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Could a diabetes drug help heart muscle disease? large trial underway

NCT ID NCT06481891

Ongoing Symptom relief Sponsor: Lexicon Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 30, 2026 · Updated 4 times

Summary

This Phase 3 study tests whether the drug sotagliflozin can improve symptoms and daily function in 500 adults with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle thickens. Participants take either the drug or a placebo pill once daily for 26 weeks. The main goal is to see if symptoms like shortness of breath and fatigue get better, measured by a standard heart-disease questionnaire.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
sotagliflozin
What this could lead to
If it works, this could offer a new daily pill to ease symptoms and improve quality of life for people with hypertrophic cardiomyopathy.
What could go wrong
This is a Phase 3 trial, but it is still experimental. The drug may not prove more effective than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypertrophic cardiomyopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY OBSTRUCTIVE CARDIOMYOPATHY, HYPERTROPHIC

Contacts and locations

Locations

  • Lexicon Investigational Site (1012)

    Genk, 3600, Belgium

  • Lexicon Investigational Site (1111)

    Sofia, 1407, Bulgaria

  • Lexicon Investigational Site (1112)

    Rousse, 7013, Bulgaria

  • Lexicon Investigational Site (1210)

    Rijeka, 51000, Croatia

  • Lexicon Investigational Site (1212)

    Opatija, 51410, Croatia

  • Lexicon Investigational Site (1213)

    Zagreb, 10000, Croatia

  • Lexicon Investigational Site (1215)

    Krapinske Toplice, 49217, Croatia

  • Lexicon Investigational Site (1310)

    Prague, 128 08, Czechia

  • Lexicon Investigational Site (1311)

    Brno, 602 00, Czechia

  • Lexicon Investigational Site (1312)

    Ústí nad Labem, 400 11, Czechia

  • Lexicon Investigational Site (1510)

    Poitiers, 86021, France

  • Lexicon Investigational Site (1511)

    Marseille, 13005, France

  • Lexicon Investigational Site (1512)

    Rennes, 35033, France

  • Lexicon Investigational Site (1513)

    Paris, 75651, France

  • Lexicon Investigational Site (1514)

    Chambray-lès-Tours, 37170, France

  • Lexicon Investigational Site (1515)

    Toulouse, 31059, France

  • Lexicon Investigational Site (1610)

    Tbilisi, 0131, Georgia

  • Lexicon Investigational Site (1611)

    Tbilisi, 0112, Georgia

  • Lexicon Investigational Site (1612)

    Tbilisi, 0144, Georgia

  • Lexicon Investigational Site (1613)

    Tbilisi, 0186, Georgia

  • Lexicon Investigational Site (1710)

    Budapest, 1122, Hungary

  • Lexicon Investigational Site (1711)

    Pécs, 7624, Hungary

  • Lexicon Investigational Site (1712)

    Szeged, 6725, Hungary

  • Lexicon Investigational Site (1713)

    Zalaegerszeg, 8900, Hungary

  • Lexicon Investigational Site (1811)

    Brescia, 25123, Italy

  • Lexicon Investigational Site (1813)

    Naples, 80131, Italy

  • Lexicon Investigational Site (1814)

    Arezzo, 52100, Italy

  • Lexicon Investigational Site (2110)

    Wroclaw, 50-981, Poland

  • Lexicon Investigational Site (2113)

    Lodz, 92-213, Poland

  • Lexicon Investigational Site (2114)

    Lodz, 91-347, Poland

  • Lexicon Investigational Site (2115)

    Oświęcim, 32-600, Poland

  • Lexicon Investigational Site (2210)

    Braga, 4710-243, Portugal

  • Lexicon Investigational Site (2211)

    Lisbon, 1350-352, Portugal

  • Lexicon Investigational Site (2213)

    Faro, 8000-386, Portugal

  • Lexicon Investigational Site (2215)

    Lisbon, 1500-650, Portugal

  • Lexicon Investigational Site (2216)

    Lisbon, 1998-018, Portugal

  • Lexicon Investigational Site (2217)

    Porto, 4200-319, Portugal

  • Lexicon Investigational Site (2218)

    Lisbon, 1649-035, Portugal

  • Lexicon Investigational Site (2310)

    Niš, 18108, Serbia

  • Lexicon Investigational Site (2311)

    Belgrade, 11040, Serbia

  • Lexicon Investigational Site (2312)

    Belgrade, 11000, Serbia

  • Lexicon Investigational Site (2313)

    Belgrade, 11040, Serbia

  • Lexicon Investigational Site (2314)

    Belgrade, 11000, Serbia

  • Lexicon Investigational Site (2510)

    Stockholm, 17164, Sweden

  • Lexicon Investigational Site (2710)

    Liverpool, L14 3PE, United Kingdom

  • Lexicon Investigational Site (2711)

    London, EC1M 6BQ, United Kingdom

  • Lexicon Investigational Site (2712)

    Glasgow, G51 4TF, United Kingdom

  • Lexicon Investigational Site (2713)

    Leicester, LE3 9QP, United Kingdom

  • Lexicon Investigational Site (2810)

    München, 80336, Germany

  • Lexicon Investigational Site (2811)

    Leipzig, 04289, Germany

  • Lexicon Investigational Site (2812)

    Hamburg, 22041, Germany

  • Lexicon Investigational Site (2813)

    Berlin, 13353, Germany

  • Lexicon Investigational Site (2910)

    Baloteşti, 077015, Romania

  • Lexicon Investigational Site (2911)

    Târgu Mureş, 540124, Romania

  • Lexicon Investigational Site (2912)

    Târgu Mureş, 540143, Romania

  • Lexicon Investigational Site (2913)

    Suceava, 720049, Romania

  • Lexicon Investigational Site (4010)

    Seattle, Washington, 98195, United States

  • Lexicon Investigational Site (4011)

    Philadelphia, Pennsylvania, 19104, United States

  • Lexicon Investigational Site (4012)

    Los Angeles, California, 90048, United States

  • Lexicon Investigational Site (4013)

    St Louis, Missouri, 63110, United States

  • Lexicon Investigational Site (4015)

    Portland, Oregon, 97239, United States

  • Lexicon Investigational Site (4016)

    Boston, Massachusetts, 02115, United States

  • Lexicon Investigational Site (4017)

    Cleveland, Ohio, 44195, United States

  • Lexicon Investigational Site (4018)

    Atlanta, Georgia, 30322, United States

  • Lexicon Investigational Site (4019)

    Germantown, Tennessee, 38138, United States

  • Lexicon Investigational Site (4021)

    Baltimore, Maryland, 21218, United States

  • Lexicon Investigational Site (4022)

    Marshfield, Wisconsin, 54449, United States

  • Lexicon Investigational Site (4024)

    Tulsa, Oklahoma, 74104, United States

  • Lexicon Investigational Site (4026)

    Morrisville, North Carolina, 27560, United States

  • Lexicon Investigational Site (4027)

    Rochester, Minnesota, 55905, United States

  • Lexicon Investigational Site (4028)

    Ann Arbor, Michigan, 48109, United States

  • Lexicon Investigational Site (4029)

    Morristown, New Jersey, 07960, United States

  • Lexicon Investigational Site (4031)

    Cincinnati, Ohio, 45219, United States

  • Lexicon Investigational Site (4032)

    Charlottesville, Virginia, 22908, United States

  • Lexicon Investigational Site (4033)

    Evanston, Illinois, 60208, United States

  • Lexicon Investigational Site (4034)

    Orlando, Florida, 32804, United States

  • Lexicon Investigational Site (4035)

    Pomona, California, 91767, United States

  • Lexicon Investigational Site (4036)

    Merrillville, Indiana, 46410, United States

  • Lexicon Investigational Site (4037)

    Scottsdale, Arizona, 85260, United States

  • Lexicon Investigational Site (4038)

    Grand Rapids, Michigan, 49525, United States

  • Lexicon Investigational Site (4039)

    Manhasset, New York, 11030, United States

  • Lexicon Investigational Site (4040)

    Milwaukee, Wisconsin, 53215, United States

  • Lexicon Investigational Site (4041)

    Phoenix, Arizona, 85054, United States

  • Lexicon Investigational Site (4042)

    Boston, Massachusetts, 02118, United States

  • Lexicon Investigational Site (4043)

    New York, New York, 10016, United States

  • Lexicon Investigational Site (4044)

    San Francisco, California, 94143, United States

  • Lexicon Investigational Site (4045)

    Seattle, Washington, 98101, United States

  • Lexicon Investigational Site (4046)

    Jacksonville, Florida, 32224, United States

  • Lexicon Investigational Site (5010)

    Córdoba, 5002, Argentina

  • Lexicon Investigational Site (5011)

    Salta, 4400, Argentina

  • Lexicon Investigational Site (5012)

    Rosario, Santa Fe Province, 2000, Argentina

  • Lexicon Investigational Site (5013)

    Córdoba, X5000AAX, Argentina

  • Lexicon Investigational Site (5014)

    Santa Fe, 3000, Argentina

  • Lexicon Investigational Site (5015)

    Corrientes, W3400CDS, Argentina

  • Lexicon Investigational Site (5016)

    Santa Rosa, La Pampa Province, L6304BWE, Argentina

  • Lexicon Investigational Site (5110)

    Campinas, São Paulo, 13060-080, Brazil

  • Lexicon Investigational Site (5112)

    Recife, 52051-380, Brazil

  • Lexicon Investigational Site (5114)

    Salvador, Estado de Bahia, 40170-130, Brazil

  • Lexicon Investigational Site (5115)

    São Paulo, 04039-000, Brazil

  • Lexicon Investigational Site (7011)

    Jerusalem, 9112001, Israel

  • Lexicon Investigational Site (7012)

    Ramat Gan, 5265601, Israel

  • Lexicon Investigational Site (7013)

    Haifa, 3109601, Israel

  • Lexicon Investigational Site (7014)

    Haifa, 3339419, Israel

  • Lexicon Investigational Site (7015)

    Holon, 5822012, Israel

  • Lexicon Investigational Site (7016)

    Petah Tikva, 4941492, Israel

  • Lexicon Investigational Site (7017)

    Be’er Ya‘aqov, 7033001, Israel

  • Lexicon Investigational Site (7019)

    Tel Aviv, 6423906, Israel

  • Lexicon Investigational Stie (4014)

    Houston, Texas, 77030, United States

More trials for these conditions

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