Glaucoma

This registry tracks 320 adults with open-angle glaucoma who receive the MINIject implant, a tiny device placed in the eye to help drain fluid and lower pressure. Researchers collect information on any unexpected complications and how surgeons rate the device's ease of use over t…

This study follows 116 people with open-angle glaucoma who already have a MINIject implant in their eye. Researchers will track them for up to 5 years to see if any serious device-related problems occur. No new treatment is given—this is a safety check to see how well the implant…

This study tests whether Rhopressa eye drops can further lower eye pressure in people with glaucoma or high eye pressure who recently had laser surgery (SLT) in both eyes. About 70 adults will receive either Rhopressa or placebo drops daily for several weeks. The goal is to see i…

This study is testing a device called XEN63, a small implant placed in the eye to help drain fluid and lower pressure in people with glaucoma. Researchers will follow 96 patients for 24 months to see if the implant safely reduces eye pressure and the need for daily eye drops. The…

This study is watching 300 people with open-angle glaucoma who get a new type of eye surgery called bio-reinforced canaloplasty. The surgery aims to improve fluid drainage inside the eye to lower pressure. Participants will have regular eye check-ups for two years to see how well…

This study tests an implant called AGN-193408 SR that is placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. About 100 participants will receive the implant, and some will also get standard eye drops for comparison. The goal is to se…

This study tests a new laser procedure called Direct Selective Laser Trabeculoplasty (DSLT) in 40 ethnic Chinese patients with glaucoma or high eye pressure. The laser aims to improve fluid drainage in the eye and reduce pressure. Researchers will check if the treatment is safe a…

This study tests a new eye drop called DE-117B in 345 Chinese adults with open-angle glaucoma or high eye pressure. The goal is to see if it safely lowers eye pressure better than an existing drug. Participants use the drops once daily for at least 4 weeks, with long-term follow-…

This Phase 2 trial tests an experimental eye drop called BL1107 against a standard treatment (timolol) in 252 adults with glaucoma or high eye pressure. Participants use the drops twice daily for 28 days. The study measures changes in vision and eye pressure to see if BL1107 is s…

This study tests a small device called XEN45 that is implanted in the eye to help drain fluid and lower pressure in people with open-angle glaucoma. About 120 adults in China will receive either the XEN45 implant or standard glaucoma surgery. Researchers will track eye pressure a…

This early-stage trial is testing a single biodegradable implant placed in the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. The implant slowly releases medication over time and then dissolves. The study includes 12 adults and focuses on safety,…

This study tests a small implant placed inside the eye to help drain fluid and lower pressure in people with open-angle or narrow-angle glaucoma. It is for adults whose eye pressure is not well controlled with eye drops. The main goal is to see if the implant safely reduces press…

This study tests whether long-term, mild electrical stimulation using a home device can safely slow vision loss in people with open-angle glaucoma. About 45 adults with moderate vision damage will use the device regularly. The goal is to see if this approach can protect the optic…

This early study tests a new drainage device for people with glaucoma, a condition where pressure builds up in the eye. The device is designed to self-adjust to help lower eye pressure. Ten participants will be followed to see if the device is safe and effective at reducing press…

This early study tests a new device called the GORE Glaucoma Drainage Implant in 30 adults with primary open-angle glaucoma that eye drops cannot control or who are at high risk of scarring from standard surgery. The goal is to see if the implant safely lowers eye pressure by at …

This study reviews 100 patients with open-angle glaucoma who had two minimally invasive surgeries (Hydrus microstent and iTrack canaloplasty) along with cataract surgery. Researchers want to see if this combination lowers eye pressure and reduces the need for glaucoma medications…

This study follows 300 adults with open-angle glaucoma who had a surgery called CycloPen™ to lower eye pressure. Researchers will check if the surgery safely reduces eye pressure by at least 20% and if patients need fewer eye drops over 24 months. The goal is to see how well this…

This study tests whether high-intensity interval training (HIIT) can improve eye health and slow disease progression in people with glaucoma. 168 adults aged 40-75 with open-angle glaucoma will be randomly assigned to either a supervised HIIT program or standard care with lifesty…

This study tests a new device called the VividWhite Glaucoma Implant, which is surgically placed in the eye to help lower pressure in people with glaucoma. Sixty-five participants will be followed for 12 months to see if the implant safely reduces eye pressure and lessens the nee…

This study tests whether taking nicotinamide and pyruvate supplements can help protect the eyes of people with open-angle glaucoma. About 250 adults aged 35 to 85 will take either the supplements or a placebo for 20 months, while continuing their standard glaucoma medications. Th…

This pilot study tests whether placing a slow-release steroid insert (Yutiq) during glaucoma drainage surgery helps reduce scarring and keeps eye pressure lower. About 5 adults with glaucoma will receive the implant along with their surgery. Researchers will compare their pressur…

This phase 2 trial tests a small implant (NT-501) placed inside the eye to protect nerve cells and slow vision loss in people with glaucoma. 54 participants will either get the implant or a sham surgery, and their vision will be tracked for 2 years. The implant releases a protein…

This phase 2 trial tests whether an implant placed in the eye can slow vision loss in people with glaucoma. The implant releases a protein that may protect nerve cells. Thirty participants will receive either the real implant or a sham procedure and be followed for two years.

This study compares different ways of performing a laser treatment called selective laser trabeculoplasty (SLT) for people with open-angle glaucoma or high eye pressure. 400 participants will receive SLT using one of several protocols, and researchers will track how much their ey…

This study looks at the best way to repeat a laser treatment called SLT for people with open-angle glaucoma or high eye pressure. Researchers will compare different treatment methods in 400 participants who were already in an earlier SLT trial. The goal is to see how well repeat …

This study tests a new, less invasive drainage procedure for people with advanced neovascular glaucoma whose eye pressure remains high despite treatment. The goal is to safely lower eye pressure and reduce the need for pressure-lowering drugs. The study involves 30 participants a…

This study tests if a new, automated laser treatment (DSLT) works as well as the standard laser treatment (SLT) for lowering eye pressure in people with open-angle glaucoma. About 51 adults will receive one of the two treatments and be followed for 12 months. The goal is to see i…

This study tests two different spots (temporal vs inferior) for a YAG laser iridotomy in people with angle-closure glaucoma. Each patient gets one spot in each eye, and doctors track pressure, symptoms, and complications over six months. The goal is to find which location is safe…

This trial tests a small implant called MINIject that is placed inside the eye to help drain fluid and lower pressure in people with open-angle glaucoma. About 975 adults who have already had cataract surgery are taking part. The goal is to see if the implant safely reduces eye p…

This study follows 23 people who received a special lens implant that slowly releases a glaucoma drug (bimatoprost) during cataract surgery. Researchers want to see if it keeps eye pressure low and vision clear for up to 7 years. The goal is to learn whether this combination devi…

This study tests smart soft contact lenses that measure eye pressure continuously for 24 hours in people with glaucoma and healthy adults. Researchers will check how accurate and comfortable the lenses are compared to standard eye pressure tests. The goal is to improve glaucoma c…

This study tests whether a computer-based AI tool can teach glaucoma patients how to take a visual field test more accurately. The test checks side vision, which is important for monitoring glaucoma. If the tool works, it could lead to more reliable results, fewer repeat visits, …

This study looks at how a common glaucoma eye drop (latanoprost with preservatives) changes the natural bacteria living on the eye's surface. Researchers will compare the eye bacteria of 45 newly diagnosed glaucoma patients before and after at least 6 months of treatment. The goa…

This study looks at whether images of the optic nerve head taken at two different eye pressures can predict how glaucoma will change over time. Researchers will compare these strain measurements to actual vision loss in 130 glaucoma patients. The goal is to develop a new biomarke…

This study looks at how common Charles Bonnet Syndrome (CBS) is in people with vision loss from conditions like macular degeneration or glaucoma. CBS causes complex visual hallucinations without mental illness. Researchers will survey 640 participants to measure how often it happ…

This pilot study examines proteins in the vitreous (the gel-like fluid inside the eye) of patients with pseudoexfoliation syndrome (PEX), a condition that can lead to glaucoma. Researchers will compare protein levels between eyes with and without PEX in 24 adults undergoing eye s…

This study follows 250 people with open-angle glaucoma who had a new type of surgery called CycloPen, which aims to improve fluid drainage from the eye. Researchers will measure eye pressure at 3, 4, and 5 years after surgery to see if the benefits last. The goal is to understand…

This study looks at 116 adults who had glaucoma stent surgery up to 2 years ago. Researchers use a special eye scan (OCT) to check if the tiny stents are in the right position and how that affects eye pressure. The goal is to learn how often stents are misplaced and whether prope…

This study looks at how changing your body position or drinking water can cause temporary spikes in eye pressure. Researchers will measure these changes in healthy volunteers and in people with glaucoma or autonomic dysfunction. The goal is to better understand what challenges th…

This study reviewed medical records of 523 people with severe glaucoma who had one of two surgeries: trabeculectomy or Ahmed glaucoma valve implantation. Researchers wanted to see which factors, like early eye pressure control, were linked to central vision loss after surgery. Th…

This study gathers vision data from 100 healthy adults to teach an AI system how normal eyes see. The goal is to make a new eye test that can find problems like glaucoma more accurately. Participants do not receive any treatment, and the results will help improve future diagnosis…

This study follows 300 patients with chronic eye conditions like glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy who recently received treatment. Researchers will measure changes in eye pressure, vision, and other outcomes over time. The goal is to unde…

This study offers free vision screenings to underserved adults over 40 living in affordable housing in Harlem and Washington Heights. The goal is to find eye problems like glaucoma, cataracts, and diabetic retinopathy early and connect people with follow-up care. About 749 partic…

This study looks at how vision loss from glaucoma affects the daily mobility of older adults. Researchers will give questionnaires to 88 people with glaucoma to measure how far they typically go from home and how they manage in dim light. The goal is to better understand the real…