Peripheral arterial disease

This study tests whether injections of cells from donated human placentas can help heal foot ulcers in people with diabetes. The trial includes patients with and without peripheral artery disease, a common complication that slows healing. Participants receive either the cell trea…

This study tested a drug called CardiolRx in 90 hospitalized COVID-19 patients who also had heart disease or risk factors like diabetes or high blood pressure. The goal was to see if the drug could lower the chance of death, needing intensive care, or having heart problems. The t…

This study tested a special balloon that uses sound waves (shockwaves) to crack open hard calcium blockages in the leg arteries of people with critical limb ischemia, a condition where poor blood flow can lead to pain, wounds, or even amputation. The goal was to see if the balloo…

This study looked at whether screening people for high platelet reactivity (a condition where blood clots easily) before leg artery procedures could improve outcomes. It involved 31 adults with peripheral artery disease who were scheduled for angioplasty or stenting. The trial wa…

This study tested a gene therapy called VM202 to help heal chronic foot ulcers in people with diabetes and poor leg circulation. The treatment was given as injections into the calf muscle. The study was stopped early after enrolling only 44 participants, so results are limited.

This study tested whether injecting a long-acting numbing drug (liposomal bupivacaine) during leg artery surgery could lower the amount of narcotics patients need during and after the procedure. The trial planned to enroll adults having elective lower extremity revascularization,…

This study tested a new, non-invasive way to measure blood flow in the legs of people with peripheral artery disease (PAD). Researchers compared the new method to standard ultrasound in 29 patients scheduled for a procedure to open blocked leg arteries. The goal was to see if the…

This study looked at how two common pain relievers—celecoxib (a Coxib) and naproxen (an NSAID)—affect blood clotting in people with rheumatoid arthritis who also have heart disease or are at high risk for it. All participants took low-dose aspirin daily. The goal was to see if on…

This study tested whether a device that uses near-infrared light (NIRS) can measure blood flow in the remaining leg after a below-knee amputation better than the standard method (TcPO2). Researchers planned to include 50 patients in two groups: those with a permanent prosthetic l…