Birth control IUD could treat Pre-Cancer uterine condition

NCT ID NCT06904274

Recruiting now Disease control Sponsor: Bayer Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether the Mirena IUD, a birth control device that releases hormones, can reverse a noncancerous thickening of the uterine lining better than daily hormone pills. About 207 women with nonatypical endometrial hyperplasia will be randomly assigned to get either Mirena or oral medroxyprogesterone for 6 months. The goal is to see whose uterine lining returns to normal.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Mirena (levonorgestrel-releasing intrauterine system) and medroxyprogesterone acetate (oral tablet)

What this could lead to

If Mirena works, it could become a standard non-surgical treatment for noncancerous endometrial hyperplasia, helping women avoid more invasive procedures.

What could go wrong

This is a Phase 3 trial, but results may not confirm superiority over existing off-label treatments. The study is relatively small (207 participants) and does not assess long-term cancer prevention.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Endometrial Hyperplasia endometrial hyperplasia without atypia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL HYPERPLASIA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AIH Research- Broadway
RECRUITING

Pearland, Texas, 77584, United States
AMR - Fort Myers, FL
NOT_YET_RECRUITING

Fort Myers, Florida, 33912, United States
AMR - Mobile, AL
NOT_YET_RECRUITING

Mobile, Alabama, 36608, United States
Affiliated Clinical Research, Inc. | Las Vegas, NV
NOT_YET_RECRUITING

Las Vegas, Nevada, 89113, United States
Allen Clinical Research LLC
NOT_YET_RECRUITING

Gardena, California, 90247, United States
Alliance Clinical West Hills
RECRUITING

West Hills, California, 91307, United States
Biopharma Informatic - West Houston
RECRUITING

Houston, Texas, 77043, United States
Bosque Women's Care | Albuquerque, NM
RECRUITING

Albuquerque, New Mexico, 87109, United States
Centres Investigation Clinique Mauricie
RECRUITING

Trois-Rivières, Quebec, G8T 7A1, Canada
Chattanooga Medical Research, LLC. | Chattanooga, TN
RECRUITING

Chattanooga, Tennessee, 37412, United States
Chemidox Clinical Trials, Houston
NOT_YET_RECRUITING

Houston, Texas, 77071, United States
Chengdu Women & Children's Central Hospital
RECRUITING

Chengdu, Sichuan, 610091, China
China-Japan Friendship Hospital
RECRUITING

Beijing, Beijing Municipality, 100029, China
Chongqing Maternal and Child Health Care Hospital
RECRUITING

Chongqing, Chongqing Municipality, 401147, China
ClinOhio Research Services, LLC. | Columbus, OH
RECRUITING

Columbus, Ohio, 43213, United States
Clinical Research Prime
NOT_YET_RECRUITING

Idaho Falls, Idaho, 83404, United States
Columbia University Medical Center - Gynecology
WITHDRAWN

New York, New York, 10032, United States
Cornerstone Clinic for Women - Aldersgate
RECRUITING

Little Rock, Arkansas, 72205, United States
Discovery Clinical Trials - Dallas
RECRUITING

Dallas, Texas, 75231, United States
Elite Clinical Network (ECN) | Las Vegas Clinical Trials, LLC
NOT_YET_RECRUITING

North Las Vegas, Nevada, 89030, United States
Emerald Coast Clinical Research
RECRUITING

Panama City, Florida, 32405, United States
Entrust Clinical Research
RECRUITING

Palmetto Bay, Florida, 33176, United States
Foshan Women and Child Health Care Hospital
NOT_YET_RECRUITING

Foshan, Guangdong, 528000, China
Gadolin Research
NOT_YET_RECRUITING

Beaumont, Texas, 77702, United States
Gynecologic Oncology Associates
WITHDRAWN

Shreveport, Louisiana, 71103, United States
Hutzel Women's Hospital
NOT_YET_RECRUITING

Detroit, Michigan, 48201, United States
Inova Fairfax Hospital - OBGYN
NOT_YET_RECRUITING

Falls Church, Virginia, 22042, United States
Jiangxi Maternal and Child Health Hospital
RECRUITING

Nanchang, Jiangxi, 330006, China
K2 Medical Research - South Orlando
WITHDRAWN

Orlando, Florida, 32751, United States
Lyndhurst Clinical Research
RECRUITING

Winston-Salem, North Carolina, 27103, United States
Marchand OB/GYN
NOT_YET_RECRUITING

Mesa, Arizona, 85209, United States
Maximos Ob/Gyn
NOT_YET_RECRUITING

League City, Texas, 77573, United States
McFarland Clinic - Medical Arts Building - OBGYN
NOT_YET_RECRUITING

Ames, Iowa, 50010, United States
McGill Family Practice
NOT_YET_RECRUITING

Papillion, Nebraska, 68046, United States
Mesa Obstetricians and Gynecologists | Research Department
WITHDRAWN

Mesa, Arizona, 85206, United States
Montefiore Medical Park - Eastchester - OBGYN
NOT_YET_RECRUITING

The Bronx, New York, 10461, United States
Mount Sinai Hospital Toronto | Gynecology
NOT_YET_RECRUITING

Toronto, Ontario, M5G 1Z5, Canada
Nanjing Maternity and Child Health Care Hospital
RECRUITING

Nanjing, Jiangsu, 210004, China
Nanjing Medical University (NMU) - The Second Affiliated Hospital
RECRUITING

Nanjing, Jiangsu, 210011, China
New Age Medical Research Corp.
RECRUITING

Miami, Florida, 33186, United States
North Valley Women's Care
NOT_YET_RECRUITING

Glendale, Arizona, 85308, United States
OB/GYN Associates of Erie
RECRUITING

Erie, Pennsylvania, 16507, United States
OB/GYN Department_Comprehensive Women's Health Center
NOT_YET_RECRUITING

Denver, Colorado, 80230, United States
Office of Dr. Cindy Basinski, LLC
RECRUITING

Evansville, Indiana, 47715, United States
Omni Fertility and Laser Institute
RECRUITING

Shreveport, Louisiana, 71118, United States
Paradigm Clinical Research, San Diego
NOT_YET_RECRUITING

San Diego, California, 92108, United States
Paramount Research Solutions | College Park Location
RECRUITING

Atlanta, Georgia, 30327, United States
Paramount Research Solutions-Nashville
NOT_YET_RECRUITING

Nashville, Tennessee, 37203, United States
Peking Union Medical College Hospital CAMS
RECRUITING

Beijing, Beijing Municipality, 100730, China
Peking University Shenzhen Hospital
RECRUITING

Shenzhen, Guangdong, 518036, China
Physician Care Clinical Research LLC | Sarasota, FL
NOT_YET_RECRUITING

Sarasota, Florida, 34239, United States
Progressive Women's Health Pllc
NOT_YET_RECRUITING

Houston, Texas, 77089, United States
Reply OBGYN and Fertility PLLC
WITHDRAWN

Durham, North Carolina, 27713, United States
Revive Research Institute - Michigan - Women's Health
RECRUITING

Dearborn Heights, Michigan, 48127, United States
Rosemark Women Care Specialists
NOT_YET_RECRUITING

Idaho Falls, Idaho, 83404, United States
Rutgers Robert Wood Johnson Medical School - OBGYN
NOT_YET_RECRUITING

New Brunswick, New Jersey, 08901, United States
SKY integrative Medical Center
WITHDRAWN

Ridgeland, Mississippi, 39157, United States
Shaanxi Provincial People's Hospital
RECRUITING

Xi'an, Shaanxi, 710068, China
Solace Clinical Research
NOT_YET_RECRUITING

San Juan, 00907, Puerto Rico
South Texas Clinical Research
NOT_YET_RECRUITING

Corpus Christi, Texas, 78404, United States
Southern Clinical Research Associates
RECRUITING

Metairie, Louisiana, 70001, United States
St. Dominic's Gynecology/Oncology
NOT_YET_RECRUITING

Jackson, Mississippi, 39216, United States
Sweet Hope Research Specialty, Inc. - Hialeah
RECRUITING

Hialeah, Florida, 33016, United States
Tangshan Maternal and Child Health Care Hospital
RECRUITING

Tangshan, Hebei, 063014, China
The Levi Watkins Jr. MD Outpatient Center - Obstetrics and Gynecology
NOT_YET_RECRUITING

Baltimore, Maryland, 21287, United States
The Ottawa Hospital, Riverside Campus - Department of Obstetrics, Gynecology and Newborn Care
RECRUITING

Ottawa, Ontario, K1H 7W9, Canada
The Third Affiliated Hospital of Southern Medical University - Gynecology Department
RECRUITING

Guangzhou, Guangdong, 510630, China
TriHealth Women's Servies - Seven Hills Women's Health Center
NOT_YET_RECRUITING

Cincinnati, Ohio, 45255, United States
Tufts Medical Center - OB/GYN
NOT_YET_RECRUITING

Boston, Massachusetts, 02111, United States
UAB Medicine Center for Research in Women's Health
NOT_YET_RECRUITING

Birmingham, Alabama, 35233, United States
UC Davis Health Lawrence J Ellison Ambulatory Care Center - OB/GYN
NOT_YET_RECRUITING

Sacramento, California, 95817, United States
UF Health Women's Specialists - Emerson
NOT_YET_RECRUITING

Jacksonville, Florida, 32207, United States
USF Health South Tampa Center for Advanced Healthcare - Gynecology
NOT_YET_RECRUITING

Tampa, Florida, 33606, United States
UTHealth Womens Research Program | Memorial City
NOT_YET_RECRUITING

Houston, Texas, 77054, United States
UVA Health Midlife Health and Gynecologic Specialties Northridge
NOT_YET_RECRUITING

Charlottesville, Virginia, 22903, United States
Unified Women's Clinical Research - Centre OB/GYN
RECRUITING

Raleigh, North Carolina, 27607, United States
University Hospitals | UH Cleveland Medical Center - MacDonald Clinical Trials Unit
NOT_YET_RECRUITING

Mayfield Heights, Ohio, 44124, United States
Velocity Clinical Research - Blue Ash, Cincinnati
NOT_YET_RECRUITING

Montgomery, Ohio, 45242, United States
Velocity Clinical Research - Lafayette
RECRUITING

Lafayette, Louisiana, 70508, United States
Velocity Clinical Research - Mobile
NOT_YET_RECRUITING

Mobile, Alabama, 36608, United States
Velocity Clinical Research - Phoenix
RECRUITING

Phoenix, Arizona, 85006, United States
Velvet Clinical Research
NOT_YET_RECRUITING

Burbank, California, 91506, United States
Virginia Women's Health Associates
NOT_YET_RECRUITING

Reston, Virginia, 20190, United States
Women and Children's Hospital, Qingdao University - Gynecology department
RECRUITING

Qingdao, Shandong, 266034, China
Women's Health Alliance of Mobile
NOT_YET_RECRUITING

Mobile, Alabama, 36604, United States
Women's Hospital School of Medicine Zhejiang University
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310006, China
Women's Wellness / SKYCRNG
WITHDRAWN

Chicago, Illinois, 60644, United States
Xiamen Maternity and Child Health Care Hospital - Gynecology Department
RECRUITING

Xiamen, Fujian, 361003, China
Zillan Clinical Research
NOT_YET_RECRUITING

Inglewood, California, 90303, United States