Hypertrophic cardiomyopathy

This phase 2 trial tests whether a single dose of LX2006 gene therapy can improve heart muscle thickening and damage in people with Friedreich ataxia, a genetic disorder that often leads to life-threatening cardiomyopathy. Participants aged 6 and older with confirmed heart enlarg…

This study is testing a drug called mavacamten in adults with a type of heart disease called obstructive hypertrophic cardiomyopathy (HOCM) in Japan. The goal is to see if mavacamten can improve heart function and symptoms when added to their current treatment. About 36 participa…

This study looks at how well the drug mavacamten works for Chinese adults with obstructive hypertrophic cardiomyopathy, a condition where the heart muscle is too thick. About 500 people will be followed in regular clinic settings. The main goal is to see if the drug improves bloo…

This study looks at whether the heart medication Camzyos (Mavacamten) can improve blood flow to the heart muscle in people with hypertrophic obstructive cardiomyopathy (HOCM). Researchers will use special PET-CT scans to measure blood flow before and after 12 months of treatment.…

This study looks at whether people with a type of heart disease called obstructive hypertrophic cardiomyopathy can safely switch from one medication (mavacamten) to another (aficamten). The goal is to keep the heart working better and reduce symptoms. About 40 adults who are alre…

This study tests a gene therapy called RP-A501 in 14 males with Danon disease, a rare genetic condition that causes heart problems. The treatment uses a harmless virus to deliver a working copy of the LAMP2 gene, aiming to improve heart muscle function and reduce thickening. Part…

This study tests a medicine called ademetionine in 44 adults with a heart condition that blocks blood flow. Participants will take either the medicine or a placebo for 16 weeks. Researchers will check if it helps with exercise, symptoms, and heart function.

This study tests a new gene therapy called TN-201 in 30 adults with hypertrophic cardiomyopathy caused by a specific genetic mutation (MYBPC3). The therapy is given as a one-time IV infusion and aims to correct the underlying genetic defect. The main goals are to check safety and…

This early study tests whether sotagliflozin, a drug already used for heart failure, can help people with a type of hypertrophic cardiomyopathy that doesn't block blood flow. Twenty-six adults will take the drug or a placebo for 12 weeks, then switch, to see if it improves exerci…

This study monitors the real-world safety and effectiveness of mavacamten in about 200 people in Japan who have obstructive hypertrophic cardiomyopathy, a condition where the heart muscle thickens and blocks blood flow. Participants will be followed to track any side effects and …

This study compares a new pacing method (left bundle branch pacing) with a standard pacemaker-defibrillator in 30 people who have hypertrophic cardiomyopathy and a specific heart block after myectomy surgery. The goal is to see if the new method better prevents heart failure wors…

This study tests a new procedure that uses radiofrequency energy to reduce thickened heart muscle in people with obstructive hypertrophic cardiomyopathy. About 124 adults with symptoms like chest pain or shortness of breath will be randomly assigned to receive the active procedur…

This study is checking the long-term safety of a drug called HRS-1893 in 300 people with hypertrophic cardiomyopathy, a condition where the heart muscle thickens. Participants have already taken HRS-1893 in earlier studies. The main goal is to see how many side effects occur and …

This study tests whether a new radioactive dye, 68Ga-FAPI, can spot active scarring in the heart muscle using PET-MR scans. Researchers will scan about 290 people with various heart muscle conditions, such as heart failure with preserved ejection fraction, hypertrophic cardiomyop…

This study looks at tissue removed during back surgery to find early signs of a heart condition called ATTR cardiac amyloidosis. Researchers will test spine samples from 1,663 older adults for abnormal protein deposits. If found, participants will get further heart tests to confi…

This study explores whether a quick, painless cheek swab can spot protein changes linked to inherited heart conditions that cause sudden cardiac death in young people. Researchers will collect samples from 26 patients with arrhythmic disorders or family members at risk. If the te…

This study tests whether artificial intelligence can help doctors interpret echocardiograms (heart ultrasounds) more accurately and quickly. Researchers at Mayo Clinic will deploy AI algorithms to flag signs of genetic cardiomyopathy, ischemic heart disease, and cardiac amyloidos…

This study tests a new radioactive dye called 68Ga-NI-FAPI for PET/CT scans. It aims to better detect diseases like tumors, heart problems, and lung scarring by targeting a protein linked to tissue damage. About 30 people, including healthy volunteers and patients, will take part…

This study uses artificial intelligence to analyze standard electrocardiograms (ECGs) to accurately diagnose hypertrophic cardiomyopathy (HCM), a condition where the heart muscle thickens. The AI will also help tell HCM apart from other diseases that look similar, like high blood…

This study tests new, faster MRI techniques to get detailed images of the heart muscle in people with heart conditions like cardiomyopathy, myocarditis, and ischemic heart disease. The goal is to improve diagnosis and treatment planning. About 240 adults who already need a heart …

This study tests whether the blood thinner rivaroxaban can prevent strokes, heart attacks, and death in people with hypertrophic cardiomyopathy (HCM) who have early signs of atrial damage but normal heart rhythm. About 532 adults aged 40-80 with HCM and reduced left atrial strain…

This study looks at whether giving children with hypertrophic cardiomyopathy (a condition where the heart muscle is thicker than normal) a personalized exercise plan is safe and helpful. Ten children aged 10 to 18 will receive an exercise prescription from a physiotherapist and b…

This study tests a drug called ninerafaxstat in people with a type of heart muscle disease that makes the heart stiff and causes symptoms like shortness of breath and fatigue. The trial involves 165 participants who will receive either the drug or a placebo. The main goal is to s…

This study looks at whether adding a structured exercise program is safe and helpful for people with hypertrophic obstructive cardiomyopathy who are already taking the drug mavacamten. About 24 adults with mild symptoms will either do supervised endurance and strength training fo…

This study tests whether 24 weeks of moderate exercise (three 60-minute sessions per week) can improve symptoms and heart function in people with hypertrophic cardiomyopathy, a condition where the heart muscle is thickened. About 70 participants will be randomly assigned to eithe…

Researchers are following 3,000 Chinese adults with hypertrophic cardiomyopathy, a condition that thickens the heart muscle and can disrupt blood flow. The study records how patients are treated in everyday hospitals and tracks health events such as stroke, heart failure hospital…

This study will look at 40 people with both hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF) to understand why AF is more common and harder to treat in HCM. Researchers will measure electrical signals in the heart and use advanced imaging. The goal is to find clues …

This study is a large registry that will follow about 1,700 people with obstructive hypertrophic cardiomyopathy in the US and Europe. Researchers will track how patients respond to mavacamten or other standard treatments in real-world settings, focusing on safety and effectivenes…

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study is looking at whether advanced heart imaging, especially cardiac MRI, can help identify the cause of cardiomyopathy and predict risks like death or heart failure in a diverse group of patients. The research focuses on adults in the Bronx, including many from Hispanic a…

This registry tracks 2,000 adults with congenital heart disease who are on the waiting list for a heart or heart-lung transplant. The goal is to understand why some patients get worse or die while waiting, while others improve enough to be removed from the list. By collecting dat…

This study tests a new PET scan technique to better track heart damage in people with a condition called ATTR-CM, a progressive heart muscle disease. Researchers will scan 140 participants to see if the imaging can show how well treatments are working. The goal is to improve moni…

This study aims to uncover the genetic causes of cardiomyopathy in children by analyzing DNA from affected individuals and their families. Researchers hope to identify mutations that lead to different types of cardiomyopathy, which could improve genetic counseling and deepen unde…

This study is building a registry of 1,211 people in Brazil who have inherited heart conditions like cardiomyopathy, arrhythmias, and Marfan syndrome. Researchers will collect DNA samples and medical information to discover which genes are most commonly affected and how often the…

This study is a national registry in the UK that collects health information from 2500 people with hypertrophic cardiomyopathy (HCM), a common inherited heart condition. Researchers will gather data from medical records, heart scans, blood tests, and genetics to better understand…

This study is looking for new genes and blood markers linked to arrhythmogenic cardiomyopathy (AVC), a genetic heart condition that can lead to heart failure and sudden cardiac arrest. Researchers will enroll 1,000 people, including patients with AVC or unexplained cardiac arrest…

This study is following about 362 adults with a type of heart disease called obstructive hypertrophic cardiomyopathy who are taking the drug mavacamten. Researchers want to see how the drug works in real doctor's offices, not just in strict research settings. They will track thin…

This study is building a large online registry of 10,000 adults with cardiomyopathy or myocarditis, plus those with a strong family history. Researchers will track participants over time to see how many experience serious events like heart failure, dangerous heart rhythms, or dea…

This study is testing whether a non-invasive blood pressure monitor can accurately detect blockages in the heart's main pumping chamber in people with hypertrophic cardiomyopathy (HCM). Researchers will compare blood pressure readings with standard invasive measurements in 800 ad…

This study follows up on people with hypertrophic cardiomyopathy (HCM), a genetic condition that thickens the heart muscle. Researchers want to see how scarring in the heart (called late gadolinium enhancement, or LGE) changes over at least 7 years and whether it predicts serious…

This study looks back at medical records of 100 children with a genetic condition called RASopathy that causes severe heart thickening and heart failure. Researchers want to collect detailed information on how the disease progressed in the past. This will help design future studi…

This study uses advanced heart MRI scans to look at blood flow patterns in people with different types of hypertrophic cardiomyopathy (thick heart muscle), including rare forms like Anderson-Fabry disease and cardiac amyloidosis. Researchers will also study first-degree relatives…

This early-phase study tests a new MRI method that uses a special injection called hyperpolarized pyruvate to see how the heart uses energy. Researchers will scan the hearts of up to 112 people with high blood pressure, heart thickening, or heart failure. The goal is to see if th…

This study looks at heart tissue samples from 216 adults who already need a biopsy as part of their care. Researchers want to find unique molecular patterns in different heart conditions, including after a heart transplant. The goal is to improve how these diseases are diagnosed …

This study will use cardiac MRI scans to measure heart tissue in 2000 people with various heart conditions, such as heart attacks, cardiomyopathies, and myocarditis. The goal is to create a reference map of normal and abnormal tissue values, which may help doctors diagnose diseas…

This study is creating a large database to collect information on people with rare diseases like amyloidosis, sarcoidosis, and Gaucher disease. Researchers will track patients' health over time, including their symptoms, treatments, and outcomes. The goal is to improve diagnosis …

This pilot study is testing a new type of PET/CT scan that uses a radioactive tracer called 68Ga-FAPI to detect active scarring (fibrosis) in the hearts of 30 people with heart failure. The goal is to see if this scan can spot early or ongoing scarring better than current MRI met…

This study is a registry that will collect health information from 1000 people with hypertrophic cardiomyopathy (HCM) across Austria. Researchers will track symptoms, medical history, test results, and genetics to better understand the disease and improve future care. Participant…

This observational study is looking at the safety of the heart medication mavacamten when taken during pregnancy or while breastfeeding. Researchers will follow about 20 people who have taken at least one dose of mavacamten during pregnancy or breastfeeding, tracking outcomes for…

This study looks at 20 people with hypertrophic obstructive cardiomyopathy who are already on optimal medical therapy. Researchers want to see if changes in heart blood flow over one year are linked to changes in how far they can walk in six minutes. Participants will have two he…