Peripheral arterial disease

This study looked at whether screening people for high platelet reactivity (a condition where blood clots easily) before leg artery procedures could improve outcomes. It involved 31 adults with peripheral artery disease who were scheduled for angioplasty or stenting. The trial wa…

This study tests whether injections of cells from donated human placentas can help heal foot ulcers in people with diabetes. The trial includes patients with and without peripheral artery disease, a common complication that slows healing. Participants receive either the cell trea…

This study tested a special balloon that uses sound waves (shockwaves) to crack open hard calcium blockages in the leg arteries of people with critical limb ischemia, a condition where poor blood flow can lead to pain, wounds, or even amputation. The goal was to see if the balloo…

This study tested a gene therapy called VM202 to help heal chronic foot ulcers in people with diabetes and poor leg circulation. The treatment was given as injections into the calf muscle. The study was stopped early after enrolling only 44 participants, so results are limited.

This trial tests whether applying a microbial sealant called Integuseal to the skin before leg bypass surgery can reduce postoperative wound infections. About 450 people scheduled for lower-limb arterial bypass procedures will be randomly assigned to receive the sealant or standa…

This study tested whether injecting a long-acting numbing drug (liposomal bupivacaine) during leg artery surgery could lower the amount of narcotics patients need during and after the procedure. The trial planned to enroll adults having elective lower extremity revascularization,…

This trial investigates whether using 3D image fusion during iliac angioplasty reduces the amount of radiation patients receive compared to standard practice. The study involves 37 adults with iliac artery narrowing who need angioplasty. Researchers will measure radiation exposur…

This study tested a new, non-invasive way to measure blood flow in the legs of people with peripheral artery disease (PAD). Researchers compared the new method to standard ultrasound in 29 patients scheduled for a procedure to open blocked leg arteries. The goal was to see if the…

This study tested whether a device that uses near-infrared light (NIRS) can measure blood flow in the remaining leg after a below-knee amputation better than the standard method (TcPO2). Researchers planned to include 50 patients in two groups: those with a permanent prosthetic l…