AIDS

This study tests whether a combined approach—offering HIV PrEP (pills or injections) and STI prevention (doxycycline after sex) along with smartphone tools—helps young men at high risk stay protected. About 400 men aged 18-29 who have sex with men will be followed for a year to s…

This pilot study tests a program called Kisoboka Amaka for men living with HIV who drink heavily and have pregnant partners. The program combines counseling, financial training, and mobile savings to help men drink less and take their HIV medication consistently. Researchers will…

This study tests whether the drug elranatamab can help keep plasmablastic lymphoma, a rare and aggressive blood cancer, from returning after initial chemotherapy. About 17 adults with or without HIV who have already responded to first treatment will receive elranatamab injections…

This early-stage trial tests whether combining two drugs—ibalizumab and chidamide—can safely reduce the hidden HIV reservoir in people living with HIV. The study will enroll up to 29 adults on stable antiretroviral therapy. Researchers will monitor side effects and measure change…

This study will test a mobile app called MindBodyU designed to help young people (ages 16-25) living with HIV in South Carolina stay connected to their care and take their HIV medication regularly. The goal is to see if the app is easy to use, liked by users, and helps improve me…

This phase 2 trial tests whether a mix of intensified antiretrovirals, a latency-reversing drug, an anti-proliferative drug, and a personalized vaccine can shrink the hidden HIV reservoir enough to allow people to stop their daily medication. The study will enroll 70 adults with …

This study tests a smartphone app called ESCAPE, designed specifically for Black adults with HIV who smoke. The app teaches ways to handle stress, anxiety, and nicotine cravings, and is paired with nicotine patches or gum. 300 participants across the US will be randomly assigned …

This early-stage trial tests a combination therapy to target hidden HIV reservoirs. Twenty HIV-positive adults on stable antiretroviral therapy will receive chidamide (to reactivate dormant virus) followed by infusions of engineered NK cells designed to kill the reactivated cells…

This study tests a drug called Sintilimab, which is normally used for cancer, to see if it can help people with HIV who have infections that won't go away with standard treatment. The drug works by 'waking up' exhausted immune cells. Fifty adults with HIV and a hard-to-treat infe…

This early-stage trial tests a topical ointment called ACU-D1 for HPV-related vulvar and perianal lesions in people with HIV. Nine participants will apply the cream twice daily for 4 weeks. The main goal is to find the safest dose and see if the treatment can boost immune markers…

This study tests whether a one-visit, point-of-care test and treat approach helps more people with HIV, hepatitis B, or hepatitis C complete hepatitis C treatment within 24 weeks compared to standard care. About 1,280 participants will be randomly assigned to either the simplifie…

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This study compares vaginal estradiol tablets (Vagifem) to a vaginal moisturizer (Replens) for treating menopause-related vaginal and urinary symptoms in women living with HIV. Researchers will also check how these treatments affect the vaginal microbiome. The study includes 62 p…

This early-stage study tests a new experimental HIV drug called VH4770359 in 214 healthy adults aged 18-55. The goal is to check its safety, side effects, and how the body processes it. Participants will take either the drug or a placebo, and some will also receive midazolam to s…

This study looks at whether people with HIV who have stopped their medication for at least 12 weeks can safely restart treatment with a single daily pill (B/F/TAF) on the same day they return to care. About 200 adults will take part to see if this quick restart helps lower the vi…

This study tests a 3-session telehealth counseling program called IDEAS for Hope, delivered by nurses, to help adults living with HIV in Tanzania who have had recent thoughts of suicide. The goal is to reduce suicidal thinking and improve engagement in HIV care, including medicat…

This study offers continued access to HIV medications (fostemsavir or dolutegravir/lamivudine) for 183 people who completed earlier ViiV Healthcare studies and are still benefiting. The goal is to provide treatment while collecting more safety information. Participants must have …

This early-stage trial tests whether a combination of three existing drugs (topiramate, lenalidomide, and pyrimethamine) can wake up dormant HIV hiding in the body and then help the immune system eliminate those infected cells. The goal is a 'functional cure' where the virus is c…

This study tests whether valganciclovir, a drug that stops CMV from multiplying, can safely lower CMV levels in the blood of people with advanced HIV. About 130 adults and adolescents with very weak immune systems will be randomly assigned to take either valganciclovir or a place…

This study tests whether two different chemotherapy drugs, paclitaxel and pegylated liposomal doxorubicin, work equally well for treating Kaposi sarcoma in people living with HIV in sub-Saharan Africa. About 130 participants will receive one of the drugs every three weeks for six…

This study will test two ways to find TB in pregnant women with HIV: using symptoms or a blood test. It will also compare starting TB prevention medicine right away versus after giving birth. The goal is to reduce harm to mothers and babies. About 1,500 pregnant women in Uganda w…

This pilot study tests whether a peer-led program called Yuva Sath can help young people (ages 18-29) who inject drugs stay engaged in substance use treatment and HIV prevention. The program includes six one-on-one sessions with a peer counselor and weekly text check-ins. Researc…

This study tests an immunotherapy called PDS0101 in 27 adults with both HIV and HPV 16. The goal is to see if it is safe and can strengthen the immune system's response against HPV, which can cause cancers like anal and cervical cancer. All participants will receive three doses o…

This study will test a new computer tool that helps emergency doctors spot patients at high risk for hepatitis C and HIV. The tool uses a machine learning algorithm to analyze patient data and pops up an alert for the doctor. Researchers will compare this targeted screening with …

This study will check if a new device called MagIA H3S can accurately detect HIV, hepatitis B, hepatitis C, and syphilis in pregnant women in the Democratic Republic of the Congo. About 7,500 pregnant women will take part. The goal is to see if this quick test works as well as st…

This study will test if using two heat probes instead of one can better prevent cervical cancer in 300 women with HIV in Zimbabwe. The standard single-probe treatment often fails in these women. The goal is to see if the two-probe method is safe, acceptable, and more effective at…

This study tests whether using two probes during a heat-based treatment (thermal ablation) works better than the usual one-probe method to prevent cervical cancer in women living with HIV. About 200 women aged 25-49 with HIV and cervical precancer will be enrolled. The goal is to…

This study tests a new program where trained village health workers use tablet-based tools to provide HIV prevention services, including PrEP and emergency PEP, to people at high risk in rural Lesotho. About 380 participants will be enrolled to see if this approach increases mont…

This study tests whether a short course of the steroid prednisolone can prevent paradoxical immune reconstitution inflammatory syndrome (IRIS) in people with AIDS who have low CD4 counts and are starting HIV treatment. About 131 participants will receive either prednisolone or no…

This study will test whether using two heat probes instead of one to treat cervical precancer works better for women living with HIV. Researchers in Rwanda will enroll 300 women to see if the two-probe approach is safe, acceptable, and more effective at clearing HPV. The goal is …

This study tests a digital teleconsultation program called E-PrevenT to help transgender sex workers and their clients access HIV and STI prevention services. The program aims to reach people who are often left out of traditional prevention efforts. Researchers will enroll 250 pa…

This study tests whether using two heat probes instead of one can better prevent cervical cancer in women living with HIV, who face a much higher risk. Researchers will enroll 300 women in Kenya to see if the two-probe method is safe, acceptable, and more effective at clearing HP…

This study tests whether making HIV and STI testing and PrEP navigation a routine, opt-out part of primary care increases their use. About 700 adults aged 18-45 at health centers in Mississippi will take part. Researchers will compare a standard-care period to an integrated-care …

This study tests a training package called YACHT in 42 HIV testing clinics across Florida. The training helps staff use motivational interviewing to improve HIV testing and PrEP referrals for young men who have sex with men. Researchers will track whether testing rates and servic…

This study tests whether nurses, instead of doctors, can safely and effectively give long-acting HIV prevention shots in rural public health clinics. About 250 adults at risk for HIV will take part across several clinics in Missouri. The goal is to see if this nurse-driven approa…

This study will adapt two proven prevention programs (SISTA/SIHLE) to help Black adolescent girls in Paterson, New Jersey avoid HIV/AIDS and substance abuse. Researchers will use focus groups with 10 girls aged 13-18 to understand their needs and then measure changes in drug use,…

This study tests an enhanced version of depression treatment (COMBEX) for youth aged 15-24 with HIV. It combines therapy, medication management, and extra support strategies to improve mood and HIV care. Researchers will compare it to standard combination therapy over 72 weeks in…

This study tests whether metformin, a standard diabetes drug, can help treat depression in people living with HIV. Researchers will enroll 600 adults with HIV and depression, giving them metformin, fluoxetine (a standard antidepressant), both, or a placebo for up to 12 weeks. The…

This study tests whether a smartphone app that plays personalized music can help people with HIV manage chronic pain. Sixty participants will either use the music app daily for 3 months or receive educational materials about pain. The main goal is to see if the app is practical a…

This early-stage study looks at how a common tuberculosis drug, rifampin, affects levels of a new HIV prevention medicine called MK-8527. Fourteen adults with latent TB (no active symptoms) will take MK-8527 with and without rifampin. The goal is to see if the two drugs can be us…

This observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…

This study looks at sleep health in people with HIV who are on different antiretroviral therapies. Some participants switch from a dolutegravir-based regimen to a doravirine-based one, while others stay on dolutegravir. Sleep is measured using questionnaires, wrist-worn activity …

This study investigates whether a simple coronary CT scan can detect early signs of heart disease in people with HIV. Researchers will measure calcium buildup in the heart arteries of 384 Mexican adults with HIV who have undetectable viral loads. The goal is to better understand …

This study will look at over 12,000 adults in the Basque Country to compare how common multiple health conditions, taking many medications, and getting risky prescriptions are among people with HIV versus the general population. Researchers will use electronic health records to g…

This research project aims to understand why older adults get more infections and why those infections can be more serious. By following 23,000 people aged 60 and older, scientists will collect health data and samples like blood and stool to study how the immune system changes wi…

This study looks at how HIV might change the way the body handles fats in the liver, leading to fatty liver disease. Researchers will collect one blood sample from 120 adults: people with HIV and fatty liver, people without HIV but with fatty liver, and healthy controls. By analy…

This observational study will use cardiac MRI to examine how stimulant and polysubstance use affects heart scarring and inflammation in 400 people with and without HIV. Participants will have one study visit for a detailed heart scan. The goal is to better understand the combined…

This study looks at how to make cervical cancer screening easier for women with HIV, who are at higher risk for this cancer. Researchers will talk to patients and doctors to find out what gets in the way of screening and follow-up care. They will also explore using HPV self-testi…

This study looks at better ways to screen for HPV and prevent cervical cancer in women living with HIV. Researchers will test a new method that identifies specific HPV types and viral load. The goal is to see if this approach is practical for a larger future study. About 750 wome…

This study aims to reduce medical mistrust and improve HIV prevention among Hispanic/Latino gay and bisexual men in Mecklenburg County, NC. Researchers will train peer navigators to support their social networks for 12 months, then measure changes in mistrust, HIV testing, and Pr…

This study looks at how satisfied young people and those with low incomes are with free HIV and STI testing and counselling in Lucerne and Zurich. Around 1,800 participants will fill out a questionnaire after their visit. The goal is to see if these free services meet people's ne…

This study surveys 480 Italian dental students to understand their attitudes, knowledge, and any discriminatory behavior toward HIV-positive patients. Participants answer anonymous questions about their comfort, knowledge of HIV, and use of safety protocols. The goal is to identi…

This study tests a 12-week group program for HIV-negative Latino men who have sex with men and use methamphetamine. The program aims to help them cope with stigma, build resilience, and reduce meth use while also improving their interest in and use of PrEP, a medication that prev…

This study tests whether a multi-day training program can reduce stigma that doctors in Vietnam show toward people with HIV and men who have sex with men. Researchers will send trained actors ("standardized patients") to clinics to pose as real patients and measure how doctors tr…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…

This study will test a new way to screen and treat cervical cancer in women with HIV in Mozambique. About 8,445 women aged 25-49 who are already receiving HIV care will be offered HPV testing and same-day treatment if needed. The goal is to see if this approach can screen more wo…

This study looks at whether making it easier for teens to have private, confidential talks with their doctor can increase HIV testing. Researchers will work with 4 pediatric clinics to see if this approach is practical and well-liked by staff. The goal is to learn how to make HIV…

This study tests a software tool called smART that helps doctors pick the best combination of HIV drugs for each patient. The tool considers drug resistance, other health conditions, and medication safety. Researchers will compare treatment choices made with and without the tool …

This pilot study will enroll 65 people living with HIV to see if two simple body shape calculations (the Body Roundness Index and A Body Shape Index) can accurately estimate how much body fat and visceral fat a person has. Participants will have their waist, height, and weight me…

This study looks at whether inflammation from HIV affects thinking skills in teens aged 13-19 in Eswatini. Researchers will compare 50 HIV-positive teens on antiretroviral therapy with 30 HIV-negative teens. They will test memory, attention, and processing speed, and measure infl…