Peripheral arterial disease

This trial is testing whether preparing a blocked leg artery with a special 'scoring' balloon before using a drug-coated balloon improves outcomes compared to using a standard balloon. The study involves people with severe leg artery disease (critical limb-threatening ischemia) w…

This study tests a new biological graft, LineMatrix®, for replacing or bypassing damaged arteries in the lower body. About 15 adults with peripheral artery disease or other artery damage will receive the graft during surgery. Researchers will track how well the graft stays open w…

This study compares two ways to guide a minimally invasive procedure that opens blocked arteries below the knee in people with chronic limb-threatening ischemia, a severe form of peripheral artery disease. One group receives standard X-ray guidance (angiography) alone; the other …

This pilot study is testing whether a smartphone app called HeartMate can help people with heart disease manage their condition from home. Over six weeks, participants use the app for daily heart checks, guided exercise, breathing training, and a mind program, with weekly coachin…

This study tests a new type of bypass graft made from a biodegradable polymer for people with peripheral artery disease who need leg bypass surgery. The graft is designed to restore blood flow and then gradually be replaced by the body's own tissue. The trial will enroll 15 parti…

This study tests whether secukinumab, a drug that blocks inflammation, can reduce the risk of major heart problems and kidney decline in people with cardiorenal metabolic syndrome and hardened arteries. About 100 adults will receive either secukinumab injections plus standard car…

This Europe-wide study will follow 400 people with severe leg artery disease (chronic limb-threatening ischemia) to see if a new dissolvable, drug-coated scaffold can keep leg arteries open better than standard treatments. The scaffold releases medication to prevent re-blockage a…

This study will follow 250 people with chronic limb-threatening ischemia (CLTI) across Europe to see how well orbital atherectomy works in real life. The procedure uses a tiny spinning tool to gently remove hard calcium from leg arteries, making it easier for balloons or stents t…

This trial tests a special balloon coated with a drug (paclitaxel) to treat blockages in the leg arteries caused by cholesterol buildup. The balloon is inflated to open the artery and release the drug to help keep it open. The study will include 200 people and check if the balloo…

This study tests whether a wearable monitoring system (ECG patch, temperature patch, and pulse oximeter) can reduce major heart complications in hospitalized patients with heart disease. About 1500 adults will be monitored either with standard care (vital signs every 4-8 hours) o…

This early study tests a new device that combines a balloon with sound waves to treat blocked arteries in the legs, a condition called peripheral artery disease (PAD). The device is designed to crack hard plaque and widen the artery. The study will include 30 people with moderate…

This phase 1/2 trial tests whether a patient's own stem cells, taken from belly fat and grown in a lab, can heal leg ulcers caused by severe peripheral artery disease. 40 participants will either receive stem cell injections and a special cell-containing dressing, or standard hyd…

This study compares two drug-coated balloons for treating narrowed or blocked arteries in the leg. The experimental balloon uses sirolimus, a drug that stops cells from growing and blocking the artery again, while the standard balloon uses paclitaxel. About 478 people with leg ar…

This pilot study tests a simple method to reduce wound complications after groin vascular surgery. Surgeons will inject a blue dye into the skin around the surgical wound to make any lymphatic leaks visible, then repair them immediately. The study will enroll 60 adults and track …

This trial tests whether using a laser device (Auryon Atherectomy System) along with standard balloon angioplasty is safer and more effective than balloon angioplasty alone for treating severe blockages in the lower leg arteries. The study will enroll 50 people with critical limb…

This study tests if a special balloon called the Chocolate PTA balloon prepares leg arteries better than a standard balloon before using a drug-coated balloon to treat blockages. About 242 adults with peripheral artery disease will take part. The goal is to see if the Chocolate b…

This study tests whether adding FoundationDRS Solo to usual wound care helps heal chronic foot ulcers in people with diabetes. About 124 adults with a nonhealing ulcer will get either the new treatment plus standard care or standard care alone for 12 weeks. The main goal is to se…

This study will test a special balloon coated with the drug paclitaxel to treat long blockages in the leg arteries. About 300 people with severe leg pain or wounds will receive the balloon treatment during a standard angioplasty procedure. Researchers will track how well the arte…

This study compares two treatments for when a leg artery stent narrows again (in-stent restenosis). About 578 patients will receive either a drug-coated balloon or a drug-eluting stent, both of which release medication to keep the artery open. The goal is to see which approach re…

This study tests a new device that uses sound waves to break up hard calcium deposits in leg arteries of people with peripheral artery disease (PAD). About 110 adults will receive the minimally invasive procedure and be followed for 6 months. Researchers will check if the artery …

This study tests a drug-coated balloon to treat blockages in the leg's main artery. About 150 people with moderate to severe symptoms will receive the balloon treatment. The goal is to see if it keeps arteries open for at least 12 months and reduces the need for further procedure…

This Phase IIa trial tests the safety and tolerability of a new drug called etrinabdione in 30 adults with peripheral arterial disease (PAD). Participants take the drug twice daily for 12 months, starting with a low dose and possibly moving to a higher dose if safe. Researchers w…

This trial tests whether a portable handheld Doppler device can help nurses quickly detect arterial insufficiency in people with diabetes who have foot ulcers. The device checks for blood flow in the great toe, and the goal is to see if it can reliably flag patients who need furt…

This early-phase trial tests whether a fluorescent dye called LUMISIGHT (pegulicianine) can light up inflammation in artery plaques removed during surgery. Inflammation is a key driver of heart attacks, but current imaging can't see it clearly. Researchers will compare the dye to…

This study tests whether a special camera that measures oxygen in leg tissues can help diagnose peripheral artery disease (PAD). About 200 adults with suspected or confirmed PAD will have their legs lifted while the camera takes images. The goal is to see if these oxygen patterns…

This study tests whether washing the surgical wound and the new prosthetic graft with a hypochlorous acid solution at the end of surgery can prevent infections. Participants are adults having open surgery to insert a synthetic bypass graft for narrowed or blocked arteries. The st…

This study tests whether adding a traditional Chinese medicine formula called Bu Yang Huanwu Decoction (in capsule form) to standard treatment can prevent leg pain at rest or foot ulcers in people with diabetic lower extremity vascular disease. About 300 adults aged 18 to 70 with…

This study tests whether a single dose of cold atmospheric plasma applied to the wound during groin surgery can prevent healing complications in 214 high-risk patients with peripheral artery disease. Half will get the real plasma device, half a sham device. Researchers will track…

This study tests whether applying heat to the legs for 90 minutes each day at home can improve walking distance and leg function in adults over 50 with peripheral artery disease (PAD). Participants are randomly assigned to receive either active heat therapy or a sham (low-heat) v…

This study tests whether using the Replexa+ device twice daily for 3 months can improve blood flow in the lower legs and feet of veterans with peripheral artery disease (PAD) and peripheral neuropathy. Ten participants will have their blood flow measured before and after treatmen…

This study tests whether a 24-week recreational team handball program can improve walking ability and overall health in 60 men aged 60-80 with peripheral artery disease (PAD) and leg pain when walking. Participants will be randomly assigned to either the handball program or usual…

This study tests a hybrid cardiac rehabilitation program for people with peripheral artery disease (PAD), a condition that reduces blood flow to the legs and causes pain while walking. The program combines in-person supervised exercise sessions with home-based telerehabilitation …

This early-phase study tests whether taking vitamin B6 for up to 31 days can reduce the sharp rise in blood pressure that happens during exercise after a temporary lack of blood flow (like a leg injury). Researchers will measure blood pressure, heart rate, nerve activity, and wal…

This study tests whether wearing a virtual reality headset with calming scenes and hypnotic speech can lower pain and anxiety during minimally invasive leg artery surgery done under local anesthesia. About 90 adults with peripheral artery disease will take part. The main goal is …

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This study looks at whether a hospital rehab and prosthetic training program helps people who lost a leg due to diabetes or blood vessel disease use their artificial limb regularly. Researchers will review past patient records and follow new patients for up to 6 months after they…

This observational study will look at how exercise changes blood flow in the legs of people with or at risk for peripheral arterial disease (PAD). About 85 participants will walk for 6 minutes and have their ankle-brachial index (ABI) measured before and after. The goal is to see…

This study compares two methods of accessing the brachial artery in the arm for treating blocked leg arteries: a needle poke through the skin (percutaneous) versus a small cut (open). About 246 adults will be randomly assigned to one method. The goal is to see which approach caus…

This study looks at whether a CT scan already done for routine care can predict which patients with leg artery disease will improve with supervised exercise therapy. About 40% of patients don't get enough benefit from exercise and need a procedure to open blocked arteries. Resear…

This study tests a new, non-invasive imaging method (multispectral optoacoustic tomography) to measure oxygen levels in leg muscles during exercise. Researchers will compare results from endurance athletes, strength athletes, healthy controls, and people with peripheral arterial …

This observational study will examine whether a protein called the GLP-1 receptor is more active in patients with severe leg artery disease compared to those with milder symptoms. Researchers will take one extra blood sample from 50 adults with peripheral artery disease to measur…

This study looks back at medical records of 300 adults who had a minor amputation (at or below the ankle) to see if the type of anesthesia used affects their recovery. Early data suggests that using a nerve block instead of general anesthesia may lead to fewer complications and a…

This study will test 16 people with peripheral arterial disease (PAD) to see how different types of exercise—walking on a treadmill, traditional strength training, and circuit training—affect blood flow, oxygen levels, and leg pain. Participants will try each exercise type in ran…

This study tests a computer tool that helps doctors and cancer survivors decide together on the best heart-protective medications and tests. Researchers will enroll 60 cancer survivors at risk for heart problems. The goal is to see if the tool is easy to use and helps people foll…

This study will collect data from 1100 people with peripheral artery disease or abdominal aortic aneurysm across six European centers. Researchers will use artificial intelligence to analyze clinical data, blood samples, imaging, and wearable device information to build tools tha…

This study tests whether two widely used anti-platelet drugs, aspirin and clopidogrel, can reduce inflammatory markers in people with silent atherosclerosis (hardening of the arteries without symptoms). Researchers will measure changes in monocyte-platelet aggregates, a sign of i…