Angle-closure glaucoma

This study is tracking 480 people with neovascular glaucoma, a serious eye condition, who are receiving the drug Eylea (aflibercept) as part of their normal care. Researchers are monitoring side effects and how well the drug controls eye pressure and vision over 6 months. The goa…

This study tests whether adding an extra step (a special blade to open drainage channels) to standard cataract-and-glaucoma surgery can better lower eye pressure in people with chronic angle-closure glaucoma and cataracts. About 68 adults will be randomly assigned to one of two s…

This study tests whether a daily supplement called BrudyGlauco (containing DHA and citicoline) can help protect eyesight in people with glaucoma. About 108 participants will take either the supplement or a placebo for 12 months. The goal is to see if it slows vision loss and impr…

This study compares two surgical procedures for people with primary angle-closure glaucoma: Phaco-GSL (cataract surgery combined with a procedure to open the eye's drainage angle) and trabeculectomy (a standard glaucoma surgery that creates a new drainage pathway). Researchers wa…

This study screens people with eye diseases to see if they can join other research studies at the National Eye Institute. No treatment is given. Participants undergo eye exams, blood tests, and other procedures to diagnose or evaluate their condition. The goal is simply to determ…

This study tests a special camera that takes super-detailed pictures of the back of the eye (the retina). The goal is to see if this technology can find eye diseases earlier than standard methods. Up to 1,000 people aged 12 and older, with or without eye disease, will have their …

This study aims to learn more about eye diseases by observing and providing standard care to up to 1,000 people over 5 years. Participants receive regular eye exams, tests, and treatments as needed. The goal is to better understand how eye diseases progress and are inherited, not…

This study will use advanced eye scans (OCT and OCTA) to compare the structure and blood flow of the choroid and retina in people with two main types of glaucoma: primary angle-closure disease and primary open-angle glaucoma. Researchers aim to better understand how these conditi…

This study looks at why some people with primary angle-closure glaucoma have loose eye lenses (zonular laxity). Researchers will compare molecules from 150 participants—those with and without this lens looseness, plus healthy controls—to find key differences. The goal is to bette…

This study looks at how tiny fibers in the eye, called the vitreous zonule, might play a role in causing primary angle-closure glaucoma, a serious eye condition. Researchers will use advanced 3D ultrasound to take detailed pictures of these fibers in 440 adults, including those w…

This study follows 132 adults having glaucoma surgery to see how their quality of life changes over six months. Patients fill out a questionnaire about vision-related daily activities before and after surgery. The goal is to compare different surgical techniques from the patient'…

This study tests whether artificial intelligence can create simple summaries of eye doctor notes that are easier for patients to understand. About 460 English-speaking adults receiving eye care will get either standard notes or notes plus an AI-generated plain language summary. P…

This study tests a new 4D microscope-integrated OCT system for the first time in people during eye surgery. Researchers want to see if the system is easy to use, safe, and can clearly show eye structures. Five adults having eye surgery will take part. The goal is to improve imagi…

This study uses special cameras to watch how eye tissues heal after minimally invasive glaucoma surgery. Researchers will follow 300 glaucoma patients to measure changes in the eye's drainage angle over time. The goal is to learn more about healing patterns and help improve futur…

This study gathers standard eye movement and pupil data from 200 healthy volunteers, children, and people with eye or brain conditions using a VR headset called neos™. The headset shows images and tracks where participants look, how their pupils react, and how their eyes move. Th…

This study tests a new, more comfortable eye camera (WiSLO) designed for children and adults. Researchers want to see if it takes better pictures and is less bothersome than current cameras. About 42 people with or without eye disease will have their eyes photographed with both t…