New drug aims to ease symptoms of stiff heart muscle
NCT ID NCT07023614
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests a drug called ninerafaxstat in people with a type of heart muscle disease that makes the heart stiff and causes symptoms like shortness of breath and fatigue. The trial involves 165 participants who will receive either the drug or a placebo. The main goal is to see if the drug improves quality of life and exercise ability.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ninerafaxstat
What this could lead to
If successful, this could lead to a new treatment option that eases symptoms and improves daily life for people with this type of heart disease.
What could go wrong
This is a mid-stage trial with only 165 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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Imbria Investigational Site
RECRUITINGLa Jolla, California, 92037, United States
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Imbria Investigational Site
RECRUITINGLos Angeles, California, 90048, United States
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Imbria Investigational Site
RECRUITINGSan Francisco, California, 94143, United States
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Imbria Investigational Site
RECRUITINGWashington D.C., District of Columbia, 20010, United States
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Imbria Investigational Site
RECRUITINGMiami, Florida, 33136, United States
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Imbria Investigational Site
RECRUITINGChicago, Illinois, 60611, United States
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Imbria Investigational Site
NOT_YET_RECRUITINGOak Lawn, Illinois, 60453, United States
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Imbria Investigational Site
RECRUITINGBaltimore, Maryland, 21218, United States
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Imbria Investigational Site
RECRUITINGBoston, Massachusetts, 02114, United States
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Imbria Investigational Site
RECRUITINGBurlington, Massachusetts, 01805, United States
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Imbria Investigational Site
RECRUITINGGrand Rapids, Michigan, 49503, United States
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Imbria Investigational Site
RECRUITINGRochester, Minnesota, 55905, United States
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Imbria Investigational Site
RECRUITINGSt Louis, Missouri, 63110, United States
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Imbria Investigational Site
RECRUITINGNew York, New York, 10016, United States
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Imbria Investigational Site
RECRUITINGCharlotte, North Carolina, 28204, United States
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Imbria Investigational Site
RECRUITINGPortland, Oregon, 97239, United States
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Imbria Investigational Site
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Imbria Investigational Site
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
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Imbria Investigational Site
RECRUITINGHouston, Texas, 77030, United States
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Imbria Investigational Site
RECRUITINGPlano, Texas, 75093, United States
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Imbria Investigational Site
RECRUITINGCharlottesville, Virginia, 22903, United States
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Imbria Investigational Site
RECRUITINGRichmond, Virginia, 23298, United States
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Imbria Investigational Site
RECRUITINGGraz, 8036, Austria
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Imbria Investigational Site
RECRUITINGEdegem, 2650, Belgium
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Imbria Investigational Site
RECRUITINGMontpellier, 34295, France
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Imbria Investigational Site
RECRUITINGParis, 75015, France
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Imbria Investigational Site
RECRUITINGSaint-Herblain, 44800, France
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Imbria Investigational Site
RECRUITINGBad Oeynhausen, 32545, Germany
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Imbria Investigational Site
RECRUITINGGöttingen, 37075, Germany
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Imbria Investigational Site
RECRUITINGHeidelberg, 69120, Germany
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Imbria Investigational Site
NOT_YET_RECRUITINGJena, 07747, Germany
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Imbria Investigational Site
RECRUITINGFlorence, 50139, Italy
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Imbria Investigational Site
RECRUITINGMassa, 54100, Italy
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Imbria Investigational Site
RECRUITINGMilan, 20131, Italy
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Imbria Investigational Site
RECRUITINGMilan, 20146, Italy
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Imbria Investigational Site
RECRUITINGMilan, 20162, Italy
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Imbria Investigational Site
RECRUITINGNaples, 80131, Italy
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Imbria Investigational Site
RECRUITINGAmsterdam-Zuidoost, 1105 AZ, Netherlands
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Imbria Investigational Site
NOT_YET_RECRUITINGLeiden, 2333ZC, Netherlands
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Imbria Investigational Site
NOT_YET_RECRUITINGNijmegen, 6525 GA, Netherlands
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Imbria Investigational Site
RECRUITINGRotterdam, 3015 AA, Netherlands
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Imbria Investigational Site
RECRUITINGKatowice, 40-555, Poland
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Imbria Investigational Site
RECRUITINGWarsaw, 02-507, Poland
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Imbria Investigational Site
RECRUITINGWroclaw, 53-114, Poland
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Imbria Investigational Site
RECRUITINGGuimarães, 4835-044, Portugal
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Imbria Investigational Site
RECRUITINGLisbon, 1169-024, Portugal
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Imbria Investigational Site
RECRUITINGLisbon, 1500-650, Portugal
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Imbria Investigational Site
RECRUITINGBarcelona, Barcelona, 08035, Spain
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Imbria Investigational Site
RECRUITINGA Coruña, Galicia, 15006, Spain
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Imbria Investigational Site
RECRUITINGMadrid, Madrid, 28034, Spain
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Imbria Investigational Site
RECRUITINGVigo, Pontevedra, 36312, Spain
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Imbria Investigational Site
RECRUITINGSeville, Sevilla, 41009, Spain
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Imbria Investigational Site
RECRUITINGSeville, Sevilla, 41013, Spain
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Imbria Investigational Site
RECRUITINGBarcelona, 8036, Spain
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Imbria Investigational Site
RECRUITINGBarcelona, 8041, Spain
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Imbria Investigational Site
RECRUITINGBarcelona, 8907, Spain
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Imbria Investigational Site
RECRUITINGEl Palmar, 30120, Spain
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Imbria Investigational Site
RECRUITINGMadrid, 28222, Spain
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Imbria Investigational Site
RECRUITINGPalma de Mallorca, 07198, Spain
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Imbria Investigational Site
RECRUITINGSalamanca, 37007, Spain
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Imbria Investigational Site
RECRUITINGValencia, 03010, Spain
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Imbria Investigational Site
RECRUITINGValencia, 46026, Spain
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Imbria Investigational Site
RECRUITINGLondon, England, W12 0HS, United Kingdom
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Imbria Investigational Site
RECRUITINGGlasgow, Scotland, G51 4TF, United Kingdom
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Imbria Investigational Site
RECRUITINGLondon, EC1A 7BE, United Kingdom
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Imbria Investigational Site
RECRUITINGLondon, SW3 6HP, United Kingdom
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Imbria Investigational Site
RECRUITINGOxford, OX3 9DU, United Kingdom
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