Heart drug mavacamten under the microscope: new registry tracks Real-Life results

NCT ID NCT05489705

Recruiting now Knowledge-focused Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is a large registry that will follow about 1,700 people with obstructive hypertrophic cardiomyopathy in the US and Europe. Researchers will track how patients respond to mavacamten or other standard treatments in real-world settings, focusing on safety and effectiveness. The goal is to better understand long-term outcomes and treatment patterns outside of controlled clinical trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mavacamten
What this could lead to: If successful, this study could provide a clearer picture of how well mavacamten works and its safety in everyday medical practice for people with obstructive hypertrophic cardiomyopathy.
What could go wrong: This is an observational registry, not a controlled trial, so it cannot prove cause and effect. Results may be influenced by differences in patient care and reporting across sites.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

heart failure hypertrophic cardiomyopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY

Contacts and locations

Locations

AHN Allegheny General Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Alaska Heart Institute
RECRUITING

Anchorage, Alaska, 99508, United States
BI Research Center
RECRUITING

Houston, Texas, 77084, United States
Bassett Medical Center
RECRUITING

Cooperstown, New York, 13326, United States
Baylor Scott & White Medical Centre - Temple
RECRUITING

Temple, Texas, 76508, United States
Baylor Scott & White Research Institute
RECRUITING

Dallas, Texas, 75246, United States
Baylor Scott & White The Heart Hospital Plano
RECRUITING

Plano, Texas, 75093, United States
CHI Health Reseach Center
RECRUITING

Omaha, Nebraska, 68124, United States
CHU Amiens-Picardie
RECRUITING

Amiens, Somme, 80054, France
CHU De Poitiers - Hopital De La Miletrie
RECRUITING

Poitiers, Vienne, 86000, France
CHU Nantes Hopital Nord Laennec
RECRUITING

Saint-Herblain, Loire Atlantique, 44800, France
Cardiology Associates Research, Llc
RECRUITING

Tupelo, Mississippi, 38801, United States
Carilion Clinic; Virginia Tech-Carilion School of Medicine
RECRUITING

Roanoke, Virginia, 24014, United States
Centre Hospitalier Haguenau
RECRUITING

Haguenau, Bas Rhin, 67500, France
Christ Hospital Health Network
RECRUITING

Cincinnati, Ohio, 45219, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Duke University Health System
RECRUITING

Durham, North Carolina, 27710, United States
Focus Clinical Research
RECRUITING

Charlotte, North Carolina, 28207, United States
Franciscan Physician Network-Indiana Heart Physicians
RECRUITING

Indianapolis, Indiana, 46237, United States
Geisinger Health System
RECRUITING

Wilkes-Barre, Pennsylvania, 18711, United States
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Hartford HealthCare
RECRUITING

Hartford, Connecticut, 06106, United States
Harvard (Massachusetts General Hospital)
RECRUITING

Boston, Massachusetts, 02114, United States
Harvard Medical School - Brigham and Women's Hospital (BWH)
RECRUITING

Boston, Massachusetts, 02215, United States
Henry Ford Health System
RECRUITING

West Bloomfield, Michigan, 48322, United States
Hospital Clinico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital Clinico Universitario Virgen de La Victoria
RECRUITING

Málaga, 29010, Spain
Hospital Fundacion Son Llatzer
RECRUITING

Palma de Mallorca, Balearic Islands, 07198, Spain
Hospital Universitario Central de Asturias
RECRUITING

Oviedo, Principality of Asturias, 33011, Spain
Hospital Universitario Puerta de Hierro Majadahonda
RECRUITING

Majadahonda, Madrid, 28222, Spain
Hospital Universitario Virgen de La Arrixaca
RECRUITING

El Palmar, Murcia, 30120, Spain
Hospital Universitario de Burgos
RECRUITING

Burgos, 09006, Spain
Hôpital Saint Vincent-de-Paul
RECRUITING

Lille, Nord, 59000, France
Hôpital Sainte Musse
RECRUITING

Toulon, Var, 83000, France
Immanuel Klinikum Bernau
RECRUITING

Bernau, State of Berlin, 16321, Germany
Imperial College Healthcare NHS Trust
RECRUITING

London, Greater London, W6 8RF, United Kingdom
Indiana. University
RECRUITING

Indianapolis, Indiana, 46202, United States
KH St.Josef Braunau am Inn
RECRUITING

Braunau am Inn, 5280, Austria
Kardiologische und angiologische Praxen im Spreebogen
RECRUITING

Berlin, 10719, Germany
Keck School of Medicine of USC-Usc
RECRUITING

Los Angeles, California, 90033, United States
Kepler Universitätsklinikum Linz
RECRUITING

Linz, 4021, Austria
LKH-Univ. Klinikum Graz
RECRUITING

Graz, 8036, Austria
Lancaster General Hospital
RECRUITING

Lancaster, Pennsylvania, 17603, United States
Leeds General Infirmary
RECRUITING

Leeds, West Yorkshire, LS1 3EX, United Kingdom
Liverpool Heart and Chest Hospital
RECRUITING

Liverpool, Merseyside, L14 3PE, United Kingdom
Local Institution - 0083
NOT_YET_RECRUITING

Vienna, 1090, Austria
Local Institution - 0084
WITHDRAWN

Klagenfurt, 9020, Austria
Local Institution - 0085
NOT_YET_RECRUITING

Sankt Pölten, 3100, Austria
Local Institution - 0088
NOT_YET_RECRUITING

Innsbruck, 6020, Austria
Local Institution - 0101
WITHDRAWN

Erlangen, Bavaria, 91054, Germany
Local Institution - 0102
WITHDRAWN

Madrid, 28007, Spain
Local Institution - 0113
NOT_YET_RECRUITING

London, Greater London, SW3 6NP, United Kingdom
Local Institution - 0117
WITHDRAWN

Montpellier, 34000, France
MedStar Health Research Institute
RECRUITING

Baltimore, Maryland, 21218, United States
MedStar Washington Hospital Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Medical College of Wisconsin, Inc (PI Address)
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Minneapolis Heart Institute Foundation
RECRUITING

Minneapolis, Minnesota, 55407, United States
Morristown Medical Center
RECRUITING

Morristown, New Jersey, 07960, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
Mount Sinai West
RECRUITING

New York, New York, 10019, United States
North Texas Cardiology Center
RECRUITING

Dallas, Texas, 75208, United States
Northwell Health
RECRUITING

Manhasset, New York, 11030, United States
Ostalb-Klinikum Aalen
RECRUITING

Aalen, Baden-Wurttemberg, 73430, Germany
Pima Heart and Vascular
RECRUITING

Tucson, Arizona, 85704, United States
Praxisklinik Herz Und Gefasse-Klinikum Weisser Hirsch
RECRUITING

Dresden, Saxony, 01099, Germany
Prisma Health - Upstate
RECRUITING

Greenville, South Carolina, 29605, United States
Research & Cardiovascular Corp
RECRUITING

Ponce, 00717-1322, Puerto Rico
Saint Francis Hospital
RECRUITING

Roslyn, New York, 11576, United States
Saint Thomas Health
RECRUITING

Nashville, Tennessee, 37205-2018, United States
Spectrum Health Medical Group
RECRUITING

Grand Rapids, Michigan, 49525, United States
St. Luke's Mid-America Heart Institute
RECRUITING

Kansas City, Missouri, 64111, United States
St. Luke's University Health Network
RECRUITING

Bethlehem, Pennsylvania, 18015, United States
Stanford Health Care Hospital & Clinics
RECRUITING

Palo Alto, California, 94304, United States
The Methodist Hospital, Methodist Cancer Cencer
RECRUITING

Houston, Texas, 77030, United States
The Rector and Visitors of the Univ of Virginia
RECRUITING

Charlottesville, Virginia, 22908, United States
Tristar Centennial Medical Ctr
RECRUITING

Nashville, Tennessee, 37203, United States
UAMS
RECRUITING

Little Rock, Arkansas, 72205-7199, United States
UC Denver, AMC
RECRUITING

Aurora, Colorado, 48377, United States
UC San Diego School of Medicine
RECRUITING

La Jolla, California, 92037, United States
Uf Health Jacksonville
RECRUITING

Jacksonville, Florida, 32209, United States
Universitaetsklinikum Leipzig Aoer
RECRUITING

Leipzig, Saxony, 04103, Germany
Universitatsklinikum Muenster
RECRUITING

Münster, North Rhine-Westphalia, 48149, Germany
University Hospital of Wales
RECRUITING

Cardiff, CF14 4XW, United Kingdom
University Hospitals Birmingham NHS Foundation Trust
RECRUITING

Birmingham, West Midlands, B15 2GW, United Kingdom
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University Of California San Francisco Medical Center
RECRUITING

San Francisco, California, 94117, United States
University Of Kansas Medical Center & Medical Pavilion
RECRUITING

Kansas City, Kansas, 66160, United States
University Of Manchester
RECRUITING

Manchester, Greater Manchester, M13 9WL, United Kingdom
University Of Maryland, Ihv
RECRUITING

Baltimore, Maryland, 21201, United States
University Of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University Of Wisconsin - Madison
RECRUITING

Madison, Wisconsin, 53792, United States
University of Chicago Dept of Medicine
RECRUITING

Chicago, Illinois, 60637, United States
University of Hawaii Cancer Center
RECRUITING

Honolulu, Hawaii, 96813, United States
University of Iowa Hospitals & Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
VCU Medical Center
RECRUITING

Richmond, Virginia, 23298, United States
Virginia Mason Medical Center
RECRUITING

Seattle, Washington, 98101, United States
WMCHealth Advanced Physician Services
RECRUITING

Valhalla, New York, 10595, United States
WVU Hospitals
RECRUITING

Morgantown, West Virginia, 26506, United States
Washington University
RECRUITING

St Louis, Missouri, 63110, United States

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