Can Vitamin-Like supplements save sight in glaucoma?

NCT ID NCT05695027

Ongoing Disease control Sponsor: Columbia University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 16, 2026 · Updated 3 times

Summary

This study tests whether taking nicotinamide and pyruvate supplements can help protect the eyes of people with open-angle glaucoma. About 250 adults aged 35 to 85 will take either the supplements or a placebo for 20 months, while continuing their standard glaucoma medications. The goal is to see if the supplements slow damage to the optic nerve and preserve vision.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nicotinamide and pyruvate (dietary supplements)
What this could lead to: If it works, this could offer a simple, safe supplement to help preserve vision in people with glaucoma.
What could go wrong: This is a mid-stage trial with 250 participants, so results may not apply to everyone. Supplements may not slow vision loss beyond standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

exfoliation syndrome open-angle glaucoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY OPEN ANGLE GLAUCOMA

Contacts and locations

Locations

Columbia University Irving Medical Center - 622 W 168th St

New York, New York, 10032, United States
ColumbiaDoctors Ophthalmology - 880 Third Avenue

New York, New York, 10022, United States
Stanford University Department of Ophthalmology

Palo Alto, California, 94303, United States

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