Peripheral arterial disease

This study follows 284 people with blocked leg arteries (peripheral arterial disease) who are treated with a paclitaxel-coated balloon. The balloon is inflated inside the artery to open it and release a drug that helps prevent it from narrowing again. Researchers are tracking saf…

This trial is testing a temporary stent system designed to open blocked arteries below the knee in people with peripheral arterial disease. The stent is used along with a drug-coated balloon to help keep the vessel open. The study will check how well the treated arteries stay ope…

This study looks at whether a special blood test (TEG-PM) can guide doctors in adjusting blood-thinning medications for people who have had leg artery surgery for peripheral artery disease. About 130 adults will have their blood tested before and up to 9 months after surgery, and…

This phase 3 trial is testing whether the drug retatrutide can lower the chance of serious heart problems (like heart attacks and strokes) and slow kidney disease in 10,000 overweight adults who already have heart or kidney disease. Participants receive either retatrutide or a pl…

This trial tests whether a dietary supplement called Tertinat, containing epigallocatechin-3-gallate, can reduce major heart problems in people with atherosclerosis who have recently had bypass or stent surgery. Over two years, participants take either the supplement or a placebo…

This study is following 300 people with peripheral artery disease who received the MicroStent, a small mesh tube placed in leg arteries to improve blood flow. Researchers are tracking how well the arteries stay open over time and whether patients avoid major complications like am…

This early study tests a special scaffold that dissolves over time in 10 people with severe leg artery disease (critical limb-threatening ischemia). The scaffold is placed in arteries below the knee to help keep them open after balloon treatment. Researchers check safety and how …

This study compares a new stent (Supera) to standard surgery for treating blockages in the leg's main artery. About 286 people with moderate to severe leg pain or sores will be randomly assigned to get either the stent or surgery. Researchers will check if the stent keeps the art…

This study tests whether a new drug-coated balloon (Passeo-18 Lux) is as safe and effective as an existing one (IN.PACT Admiral) for opening blocked leg arteries in people with peripheral artery disease. About 302 participants with moderate to severe symptoms are randomly assigne…

This study was designed to test a new surgical technique called transverse tibial bone transport in people with chronic limb-threatening ischemia (CLTI) who have no standard treatment options left. The procedure involves slowly moving a small piece of shinbone to stimulate new bl…

This study planned to test a special shockwave device that uses sound waves to crack calcium buildup in leg arteries before placing a stent. The goal was to improve stent fit and long-term blood flow in people with severe peripheral artery disease. However, the trial was withdraw…

This study is following 450 people with long blockages in their leg arteries who are treated with the DETOUR System, a device that creates a bypass inside the artery. The goal is to see how well it works and how safe it is in everyday medical practice. Participants are chosen by …

This study compares two treatments for complex blockages in the leg's main artery: one avoids stents by using a drug-coated balloon, the other uses a stent. About 120 people with peripheral arterial disease will be randomly assigned to one approach. The goal is to see which keeps…

This study tested whether injections of cells from donated placentas could improve blood flow and help heal foot ulcers in people with diabetes and blocked leg arteries. The trial planned to enroll about 24 adults with hard-to-heal foot sores. However, the study was withdrawn bef…

This study tests a new device called the MicroStent, a small mesh tube placed in leg arteries below the knee to keep them open. It involves 177 adults with severe peripheral artery disease who have pain at rest or non-healing sores. Half get the stent plus standard balloon treatm…

This study tests a special balloon designed to open up hardened leg arteries in people with peripheral artery disease. About 58 participants with moderate to severe calcium buildup will receive the balloon treatment. Researchers will check if the balloon successfully widens the a…

This study tests whether giving stroke patients extra tests—like checking for hidden heart problems, artery stiffness, and leg circulation—can lower their chance of having another stroke or heart attack. About 600 people in Stockholm will get this expanded check-up and a personal…

This study compares a paclitaxel-coated balloon (Legflow DCB) to a standard uncoated balloon for treating blocked leg arteries in people with peripheral artery disease. About 150 participants with moderate to severe symptoms will be randomly assigned to one of the two treatments.…

This study looks at how well minimally invasive procedures (like balloons and stents) work for people with severe blockages in the leg arteries. It will track 1000 patients to see if these treatments restore blood flow and keep arteries open over time. The goal is to find the bes…

This study follows 300 people with blocked leg arteries who received a treatment using a balloon coated with paclitaxel and vitamin E. The goal is to see if the balloon keeps the artery open and prevents the need for repeat procedures over one year. Participants are adults with m…

This study is tracking 200 people with blocked leg arteries who are receiving a special balloon coated with the drug paclitaxel (GENOSS PCB). The balloon is inflated inside the artery to open it and release the drug, which helps prevent the artery from narrowing again. Researcher…

This study tests a device called Pulse IVL that uses sound waves to break up hard calcium deposits in leg arteries, helping blood flow better in people with peripheral artery disease (PAD). About 115 adults with moderate to severe PAD will receive the treatment. The goal is to se…

This study compares a balloon coated with sirolimus (a drug) to a standard balloon for opening blocked leg arteries in people with peripheral artery disease. About 1,200 adults will be randomly assigned to one of the two treatments. The main goal is to see if the drug-coated ball…

This study tests a special balloon coated with a drug (SELUTION SLR™ 018) to open narrowed leg arteries in people with peripheral arterial disease. About 300 participants will be randomly assigned to receive either the drug-coated balloon or a standard uncoated balloon. The goal …

This study compares a special balloon coated with sirolimus (a drug that prevents re-blockage) to a standard balloon for opening blocked arteries below the knee in people with peripheral artery disease. About 230 participants will be randomly assigned to one of the two treatments…

This study compares two types of drug-coated balloons used to open blocked arteries in the leg. About 478 people with peripheral artery disease will receive either a sirolimus-coated balloon or a paclitaxel-coated balloon. The goal is to see if the sirolimus balloon works as well…

This study tests a device called SWM-831 in 81 people with moderate to severe hardening of the leg arteries (peripheral arterial disease). The device is used before balloon or stent treatment to break up calcium deposits and improve blood flow. The main goal is to see if the proc…

This study is tracking how well a drug-coated balloon called SELUTION SLR works in real-world patients with peripheral artery disease (PAD). The balloon is inflated in narrowed leg arteries to open them and release a drug that helps keep them open. Researchers are following 723 p…

This study tests whether portable ultrasound and blood glucose monitors can help doctors catch chronic conditions like diabetes, heart disease, and kidney disease earlier than usual. About 200 adults will use these devices or receive standard care for 6 months. The goal is to see…

This study was designed to see if measuring blood flow resistance in tiny leg vessels could predict whether a limb could be saved after artery-opening procedures in people with critical limb ischemia. It planned to enroll patients with severe leg artery disease and use a special …

This study tests whether applying shockwave therapy to the calf muscles can improve blood flow and reduce pain in people with peripheral artery disease. About 138 adults with stable leg pain when walking will receive the treatment. The goal is to see if it helps them walk longer …

This study tests whether using a far red light device on the legs for 10 minutes twice a day can improve walking distance in people with peripheral artery disease (PAD). The trial involves 32 adults aged 50 and older with PAD. Participants use the light at home for four months, a…

This study tests whether wearing inflatable leg cuffs (intermittent pneumatic compression) for six months can improve walking distance in people with peripheral artery disease (PAD). Some participants also combine the cuffs with walking exercise. The goal is to see if the cuffs h…

This early study tests whether a combination of arginine, tetrahydrobiopterin, and vitamin C can boost nitric oxide levels in the blood and help people with peripheral artery disease walk longer without pain. Ten participants will take the therapy and be monitored for changes in …

This study tests whether a 12-week telehealth-supervised exercise program can improve walking ability and quality of life in veterans with peripheral artery disease (PAD). Participants exercise three times a week at a location of their choice. The study measures walking distance,…

This study tests whether a behavior change program can increase physical activity in people with peripheral artery disease who have just had a procedure to open blocked leg arteries. About 30 participants aged 50-80 will receive a structured walking program designed to improve wa…

This study surveys doctors who use Concerto Versa detachable coils to treat various blood vessel conditions like aneurysms and varicose veins. About 30 patients will be included, and doctors report how well the coils work and any problems within 72 hours. The goal is to collect e…

This study looks at how blood flow in the feet changes during a 12-week heart and blood vessel rehab program for people with narrowed arteries. Researchers will track 80 adults with conditions like peripheral artery disease or coronary artery disease. The goal is to better unders…

This study was designed to see if a device called AirGlove, which applies heat, could improve blood flow in the legs of people with peripheral arterial disease (PAD). It planned to include healthy volunteers and people with PAD who experience leg pain when walking. However, the s…

This study looks at whether special imaging features from scans can help predict serious outcomes like amputation or death in people with peripheral artery disease (PAD) after they have had a procedure to open blocked leg arteries. Researchers will analyze 200 patients' scans to …

This study follows 500 people with peripheral artery disease (PAD) who undergo a procedure to open blocked leg arteries. Researchers check blood and heart ultrasound before and after the procedure to find hidden heart injury. The goal is to see if certain markers can predict futu…

This study is a registry that collects safety and performance data on the GORE® VIABAHN® VBX Stent Graft when used in peripheral vessels. It involves 280 adults who need this device to treat peripheral vascular disease. The goal is to see how well the stent graft works and if the…

This study looks at how arm crank exercise (like pedaling with your arms) changes blood flow in people with peripheral artery disease (PAD) compared to healthy adults. Researchers will measure blood vessel function and oxygen levels in the calf before and after exercise. The goal…

This study examines whether a common gene variation (CYP2C19) influences the long-term risk of serious heart and blood vessel events, such as heart attacks, strokes, and limb problems, in people with vascular disease. Researchers will analyze genetic and health data from 13,000 p…

This study looks at how often cancer patients with risk factors like age, diabetes, or smoking have peripheral arterial disease (PAD), a condition where blood vessels narrow. Researchers will test 114 patients before surgery using simple ankle and toe blood pressure measurements.…

This study is tracking over 600 people who received the GORE VIABAHN stent-graft as part of their normal medical care for conditions like peripheral artery disease or aneurysms. Researchers are monitoring how often serious device-related problems occur. The goal is to see how saf…

This study tests whether using a high-detail imaging tool called optical coherence tomography (OCT) helps doctors make better decisions when placing stents to open blocked leg arteries. About 25 adults with leg artery narrowing will be enrolled. Doctors will first plan treatment …

This study tests a new wireless sensor that is injected under the skin to measure oxygen levels in the legs of people with peripheral artery disease (PAD). The sensor tracks how oxygen changes when blood flow is altered by a pressure cuff or changing position. Researchers want to…

This study was designed to see if a plant-based supplement called PB125 could help veterans with peripheral artery disease (PAD) get more benefit from exercise. The idea was that PB125 might reduce inflammation and oxidative stress, making it easier for patients to walk and exerc…

This study is collecting information from 458 people with critical limb-threatening ischemia, a severe form of peripheral artery disease that can lead to amputation. The goal is to learn how different treatments affect patients' daily lives and health outcomes. Researchers hope t…

This study was designed to find better ways to manage heart disease in veterans with severe peripheral artery disease (poor leg blood flow) who had leg surgery. It planned to track major heart problems like heart attacks or heart-related death. However, the study was withdrawn be…

This study follows one cyclist with a rare leg artery condition that limits blood flow during intense exercise. Researchers will review the cyclist's training power data and medical scans to better understand how the disease affects performance and how to diagnose it. The goal is…

This study was designed to see if a short-term protein-calorie restriction diet before elective vein graft surgery is practical and how it affects the body. It planned to enroll adults scheduled for non-emergency lower extremity vein bypass surgery. However, the trial was withdra…