Intervertebral disk degenerative disorder

This study tests a hydrogel implant injected into damaged spinal discs to treat degenerative disc disease. About 225 adults with chronic low back pain will receive either the implant or standard care like physical therapy. The goal is to see if the implant safely improves pain an…

This study tests a one-time injection called VIA Disc NP for people with long-term low-back pain caused by disc disease. The injection adds material to the damaged disc to help cushion it. About 496 adults will receive either the real injection or a sham procedure, and researcher…

This study compares a new spine cage device (MDT-0123) to a standard bone graft for patients needing two-level spinal fusion in the lower back. About 140 adults with disc degeneration or spinal deformity will be enrolled in Japan. The main goal is to see if the device leads to be…

This Phase 3 trial tests whether a single injection of IDCT (rebonuputemcel), a cell therapy, can safely reduce pain and disability in people with mild to moderate lumbar disc degeneration. About 162 adults with chronic low back pain will receive either the cell injection or a sh…

This study is testing a new synthetic bone graft called FIBERGRAFT Aeridyan Matrix in people having lumbar spine fusion surgery. The graft is designed to help the bones heal together. Researchers will compare it to standard grafts in 316 participants across the US to see if it le…

This trial compares two bone graft materials used during spinal fusion surgery: ViviGen, a cellular bone matrix, and rhBMP-2, a protein that stimulates bone growth. The goal is to see if ViviGen helps bones fuse together as effectively as rhBMP-2. Adults aged 18-70 with certain s…

This study tests a new device called LDGraft, which contains a protein that helps bone grow, for people with degenerative disc disease needing spinal fusion. Forty adults aged 22 to 80 will be randomly assigned to receive either LDGraft or standard bone graft during surgery. The …

This study tests a new material called Novosis Putty used during spinal fusion surgery for people with degenerative disc disease in the lower back. The putty is meant to help the bones fuse together more successfully. About 316 adults who have not improved with other treatments w…

This study is tracking 200 adults who receive the Ennovate Cervical Spinal System, a metal implant used to stabilize the neck and upper back after fractures, disc disease, or tumors. Researchers will measure changes in pain and quality of life over time. The goal is to confirm th…

This study tests whether adding a bone-marrow concentrate injection during routine back surgery helps the spinal disc heal better. About 90 adults with a herniated disc will get either surgery alone or surgery plus the injection. Researchers will use MRI scans and pain questionna…

This study tests a new disc implant called PerQdisc for people with chronic low back pain from degenerative disc disease. The implant is placed in the spine after removing the damaged disc material. Researchers will track 72 participants to see if the implant improves pain and fu…

This study compares two bone graft materials used in spine fusion surgery for patients with degenerative disc disease and back or leg pain. One is a synthetic material called MagnetOs Flex Matrix, and the other is a donor-based graft called Trinity Elite. About 100 adults will be…

This study is following over 5,200 people who have had or will have spine surgery using Stryker devices, such as spinal fusion or deformity correction. The goal is to see how well these devices improve pain and function, and to track any side effects or complications. Participant…

This study tests whether carbon fiber screws work as well as titanium ones for spinal fusion in people with degenerative disc disease. Carbon fiber allows clearer MRI and CT scans after surgery, which may help doctors monitor healing better. About 118 adults needing one or two le…

This early-stage trial tests whether a person's own disc cells, grown in a lab and injected back into the damaged disc, can safely treat degenerative disc disease. Twelve adults with disc herniation and persistent back pain will receive one injection of these cells. Researchers w…

This study tests a synthetic bone graft material called MagnetOs Easypack Putty in people having spinal fusion surgery for back pain or spine instability. The putty is used alone to help bones fuse together. Researchers want to see if it works as well as or better than current tr…

This study is testing the safety and performance of a spinal implant called the Hexanium TLIF system in adults with degenerative disc disease. The implant is placed during surgery to fuse the spine and restore disc height. Researchers will track pain, disability, and any serious …

This study compares two bone substitutes used during spinal fusion surgery for disc degeneration. One is a new material designed to help bones fuse more effectively. Researchers will track 100 adults for 12 months to see if the new substitute improves pain, disability, and fusion…

This study compares two FDA-approved artificial disc implants used in neck surgery for conditions like herniated discs or arthritis. Twenty adults aged 18 to 60 will be randomly assigned to receive either the Biomet Zimmer Mobi-C or Nuvasive Simplify implant. Researchers will mea…

This study is testing two medical devices—conduit cages and Fibergraft—used together in spine surgery for people with degenerative disc disease or herniated discs. The cages help restore space between vertebrae, while Fibergraft is designed to support natural bone healing. Resear…

This study is testing a moldable bone graft material called OssiMend Bioactive Moldable in people having lumbar spine fusion surgery for degenerative disc disease. The goal is to see if it helps the bones fuse together successfully and reduces pain and disability. About 120 adult…

This early-stage study tests whether a new drug called EC5026 is safe and can reduce nerve pain in people with spinal cord injury. About 36 adults with pain from traumatic or non-traumatic spinal cord injury will take either the drug or a placebo daily for 14 days. Researchers wi…

This study compares two minimally invasive spine surgeries (Mini-TLIF and MIDLIF) for people with chronic low back pain from disc disease. 100 adults who haven't improved with other treatments will be randomly assigned to one surgery and followed for a year. The goal is to see wh…

This study looks at whether avoiding opioids during back surgery can still control pain and reduce side effects like nausea and constipation. About 75 adults having elective lumbar spine surgery will be placed into one of three groups based on their anesthesia plan. The goal is t…

This study tests whether a nerve block called an erector spinae plane block can help control pain and reduce the need for opioid painkillers after minimally invasive lumbar spine surgery. About 125 adults having specific types of back surgery will receive either the nerve block o…

This study tests whether giving a single dose of the steroid dexamethasone just before minimally invasive spine fusion surgery can lower back pain afterward and reduce the need for strong painkillers like morphine. Sixty adults aged 50–80 having one- or two-level spine fusion wil…

This study aims to find out if spinal fusion surgery truly helps people with long-term low back pain. Ninety adults with severe, persistent pain will undergo surgery, but half will receive a placebo procedure without fusion. Neither the patients nor their care team will know whic…

This study looks at two ways to fix a damaged disc in the neck: using a bone graft with a metal plate or a special titanium cage. Researchers will check how well the bones fuse together and track any problems. About 60 adults with degenerative disc disease will take part, and the…

This study will check if a protein called periostin in the blood is related to how much back pain limits daily activities and quality of life. Researchers will measure periostin in 38 adults with lumbar disc problems and compare it to their scores on disability and health questio…

This registry is following 450 adults undergoing spine fusion surgery who receive an OssDsign bone graft substitute. The goal is to see how well the bones fuse together and how patients' quality of life changes over time. It is an observational study, meaning no new treatment is …

This study looks at how inhaled cannabis affects the brain in people with chronic low back pain. Researchers will use MRI scans to measure changes in brain blood flow and oxygen levels, and ask participants to rate their pain. The goal is to understand the brain mechanisms behind…

This study is tracking 561 people who have already had spine surgery using METROSAN spinal implants and BONEGRAFT bone fillers. Researchers want to see how well these devices work and if any new safety issues pop up over a year. It's an observational study, meaning patients get s…

This study follows 5,000 adults with spinal conditions to track their pain, work status, and quality of life over time. Participants fill out questionnaires before and after treatment. The goal is to learn which treatments work best for different types of spinal disease.

This study follows 330 adults who have received SpineVision spinal implants (Lumis, Plus, or Ulis) as part of their standard care for degenerative disc disease. Researchers will track pain, disability, and any side effects for up to 24 months after surgery to confirm the implants…

This study uses a smartphone app to track how patients feel before and after neurosurgery for conditions like disc disease, spine instability, brain tumors, or aneurysms. Researchers aim to understand normal recovery patterns and how complications affect well-being. 400 adults wh…

This study aims to create a realistic 3D bioprinted model of a spinal disc using human cells from five patients undergoing spine surgery. Researchers will compare the gene activity of cells in the model to real disc cells to see how well the model mimics the body. The goal is to …