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Can a modified glaucoma surgery match the standard one?

NCT ID NCT07800637

Disease control Sponsor: Minia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This trial compares two surgical procedures for people with primary open-angle glaucoma whose eye pressure stays high despite maximum medication. One group receives deep sclerectomy with scleral bed fenestration, a modified drainage surgery, while the other receives trabeculectomy with mitomycin C, the standard approach. Researchers measure eye pressure after surgery to see if the modified procedure can achieve results similar to trabeculectomy. The study includes adults over 40 with uncontrolled glaucoma who have not had prior laser treatment for the condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Two surgical procedures: deep sclerectomy with scleral bed fenestration (a modified drainage surgery) and trabeculectomy with mitomycin C (the standard drainage surgery)
What this could lead to
If the modified deep sclerectomy works as well as trabeculectomy, it could offer a safer or equally effective surgical option for people with glaucoma that eye drops no longer control.
What could go wrong
The trial is small (39 participants) and early, so results may not apply to everyone. Surgery carries risks like infection, bleeding, or too-low eye pressure, and the modified procedure might not match trabeculectomy's effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

39 people

The number who actually took part.

Started

Feb 2025

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients above 40 years old. 2. Primary open angle glaucoma patients who are uncontrolled on maximally tolerated medical therapy. 3. لاPhakic (with clear lens or visually insignificant cataract) patients Exclusion Criteria: 1. Patients with any other type of glaucoma except for primary open angle glaucoma. 2. Patients who received previous laser therapy for glaucoma as laser trabeculoplasty. 3. Patients with severe ocular surface diseases as ocular cicatricial pemphigoid and severe dry eye 4. Previous ocular surgeries. 5. Patients with significant cataract.

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Conditions

The condition(s) this trial relates to.

open-angle glaucoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Deep sclerectomy Open angle glaucoma (OAG) Open angle glaucoma (OAG) surgeries

Contacts and locations

Locations

  • Faculty of medicine, Minia university

    Minya, Minya Governorate, 61111, Egypt

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