Obsessive-compulsive disorder

This study tests a new behavioral therapy called OPT-A for teenagers who have both substance use problems and mood or anxiety disorders. 140 teens aged 10-17 will receive either OPT-A or standard treatment. Researchers will track substance use and mental health for 18 months to s…

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This study tested whether a team-based care model can help people with both opioid use disorder and mental health issues like depression or anxiety. 254 adults in primary care received either full collaborative care for both conditions or just mental health support. The goal was …

This completed study tested whether a Mediterranean diet could improve metabolic syndrome markers in 30 hospitalized adults with psychiatric conditions. Participants followed either a Mediterranean diet or a standard hospital diet for 8 weeks, then switched. Researchers measured …

This study tested a counseling program called Youth Friendship Bench SA for young women aged 18-25 in South Africa who had symptoms of depression, anxiety, or stress. The program included individual and group counseling sessions, plus optional text reminders. The goal was to see …

This study tested whether adding dog-assisted therapy to usual care helps teens aged 12-18 with mental health issues like anxiety, depression, and emotional dysregulation. 70 teens in a day hospital were randomly assigned to either get dog therapy plus usual care or usual care al…

This completed study tested two psychological techniques—imagery rescripting and imaginal exposure—in 6 adults with obsessive-compulsive disorder (OCD) who experience distressing future-oriented images. Participants completed daily and periodic questionnaires to track symptoms. T…

This study tests if group cognitive behavioral therapy (CBT) can reduce anxiety and insomnia in teens aged 12-20. About 171 participants with both conditions will receive either CBT for anxiety or CBT for insomnia. The goal is to see which approach better improves symptoms, sleep…

This study tested a device called Reacor that uses biofeedback to teach mindfulness by showing your heart rate and brain waves in real time. 188 adults with anxiety disorders were split into three groups: biofeedback alone, the medication escitalopram alone, or both together. The…

This Phase 3 trial tested whether adding troriluzole to standard OCD medications could reduce symptoms better than a placebo. The study enrolled 589 adults with OCD who had not responded well enough to their current treatment. After 8 weeks, troriluzole did not lead to significan…

This study tested whether a 4-week program using active video games (exergames) on the Nintendo Switch could help adults with mental illness feel better and stay motivated. Twelve participants were split into two groups: one played exergames, the other continued their usual routi…

This study tested whether a 6-week group therapy program (cognitive behaviour therapy) could help reduce anxiety and stress in pregnant women and new mothers. 72 women from Manitoba, Canada, who were pregnant or within 12 months postpartum and had an anxiety disorder took part. T…

This study tested whether a 6-session educational program could help people receiving electroconvulsive therapy (ECT) feel less stigma and anxiety about their mental health treatment. Sixty adult inpatients with conditions like depression or bipolar disorder took part. Those who …

This study tested a type of talk therapy called natural psychotherapy, based on Morita therapy and adapted for Chinese culture, in 80 adults with obsessive-compulsive disorder (OCD). The goal was to see if it could reduce OCD symptoms, measured by standard scales. Participants at…

This study tested a 30-minute web-based program for parents of children with anxiety who are waiting for cognitive behavioral therapy. The program aims to reduce how much parents accommodate their child's anxiety, which can make anxiety worse. Researchers recruited 47 parents and…

This study tested a brief virtual therapy called MAPP (Mindful Adaptive Practice in Pregnancy) to help pregnant women manage COVID-19-related anxiety. 69 women participated, comparing MAPP to usual care. The goal was to see if the therapy is feasible and acceptable, not yet to pr…

This study tested whether taking part in art activities like theatre, dance, visual arts, music, or cinema can improve mental health. 541 adults with psychiatric diagnoses were randomly assigned to either an art program or a waitlist. Researchers measured changes in depression an…

This completed Phase 1 trial tested transcranial direct current stimulation (tDCS) in 42 adults with obsessive-compulsive disorder (OCD). Participants received 10 sessions of either low-dose, higher-dose, or fake (sham) electrical stimulation over five days. The goal was to see i…

This study tested a type of therapy called Emotion Regulation Therapy - Attention Regulation (AR-ERT) to help people with obsessive-compulsive disorder, generalized anxiety disorder, or major depressive disorder who struggle with repetitive negative thinking. 65 adults in Massach…

This study tested a new anxiety program designed for autistic youth ages 7 to 17. The program was delivered in community care centers to make it more accessible. Researchers wanted to see if it was practical and helpful for reducing anxiety symptoms. The study involved 32 partici…

This study tested whether a gentle electrical current applied to the scalp (tDCS) can reduce symptoms of major depression, schizophrenia, OCD, generalized anxiety, and insomnia. 320 adults aged 16–65 received multiple sessions over weeks. Researchers measured symptom changes usin…

This study tested whether a non-invasive brain stimulation technique called TMS could reduce symptoms of obsessive-compulsive disorder (OCD) in 26 adults. The treatment targeted a brain area involved in movement planning. Researchers also looked for clues about how TMS works and …

This small study tested whether Epidiolex (a prescription CBD oil) can safely reduce symptoms of obsessive-compulsive disorder, hair-pulling, Tourette syndrome, and hoarding. Four adults took the drug for two weeks. The goal was to see if symptoms improved and if the drug was wel…

This study tested a 10-week peer support program called 'Paths to everyday life' for adults with mental health difficulties. Participants were randomly assigned to either the peer support group plus usual services, or usual services alone. The goal was to see if the program impro…

This study tested a new way of delivering care for people with anxiety and depression in Danish general practices. 302 adults with conditions like panic disorder, social anxiety, or PTSD took part. The model involved a team of doctors, nurses, and therapists working together, and…

This study tested two types of online therapy for anxiety and depression in 2477 adults. Participants received either a cognitive behavioral treatment or a psychodynamic treatment, delivered over 8 or 16 weeks, with or without a support forum. The goal was to see which combinatio…

This completed study tested a free mobile app called Ísland that uses artificial intelligence and virtual reality to help teens aged 13–19 manage anxiety. The app combines four proven therapies, offers private journaling, video group sessions, and VR exercises to face fears safel…

This completed Phase 2/3 trial tested whether adding troriluzole to standard antidepressant treatment can reduce OCD symptoms. 426 adults with moderate-to-severe OCD who had not responded well enough to their current medication took either troriluzole or a placebo for 12 weeks. T…

This study tested whether a stepped-care internet-based cognitive behavior therapy (ICBT) with reduced support is as effective as traditional group therapy for obsessive-compulsive disorder (OCD). 95 adults with moderate to severe OCD took part. The goal was to see if the online …

This study tested an 8-week mindfulness-based psychoeducation program in 50 adults diagnosed with anxiety disorders. Half took the program, half did not. Researchers measured changes in perceived stress, intolerance of uncertainty, and cognitive flexibility. The goal was to see i…

This study tested whether adding troriluzole to standard OCD treatment works better than a placebo. It involved 456 adults with OCD who hadn't fully responded to their current medication. The main goal was to see if troriluzole could further reduce OCD symptoms and improve daily …

This study tested a mobile app called GGOC-AD designed to reduce obsessive-compulsive disorder (OCD) symptoms in adolescents aged 15 to 18. The app presents statements that users accept or reject to challenge unhelpful beliefs linked to OCD. Researchers compared the app to a neut…

This study tested an online program called ALDER that teaches older adults skills to boost positive emotions and reduce anxiety. 33 people aged 65 and older who used benzodiazepines (anti-anxiety or sleep medications) at least twice a week took part. Over 5 weeks, they learned an…

This study tested a new, short, and intensive therapy called HANDS-ON for 12 teens (ages 10-18) with anxiety or obsessive-compulsive disorder (OCD) who hadn't improved with standard therapy. The treatment involved personalized exposure exercises done at home and school, with help…

This study tested whether virtual reality (VR) sessions can help reduce anxiety and depression in people aged 12 to 25 who do not want to take medication. Forty participants completed five weekly VR sessions focused on relaxation, coping skills, and healthy habits. Researchers me…

This study tested a single-session program for children ages 7 to 17 with anxiety and their parents. The program teaches kids how to manage anxious thoughts and feelings, and shows parents how to support them. Researchers wanted to see if this quick help could reduce anxiety symp…

This study tested a 10-session dog-assisted therapy program for 60 adults with severe mental illness. The goal was to see if spending time with trained therapy dogs could help participants build positive mental health behaviors like communication and socialization. Researchers me…

This study tested a treatment called repetitive Transcranial Magnetic Stimulation (rTMS) for Obsessive Compulsive Disorder (OCD). 30 adults with OCD received either real or fake (placebo) rTMS to see if it changes blood flow in a brain area linked to OCD. The goal was to understa…

This study tested whether taking part in art activities (like painting, music, or dance) can improve mental well-being. 382 people with mental health issues such as anxiety, depression, or emotional disorders were randomly assigned to either an art program or a waitlist. The stud…

This study tested whether adding cognitive behavioral therapy (CBT) to a gradual benzodiazepine taper helps patients with anxiety who also take prescription opioids reduce their benzodiazepine use. 42 primary care patients were randomly assigned to receive either CBT or a health …

This study tested a 6-week supervised physical activity program for university students dealing with mild-to-moderate mental health issues like stress, anxiety, or feeling isolated. Seventeen students took part in group exercise sessions including walking, aerobics, and strength …

This study tested a group version of a therapy program called the Unified Protocol for teens with emotional disorders like anxiety and depression. Thirty-one adolescents took part in 16 weekly group sessions at a public mental health center in Spain, along with three parent sessi…

This study tested whether a computerized training program that targets emotional reactions can help relieve obsessive thoughts and compulsive behaviors in people with OCD. Five adults with OCD completed 14 training sessions over three weeks. The goal was to see if this approach c…

This study looks at how the brains of children aged 9 to 12 with anxiety disorders respond to making mistakes. Researchers measure two types of brain activity: one after an error and one after a balance disturbance. Half of the children will use a 45-minute computer program desig…

This study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…

This study tested a web application called PRATICAdr 2.0, designed to help healthcare workers on sick leave due to common mental disorders like depression or anxiety return to work. The app helps coordinators track progress and improve communication. Researchers compared workers …

This study tested whether artificial intelligence (AI) can realistically simulate conversations between a therapist and a person with a mental health problem. Researchers used 520 simulated sessions to see if the AI could follow proper therapy techniques. The goal is to use these…

This study looked at how thinking skills and brain activity differ in people who self-harm compared to those who don't. Researchers interviewed 316 adults and gave them thinking tests, with some also having brain scans. The goal was to better understand self-harm to help create m…

This study looked at how electrical brain stimulation influences approach and avoidance behavior in 13 patients with deep brain stimulators for OCD, depression, or epilepsy. Participants played a computer task with their stimulator turned on and off. The goal was to understand br…

This study tested a program called Recovery Bridge, where trained peer specialists (people with lived experience of mental illness) helped veterans leaving a psychiatric hospital connect to outpatient care and community life. Fifteen veterans took part to see if the program was f…

This study looked at whether watching short science videos can change how adults with anxiety think about psychological therapy. 262 participants watched 30 minutes of educational videos and filled out surveys about their beliefs and expectations. The goal was to understand if sc…

This completed study looked at 400 people with both heart disease and a mental health condition (like depression or anxiety). Researchers used questionnaires, blood tests, and imaging to find shared risk factors and biological markers. The goal was to better understand how these …

This study tested whether an anti-stigma training program for healthcare providers improves attitudes toward people with mental illness or substance use problems. About 485 staff and clients from six health centers took part, with three centers receiving the training and three no…

This study looked at how often insomnia occurs in people hospitalized for psychiatric conditions. Researchers checked 427 patients at 11 hospitals in Switzerland and Germany. They also explored whether age, gender, or type of disorder made insomnia more likely.

This completed study surveyed 3,100 adults in Slovakia to find out how many people have mental disorders like depression, anxiety, PTSD, or addiction. Researchers used a standard interview tool to measure current and lifetime rates, and looked at who gets help and who doesn't. Th…

This study tested whether non-invasive brain stimulation combined with computer-based training can change brain activity and reduce compulsive behaviors in people with OCD. 203 adults with problematic compulsions participated. The goal was to understand how a specific brain regio…

This study tested a program called IPS-MA, which helps people with mood or anxiety disorders find and keep jobs or return to school. 326 adults who were unable to work within three months took part. The goal was to see if this support, added to their usual treatment, helped them …

This study tested an 8-month program called 'Meaningful Activities and Recovery' (MA&R) for people with mental illness. The program helps people take part in activities that matter to them. 139 adults took part to see if the program improves activity engagement, recovery, and qua…

This study looked at how attention and daydreaming influence obsessive thoughts in people with Obsessive Compulsive Disorder (OCD). Researchers compared 80 participants—some with OCD and some without—to see if obsessions change depending on how much the mind wanders. The goal was…

This study tested a program called iCOT to improve how occupational therapy interns communicate with patients in mental health settings. The program included online training and feedback from patients, supervisors, and experts. Researchers compared interns who received iCOT to da…

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This study tested a mobile app called esTOCma, a serious game designed to teach teachers about obsessive-compulsive disorder (OCD) and reduce stigma. 175 teachers used the app for 10 days or did nothing. Researchers measured changes in OCD knowledge, attitudes, and confidence in …

This study looked at how people with obsessive-compulsive disorder (OCD) balance between using habits and goal-directed thinking when making decisions. Researchers used brain scans and mild electrical stimulation to understand the brain circuits involved. The goal was to learn mo…

This study tested different parts of a family navigation program to see which ones work best for helping low-income and minority families get mental health services for their children. 312 children aged 3-12 who showed signs of behavioral health concerns took part. The goal was t…

This study used artificial intelligence to predict how engaged people would be in online therapy and how much their symptoms would improve. Researchers analyzed data from over 6,600 adults who took part in a digital psychotherapy program. The goal was to create fair and accurate …

This study created and tested a mobile app called VetEd for student veterans dealing with mental health issues like depression, PTSD, or anxiety. The goal was to help them manage academics, mental health, and find resources. Researchers worked with 13 veterans to see if the app w…

This study followed 559 children and teens ages 6 to 19 in the McLean Anxiety Mastery Program to see if their anxiety and depression improved with treatment. Researchers compared patients who received treatment to those on a waitlist and checked if gains lasted three months after…

This completed study looked at 224 adults who already had at least one psychiatric condition to see how many also had undiagnosed ADHD. Researchers measured how often ADHD was missed and tracked quality of life in those diagnosed. The goal is to highlight the need for better dete…

This study looked at whether using very low nicotine cigarettes along with nicotine-containing e-cigarettes can reduce harmful chemical exposure in smokers with mental health conditions. 88 participants were assigned to different combinations of cigarettes and e-cigarettes. The m…

This completed study at Massachusetts General Hospital tested whether a gentle brain stimulation technique called tDCS could help 86 adults with obsessive-compulsive disorder (OCD) unlearn fear responses. Participants received either real or fake (sham) stimulation while undergoi…

This study looked at how two different types of cognitive behavioral therapy (CBT) affect brain activity in people with obsessive-compulsive disorder (OCD). Thirty-five adults with OCD completed 15 therapy sessions and had brain scans before, during, and after treatment. The goal…