New drug aims to ease symptoms of stiff heart muscle

NCT ID NCT07023614

Recruiting now Symptom relief Sponsor: Imbria Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests a drug called ninerafaxstat in people with a type of heart muscle disease that makes the heart stiff and causes symptoms like shortness of breath and fatigue. The trial involves 165 participants who will receive either the drug or a placebo. The main goal is to see if the drug improves quality of life and exercise ability.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ninerafaxstat
What this could lead to: If successful, this could lead to a new treatment option that eases symptoms and improves daily life for people with this type of heart disease.
What could go wrong: This is a mid-stage trial with only 165 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypertrophic cardiomyopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Imbria Investigational Site
RECRUITING

La Jolla, California, 92037, United States
Imbria Investigational Site
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Los Angeles, California, 90048, United States
Imbria Investigational Site
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San Francisco, California, 94143, United States
Imbria Investigational Site
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Washington D.C., District of Columbia, 20010, United States
Imbria Investigational Site
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Miami, Florida, 33136, United States
Imbria Investigational Site
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Chicago, Illinois, 60611, United States
Imbria Investigational Site
NOT_YET_RECRUITING

Oak Lawn, Illinois, 60453, United States
Imbria Investigational Site
RECRUITING

Baltimore, Maryland, 21218, United States
Imbria Investigational Site
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Boston, Massachusetts, 02114, United States
Imbria Investigational Site
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Burlington, Massachusetts, 01805, United States
Imbria Investigational Site
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Grand Rapids, Michigan, 49503, United States
Imbria Investigational Site
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Rochester, Minnesota, 55905, United States
Imbria Investigational Site
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St Louis, Missouri, 63110, United States
Imbria Investigational Site
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New York, New York, 10016, United States
Imbria Investigational Site
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Charlotte, North Carolina, 28204, United States
Imbria Investigational Site
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Portland, Oregon, 97239, United States
Imbria Investigational Site
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Philadelphia, Pennsylvania, 19104, United States
Imbria Investigational Site
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Philadelphia, Pennsylvania, 19107, United States
Imbria Investigational Site
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Houston, Texas, 77030, United States
Imbria Investigational Site
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Plano, Texas, 75093, United States
Imbria Investigational Site
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Charlottesville, Virginia, 22903, United States
Imbria Investigational Site
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Richmond, Virginia, 23298, United States
Imbria Investigational Site
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Graz, 8036, Austria
Imbria Investigational Site
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Edegem, 2650, Belgium
Imbria Investigational Site
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Montpellier, 34295, France
Imbria Investigational Site
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Paris, 75015, France
Imbria Investigational Site
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Saint-Herblain, 44800, France
Imbria Investigational Site
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Bad Oeynhausen, 32545, Germany
Imbria Investigational Site
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Göttingen, 37075, Germany
Imbria Investigational Site
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Heidelberg, 69120, Germany
Imbria Investigational Site
NOT_YET_RECRUITING

Jena, 07747, Germany
Imbria Investigational Site
RECRUITING

Florence, 50139, Italy
Imbria Investigational Site
RECRUITING

Massa, 54100, Italy
Imbria Investigational Site
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Milan, 20131, Italy
Imbria Investigational Site
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Milan, 20146, Italy
Imbria Investigational Site
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Milan, 20162, Italy
Imbria Investigational Site
RECRUITING

Naples, 80131, Italy
Imbria Investigational Site
RECRUITING

Amsterdam-Zuidoost, 1105 AZ, Netherlands
Imbria Investigational Site
NOT_YET_RECRUITING

Leiden, 2333ZC, Netherlands
Imbria Investigational Site
NOT_YET_RECRUITING

Nijmegen, 6525 GA, Netherlands
Imbria Investigational Site
RECRUITING

Rotterdam, 3015 AA, Netherlands
Imbria Investigational Site
RECRUITING

Katowice, 40-555, Poland
Imbria Investigational Site
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Warsaw, 02-507, Poland
Imbria Investigational Site
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Wroclaw, 53-114, Poland
Imbria Investigational Site
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Guimarães, 4835-044, Portugal
Imbria Investigational Site
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Lisbon, 1169-024, Portugal
Imbria Investigational Site
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Lisbon, 1500-650, Portugal
Imbria Investigational Site
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Barcelona, Barcelona, 08035, Spain
Imbria Investigational Site
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A Coruña, Galicia, 15006, Spain
Imbria Investigational Site
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Madrid, Madrid, 28034, Spain
Imbria Investigational Site
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Vigo, Pontevedra, 36312, Spain
Imbria Investigational Site
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Seville, Sevilla, 41009, Spain
Imbria Investigational Site
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Seville, Sevilla, 41013, Spain
Imbria Investigational Site
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Barcelona, 8036, Spain
Imbria Investigational Site
RECRUITING

Barcelona, 8041, Spain
Imbria Investigational Site
RECRUITING

Barcelona, 8907, Spain
Imbria Investigational Site
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El Palmar, 30120, Spain
Imbria Investigational Site
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Madrid, 28222, Spain
Imbria Investigational Site
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Palma de Mallorca, 07198, Spain
Imbria Investigational Site
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Salamanca, 37007, Spain
Imbria Investigational Site
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Valencia, 03010, Spain
Imbria Investigational Site
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Valencia, 46026, Spain
Imbria Investigational Site
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London, England, W12 0HS, United Kingdom
Imbria Investigational Site
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Glasgow, Scotland, G51 4TF, United Kingdom
Imbria Investigational Site
RECRUITING

London, EC1A 7BE, United Kingdom
Imbria Investigational Site
RECRUITING

London, SW3 6HP, United Kingdom
Imbria Investigational Site
RECRUITING

Oxford, OX3 9DU, United Kingdom

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