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Can eye surgery restore blood flow in glaucoma?

NCT ID NCT01931904

Knowledge-focused Sponsor: Oregon Health and Science University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

Researchers are studying whether lowering the pressure inside the eye improves blood flow to the eye in people with glaucoma. The study follows adults with open-angle or chronic angle-closure glaucoma who are scheduled for glaucoma surgery. Using imaging scans, the team measures eye pressure and blood flow before and after surgery to see if they are linked.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Glaucoma surgery (trabeculectomy or tube shunt surgery)
What this could lead to
If lowering eye pressure improves blood flow, it could point to better ways to protect vision in glaucoma patients.
What could go wrong
This is a small observational study, so it may not prove cause and effect. Results may not apply to all glaucoma patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 21 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2014

Expected to finish

May 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study will measure blood flow changes in 46 glaucoma patients undergoing trabeculectomy or shunt surgery to lower IOP.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subjects diagnosed with perimetric open angle glaucoma or chronic angle closure glaucoma. * Subjects scheduled to undergo trabeculectomy or tube shunt surgery Exclusion Criteria: * Best-corrected visual acuity less than 20/40 * Age \< 18 or \>85 years * Refractive error of \> +3.00 D or \< -7.00 D * Previous vision correction surgery such as Laser-Assisted in situ Keratomileusis (LASIK) or Photorefractive Keratectomy (PRK) * Previous intraocular surgery except for uncomplicated cataract extraction with posterior chamber intraocular lens implantation * Diabetic retinopathy * History of heart failure, myocardial infarction, transient ischemic attack or stroke * Other diseases that may cause VF loss or optic disc abnormalities * Inability to clinically view or photograph the optic discs due to media opacity or poorly dilating pupil * Inability to perform reliably on automated VF testing * Life-threatening or debilitating illness making it unlikely patient will successfully complete the study. * Refusal of informed consent or of commitment to the full length of the study

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Conditions

The condition(s) this trial relates to.

chronic closed-angle glaucoma glaucoma open-angle glaucoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Glaucoma

Contacts and locations

Locations

  • OHSU

    Portland, Oregon, 97239, United States

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