Glaucoma

This study tests whether a combination eye drop (netarsudil/latanoprost) can improve vision and reduce corneal thickness in people with glaucoma and a condition called pseudophakic bullous keratopathy, where the cornea swells after cataract surgery. Half of the 50 participants re…

This study looked at whether placing a tiny device called iStent during cataract surgery helps lower eye pressure in people with primary open-angle glaucoma. Researchers compared 80 patients who got the implant plus cataract surgery to those who had cataract surgery alone. The go…

This completed trial tested the ELIOS System, a device used during cataract surgery to lower eye pressure in adults with mild-to-moderate open-angle glaucoma. The study enrolled 318 participants and measured how many achieved a 20% or greater drop in eye pressure without medicati…

This study tests a device called the ELIOS System to safely lower eye pressure in adults with mild to moderate open-angle glaucoma. The procedure is done alone, without other surgeries, and aims to reduce pressure by at least 20% while possibly using fewer medications. Researcher…

This study tested a new implant called PER-001 placed inside the eye to treat open-angle glaucoma. The trial included 33 adults and checked for safety and how well it controlled eye pressure. The implant is designed to release medication over time, potentially reducing the need f…

This study compared two small eye implants, Hydrus and iStent, placed during cataract surgery to help lower eye pressure in people with open-angle glaucoma. 65 patients were followed long-term to see which device worked better and was safer. The goal was to reduce the need for gl…

This study compared two treatments for advanced open-angle glaucoma: a gentle laser (subthreshold diode laser) and a surgical procedure (trabeculotomy). 80 adults with severe glaucoma that was not controlled by maximum medications took part. The goal was to see which treatment be…

This study compared two types of glaucoma surgery—standard trabeculectomy and a smaller 'micro' version—to see which one lowers eye pressure better and causes fewer complications. Researchers followed 100 patients for 3 months after surgery. The goal is to find out if the smaller…

This study tested a small implant called Supraflow v2.2 in 57 adults with open-angle or narrow-angle glaucoma. The implant is placed inside the eye to help drain fluid and lower eye pressure. The goal was to see if it safely reduces pressure and the need for daily eye drops over …

This study tested a new eye drop called Reformulated PG324 to see how well it lowers eye pressure in people with open-angle glaucoma or high eye pressure. About 489 adults took part. The goal was to measure the drop's safety and effectiveness in controlling eye pressure, which is…

This study tested a minimally invasive surgery called GATT in 30 children who developed glaucoma after cataract surgery. The procedure aims to lower eye pressure by improving fluid drainage inside the eye. Researchers measured changes in eye pressure and the number of glaucoma me…

This study compared two types of tube shunts (Baerveldt 350 and Ahmed ClearPath 250) in 80 adults with glaucoma that was not controlled by other treatments. The goal was to see which device lowers eye pressure better and is safer. Both implants are used to drain fluid and protect…

This study tested a new eye drop called QLS-111 in 37 people with normal tension glaucoma, a type of glaucoma where eye pressure is not high but vision still gets damaged. The goal was to see if QLS-111 is safe and can lower eye pressure better than a standard drop called timolol…

This study tested a new, less invasive surgery called MIMS for people with glaucoma. The goal was to see if it lowers eye pressure as well as traditional surgery but with fewer side effects. 23 adults with glaucoma took part. The results will help doctors understand if MIMS is a …

This study looked at 70 people with mild to moderate glaucoma or high eye pressure. All received a laser treatment called selective laser trabeculoplasty (SLT). Afterward, half used Rocklatan eye drops and half used artificial tears. The goal was to see if Rocklatan lowered eye p…

This study from the Mayo Clinic tested a laser procedure called MP-TSCPC in 65 glaucoma patients to see how well it lowers eye pressure. Researchers tracked patients for one year after the procedure, measuring changes in eye pressure, medication use, and vision. The goal was to e…

This study tested a gel stent implant for open-angle glaucoma, a leading cause of blindness. 74 adults aged 45+ received the implant and were followed for 12 months. The goal was to safely lower eye pressure and reduce the need for glaucoma medications.

This study tested a modified surgical technique for open-angle glaucoma, adding a tiny mattress stitch to the standard deep sclerectomy procedure. 26 adults with glaucoma that was not controlled by eye drops were randomly assigned to receive either the standard or modified surger…

This study tested a small implant called XEN in 150 people whose glaucoma was still out of control despite previous surgeries. The implant was placed in the eye to help drain fluid and lower pressure. Researchers tracked eye pressure, vision changes, and how many medications pati…

This study tested a new eye drop called SBI-100 in 56 adults with glaucoma or high eye pressure. Participants received either a low dose, high dose, or placebo drop twice daily for 14 days. Researchers measured how well the drops lowered eye pressure and checked for side effects.

This study tested a small device called the Hydrus Microstent in 217 adults with open-angle glaucoma that was not well controlled with other treatments. The goal was to see if the implant could safely lower eye pressure. After 12 months, many patients had a significant drop in ey…

This study tested two different laser treatment locations for open-angle glaucoma: one targeting the nasal side of the eye and one targeting the inferior side. 13 patients received the laser procedure to see which location better lowers eye pressure. The goal is to find the most …

This completed Phase 2 trial tested two strengths of a new eye drop called T4090 against the existing drug Rhopressa in 161 adults with open-angle glaucoma or ocular hypertension. The goal was to see which better lowers eye pressure over 7 weeks. Participants used one drop daily …

This completed Phase 4 trial tested the drug Mexidol in 80 people with advanced primary open-angle glaucoma. The goal was to see if the drug could improve the function of mitochondria in cells and protect the optic nerve. Participants were randomly assigned to receive Mexidol or …

This study tested different doses of the drug Mexidol in 102 adults with moderate to advanced open-angle glaucoma. The goal was to see if the drug could improve vision compared to a placebo. Participants took the drug or placebo in a sequence over several months, and their vision…

This early-stage study tested a tiny implant placed inside the eye that slowly releases medication to lower eye pressure in people with mild-to-moderate open-angle glaucoma. The goal was to find a dose that works well with few side effects. 37 adults took part, and researchers mo…

This phase 2 trial tested two new eye drop formulas, AR-17043 and PG043, in 426 people with open-angle glaucoma or ocular hypertension. The goal was to see if they safely lower eye pressure better than existing drops. Participants received different doses of the study drops or st…

This study looked at 100 adults with normal tension glaucoma who were already using the eye drop latanoprost. Researchers added either netarsudil or brimonidine to see which combination lowered eye pressure more effectively. The goal was to find a better way to control the diseas…

This study tested whether a daily oral solution containing citicoline and nicotinamide (Kron) could improve eye function in 30 people with open-angle glaucoma. Participants took the supplement and had their retinal and visual cortex activity measured. The goal was to see if the c…

This study tested a gel called MINIVISC® PLUS, used during eye surgeries like cataract removal and glaucoma surgery to protect delicate tissues and keep the eye stable. Researchers checked if the gel was safe and worked well in 134 patients. The main focus was on eye pressure aft…

This phase 3 trial tested whether a new eye drop called NCX 470 can lower eye pressure better than the standard drop latanoprost in people with open-angle glaucoma or ocular hypertension. About 696 participants used one drop in each eye every evening for up to 12 months. The stud…

This study tested a device that combines a bimatoprost implant with a special intraocular lens to treat both cataracts and glaucoma or high eye pressure. Twenty-four participants received the implant during cataract surgery. The main goals were to see if it lowers eye pressure an…

This study tests whether a smartphone-based camera can accurately screen for eye diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration. About 550 patients will have photos taken with both the smartphone camera and standard equipment. Ophthalmologis…

This study tested an AI tool called VeriSee GLC that analyzes color images of the back of the eye to find signs of glaucoma. Researchers looked at 773 adults' existing eye images to see how well the AI could identify people who might have glaucoma, comparing its results to a pane…

This study tested whether an AI tool can help eye doctors diagnose four common retinal diseases (diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, and glaucoma) more accurately and quickly. Ten doctors from five hospitals read fundus images both with…

This study tested whether a high-resolution eye scan called SD-OCT can diagnose glaucoma more accurately than standard methods. Researchers compared 109 people with and without glaucoma using the scan. The goal was to see if this technology could catch the disease earlier, before…

This study compared three different devices that measure side vision in people with glaucoma. Fifty-four adults each took all three tests in one visit. Researchers timed how long each test took and checked how well the results matched. The goal is to find which test is fastest an…

This study tested a new smart contact lens called miLens that records eye pressure patterns over 24 hours in 86 adults with glaucoma and healthy volunteers. Participants wore the lens in one eye and took smartphone readings every 15 minutes while awake. Researchers compared the l…

This study tested a new imaging device called the P200TE on 53 people with glaucoma. The goal was simply to see how well it could capture images of the back of the eye. It was not a treatment study, so there were no health benefits or risks for participants.

This study tested how well two different eye imaging machines (Topcon Maestro2 and Zeiss Cirrus 5000) agree when measuring retinal thickness in people with glaucoma. Researchers scanned 141 eyes from patients with mild to severe glaucoma using both devices. The goal was to see if…

This study looked at whether people with glaucoma can use portable devices at home to check their eye pressure and vision. Over two years, 53 patients measured their eye pressure three times a day for a week every three months and tested their vision weekly. The goal was to see i…

This study tested four new types of tonometer tips that can measure eye pressure without numbing drops. 49 adults getting routine eye exams tried the new tips and rated them for comfort. The goal is to find the best design for a home-use device that makes glaucoma monitoring easi…

This study looked at whether a supplement called citicoline can improve vision in people with glaucoma after they have eye surgery. Six adults took either citicoline or a placebo for a short time. The goal was to see if citicoline could help protect the optic nerve and improve vi…

This study looked at whether playing music helps children with glaucoma stay focused during a visual field exam (a test that checks side vision). 38 children took part, and researchers measured how often they made mistakes or lost focus. The goal was to see if music could make th…

This study tested whether warming the intravenous (IV) mannitol fluid before giving it to people with sudden high eye pressure can reduce pain and improve comfort. 142 adults took part, with half getting warmed mannitol and half getting standard (room temperature) mannitol. The g…

This study tested a mobile app that teaches Acceptance and Commitment Therapy (ACT) to help people with glaucoma cope with anxiety, depression, and emotional distress. Researchers worked with 28 patients to see if the app was acceptable and easy to use. The goal was to lay the gr…

This study tested a six-month personalized coaching program for glaucoma patients who struggle to use their eye drops regularly. 236 participants received either coaching or standard care. The program used motivational interviewing and tailored education to help patients overcome…

This trial tests a new device called P200TxE that takes detailed images of the back of the eye. Researchers want to see how well it captures images in people with retinal diseases like glaucoma or macular degeneration. The study involves adults aged 22 and older who have been dia…

This study used MRI to measure blood flow in the eye's main artery in 20 adults with untreated glaucoma and compared it to healthy people. The goal was to understand how blood flow problems might contribute to glaucoma damage. Participants had one MRI scan, and no treatment was g…

This study used high-powered 3-Tesla MRI to compare the visual pathways in the brains of 114 people with glaucoma and healthy volunteers. Researchers looked at the structure and volume of brain areas involved in vision to see if glaucoma causes damage beyond the eye. The goal was…

This study looked at how eye pressure changes when breath-hold divers hold their breath. Forty divers had their eye pressure, oxygen levels, heart rate, and blood pressure measured before, during, and after holding their breath. The goal was to understand these changes and how th…

This study followed 326 people newly diagnosed with glaucoma or high eye pressure to see how many got worse over 2 to 4 years of standard monitoring in hospital eye clinics. Researchers measured the rate of disease progression and looked for factors that might predict worsening. …

This study tested four different approaches to find and treat eye diseases like cataracts, glaucoma, and diabetic retinopathy in communities in Nepal. Over 87,000 people aged 50 and older took part. The goal was to see which method—comprehensive screening, cataract camps, communi…

This study examined whether pseudoexfoliation syndrome (an eye condition) is related to carpal tunnel syndrome (a wrist nerve problem). Researchers measured blood markers in 159 adults aged 50-80. The goal was to see if these conditions share a common cause, not to test a treatme…

This study looked at how the eye produces and drains fluid to understand why glaucoma medications lower eye pressure more in some people than others. Researchers measured eye fluid production, drainage, and pressure in 59 adults with glaucoma or high eye pressure before and after…

This small, completed study looked at how many Hydrus microstent surgeries glaucoma fellows need to perform before they become skilled. Researchers graded videos of surgeries from 5 fellows at three eye centers. The goal was to find the average number of cases needed to reach an …

This study looked at whether a central monitoring station outside the operating room could safely replace having an anesthesia nurse in each room during eye surgeries like cataract removal. Researchers compared the rate of complications (like high blood pressure or low oxygen) be…

This study looked at 120 children with glaucoma or suspected glaucoma who needed eye exams under anesthesia. The goal was to see if a standard anesthesia plan could produce consistent and reliable eye pressure measurements. Researchers measured how deep the anesthesia was and com…

This study tested whether a simple app, available in English, Spanish, and Cantonese, could help glaucoma patients better remember their multiple eye drop schedules. Twenty participants either used the app or received standard instructions. After one month, researchers compared h…

This study looked at 60 people with glaucoma to see how changes in the eye's structure relate to vision loss. Researchers used eye scans (OCT) and vision field tests to measure nerve thickness, blood vessel density, and light sensitivity. The goal was to better understand the lin…

This study followed 250 children under 4 years old with congenital glaucoma in France. Researchers wanted to see if finding the disease earlier leads to better eyesight at age 4. They measured vision and eye pressure to understand how timing of diagnosis affects long-term outcome…

This study looked back at the medical records of 400 people with neovascular glaucoma, a severe eye condition. Researchers wanted to see how it relates to other diseases, lifestyle factors, and inflammation. The goal is to better understand the condition and guide future treatmen…

This completed study tested NCX 470 eye drops in 18 healthy adults to see how they change fluid dynamics inside the eye. Participants received either the active drop or a placebo for 8 days. The goal was to measure fluid production, drainage, and pressure. Results will help resea…

This study surveyed 379 eye clinic patients in Pakistan to find out how much they know about glaucoma, a disease that can cause blindness without early treatment. Participants answered a questionnaire about their eye history, knowledge of glaucoma, and beliefs about its curabilit…