Combat disorder

This trial tests whether an internet-based form of cognitive behavior therapy (CBT) can reduce symptoms of common mental disorders like anxiety, depression, and stress-related conditions in adults seeking primary care. About 500 participants will be randomly assigned to either th…

This study tests whether a single 45-minute psychiatric interview, given soon after ICU discharge for sepsis, can lower the risk of developing post-traumatic stress disorder (PTSD). Many ICU survivors face long-term mental health issues, but most hospitals lack early screening an…

This study tests a stepped care program called PCT+2HOPE for women with opioid use disorder who have also experienced intimate partner violence and PTSD symptoms. The program adds group and individual therapy to standard medication treatment. Researchers will see if it helps wome…

This study tests a 9-session program called MILAP for young married women (ages 15-24) in Nepal who have experienced intimate partner violence. The program involves the woman, her husband, and her mother-in-law, aiming to reduce depression, violence, and PTSD. 900 participants wi…

This study tests whether a trauma-focused group therapy (CPT-CJ) given in prison can reduce drug use, PTSD symptoms, and re-arrest after release. 640 incarcerated adults from about 10 prisons will either receive the group therapy or a self-help workbook. Researchers will also mea…

This study tests whether giving e-cigarettes to smokers with mental illness—along with optional behavioral coaching—helps them switch from regular cigarettes and lower their exposure to harmful chemicals. The trial enrolls 250 daily smokers who have tried to quit before but aren'…

This study tests a new iPhone app called Senseye DT that uses artificial intelligence to diagnose Post-Traumatic Stress Disorder (PTSD) in adults. Participants will use the app while it records video of their face, and the AI looks for signs of PTSD. The goal is to see if the app…

This study tests whether combining virtual reality therapy with a mild brain stimulation technique can help veterans and civilians in Ukraine cope with PTSD. Participants attend 10 therapy sessions using VR goggles to safely face traumatic memories, with some also receiving a gen…

This study tests an online wellness course that teaches diet, exercise, stress reduction, and self-care to people with rheumatoid arthritis, lupus, Sjogren's syndrome, and similar conditions. Researchers want to see if the program reduces fatigue and improves quality of life. Abo…

This study tests a new anonymous online therapy program called Restory for people with PTSD after sexual abuse. It is designed for 140 adults who have experienced sexual violence at least one month ago. The therapy uses a type of talk therapy done over the internet, and the goal …

This study tests whether giving cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 kids will be randomly assigned to one of three delivery methods. The goal is to find out which approach impro…

This early-stage pilot study is testing whether psilocybin, a psychedelic compound, can be safely combined with trauma-focused psychotherapy for people with post-traumatic stress disorder (PTSD). Thirteen participants will receive two doses of psilocybin in a controlled setting, …

This study tests a new, quick brain stimulation treatment for PTSD. Fifteen adults with PTSD will get a brain scan to map their fear and control centers. Then, over 5 days, they receive many short magnetic pulses to strengthen brain connections and reduce symptoms. The study chec…

This study tests a program called Mental Gym® that uses a smartwatch and phone app to help combat veterans with PTSD. About 80 veterans will either start the program right away or wait a few months. The goal is to see if daily biofeedback exercises and group support can reduce PT…

This study tests a short, virtual therapy for pregnant women and new mothers with PTSD. About 90 participants will either receive the therapy or standard care. The goal is to see if the therapy is practical and well-liked, and to measure its effect on PTSD and depression symptoms…

This pilot study is testing whether transcranial magnetic stimulation (TMS) can help ease PTSD symptoms in veterans. Twenty veterans with moderate to severe PTSD will receive ten sessions of low-frequency TMS over 2–4 weeks. Researchers will also use brain scans and blood tests t…

This study is testing a new type of talk therapy called Process-Based Therapy (PBT) for people with anxiety. Unlike standard treatments, PBT adapts techniques from different therapies to target each person's specific struggles. Ten adults with moderate-to-severe anxiety will try …

This early study tests whether a surgically implanted device that stimulates the vagus nerve can boost the effects of talk therapy for people with chronic PTSD. Twenty adults who have not gotten better with standard treatments will receive either active or sham stimulation alongs…

This study compares a standard mobile cognitive behavioral therapy (CBT) program to a personalized version that teaches skills faster. About 100 adults aged 18-25 with anxiety, depression, or bipolar disorder will use the Maya app for 20 minutes, twice a week, for six weeks. The …

This study is testing a mobile app called MAYA that teaches cognitive behavioral therapy (CBT) skills to help older adults manage anxiety and depression. About 60 participants aged 40 and older with an anxiety or depressive disorder will use the app for at least 20 minutes, twice…

This study tests whether a special computer-based brain training program can help adults with PTSD improve memory, attention, and daily functioning. Participants will be randomly assigned to either the brain training program or regular computer games, both with group discussions,…

This study tests if a smartphone app called Sidekick can help teenagers with anxiety disorders practice exposure exercises between therapy sessions. About 46 teens aged 13-18 will use the app alongside their usual outpatient treatment. The goal is to see if the app is practical, …

This study tests a program called NurseNET, where nurses are trained to provide a short-term trauma therapy for PTSD. The goal is to make treatment easier to access for people who see their primary care nurse. Researchers will enroll 100 adults with PTSD symptoms and measure if s…

This study tests a handheld device called gammaCore that gently stimulates the vagus nerve in the neck, aiming to reduce PTSD symptoms. About 40 adults with PTSD will use the device at home for 12 weeks. Researchers will track symptom changes and safety to see if this approach co…

This study tests whether adding a digital mindfulness program to usual care helps adults aged 18-65 recover from emotional disorders like depression, anxiety, OCD, PTSD, and eating disorders. Participants attend online group sessions and use a WeChat mini-program for daily exerci…

This study tests whether a program that improves how ICU staff care for patients can lower discomfort and reduce the risk of PTSD after leaving the hospital. About 1,242 adults who have been in the ICU for at least three days will take part. The program includes better communicat…

This study tests a new therapy called AMBET (Acceptance- and Mindfulness-Based Exposure Therapy) for treating PTSD in people who survived a cardiac arrest. About 90 adults will be randomly assigned to either AMBET or a standard talk therapy (PCT) for 12 weeks. Researchers will tr…

This study tests a brief group therapy that teaches people to better understand their own and others' thoughts and feelings (called mentalization). One hundred adults with anxiety or depression will be randomly assigned to this new therapy or to standard group therapy. Researcher…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can reduce symptoms of post-traumatic stress disorder (PTSD). About 72 adults with PTSD will receive 60 treatments over 12 weeks, and researchers will track their symptoms for up t…

This early-stage study at Yale is testing whether a single 25 mg dose of psilocybin is safe and tolerable for people whose daily life is impaired by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug openly (everyone knows they get it) and be f…

This pilot study tests a new way to deliver trauma-focused therapy to teens with PTSD. It combines therapist-led video sessions with a mobile app for self-paced exercises. Researchers want to see if this blended approach is feasible and acceptable compared to standard therapy. Ab…

This study tests a group therapy method called I-Reconstruction to see if it lowers anxiety in adults. Thirty-six participants will attend ten weekly online sessions and complete questionnaires about their anxiety and mood. The researchers will compare them to a group receiving u…

This study tests whether listening to 15 minutes of frequency-filtered classical music before each cognitive processing therapy session can improve PTSD symptom relief. 100 adults with PTSD or subthreshold PTSD will be randomly assigned to hear either filtered or unfiltered music…

This study tests a new therapy called the Reconsolidation of Traumatic Memories (RTM) Protocol for people with PTSD in Ukraine. The goal is to reduce distressing symptoms like flashbacks and anxiety without requiring patients to relive their trauma in detail. The study will invol…

This study looks at whether art therapy can help active-duty military and recent veterans who have PTSD symptoms. Forty participants will attend 11 sessions over 6-8 months, including art therapy with a certified therapist and two MRI brain scans. The goal is to see if art therap…

This study tests whether 5 group sessions teaching mind-body skills can reduce PTSD symptoms and emotional problems in 120 adolescents aged 11-17 in Gaza who have experienced war-related trauma. Participants are randomly assigned to either the mind-body group or a control group, …

This study tests a quick, 5-day group therapy program for active-duty military and veterans who struggle with PTSD, insomnia, and nightmares. 160 participants will receive either cognitive-behavioral therapy or sleep education, both combined with a proven PTSD writing therapy. Th…

This study tests whether an online, therapist-guided program for insomnia can also reduce anxiety symptoms. 98 adults with both chronic insomnia and anxiety will either start the program immediately or after a delay. The program includes sleep education, behavioural strategies, a…

This study looks at whether combining two common therapy techniques—changing negative thoughts and practicing detached mindfulness—works better than using them alone for people with anxiety or depression. Researchers will compare the effects of each technique and their order. The…

This study tests a new version of a therapy called RTM-C for children aged 6-14 with PTSD. The treatment uses child-friendly language, games, and animated tools to help kids safely replay difficult memories and reduce fear. About 40 children and their parents will take part in up…

This study tests a software program designed to reduce symptoms of post-traumatic stress disorder (PTSD). About 52 adults with PTSD will use the software or a placebo version. Researchers will measure changes in PTSD severity using a standard scale over the study period.

This study is testing whether low-intensity focused ultrasound (LIFU) — a noninvasive device that sends sound waves to the brain — can help people with chronic back pain, opioid cravings, and anxiety. Researchers will enroll 25 adults and measure safety, mood, heart rate, and oth…

This study is testing whether hyperbaric oxygen therapy (HBOT) can improve thinking, mood, and quality of life in veterans who have traumatic brain injury, PTSD, anxiety, or depression. Fifty-four veterans will receive multiple HBOT sessions in a pressurized chamber while breathi…

This study tests whether brief, online self-guided programs can help parents of children ages 2-7 better manage their child's anxiety. About 90 parents will be randomly assigned to one of three programs. The goal is to see if these programs reduce how much parents accommodate the…

This pilot study tests whether a 5-day intensive therapy program can help teens aged 13–17 with PTSD. The program combines trauma-focused therapy, EMDR, physical activity, and parent support. Researchers want to see if it's practical and acceptable in Swedish child psychiatry, an…

This study tests whether brief educational videos delivered by text message can help young people aged 15-25 manage symptoms of post-traumatic stress disorder (PTSD). Participants are randomly assigned to receive the videos right away or after a 5-month wait. The study is fully o…

This study at the National Institute of Mental Health screens up to 16,000 people with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies. Participants undergo evaluations like psychiatric interviews, brain scans, and lab test…

This study looks at how people with depression or anxiety respond to different types of psychotherapy—individual sessions or an online program. It aims to find clues that predict who benefits most from each approach. By understanding these factors, doctors may better match patien…

This study investigates whether the quality of parent-adolescent communication at the start of psychiatric inpatient treatment predicts how much symptoms improve six months later. Researchers will track 60 adolescents hospitalized for depression, anxiety, or other mental disorder…

This study looks at how a stellate ganglion block injection affects sleep in U.S. service members and veterans with PTSD who are already receiving talk therapy. About 40 participants will wear an EEG headband for three nights before and three nights after the injection to measure…

This study uses a special PET scan tracer to measure a brain protein called PDE4B in people with PTSD or alcohol use disorder. Researchers want to see if levels of this protein differ from healthy individuals. The study involves 160 adults aged 18 to 70 and does not offer treatme…

This study tests whether combining a one-time session of brain stimulation (rTMS or electrical scalp stimulation) with emotion regulation training helps people with mood, anxiety, or related disorders better control their emotions. 240 participants will learn either cognitive res…

This study is testing a new questionnaire called PTSD-iMPACT to see how well it measures the ways PTSD can interfere with daily life in children and adolescents. Researchers will include 1,200 participants from Switzerland and Germany, both those with and without PTSD symptoms. T…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study uses brain imaging and a single dose of the anti-anxiety drug lorazepam to understand how people with both depression and anxiety disorders process threats differently than those with depression alone. About 165 adults will complete two sessions involving startle tests…

This study looks at what to do when the first PTSD therapy doesn't work. Researchers will test different proven therapies on 400 adults who didn't respond to initial treatment. The goal is to find out which second treatment works best and create a tool to identify early who might…

This study is looking for genetic markers linked to a side effect called behavioral activation—feeling overly excited or agitated—that can happen when children and youth take SSRI antidepressants for depression, anxiety, or OCD. Researchers will collect DNA from 160 participants …