Weill Medical College Of Cornell University

This study is testing whether calcium carbonate, a common antacid, can safely improve contractions during labor induction or augmentation. Researchers will enroll 60 first-time mothers at 36+ weeks of pregnancy. The main goal is to see if a larger trial is possible, not yet to pr…

This study tests a method to sort sperm by gender (X or Y chromosome) using a density gradient. The goal is to help couples undergoing IVF or insemination have a baby of a desired sex, for medical or personal reasons. About 2000 couples will take part, and researchers will check …

This study is testing whether tirzepatide, a drug used for diabetes and weight loss, is practical and acceptable for postmenopausal women who have had hormone receptor-positive breast cancer and are obese. Thirty participants will take the drug weekly for 24 weeks, with monthly c…

This study compares two types of heart bypass surgery: using one artery graft versus multiple artery grafts. Researchers want to see if using more arteries reduces the chance of death, stroke, heart attack, or the need for another procedure. About 4,300 patients will take part ac…

This study compares a standard robot-assisted prostate removal surgery to a newer, pelvic fascia-sparing approach that aims to preserve nerves and support structures. Researchers will enroll 600 men with localized prostate cancer to see if the new technique offers similar cancer …

This early-stage trial tests a new drug called TVB-2640 combined with the standard drug enzalutamide (Xtandi) in 30 men whose prostate cancer has spread and stopped responding to hormone therapy. The main goal is to find the safest dose of TVB-2640 when used with enzalutamide and…

This phase 2 study tests a new approach for people with advanced stomach, esophageal, or gastroesophageal junction cancer that is either PD-L1-negative or has stopped responding to immunotherapy. Participants receive injections of a cancer-killing virus (OBP-301) directly into th…

This early-phase trial tests whether injecting special cells from human umbilical veins (E-CEL UVEC) can safely help heal simple anal fistulas after surgery. The study involves 39 adults who are already scheduled for fistulotomy. Researchers will monitor for side effects over two…

This study compares two common procedures to restore blood flow in the heart: stenting (a less invasive method using a small tube) and bypass surgery (an open-heart operation using blood vessels from elsewhere in the body). Researchers want to see which approach leads to better s…

This study looks at whether women who had breast cancer come back after earlier lumpectomy and radiation can avoid a mastectomy by getting a second round of targeted radiation. About 120 women with small, isolated recurrences will receive partial or whole breast radiation dependi…

This study is testing whether inviting friends, family, or coworkers to join a weight-loss program helps Black or Hispanic adults with obesity lose more weight. The program focuses on improving communication and problem-solving around eating and activity. Researchers will see if …

This early-stage trial tests whether injections of special cells (E-CEL UVEC) can safely heal chronic anal fissures that haven't responded to other treatments. Twenty adults with long-lasting anal fissures will receive the cell injection directly into the fissure. The study prima…

This study tests whether adding the antifungal drug fluconazole to standard IL-23 therapy (like risankizumab or ustekinumab) improves symptoms in people with mild to moderate Crohn's disease. Researchers will compare outcomes in 120 adults who receive either fluconazole or a plac…

This study is for people with metastatic breast cancer that has spread to the brain. Participants receive an immunotherapy drug called pembrolizumab every three weeks, plus a precise, high-dose radiation treatment (stereotactic radiosurgery) to one of the brain tumors. The goal i…

This study tests whether a drug called leronlimab is safe for people with mild Alzheimer's or mild cognitive impairment. Twenty volunteers over age 50 will receive weekly injections for 12 weeks. Researchers will use brain scans and blood tests to see if the drug lowers brain inf…

This study tests whether a newer surgical method called Kono-S anastomosis can better prevent Crohn's disease from returning after bowel surgery compared to the standard side-to-side technique. About 600 adults with Crohn's disease needing bowel resection will be randomly assigne…

This early-stage trial tests whether the beta-blocker propranolol can stimulate heart muscle cell growth in infants born with Tetralogy of Fallot, a serious heart defect. Forty infants under 60 days old will receive propranolol, and researchers will measure new heart muscle cells…

This study is tracking 20 adults aged 18-65 with colorectal cancer that has spread only to the liver and cannot be surgically removed. Participants will receive a liver transplant, and researchers will monitor cancer recurrence and survival rates. The goal is to see if a transpla…

This study tests whether treating eggs and sperm before fertilization can help people who have had complete failure with standard IVF or one prior ICSI cycle. Researchers will measure fertilization rates and embryo development. The goal is to improve chances of pregnancy for thos…

This study looks at a surgery called selective laryngeal reinnervation for people whose vocal cords are paralyzed on both sides, making it hard to breathe. Researchers will track 15 adults aged 18 to 70 to see if the surgery improves breathing symptoms and lung function. The goal…

This study tests whether placing a small balloon inside the uterus after surgery to remove a septum (a wall of tissue) can prevent internal scar tissue from forming. Scar tissue can cause problems with fertility and periods. The trial will enroll 320 women and compare standard ca…

This study is for people with a dangerous heart condition called ventricular tachycardia that hasn't improved with standard treatments. Researchers want to see if giving a lower dose of radiation all at once works just as well and is as safe as splitting it into three separate do…

This study compares two treatments given before surgery for non-small cell lung cancer: immunotherapy (cemiplimab) plus chemotherapy versus immunotherapy plus targeted radiation. About 112 people with stage IB to III lung cancer will take part. After surgery, all participants con…

This early-stage study tests a gene therapy called AAVrh.10hFXN for heart disease caused by Friedreich's ataxia, a rare genetic disorder. The therapy delivers a working copy of the frataxin gene via a single IV infusion. The main goal is to check safety in 25 people aged 12 to 50…

This study compares two blood thinner strategies in 700 people with chronic heart disease who are having bypass surgery. One group takes ticagrelor plus low-dose aspirin for one month, then aspirin alone; the other takes only low-dose aspirin. The goal is to see if the short dual…

This study tests a new way to deliver radiation therapy for men with high-risk prostate cancer. Using advanced imaging (PSMA PET/MR), doctors can precisely target the tumor and give a stronger dose to the most aggressive areas. The goal is to improve the chance of staying cancer-…

This study is testing whether training religious leaders to teach their communities about blood pressure can help lower average blood pressure levels. About 24,000 adults aged 35 and older from 20 communities in Tanzania will take part. The main goal is to see if communities wher…

This study looks at whether using a biosynthetic mesh during robotic anti-reflux surgery can lower the chance that a hiatal hernia returns. About 200 adults with GERD who are already scheduled for surgery will be randomly assigned to receive either the standard repair or repair w…

This study tests whether adding targeted radiation and immunotherapy to standard hormone therapy can turn a woman's own breast tumor into a personalized vaccine. About 100 postmenopausal women with HR+ breast cancer will receive letrozole plus either radiation alone or radiation …

This study is for women with a common type of advanced breast cancer (HR+ HER2-). It tests whether adding targeted radiation to each tumor site, along with standard hormone therapy and a targeted drug, can help keep the cancer from growing longer. About 102 participants will be r…

This study tests a new vaccine, dAd5GNE, in 150 people with cocaine dependence. The vaccine aims to train the immune system to block cocaine from reaching the brain, reducing its effects. The main goal is to check safety, but researchers will also measure cocaine use and antibody…

This study tests if eating only during an 8-hour window each day, along with a healthy diet and exercise, can reduce liver fat in people with non-alcoholic fatty liver disease. About 40 adults will be split into two groups: one follows the time-restricted eating plan plus standar…

This early-phase study tests a new combination of two drugs that deliver radiation directly to prostate cancer cells. The goal is to find the safest dose that can be given together. About 42 men with advanced prostate cancer that has stopped responding to hormone therapy will tak…

This study tests a new way to help people with HIV in rural Uganda. Traditional healers will be trained to offer HIV testing, counseling, and support to take medication regularly. The goal is to see if this extra help, alongside regular clinic care, can help more people achieve a…

This study looks at two common ways to restore blood flow in women with blocked heart arteries: stenting (a less invasive procedure) and bypass surgery (open-heart surgery). Researchers want to see which approach leads to better survival and quality of life. About 600 women will …

This study tests a program called I-TRANSFER-HF for people with heart failure who need home care after leaving the hospital. The program combines early nurse visits at home with quick follow-up doctor appointments to prevent patients from returning to the hospital within 30 days.…

This study is for men with advanced prostate cancer that has spread and is no longer controlled by standard hormone therapy. It tests whether adding a targeted radiation drug (225Ac-J591) to immunotherapy (pembrolizumab) and an androgen-receptor inhibitor works better than the im…

This study tests the drug luspatercept in 50 adults with clonal cytopenias of uncertain significance (CCUS), a condition where low blood cell counts increase the risk of developing blood cancers like leukemia. Participants receive injections every three weeks for up to 48 weeks. …

This study tests different combinations of immunotherapy drugs (with or without radiation) in 24 people with colorectal cancer that has spread to the liver and who are scheduled for surgery. The goal is to see if these treatments change the immune environment inside the liver tum…

This study tests a new drug combination (polatuzumab vedotin plus chemotherapy) in 20 adults with Richter's transformation, an aggressive lymphoma that can develop from chronic lymphocytic leukemia. Participants receive up to six 21-day cycles of treatment and are monitored for s…

This study aims to improve the heart health of home health aides, a group that often has poor cardiovascular health. Participants will work with a trained peer coach over 10 weeks to learn healthy habits and positive thinking. The program is based on the American Heart Associatio…

This study tests whether support from community health workers through phone calls and telehealth can help people with dangerously high blood pressure avoid major heart problems. About 3,620 adults who come to the emergency room with very high blood pressure will either get this …

This study tests a combination of two drugs—pembrolizumab (an immunotherapy that helps the immune system fight cancer) and lutetium Lu 177 dotatate (a radioactive drug that kills cancer cells)—in 18 adults with Merkel cell carcinoma. The goal is to see if the combination can shri…

This study tests whether a simple technique called "double voiding" (urinating twice in a row) can reduce urinary tract infections (UTIs) in kidney transplant recipients. UTIs are common after transplant and can lead to serious complications. The study will follow 438 adults at o…

This early-stage study tests a gene therapy for people with alpha-1 antitrypsin deficiency, a condition that can damage the lungs. The treatment is given once through a vein and aims to produce a special protein that protects the lungs. Researchers will check safety and measure p…

This study compares two types of heart bypass surgery in 2,300 women: using one artery (single arterial grafting) versus multiple arteries (multiple arterial grafting) to reroute blood around blocked heart vessels. The goal is to see which approach reduces the risk of heart attac…

This pilot study tests whether a radioactive tracer called [Cu64]DOTATATE, combined with a handheld gamma probe, can help surgeons find meningioma tumors during surgery. Twenty adults with suspected or recurrent meningioma will receive the tracer before surgery, and the probe wil…

This study is testing whether a special type of PET/CT scan (PSMA-PET CT) can accurately detect aggressive prostate cancer in men who are on active surveillance (watchful waiting). Researchers will scan 200 men with low- or favorable intermediate-risk prostate cancer at the start…

This study aims to see if a special MRI scan (diffusion MRI) can accurately detect jaw muscle pain in people with masticatory myofascial pain syndrome. Researchers will compare MRI results from 90 adults with and without pain. If successful, this could lead to a more objective wa…

This study is testing whether a special type of PET/MRI scan (68Ga-DOTATATE) can better detect brain tumors, especially meningiomas, after surgery or radiation. The goal is to see if this scan can tell the difference between tumor regrowth and normal changes from treatment. About…

This study aims to improve how doctors find and treat breast cancer that has spread to the brain. Twenty adults with ER-positive breast cancer and brain tumors will get an extra PET scan (FES PET/CT) before their standard radiation planning. Researchers will compare this scan wit…

This study tests a middle school science curriculum called CARES4You, designed to teach students about cancer risk and healthy choices. About 1,800 students in New York City public schools will either receive the curriculum during regular science class or continue with usual less…

This study tests whether playing a video game called 'No Baby No' can help teens aged 15-20 use birth control more often and avoid unplanned pregnancy. About 850 teens will either play the game or do a different activity, and researchers will track their birth control use and pre…

This study tests a new type of talk therapy called Engage & Connect for mothers with postpartum depression. The therapy focuses on helping moms plan and do rewarding social activities to reduce feelings of isolation. Sixty participants will receive either this new therapy or a st…

This study compares two types of talk therapy for PTSD caused by military sexual trauma: exposure therapy and interpersonal therapy. Researchers want to see if interpersonal therapy works just as well as exposure therapy, which could give survivors more options. The trial will en…

This study tests a wearable device that vibrates leg muscles to reduce spasticity (stiffness) and improve walking. Twenty-five people with spasticity from a neurological condition will use the device for 15–60 minutes in the lab and at home. Researchers will measure muscle activi…

This study tests a two-phase approach to help healthcare workers suffering from PTSD and distress due to work trauma. In Phase I, participants are randomly assigned to four sessions of either medical music or narrative writing over two weeks. Those still meeting PTSD criteria can…

This pilot study tests whether a device called IVS3, which uses mirrored video to create the illusion of movement, is tolerable and easy to use for stroke survivors with arm weakness. About 25 people who had a stroke at least 6 months ago will try the device during rehab sessions…

This study tests a 10-week program called RISE-HP for people with hypersensitivity pneumonitis (HP), a lung condition that can cause anxiety, depression, and poor quality of life. Participants work one-on-one with a trained peer coach (someone who also has HP) to learn coping ski…

This study tests a special bracelet that vibrates gently whenever it senses nail biting. Ten adults with chronic nail biting will wear the device for 12 weeks and track their habits using a phone app. The goal is to see if the gentle reminder helps reduce nail biting and improve …

This pilot study tests a 12-session virtual therapy that combines proven treatments for PTSD and chronic pain. Twenty adults with both conditions will attend twice-weekly sessions over six weeks. The goal is to see if this integrated approach is feasible and acceptable, and wheth…

This study compares a standard mobile cognitive behavioral therapy (CBT) program to a personalized version that teaches skills faster. About 100 adults aged 18-25 with anxiety, depression, or bipolar disorder will use the Maya app for 20 minutes, twice a week, for six weeks. The …

This study tests a program called Living Healthy, which gives health education and positive thinking tools to home health aides. Some participants will also get a peer coach—another aide trained to offer support. The goal is to see if the program improves mood and is easy to use.…

This study tests a program called EMPOWER to help family members who make decisions for critically ill patients. The goal is to reduce their grief, PTSD, and depression symptoms. About 172 participants will be assigned to either the EMPOWER program or a supportive conversation gr…

This study tests an 8-week group program that teaches mind-body skills like meditation, guided imagery, and relaxation to help medical graduate students manage mood symptoms. About 60 students with mild anxiety or depression will participate. The main goals are to see if the prog…

This study tests a program called PATH-Pain in 100 older adults (60+) who have mild cognitive impairment or early Alzheimer's, along with chronic pain and depression. The program teaches problem-solving and uses memory aids like checklists and a tablet app to help manage emotions…

This study tests a web-based tool called CONSYDER to help young women (ages 18-44) with early-stage breast cancer make more informed decisions about their surgery. Participants use the tool before meeting their surgeon and complete surveys about their decision-making. The goal is…

This pilot study tests whether a mobile app called Maya is practical and liked by pregnant and postpartum individuals who are struggling with mood, anxiety, or stress. The app teaches cognitive behavioral skills through 12 modules. Researchers will ask 75 participants for feedbac…

This study tests whether a 9-week therapy called Engage & Connect can improve brain function related to social reward and reduce suicidal thoughts in older adults with depression. Researchers will use brain scans to measure changes in key brain networks. The study involves 128 pe…

This study tests whether one-on-one coaching from a trained peer (someone else with rheumatoid arthritis) can lower anxiety and depression in adults with RA. About 250 participants will meet weekly with a coach for 9 weeks and complete surveys. The goal is to see if this support …

This study compares two types of nerve blocks (PENG vs femoral) to see which provides better pain relief for people with hip fractures. About 352 adults with a hip fracture will receive one of the two blocks, depending on the month they come to the hospital. Researchers will meas…

This study is testing a mobile app called MAYA that provides cognitive behavioral therapy (CBT) to help adults who have had a stroke manage anxiety and depression. About 10 participants aged 40-79 will use the app and provide feedback on how easy and helpful it is. The goal is to…

This study tests a new, faster version of a brain stimulation treatment called TMS for people with depression or OCD. Instead of daily sessions for weeks, participants get 10 hours of TMS each day for just 5 days. The goal is to see if this quick approach can improve symptoms and…

This study tests whether adding non-opioid pain medicines like acetaminophen (Tylenol) and ketorolac (Toradol) can improve pain control and reduce the need for strong opioids in children on breathing machines. About 644 children aged 2 months to 17 years with acute respiratory fa…

This study tests whether virtual reality (VR) can help healthcare workers and COVID-19 patients with posttraumatic stress disorder (PTSD). Participants will use VR headsets during 10 therapy sessions over 5 weeks to safely revisit and overcome traumatic memories. The goal is to s…

This study tests a mobile app called WellPATH-PREVENT for adults aged 50-90 who were recently hospitalized for suicidal thoughts or a suicide attempt. The app teaches emotion regulation skills to help reduce suicide risk. Researchers will measure changes in brain activity, self-r…

This study tests whether a digital program on an iPad, combined with learning thinking strategies, can improve mood and mental skills in people who have had a stroke. The study will include 70 adults who had a first stroke at least 6 months ago and now have depression and trouble…

This study tests whether a procedure called embolization (blocking off abnormal veins in the pelvis) can reduce chronic pelvic pain in women. About 40 women with pelvic varicose veins and severe pain for over 6 months will be randomly assigned to either get the procedure or just …

This study is testing a mobile app called MAYA that teaches coping skills for anxiety and depression. Researchers want to see if adults aged 40 and older with anxiety or mood disorders find the app helpful and easy to use. Participants will use the app for about 20 minutes, twice…

This study tests if a gentle electrical current applied to the forehead at home can reduce severe tiredness after a stroke. Researchers will enroll 24 people who are at least 3 months past their stroke and have significant fatigue. Participants will use a headset device daily, wi…

This study tests whether using a brain scan (fMRI) to guide magnetic stimulation (rTMS) can better treat depression that hasn't improved with medication. About 348 adults aged 22-65 with major depression will receive rTMS, and researchers will track changes in depression scores. …

This study tests two types of spiritual care for people with advanced cancer. Researchers want to see if these programs improve spiritual well-being and reduce hospital visits. About 288 patients from religious communities will take part.

This study tests whether spiritual care interventions can improve spiritual well-being and readiness for advance care planning in Black patients with advanced cancer. About 64 participants will be recruited from outpatient clinics. The goal is to see if a larger trial is possible…

This study looks at whether giving a TAP block—a numbing injection in the belly wall—before surgery works better than giving it after surgery to control pain and reduce opioid use. Researchers will track pain scores and opioid amounts in 150 adults having elective abdominal or we…

This study is looking at how standard short-course radiation therapy affects the immune system in people with rectal cancer. Researchers will collect blood, stool, and tissue samples before, during, and after radiation to analyze immune changes. The goal is to better understand t…

This study looks at whether community health workers can help more women get tested for type 2 diabetes after having a baby, especially in urban slums in India where access to care is limited. About 330 women who had gestational diabetes will be offered either home-based testing …

This study tests whether connecting ambulances carrying seriously ill children to a remote doctor via a simple audio-video device improves care. Researchers in Karachi, Pakistan will compare health outcomes for 900 children who either receive a telemedicine call during transport …

This study is testing a tool called Transit-Time Flow Measurement (TTFM) that uses sound waves during heart bypass surgery to check blood flow through the new blood vessels. The goal is to see if using this tool helps the grafts stay open longer. About 1242 adults having their fi…

This study collects information from medical records and patient visits to see how well endoscopic bariatric therapies (EBTs) work for weight loss and if they are safe. It includes adults who have had or plan to have an EBT within six months. The goal is to track weight changes a…

This study aims to measure how well infants' hearts can make new muscle cells, especially in those with a heart condition called Tetralogy of Fallot. Researchers will use a special imaging technique on heart tissue that is normally removed and thrown away during surgery. The goal…

This study uses advanced heart MRI scans to understand why some COVID-19 survivors continue to have heart and lung symptoms like shortness of breath or fatigue. Researchers will follow 510 adults who were hospitalized with COVID-19 for up to 3 years. The goal is to identify heart…

This study collects and freezes ovarian tissue from females aged 0-45 who are at risk of early menopause due to cancer treatment, surgery, or other medical conditions. The goal is to develop better ways to thaw and mature eggs from the frozen tissue, so that in the future these i…

This study tests a training program called the Pain Identification and Communication Toolkit (PICT) for family caregivers of people with Alzheimer's disease or related dementias. The program teaches caregivers how to spot signs of pain and talk about it with doctors. Researchers …

This study looks at whether digital devices like smartwatches and blood pressure cuffs can help detect high blood pressure and related pregnancy problems in refugee women. About 75 pregnant refugee women will use these tools at home and complete surveys. The goal is to see if thi…

This study explores whether the gut's nervous system can reveal early signs of Parkinson's disease. Researchers will analyze gut tissue and microbiome samples from 60 people aged 45-75 during routine colonoscopies. The goal is to find biomarkers that reflect brain changes, not to…

This study is testing how long two different volumes of a common numbing medicine (lidocaine with epinephrine) keep the skin numb during dermatologic surgery. Researchers will inject either 0.5 ml or 1.0 ml into the side of the nose in 35 adults and check every 15 minutes when fe…

This study collects blood, airway, and urine samples from 2,000 healthy volunteers and people with lung diseases like COPD and IPF. Researchers aim to establish normal ranges for various measurements and learn how gene patterns in airway cells change in disease. The goal is to be…

This study collects leftover brain and spinal cord tumor tissue from 500 patients during surgery or autopsy. Researchers will use the tissue to create cell lines and models to test how different drugs work. The goal is to better understand these tumors and find new ways to treat …

This study is collecting information from 200 men with prostate cancer who are receiving or have received focal therapies (treatments that target only the tumor, not the whole prostate). The goal is to understand how these treatments are used in practice and what outcomes patient…

This study looks at how the dietary supplement L-Phenylalanine changes the levels of a natural chemical (phenylpropionic acid) and the types of fungi in the gut. Twenty healthy adults will take the supplement, and researchers will measure changes in their stool, swabs, and blood.…

This study tests whether an online program with a medical navigator and educational video helps more first-degree relatives of BRCA mutation carriers get genetic testing compared to standard care. About 820 participants will be split into two groups to see which approach works be…

This study is creating a 'live biobank' by collecting tumor samples from 400 breast cancer patients at key moments: diagnosis, surgery, and if the cancer returns or spreads. Researchers will grow mini-tumors from these samples and analyze their genes and immune cells. The goal is…

This study aims to collect tissue samples, medical data, and family histories from 1,120 adults who are being screened for colorectal or endometrial cancer. Researchers hope to discover new genes and immune system responses that could lead to better prevention and targeted treatm…

This study is testing whether an artificial intelligence (AI) tool can more accurately predict outcomes for people undergoing in vitro fertilization (IVF) or other fertility treatments. Researchers will analyze data from 4,000 participants to see if the AI can reduce doctor bias …

This study looks at whether offering genetic testing for inherited cancer risk (like BRCA1/2) during routine pregnancy or fertility care is practical and well-received. About 550 pregnant or preconception patients will be offered the screening alongside standard prenatal tests. T…

This study aims to develop a better way to measure how the brain uses sugar (glucose) for energy. Researchers will use advanced MRI-like scans at 3 or 7 Tesla strength in 20 healthy volunteers and people with Glut1 deficiency, a rare condition that affects brain fuel. Participant…

This study follows children and adults with genetic developmental and epileptic encephalopathy (DEE) to understand how the disease progresses. It does not test any treatment or drug. Instead, researchers will measure changes in development, communication, motor skills, seizures, …