STEM CELL TRANSPLANT COMPLICATIONS

This early-phase study tests a new stem cell transplant method for people with aggressive or hard-to-treat acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The approach uses specially engineered donor cells to reduce the risk of graft-versus-host disease, potentia…

This study tests a new cell therapy called tabelecleucel for people who develop a rare, aggressive cancer (EBV+ PTLD) after an organ or stem cell transplant and whose cancer did not respond to standard treatment. About 115 participants will receive this therapy, which uses specia…

This study tests whether adding ruxolitinib to standard steroids works better than steroids alone for grade II acute graft-versus-host disease (GVHD), a common complication after stem cell transplant. About 168 adults who have had a first stem cell transplant for blood cancer and…

This study tests whether adding the drug ruxolitinib to standard steroids works better than steroids alone for treating severe graft-versus-host disease (GVHD) after a stem cell transplant. About 54 adults who develop severe GVHD within 100 days of their first transplant will tak…

This study tests a stem cell transplant for children with sickle cell disease who have a family donor with a different blood type. The goal is to see if a milder treatment before transplant can reduce serious complications like red blood cell failure. Up to 12 children will take …

This study tests a digital app called SHIFT designed to help stem cell transplant survivors improve their sexual health and quality of life. About 300 adults who had a transplant more than three months ago and have sexual health concerns will use the app or receive standard care.…

This study tests whether the allergy drug loratadine can prevent bone pain caused by G-CSF, a medicine used to collect stem cells for transplant. About 78 adults with lymphoma or multiple myeloma will receive either loratadine or a placebo. The goal is to see if loratadine reduce…

This study tests whether an 8-week home exercise program, done before a stem cell transplant, can improve muscle strength and physical fitness in people with multiple myeloma. Thirty participants will either exercise or continue normal activities. The goal is to see if pre-transp…

This study looks at how antibiotics given during a stem cell transplant change the bacteria in your gut. Researchers will track these changes in 255 adults getting a transplant for blood cancers or bone marrow failure. The goal is to understand the link between antibiotics and gu…