and healthy …