New study tracks brain fog in kids after stem cell transplants
NCT ID NCT04937400
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study follows over 1,000 children aged 0-21 who are getting stem cell transplants. Researchers will check for delirium twice a day during their hospital stay. The goal is to learn how often delirium happens, what raises the risk, and how it affects recovery. This information could help doctors find better ways to prevent or manage delirium in the future.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors better predict and prevent delirium in children after stem cell transplants, improving recovery.
- What could go wrong
- This is an observational study, not a treatment trial. It will not directly test any drug or intervention, so it may not lead to immediate changes in care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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1,040 people
The number who actually took part.
- Started
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Jul 2021
- Expected to finish
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Jul 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Subjects will include all patients admitted to the five participating pediatric stem cell transplant sites for the purpose of HSCT during the study period. Enrollment goal is 1000 subjects overall, and 240 subjects for neurocognitive testing. Subjects will be seriously ill. Every patient admitted for HSCT will be eligible for inclusion, unless they are \>21 years old. Subjects will be enrolled regardless of gender, race, or ethnicity. No subgroups will be excluded, as delirium likely affects children of all ages and developmental trajectories, with no predilection based on gender, race, or ethnicity.
- Ages
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Up to 21 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 0-21 years old * Admitted for purpose of stem cell transplant Exclusion Criteria: * Age \>21 years old * Admitted for reason other than stem cell transplant (example: late post-transplant complications).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Dana Farber Cancer Center
Boston, Massachusetts, 02215, United States
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Hospital for Sick Children
Toronto, Ontario, Canada
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St Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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University of California San Francisco
San Francisco, California, 94143, United States
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Weill Cornell Medical College
New York, New York, 10065, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Could a quieter, dimmer ICU protect Patients' brains?
- Can a daily supplement shield the brain after delirium?
- Brain surgery delirium: can real-time monitoring protect older patients?
- Could daylight hold the key to preventing delirium?