Brain zapping and training may unlock secrets of OCD

NCT ID NCT04580043

Completed Knowledge-focused Sponsor: Rebecca Price Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether non-invasive brain stimulation combined with computer-based training can change brain activity and reduce compulsive behaviors in people with OCD. 203 adults with problematic compulsions participated. The goal was to understand how a specific brain region (the orbitofrontal cortex) is involved in compulsive habits, which could lead to better treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial Magnetic Stimulation (brain stimulation) and computerized brain training
What this could lead to: If successful, this research could point toward new ways to treat compulsive behaviors by targeting specific brain regions.
What could go wrong: This is an early-stage study focused on understanding brain mechanisms, not testing a treatment. The results may not lead directly to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Compulsive Behavior obsessive-compulsive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMPULSIVE BEHAVIOR OBSESSIVE-COMPULSIVE DISORDER

Contacts and locations

Locations

Western Psychiatric Institute and Clinic

Pittsburgh, Pennsylvania, 15213, United States

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