Birth control IUD could treat Pre-Cancer uterine condition

NCT ID NCT06904274

Terminated Disease control Sponsor: Bayer Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 5 times

Summary

This study tests whether the Mirena IUD, a birth control device that releases hormones, can reverse a noncancerous thickening of the uterine lining better than daily hormone pills. About 207 women with nonatypical endometrial hyperplasia will be randomly assigned to get either Mirena or oral medroxyprogesterone for 6 months. The goal is to see whose uterine lining returns to normal.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mirena (levonorgestrel-releasing intrauterine system) and medroxyprogesterone acetate (oral tablet)
What this could lead to: If Mirena works, it could become a standard non-surgical treatment for noncancerous endometrial hyperplasia, helping women avoid more invasive procedures.
What could go wrong: This is a Phase 3 trial, but results may not confirm superiority over existing off-label treatments. The study is relatively small (207 participants) and does not assess long-term cancer prevention.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Endometrial Hyperplasia endometrial hyperplasia without atypia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL HYPERPLASIA

Contacts and locations

Locations

AIH Research- Broadway

Pearland, Texas, 77584, United States
Alliance Clinical West Hills

West Hills, California, 91307, United States
Biopharma Informatic - West Houston

Houston, Texas, 77043, United States
Bosque Women's Care | Albuquerque, NM

Albuquerque, New Mexico, 87109, United States
Centres Investigation Clinique Mauricie

Trois-Rivières, Quebec, G8T 7A1, Canada
Chattanooga Medical Research, LLC. | Chattanooga, TN

Chattanooga, Tennessee, 37412, United States
Chengdu Women & Children's Central Hospital

Chengdu, Sichuan, 610091, China
China-Japan Friendship Hospital

Beijing, Beijing Municipality, 100029, China
Chongqing Maternal and Child Health Care Hospital

Chongqing, Chongqing Municipality, 401147, China
ClinOhio Research Services, LLC. | Columbus, OH

Columbus, Ohio, 43213, United States
Cornerstone Clinic for Women - Aldersgate

Little Rock, Arkansas, 72205, United States
Discovery Clinical Trials - Dallas

Dallas, Texas, 75230, United States
Emerald Coast Clinical Research

Panama City, Florida, 32405, United States
Entrust Clinical Research

Palmetto Bay, Florida, 33176, United States
Jiangxi Maternal and Child Health Hospital

Nanchang, Jiangxi, 330006, China
Lyndhurst Clinical Research

Winston-Salem, North Carolina, 27103, United States
Mount Sinai Hospital Toronto | Gynecology

Toronto, Ontario, M5G 1Z5, Canada
Nanjing Maternity and Child Health Care Hospital

Nanjing, Jiangsu, 210004, China
Nanjing Medical University (NMU) - The Second Affiliated Hospital

Nanjing, Jiangsu, 210011, China
New Age Medical Research Corp.

Miami, Florida, 33186, United States
OB/GYN Associates of Erie

Erie, Pennsylvania, 16507, United States
Office of Dr. Cindy Basinski, LLC

Evansville, Indiana, 47715, United States
Omni Fertility and Laser Institute

Shreveport, Louisiana, 71118, United States
Paramount Research Solutions | College Park Location

Atlanta, Georgia, 30327, United States
Peking Union Medical College Hospital CAMS

Beijing, Beijing Municipality, 100730, China
Peking University Shenzhen Hospital

Shenzhen, Guangdong, 518036, China
Revive Research Institute - Michigan - Women's Health

Dearborn Heights, Michigan, 48127, United States
Shaanxi Provincial People's Hospital

Xi'an, Shaanxi, 710068, China
Southern Clinical Research Associates

Metairie, Louisiana, 70001, United States
Sweet Hope Research Specialty, Inc. - Hialeah

Hialeah, Florida, 33016, United States
Tangshan Maternal and Child Health Care Hospital

Tangshan, Hebei, 063014, China
The Ottawa Hospital, Riverside Campus - Department of Obstetrics, Gynecology and Newborn Care

Ottawa, Ontario, K1H 7W9, Canada
The Third Affiliated Hospital of Southern Medical University - Gynecology Department

Guangzhou, Guangdong, 510630, China
Unified Women's Clinical Research - Centre OB/GYN

Raleigh, North Carolina, 27607, United States
Velocity Clinical Research - Lafayette

Lafayette, Louisiana, 70508, United States
Velocity Clinical Research - Phoenix

Phoenix, Arizona, 85006, United States
Women and Children's Hospital, Qingdao University - Gynecology department

Qingdao, Shandong, 266034, China
Xiamen Maternity and Child Health Care Hospital - Gynecology Department

Xiamen, Fujian, 361003, China

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