Weill Medical College Of Cornell University

This study compares two types of radiation therapy for women with early-stage breast cancer after lumpectomy. One group receives standard CT-guided radiation, while the other receives a newer MRI-guided approach. The goal is to see if MRI-guided radiation works just as well at pr…

This phase 2 trial tests a personalized approach for chronic lymphocytic leukemia (CLL). Patients first receive two oral drugs (zanubrutinib and venetoclax). Only those with remaining cancer cells after treatment get an additional infusion drug (obinutuzumab). The goal is to see …

This Phase 2 trial tests whether N-Acetylcysteine (NAC), an antioxidant, can help people with ME/CFS (chronic fatigue syndrome). Researchers will give 95 participants different doses of NAC or a placebo for four weeks, then measure brain glutathione levels and markers of oxidativ…

This phase 3 trial compares a standard 3-week radiation course to an experimental 2-week course for women with early-stage breast cancer. About 400 participants who had lumpectomy will receive whole breast radiation plus an extra boost to the tumor site. The study checks if the s…

This early-phase trial is testing whether glycerol phenylbutyrate (Ravicti), a drug already approved for a different condition, is safe and tolerable for children with genetic disorders like STXBP1 and SLC6A1 that cause seizures and developmental delays. The study will enroll 50 …

This study tests a combination of an experimental drug (paxalisib), a diabetes drug (metformin), and a high-fat, low-carbohydrate ketogenic diet in people with glioblastoma, an aggressive brain cancer. The goal is to see if this approach is safe and can slow tumor growth. The tri…

This study tests a new way to choose cord blood for transplant in people with blood cancers like leukemia or lymphoma. Patients get stem cells from a family member plus a cord blood unit, matched to target certain inherited traits. The goal is to find the lowest safe cord blood d…

This study tests whether doxycycline, an antibiotic, can slow the worsening of emphysema in people living with HIV. About 133 current or former smokers with HIV will take doxycycline for 72 weeks. Researchers will measure lung function, walking ability, and check for antibiotic r…

This study tests whether replacing a patient's own red blood cells with healthy donor cells can improve brain function in people with GLUT1 deficiency syndrome, a rare genetic condition that causes seizures and movement problems. The approach aims to boost glucose delivery to the…

This study tests whether a ketogenic diet (high fat, low carb) combined with the diabetes drug metformin is safe and tolerable for people with glioblastoma, an aggressive brain cancer. The idea is to lower blood sugar, which tumors use to grow. The 18 participants prepare their o…

This phase II trial is testing a combination of two drugs—tazemetostat pills and mosunetuzumab injections—in 23 people with follicular lymphoma who have not yet received treatment. The goal is to see if the combination is safe and leads to a complete response (disappearance of ca…

This phase 2 trial tests whether adding the drug tocilizumab to a standard transplant regimen can prevent graft failure and graft-versus-host disease in people with blood cancers receiving a special type of bone marrow transplant. The study involves 21 participants and aims to re…

This study tests a radioactive drug called 225Ac-J591 in men with advanced prostate cancer that has spread and stopped responding to hormone therapy. The first part finds a safe dose and schedule, and the second part checks if the drug lowers PSA levels by more than half. About 6…

This phase 2 trial tests whether a radioactive antibody called 177Lu-J591, combined with the hormone-blocking drug ketoconazole, can prevent prostate cancer from spreading in high-risk patients. The study enrolls 55 men whose PSA is rising despite hormone therapy but who have no …

This study tests whether leuprolide, a hormone-blocking drug, can slow memory and thinking decline in postmenopausal women with mild Alzheimer's or mild cognitive impairment. Participants also take a standard Alzheimer's medication (donepezil). The trial involves 180 women across…

This study tests adding lenalidomide to standard high-dose melphalan chemotherapy before a stem cell transplant in people with multiple myeloma that has come back. The goal is to find the safest dose and see if it improves how long the cancer stays under control. Participants the…

This study tests whether adding daratumumab back to pomalidomide and dexamethasone can improve complete remission rates in 15 adults with relapsed or refractory AL amyloidosis who have already received daratumumab. Participants receive the three-drug combination to control the di…

This early-phase study tests a new treatment for advanced liver cancer. Participants will receive focused radiation to the tumor along with two immunotherapy drugs (tremelimumab and durvalumab) to help the immune system fight the cancer. The goal is to see if this combination is …

This study tests a new approach for men with intermediate-risk prostate cancer. First, doctors use electric pulses (IRE) to destroy tumor cells, followed by precise radiation (MRgRT). The goal is to see if this combination is safe and can keep cancer away for at least a year. Abo…

This study tests a combination of three drugs (acalabrutinib, lenalidomide, and either rituximab or obinutuzumab) in people with untreated mantle cell lymphoma, a rare blood cancer. About 37 adults will receive the treatment for one year, then continue on a lower dose to keep the…

This study tests a combination of four drugs (daratumumab, clarithromycin, pomalidomide, and dexamethasone) in people with multiple myeloma whose cancer returned or didn't respond after previous treatment with daratumumab. The goal is to see if this combo can shrink tumors more e…

This study tests whether giving a precise, high-dose radiation treatment (SBRT) before prostate removal surgery is safe and effective for men with high-risk prostate cancer. Sixteen men with aggressive prostate cancer (Gleason score 8 or higher or signs of spread) will receive ra…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy and radiation can help people with a certain type of esophageal cancer. The trial involves 42 adults whose cancer has not spread far but is locally advanced. The main goal is to see if t…

This study tests whether giving two immunotherapy drugs (botensilimab and balstilimab) before surgery can help shrink colorectal cancer tumors in 26 adults. The drugs aim to boost the immune system to attack the cancer. Researchers are checking how well the tumors respond and wha…

This pilot study tests whether high doses of a radioactive sugar (FDG) can safely treat advanced cancers that no longer respond to standard therapies. FDG is taken up by cancer cells because they use a lot of glucose, and the radiation may kill them. The study involves 30 adults …

This study tested a combination of four drugs (carfilzomib, clarithromycin, lenalidomide, and dexamethasone) in 74 adults with newly diagnosed multiple myeloma, a type of blood cancer. The goal was to see how well the treatment worked and if it was safe. Patients received the dru…

This study is testing a radioactive drug called 177Lu-PSMA-617 in men with advanced prostate cancer that has spread and no longer responds to hormone therapy. The goal is to find the highest dose that can be given safely without severe side effects. About 50 participants will rec…

This study tests whether the nine-valent HPV vaccine can prevent long-lasting oral HPV infections in men who have HIV. About 700 men will receive either the vaccine or a placebo. The goal is to see if the vaccine reduces new persistent infections with HPV types linked to throat c…

This study looks at whether a central outreach program can help more people at high risk for lung cancer get a low-dose CT scan. About 2000 adults aged 50-80 who smoke or used to smoke will be invited to get screened. The goal is to catch lung cancer early, when it's easier to tr…

This study tests a behavioral program called Moving Well for people waiting for knee replacement surgery. The goal is to see if it can reduce anxiety and depression compared to a standard support program. About 79 adults aged 50 and older are taking part, all scheduled for surger…

This study tests a program called CHAT for people aged 60 and older with a type of heart failure called HFpEF. Participants get up to four sessions with a health coach and watch seven educational videos, all from home. The goal is to see if this helps them manage their condition …

This study tests a tablet-based app called COPPEhR designed to help older adults (50+) living with HIV for at least 15 years feel more socially connected and less lonely. About 68 participants will use the app or a tablet without the app for 9 months. Researchers will measure if …

This study looks at two different radiation schedules for postmenopausal women with early-stage breast cancer. One group gets 5 daily doses, the other gets 3 doses every other day. The goal is to see which schedule causes less scarring (fibrosis) in the breast. 350 women will be …

This study tests whether using a FitBit and a mobile app after surgery for stomach, liver, colon, or other GI cancers can help prevent patients from being readmitted to the hospital. About 107 adults who own a smartphone and are scheduled for surgery will be randomly assigned to …

This study tests a small, battery-powered headband that delivers a gentle electrical pulse to the scalp to help reduce chronic pain in people with end-stage kidney disease who are on dialysis. About 125 adults will use the device at home and report their pain levels. The goal is …

This study compares two shortened radiation schedules for men whose prostate cancer has come back after surgery. One group gets 20 treatments over 4 weeks, the other gets 5 treatments over 2 weeks. The main goal is to see if the shorter course causes similar or fewer bowel and ur…

This study looks at whether older adults with a specific type of heart disease (cardiac amyloidosis) feel better when they stop taking a common heart medication called a beta-blocker. Twenty participants will each go through two periods—one on the drug and one off—to compare thei…

This study looks at whether older adults (age 60+) with a type of heart failure called HFpEF can safely stop taking beta-blockers to feel better and have a better quality of life. About 240 participants will either gradually reduce their beta-blocker dose or continue it for 4 mon…

This study looks at whether a shorter, more intense course of radiation (accelerated radiation therapy) is safe and tolerable for women with breast cancer who have already had chemotherapy and surgery. About 88 participants will receive the accelerated radiation to the breast and…

This study follows over 1,000 children aged 0-21 who are getting stem cell transplants. Researchers will check for delirium twice a day during their hospital stay. The goal is to learn how often delirium happens, what raises the risk, and how it affects recovery. This information…

This study collects kidney tissue from 100 adults with autosomal dominant polycystic kidney disease (ADPKD) who are already scheduled for kidney removal. Researchers will analyze the tissue for additional genetic mutations that may drive cyst formation. The goal is to better unde…

This study looks at genetic changes in people with H. pylori infection or stomach cancer to understand how the infection can lead to cancer. Researchers will analyze tissue samples from 110 adults undergoing endoscopy. The goal is to find early warning signs and possible ways to …

This study tests a personalized approach called N-of-1 to help older adults with a type of heart failure (HFpEF) decide whether to keep taking beta-blockers. Participants will try periods on and off the medication and report their confidence and preferences. The goal is to see if…

This study aims to understand people's experiences with statin side effects and create educational materials to help new users separate real drug effects from nocebo effects (negative expectations). About 30 adults with heart risk factors will share their views through surveys an…

This study involves 55 women with chronic pelvic pain to develop a questionnaire that captures their full experience. Researchers will interview participants to understand symptoms and impacts, then test the questionnaire for clarity and completeness. The goal is to create a reli…

This study tests a new PET scan method that looks at two things at once: oxygen levels and cell growth in high-grade brain tumors. The goal is to see if these scans can help doctors understand which tumors might resist standard treatment. Only 8 adults with suspected high-grade g…

This study is creating a registry of 452 adults with a family history of Alzheimer's or early memory problems. Researchers will track their health, blood markers, and thinking skills over time to see if personalized care plans can help prevent or treat the disease. The goal is to…

This study tests whether a phone app called StudyU can help people with heart failure reach their recommended beta blocker dose. Five adults aged 65 and older with heart failure will use the app to track their medication. The goal is to see if the app is practical and acceptable …

This study checks if drinking caffeine changes blood pressure or heart rate in people taking the antifungal medication terbinafine for nail fungus. Researchers will monitor 52 adults before and after they start the drug. The goal is to understand possible side effects, not to tes…

This study follows about 3,000 adults in Port-au-Prince, Haiti, to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other heart problems. Researchers will track participants for about…