Hyperplasia

This study compares standard fluid management to a newer method using the Plethysmography Variability Index (PVI) during prostate surgery for enlarged prostate. The goal is to see if PVI-guided care reduces risks like fluid overload or low blood pressure. Fifty-eight men aged 50-…

This study compares two surgical methods for treating benign prostatic hyperplasia (BPH), a non-cancerous enlargement of the prostate. The trial involves 140 men aged 50-80 with prostates of 80 mL or larger who are candidates for holmium laser enucleation. One group receives the …

This study compares a minimally invasive water vapor treatment (REZŪM) to taking two drugs together for men with an enlarged prostate that didn't get better with one drug. It includes 155 sexually active men aged 45 and older. The goal is to see which approach better improves uri…

This phase II trial tests whether adding pterostilbene, an antioxidant found in blueberries, to the hormone drug megestrol acetate can better slow endometrial cancer growth before hysterectomy. About 44 patients will receive either megestrol acetate alone or with pterostilbene fo…

This study follows 60 men with an enlarged prostate who already used the Butterfly device for a year. Researchers will track safety and symptom relief for up to 5 years. The goal is to see if the device remains effective and safe over the long term.

This study looked at 70 men with an enlarged prostate and overactive bladder symptoms. Some received a Botox injection into the prostate during surgery, while others took standard medication after surgery. The Botox group showed better symptom scores at 12 weeks, suggesting a pot…

This early study tests a new treatment called RT-310 for men with enlarged prostate (BPH) who have bothersome urinary symptoms. RT-310 is a drug delivered directly into the prostate to reduce side effects. The study will check if it is safe and feasible in 20 men aged 50 to 80.

This study aimed to see if taking antibiotics for three days after a type of prostate surgery (HoLEP) lowers the chance of getting a urinary tract infection. It was designed for men over 40 with an enlarged prostate and no current infection. However, the study was withdrawn befor…

This study looks at whether a hormonal intrauterine device (IUD) alone or combined with the drug everolimus can treat precancerous changes or very early-stage endometrial cancer. About 100 women with these conditions will receive the IUD, and some will also take everolimus if the…

This study tests a robotic system that uses a high-pressure water jet to remove prostate tissue in men with localized prostate cancer and trouble urinating. The goal is to see if the procedure is safe and works well. About 125 men will be followed for one year after treatment.

This study looks at whether adding metformin (a diabetes drug) to standard hormone therapy (megestrol acetate) works better to control uterine pre-cancer and stop it from turning into cancer. About 51 people with this pre-cancer condition will take one or both drugs before their …

This study planned to test whether combining the weight-loss drug semaglutide with a hormone-releasing IUD could reverse endometrial hyperplasia (a precancerous condition) in premenopausal women with obesity, allowing them to keep their uterus. The trial was withdrawn before enro…

This study tests a new surgical technique for treating enlarged prostate in men who also have a penile implant. The standard approach through the urethra can damage the implant, so surgeons are trying an alternative route through the lower belly. The study will enroll 80 men and …

This early study tests a new device called RT-310, a small implant placed inside the prostate to treat bothersome urinary symptoms from an enlarged prostate. The trial includes 20 men aged 50 to 80 who have not gotten enough relief from medication. The main goal is to check if th…

This phase 2 trial tests whether taking omega-3 (EPA) supplements can reduce inflammation and slow cancer cell growth in men with high-risk prostate cancer who choose surgery. 130 participants will take either EPA capsules or a placebo for 14 months, starting before surgery. Rese…

This study is testing a new way to detect prostate cancer by looking at cells in urine using a special imaging method. Researchers will collect urine samples from 675 men aged 50-75, including those with and without prostate cancer. The goal is to see if this simple test can accu…

This phase 2 trial tests whether metformin, a widely used diabetes drug, can prevent oral cancer in 26 people with precancerous mouth lesions (leukoplakia or erythroplakia). Participants take metformin by mouth, and researchers check if the lesions shrink or disappear. The goal i…

This pilot study is testing a new device that uses pulsed field ablation to treat urinary symptoms caused by an enlarged prostate (BPH). About 100 men over age 45 who haven't gotten relief from medication will receive the treatment and be followed for safety and effectiveness. Th…

This study tests whether applying an ice pack to the lower abdomen after vNOTES hysterectomy can lower pain and reduce the need for painkillers. 122 women having surgery for benign conditions will be randomly assigned to receive either standard care or standard care plus ice pack…

This study tests a new device designed to relieve symptoms of an enlarged prostate, such as frequent or difficult urination. About 245 men aged 50 and older will be randomly assigned to receive the device or a sham procedure. The main goal is to see if the device improves symptom…

This study tests a procedure called prostatic artery embolization (PAE) in 17 men with low-risk prostate cancer who also have trouble urinating. The goal is to see if PAE can reduce urinary symptoms before they start radiation therapy. Participants will have their symptoms and pr…

This study tests a device called the ProVee Urethral Expander, which is placed in the prostate to open the urinary channel and relieve symptoms of an enlarged prostate. About 221 men with moderate to severe symptoms are enrolled, and the device is compared to a sham procedure. Th…

This study looks at two non-drug ways to help older men with an enlarged prostate. It compares electromagnetic field therapy, a gentle treatment using energy waves, to aerobic exercise like walking or cycling. The goal is to see which works better to shrink the prostate and ease …

This study looks at two procedures—prostate artery embolization (PAE) and holmium laser enucleation (HoLEP)—to see which better eases urinary symptoms caused by an enlarged prostate. It involves 45 men aged 50 or older with prostates larger than 80 grams. The main goal is to meas…

This study looks at whether doing pelvic floor exercises before prostate surgery can help men avoid urine leakage afterward. About 30 men with an enlarged prostate will either do exercises before surgery or get standard care. The goal is to see if patients and doctors find the ex…

This study tests whether placing a Urolift device in the prostate before stereotactic body radiation therapy (SBRT) can reduce urinary side effects like frequent urination, pain, and nighttime trips to the bathroom. About 20 men with both prostate cancer and benign prostatic hype…

This study looks at whether starting pelvic floor physical therapy before prostate surgery (HoLEP) helps men regain bladder control more quickly after the procedure. About 72 men who are already scheduled for HoLEP to treat an enlarged prostate will be randomly assigned to start …

This study compares two minimally invasive procedures for treating an enlarged prostate (BPH) in 120 men aged 50 and older. The goal is to see which treatment—UroLift or Rezūm—leads to fewer catheters, less need for repeat procedures, and lower medication use over 12 months. The …

This study aimed to see if giving Botox injections into the bladder at the same time as HoLEP prostate surgery could improve urinary symptoms in men with an enlarged prostate and overactive bladder. The plan was to compare symptom scores and urine flow between men who got both tr…

This study looks at how men weigh the benefits of improved urination against changes in sexual function after a prostate surgery called HoLEP. Researchers will interview participants and ask them to complete questionnaires over two years. The goal is to understand what matters mo…

This study tests a web-based tool called WellPrept that gives patients clear information before their urology procedures. Researchers want to see if it helps patients feel more confident and understand their condition better, and if it shortens clinic visits. About 300 men and wo…

This study looks at whether web-based decision support tools can help women with atypical hyperplasia or lobular carcinoma in situ (conditions that raise breast cancer risk) make informed choices about chemoprevention. About 412 women and their healthcare providers will use educa…

The RELIEF study was designed to compare different treatments for an enlarged prostate (BPH) in everyday medical practice. It planned to follow patients who received the UroLift implant, other surgeries, or medication/watchful waiting. However, the study was withdrawn before enro…

This study aimed to compare a less invasive procedure called vacuum-assisted excision (VAPE) to standard surgery for removing non-cancerous but high-risk breast lesions. The goal was to see if VAPE worked as well, was safer, and left better cosmetic results. However, the study wa…

This study looks at how patients feel physically and emotionally after having a breast biopsy for certain non-cancerous but atypical breast conditions. Over 900 participants from several hospitals answered surveys about pain and quality of life, on average nearly four years after…

This study aimed to see if a type of PET/MRI scan could predict which women with early endometrial cancer or a precancerous condition would respond to hormone therapy. It planned to enroll 8 women and follow them for 6 months. However, the study was withdrawn before any participa…

This study will compare two ultrasound techniques—lung ultrasound and inferior vena cava collapsibility index—to see which one can predict fluid overload earlier in men undergoing transurethral resection of the prostate (TURP). Sixty male patients scheduled for TURP under spinal …

This study is a large registry that will collect information from 10,000 men in Turkey who are having minimally invasive surgery for an enlarged prostate. The goal is to track which procedures are used, how well they work, and any complications. By gathering this real-world data,…