Tiny eye implant aims to lower glaucoma pressure

NCT ID NCT05821855

Ongoing Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a small device called XEN45 that is implanted in the eye to help drain fluid and lower pressure in people with open-angle glaucoma. About 120 adults in China will receive either the XEN45 implant or standard glaucoma surgery. Researchers will track eye pressure and any side effects for 5 years to see how well the device works in real-world use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: XEN45 glaucoma implant (a tiny drainage device placed in the eye)
What this could lead to: If successful, this could confirm that the XEN45 implant is a safe and effective option for lowering eye pressure in Chinese patients with open-angle glaucoma.
What could go wrong: This is a postmarketing study, so the device is already approved. However, it is still possible that side effects or limited long-term benefit may emerge, and results may not apply to all glaucoma patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

open-angle glaucoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OAG OPEN-ANGLE GLAUCOMA

Contacts and locations

Locations

Beijing Tongren Hospital Affiliated To Capital Medical University /ID# 244055

Beijing, Beijing Municipality, 100730, China
Peking University Third Hospital /ID# 243994

Beijing, Beijing Municipality, 100191, China
Peking University people s hospital /ID# 265493

Beijing, Beijing Municipality, 100044, China
Qingdao Eye Hospital Of Shandong First Medical University /ID# 243992

Qingdao, Shandong, 266071, China
Shenzhen Eye Hospital /ID# 244001

Shenzhen, Guangdong, 518034, China
The First Affiliated Hospital Of Fujian Medical University /ID# 244004

Fuzhou, Fujian, 350005, China
The Second Affiliated Hospital of Guangzhou Medical University /ID# 275493

Guangzhou, Guangdong, 510260, China
The Second Affiliated Hospital of Zhejiang University School of Medicine /ID# 243996

Hangzhou, Zhejiang, 310009, China
Tianjin Eye Hospital /ID# 243997

Tianjin, Tianjin Municipality, 300070, China
Tongji Hospital Tongji Medical College of HUST /ID# 243998

Wuhan, Hubei, 430030, China
West China Hospital, Sichuan University /ID# 243999

Chengdu, Sichuan, 610041, China
Xiamen Eye Center of Xiamen University /ID# 244000

Xiamen, Fujian, 390000, China
Zhongshan Ophthalmic Center,SunYat-Sen University /ID# 243843

Guangzhou, 510623, China

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