Glaucoma

This trial tests whether high-dose nicotinamide, a form of vitamin B3, can slow the loss of retinal nerve cells in adults with mild to moderate open-angle glaucoma. Participants already on standard glaucoma treatment will be randomly assigned to also take nicotinamide tablets or …

This study tests whether removing the ripcord from a glaucoma drainage device more than 3 months after placement lowers eye pressure. Adults with glaucoma who have had the ripcord in place for over 3 months will have it removed during a routine clinic visit. Researchers will meas…

This trial tests a support program for adults with glaucoma who struggle to take their eye drops regularly or attend clinic visits. Participants identify their main barrier, such as forgetfulness or difficulty using drops, and receive matching help like education, reminders, or t…

This study tests an experimental gene therapy called ASP2767 in people with open-angle glaucoma, a common eye disease that damages the optic nerve and can lead to vision loss. The therapy uses a harmless virus to deliver genes into the eye, helping retinal nerve cells produce pro…

This trial tests a new device called VividFlo, a small implant placed under the eye's surface to help drain fluid and lower pressure in people with glaucoma. The study involves 10 adults with glaucoma in one eye, who will receive the implant during surgery. Researchers will track…

This trial compares two surgical implants—the Baerveldt Glaucoma Implant and the Paul Glaucoma Implant—in people with glaucoma that is not well controlled by eye drops. Both devices are tiny tubes placed in the eye to drain fluid and lower pressure. The study will track which imp…

This trial investigates whether a 12-week home-based circuit training program can reduce intraocular pressure and improve retinal health in people with glaucoma. Participants are randomly assigned to either the exercise program plus standard care or standard care alone. The study…

This study aims to find the best material to cover a small drainage device used in glaucoma surgery. Glaucoma is a leading cause of blindness due to high pressure in the eye. The researchers will compare three different patch materials (donor sclera, cornea, and pericardium) in 1…

This study tests an experimental drug called REGN22530 in people with primary open angle glaucoma or ocular hypertension. The drug is designed to block a protein in the eye that causes fluid buildup and high pressure. Researchers are checking for side effects, how the drug moves …

This study compares three different devices used to perform a glaucoma surgery called goniotomy at the same time as cataract surgery. The goal is to see which device best lowers eye pressure and reduces the need for glaucoma medications over six months. About 132 adults with open…

This early study tests a small ring placed in the eye that slowly releases the drug bimatoprost to lower eye pressure in people with glaucoma or ocular hypertension. The ring is implanted during a quick surgery and may work for up to 3 years. The trial includes 24 adults and comp…

This study tests whether insulin eye drops can protect the optic nerve in people with open-angle glaucoma. Researchers will give 90 participants either insulin drops or placebo daily for up to 12 months. The main goal is to check safety, but they will also measure vision changes …

This Phase 3 trial tests a new eye drop, DNN.31.19.026, against a standard treatment (Cosopt) for people with high eye pressure or open-angle glaucoma. About 336 adults will use the drops twice daily for 56 days. The main goal is to see if the new drop lowers eye pressure better …

This study tests a new laser treatment called DSLT for people with high eye pressure or open-angle glaucoma who have already had a similar laser (SLT). The DSLT laser does not touch the eye, which may make it faster and more comfortable. Researchers want to see how well it lowers…

This study looks at children with a rare, severe eye disease called primary congenital glaucoma. It compares three different amounts of a surgery called goniotomy (120°, 240°, or 360°) to see which works best and is safest. The goal is to lower eye pressure and protect vision, bu…

This study tests whether placing a temporary stitch inside a tiny drainage device (Preserflo) can reduce the risk of dangerously low eye pressure after glaucoma surgery. The device is already used in France to lower eye pressure, but low pressure can still happen. About 192 adult…

This study tests whether a structured glaucoma awareness program helps patients in Nepal follow their treatment better. Glaucoma requires lifelong care to prevent blindness, but many patients struggle with adherence. Researchers will measure changes in adherence using a questionn…

This study tests a non-invasive laser procedure called direct selective laser trabeculoplasty (DSLT) in 40 adults with pseudoexfoliation glaucoma. The goal is to see if the laser can safely lower eye pressure by at least 20% at 6 and 12 months. Participants will have their eye pr…

This study tests whether a laser treatment called DSLT can lower eye pressure and reduce the number of eye drops needed in Asian patients with normal tension glaucoma. About 40 adults will receive the laser and be followed for 12 months. The goal is to see if the laser can help c…

This study looks at how Rocklatan eye drops change blood flow in the eyes of 30 people with early-stage glaucoma. Researchers will use special imaging to measure blood flow before and after using the drops for up to a year. The goal is to better understand the drug's effects on e…

This trial tests whether the Tomey FT-1000, a non-contact tonometer that measures eye pressure with a puff of air, agrees with the standard Goldmann applanation tonometer, which touches the eye. Researchers will enroll 30 adults with glaucoma and measure eye pressure with both de…

This study tests an artificial intelligence (AI) system called GlaukomAI that analyzes standard eye photos to detect glaucoma, a leading cause of blindness. Researchers will enroll 1,200 participants to see how accurately the AI identifies glaucoma compared to expert doctors. If …

This study explores whether a novel computer-based visual task can detect early glaucoma by measuring how well people perceive contrast-modulated motion. Glaucoma often goes unnoticed because it starts in peripheral vision, and current tests may miss early damage. The researchers…

This trial evaluates a new device called the Photobionic IOP Tonometer (PIB) that measures eye pressure without touching the eye or using an air puff. It uses a low-power infrared light and a gentle sound to detect tiny movements on the eye's surface, which a computer analyzes to…

This study will develop and test an artificial intelligence system to detect common eye diseases like glaucoma, cataracts, and diabetic retinopathy using 15,000 existing eye images from Costa Rican patients. The goal is to create a tool that works accurately for local populations…

This study will test a new artificial intelligence (AI) system that reads eye scans (OCT) to diagnose common blinding eye diseases like diabetic retinopathy, glaucoma, and age-related macular degeneration. Researchers will collect 2000 eye scans from patients at Peking Union Medi…

This study looks at 60 adults with high eye pressure or early open-angle glaucoma to see if combining advanced eye scans and vision tests can detect damage sooner. Participants will have standard eye exams plus special imaging of the optic nerve. The goal is to improve how doctor…

This study tests whether a structured referral tracking program helps adults in Pakistan complete follow-up eye care after community screenings. 500 participants will receive either standard referral or extra support like counseling and weekly reminders. The goal is to prevent bl…

This study tests whether an online meditation program can reduce stress and improve quality of life in people with glaucoma. Participants aged 65 and older will be randomly assigned to either meditation plus usual care or usual care alone. They will fill out questionnaires about …

This trial tests whether a structured reading rehabilitation module can improve reading speed and reduce errors in people with glaucoma, a condition that often impairs vision. Participants will practice the module for 20-30 minutes daily, at least 3 days a week, for 6 months. The…

This study tests a device called Nanodropper that attaches to eye drop bottles and makes each drop smaller. Many glaucoma patients have trouble getting drops into their eyes or use too much, wasting medication. The trial will see if the device helps patients finish their bottles …

This study tests a smart cap called iD2 that fits on eye drop bottles. It tracks when you remove the cap and sends reminders to your phone if you forget a dose. The goal is to help people with glaucoma take their drops more regularly, which can prevent vision loss. About 100 adul…

This study tests whether a structured blinking exercise can improve dry eye symptoms in adults with glaucoma who use eye drops. 45 participants will perform 15 close-squeeze-open blinks three times daily for two weeks. Researchers will measure symptom changes and tear film stabil…

This study tests whether a combination of gentle brain stimulation and visual exercises can improve vision and daily function in people with glaucoma who have lost some side vision. About 56 adults with open-angle glaucoma will receive both real and sham treatments in a crossover…

This study tests whether daily SMS or WhatsApp reminders can help people with primary open-angle glaucoma stick to their eye-drop schedule. About 84 adults will be split into two groups: one gets the reminders plus weekly educational messages for 3 months, the other gets standard…

This study will test whether a special type of lens implant (extended depth-of-focus, or EDOF) can give better vision and more satisfaction than standard monofocal lenses for people with both glaucoma and cataracts. About 74 adults with early-to-moderate open-angle glaucoma will …

This study tests whether Meta AI glasses, connected to the Be My Eyes network, can help people with permanent vision loss walk and move around more easily. The glasses describe scenes and objects in real time. Fifty participants will use the glasses and report changes in their qu…

This study tests whether Lumify, a low-dose brimonidine eye drop already approved for redness, can safely reduce eye redness and eyelid droop in 60 glaucoma patients who already use stronger brimonidine drops. Researchers will measure redness, eye pressure, and eyelid position af…

This study will screen over 7,000 adults aged 40+ living in affordable housing in New York City for undiagnosed high blood pressure and glaucoma. Participants who need follow-up care will be randomly assigned to receive text message reminders or usual care. The goal is to see if …

This study is testing whether a specialized eye scanner called the MONA IV can capture clear, detailed images of the retina's tiny cells and blood vessels. Researchers will use it in people with conditions like glaucoma or age-related macular degeneration, as well as in healthy v…

This study follows 70 adults aged 50 and older who are having routine cataract surgery. Half have pseudoexfoliation syndrome, a condition that can weaken eye tissues, and half do not. Researchers measure corneal stiffness before surgery and at several points afterward to see whet…

This study looks at whether a common type of glaucoma eye drop (prostaglandin analogues) can protect the eye's nerve cells directly, not just by lowering eye pressure. Researchers will review medical records from 1500 adults with glaucoma over 3 years, comparing those on prostagl…

This study looks at people with primary angle-closure glaucoma who need a specific type of eye surgery. The goal is to find out which patients are at higher risk for a rare but serious complication called ciliary block, where fluid builds up in the wrong part of the eye. Research…

This study looks at how different ways of managing a child's airway during anesthesia affect eye pressure and heart rate in children having surgery for congenital glaucoma. 75 children will be split into three groups, each receiving a different airway device. The goal is to find …

This study looks at whether different types of exercise (like walking or strength moves) and timing (morning vs. evening) can safely lower blood pressure in people with glaucoma and high blood pressure. About 60 adults will try four exercise sessions, and their blood pressure and…