Al-azhar University

Researchers at Al-Azhar University are testing whether a diode laser combined with a green dye and a remineralizing agent can reduce the surface area of white spot lesions on teeth. The trial enrolls 90 people aged 13 to 40 who have good oral hygiene and no other health condition…

This trial tests two treatments for a jaw joint condition called TMJ disc displacement with reduction, where the disc that cushions the joint slips out of place but returns to normal when the mouth opens. Researchers will compare injecting hyaluronic acid, a natural lubricant, ag…

This trial compares two attachment systems, OT-Equator and Ball and Socket, used to hold a lower denture in place with a single dental implant. Researchers will measure how much force is needed to pull the denture off, along with gum health and bone levels, over 12 months. The go…

This trial tests whether a 3D-printed version of the Twin Block, a dental device used to correct an overbite, works as well as the conventional one. Researchers will enroll 20 young people aged 9 to 16 with Class II malocclusion, a condition where the lower jaw is set back. Parti…

This trial tests whether 3D printed twin block appliances work as well as conventional ones for correcting Class II malocclusion, a condition where the lower jaw is set back. Researchers will enroll 20 growing patients aged 9 to 16 and compare dental and skeletal changes using X-…

This trial tests whether custom-made, 3D-printed titanium plates can improve surgery for cheekbone fractures. The plates are designed from CT scans of the patient's healthy side to guide precise reconstruction. Researchers will compare the surgical result to the virtual plan, and…

This trial tests whether adding the antibiotic vancomycin to a bone graft material improves the outcome of dental implants placed immediately after extracting a tooth with a chronic infection. Twenty people with badly decayed, hopeless teeth and periapical infection will receive …

This trial tests a new, less invasive surgical approach for treating advanced periodontitis (stage III). Instead of lifting the gum, doctors access the damaged bone through a small pinhole, clean the area, and place a bone graft to encourage regeneration. The study includes adult…

This trial tests whether a 577-nm diode laser can safely reduce non-inflammatory acne, such as blackheads and whiteheads. Half of each participant's face receives laser treatment, while the other half serves as an untreated control. The study includes adults aged 18-40 with at le…

This trial asks whether applying a 1% metformin gel directly around a dental implant at the time of placement can improve bone healing. Participants are adults needing immediate implants in the upper back jaw, and the gel is used alongside a standard bone-grafting procedure. The …

This trial compares three common procedures—mini-PNL, RIRS, and SWL—for treating medium-sized (10-20 mm), dense (over 1000 HU) kidney stones located outside the lower pole. Researchers aim to see which method offers the best stone-free rate, fewest complications, lowest cost, and…

This trial compares two procedures for treating hard, medium-sized kidney stones (10-20 mm) that are not in the lower pole of the kidney. One is mini-PNL, a minimally invasive surgery, and the other is SWL, which uses shock waves to break up stones. The study will randomly assign…

This trial tests whether a common kidney stone procedure called retrograde intrarenal surgery (RIRS) can be performed safely and effectively without using X-ray guidance. Instead, surgeons rely on direct visualization through a tiny camera. The goal is to reduce radiation exposur…

This study tests whether applying dimethyl sulfoxide (DMSO) to aging teeth before placing a filling improves how well the filling bonds and reduces tiny leaks that can cause decay. Thirty adults aged 50-75 with non-cavity tooth lesions will receive either DMSO or chlorhexidine pr…

This trial compares two ways to treat kidney stones in people whose kidneys are shaped or positioned abnormally from birth. One method, retrograde intrarenal surgery (RIRS), uses a thin scope passed through the urinary tract to break up stones with a laser. The other, shockwave l…

This trial tests whether a zero-profile anchored cage, used in anterior cervical discectomy and fusion, can improve outcomes for people with cervical degenerative disc disease. The study will enroll 30 adults aged 18-70 who have not had prior cervical spine surgery and whose symp…

This trial tests whether adding a procedure to shrink the inferior turbinates—small structures inside the nose—during adenoidectomy gives children aged 9 to 18 better relief from nasal blockage and sleep-disordered breathing than adenoidectomy alone. Participants have both adenoi…

This trial investigates whether ultrasound-guided injections of dextrose (a type of sugar) around and into facial muscles can improve recovery in people with Bell's palsy that has not responded to standard care after three months. Thirty participants with moderate to severe facia…

This study compares two types of dental appliances—a fixed Twin Block and a removable Twin Block—used to treat a condition where the lower jaw sits too far back in growing children and teenagers. Both appliances guide the lower jaw forward during growth. Using 3D scans before and…

This study compared a liquorice nanogel to a diode laser as extra treatments for advanced gum disease (stage III). 27 adults with deep gum pockets received one of the two treatments alongside standard care. The goal was to see which approach better reduced harmful bacteria and im…

This study looked at 80 children with a type of hypospadias (a birth defect where the urine opening is not at the tip of the penis) who had a narrow urethral plate. The researchers compared two different surgical repair methods to see which had fewer complications and better cosm…

This study tested whether a mouthwash made from Moringa extract can reduce bacteria in the mouths of children aged 8 to 12 who wear removable braces. Sixty children were split into two groups: one used the Moringa mouthwash daily, the other followed standard oral hygiene. Researc…

This study tested two different dental expanders in 30 teenagers aged 15-18 who needed their upper molars moved backward to correct a Class II bite. One device was a self-activated Leaf Expander and the other a conventional Hyrax Expander, both anchored to the jawbone. The goal w…

This completed study tested two types of attachments (ball-and-socket vs Equator) for lower jaw implant-supported dentures in 24 adults aged 55-60. Researchers measured bone loss around the implants and how bite forces were distributed. The goal was to see which attachment provid…

This study looked at whether adding 1% metformin gel to a bone graft improves bone healing and implant stability in people getting immediate dental implants. Twenty adults aged 18 to 40 with a non-restorable tooth in the front or premolar area took part. The researchers measured …

This study compared two types of hip replacement surgery in active elderly patients who broke their hip. One group received a total hip replacement (replacing the ball and socket), while the other had a partial replacement (replacing only the ball). The goal was to see which surg…

This study compared two arthroscopic surgical techniques for repairing a tear at the back of the knee's medial meniscus (a common injury that can lead to arthritis). Forty adults aged 20-50 with this tear were randomly assigned to receive either a transtibial pullout suture repai…

This completed study tested a three-step treatment for muscle invasive bladder cancer: chemotherapy, then a minimally invasive surgery to remove the tumor, followed by radiation. The goal was to treat the cancer while keeping the bladder intact, which could improve quality of lif…

This study tested a new device called the Leaf Self Expander to widen the upper jaw in 20 children with cleft lip and palate. The device was compared to the standard rapid maxillary expander. Researchers used 3D scans to measure changes in bone and tooth position. The goal was to…

This study tested two types of denture material for people with no teeth who got implant-supported overdentures. Sixteen patients received either a standard acrylic denture or a flexible resin one. Researchers measured gum pocket depth, plaque buildup, and Candida yeast growth to…

This study tested a two-part surgery for children with severe constipation that didn't get better with standard treatments. The surgery removes part of the colon and creates a small opening in the belly for enemas. The goal was to reduce accidental stool leakage (soiling). The st…

This study compared two types of laparoscopic surgery (Swenson-like and Soave) for children with Hirschsprung disease, a condition where nerve cells are missing in part of the colon. Forty children were treated at Al-Azhar University Hospitals, and researchers measured bowel func…

This completed trial compared two surgical techniques for removing benign parotid gland tumors: the standard superficial parotidectomy and a newer, less invasive intracapsular parotidectomy. The study involved 120 adults aged 20-65 with confirmed benign tumors. The goal was to se…

This study tested whether adding cabergoline to the standard drug letrozole helps women with PCOS ovulate more often. One hundred women took either letrozole alone or letrozole plus cabergoline. Researchers tracked ovulation using ultrasound starting on day 10 of the menstrual cy…

This completed study tested a special dental expander combined with tiny bone perforations (MOPs) to widen the upper jaw in 14 adults aged 17-23 with a narrow jaw and crossbite. The goal was to see if this less invasive method could effectively expand the jaw without major surger…

This study tested a gel made from kaempferol, a natural flavonoid, to see if it helps bone heal better around dental implants. Thirty patients with a missing back tooth received the gel during implant surgery. Those who got the gel showed higher levels of a bone-healing marker an…

This study develops and tests an artificial intelligence model that analyzes standard dental photographs to detect gum recession, classify its severity, and suggest treatment options. Researchers use images from adults with visible gum recession to train the AI and compare its ac…

This study tests an artificial intelligence system that measures the width of keratinized gingiva (a type of gum tissue) from smartphone photos. Researchers will compare the AI's measurements to those made by dental experts to see how accurate the tool is. The goal is to make gum…

Researchers compare two surgical techniques for rebuilding the tongue after cancer removal: the submental island pedicled flap, taken from under the chin, and the radial forearm free flap, taken from the arm. Twenty-eight adults with tongue cancer that requires partial or total r…

Researchers compare alpha hydroxy acids, both with and without nanocarriers, against a standard calcipotriol plus betamethasone ointment for plaque psoriasis. The trial enrolls 80 adults with mild to moderate psoriasis who have not used psoriasis therapy for two months. Participa…

This pilot study tests whether a 12 mm extra-short dental needle can effectively numb the lower jaw in children aged 4 to 12 during dental procedures like tooth extractions or pulp therapy. Researchers will measure how well the nerve block controls pain and whether it reduces com…

This trial tests whether placing a nano-form of the painkiller ketorolac inside the root canal can reduce pain after root canal treatment. Adults aged 18–50 with an infected tooth nerve will receive either nano-ketorolac, regular ketorolac, or a placebo gel during the procedure. …

This trial tests two non-surgical injectable treatments for a gummy smile, where too much gum shows when smiling. Twenty adults with a gummy smile of 3 mm or more received either botulinum toxin (Botox) or a hyaluronic acid filler. The study measures how much the gum exposure is …

This study looked at whether surgery to fix a blocked nose can improve snoring and sleep apnea in adults. Thirty people with nasal obstruction and sleep apnea had surgery. The main goal was to see if their breathing pauses during sleep (measured by the apnea-hypopnea index) got b…

This study looked at 100 adults with COPD who needed a breathing tube and a ventilator. It compared two approaches: giving sedation with daily breaks versus giving no sedation at all. The goal was to see which method leads to more days off the ventilator and fewer complications i…

This study tested a new breathing support method (HVNI) against standard non-invasive ventilation (NIV) in 66 COPD patients with dangerously high carbon dioxide levels. The goal was to see if HVNI could safely lower carbon dioxide and reduce the need for a breathing tube. Results…

This study tested two different attachment systems (Equator and Novaloc) for lower dentures held in place by dental implants. The goal was to see which one helps dentures stay in place better and improves quality of life for people with no teeth. 26 adults aged 60-70 took part. T…

This study tested whether a selenium gel can help treat oral lichen planus, a chronic condition that causes painful sores in the mouth. Fifty adults with the condition used either selenium gel, a standard steroid cream, or an immunosuppressant cream. The goal was to see if seleni…

This study looks at children aged 8 to 18 having surgery to repair a hole in the eardrum, a procedure called type 1 tympanoplasty. Researchers want to know if the size of the mastoid and middle ear spaces affects how well the surgery works. They will compare two graft materials, …

This study looks back at 250 patients who had surgery to widen a narrowed urethra using a graft from the inside of the cheek. The goal is to identify factors that predict whether the narrowing will return. Researchers will review medical records from the past 10 years, focusing o…

This study looks at how natural variations in the frontal sinus recess—a narrow passage that drains the frontal sinus—might affect endoscopic sinus surgery for people with frontal sinus disorders. Researchers will use CT scans and surgical observation to map these variations in 4…

This study asks whether 3D digital models can measure dental crowding as accurately and reliably as traditional plaster models. Researchers will compare Little's Irregularity Index scores from digital scans, plaster model photos, and intra-oral photos in 20 people with mild to mo…

This study investigates whether the severity of periodontitis (a serious gum infection) differs between Egyptian men and women. Researchers will examine 380 participants aged 20 to 40, all with periodontitis, using a clinical exam and a detailed questionnaire about oral hygiene, …

This study tests whether advanced ultrasound techniques (2D and 3D speckle-tracking echocardiography) can detect early signs of heart muscle dysfunction in children aged 4 to 18 with end-stage kidney disease who have been on dialysis for at least a year. Researchers aim to see if…

This completed study looked at how clear aligners and fixed braces affect bite forces after treating mild front-tooth crowding. Twelve people aged 14-22 with mild crowding and no extractions were treated with either clear aligners or fixed braces. The goal was to see which method…

This study looked at whether using computer-assisted navigation during sinus surgery helps people with nasal polyps. Researchers compared surgery with and without this technology in 40 patients. They tracked how often polyps came back and how many complications occurred.

This study looked at 400 Egyptian patients who had open-heart surgery to see if living in a hot climate affects bleeding afterward. Researchers compared patients from hot regions (Upper Egypt) with those from milder regions (Lower Egypt). The goal was to understand if climate pla…

This study looked at 201 women who had repeat C-sections to find the best time gap between surgeries. Researchers compared intervals from less than 12 months to over 48 months, tracking complications like bleeding, injuries, and blood transfusions. The goal is to help doctors and…

This study looked at 100 people aged 40 and older who had cataract surgery. Half had type 2 diabetes and half did not. Researchers measured changes in the thin cell layer on the inside of the cornea before and after surgery to see if diabetes affects recovery. The goal is to help…

This study looked at how smoking affects gum healing after non-surgical treatment for stage II gum disease. Researchers measured two proteins (PLAP-1 and Sclerostin) in the gum fluid of 36 patients—both smokers and non-smokers—before and after deep cleaning. The goal was to see i…

This study examined whether type 2 diabetes influences how well a dental procedure called pulpotomy works in adults. Researchers compared 70 diabetic and non-diabetic patients who had a molar treated for irreversible pulpitis. They checked the tooth's health, symptoms, and X-ray …

This completed study tested two methods to prevent lung collapse after upper abdominal surgery: using a breathing machine with extra pressure (PEEP) alone, or adding a short breath-hold maneuver (RM). Both groups also received fluids. Researchers used lung ultrasound to check for…

This study tested two ways to rebuild jawbone for dental implants in 40 adults with narrow upper front jaws. One method used a block of bone from the chin mixed with cow-derived bone particles; the other used a synthetic material. Researchers measured bone width changes and compl…

This completed study tested two devices—a special drill (Densah Bur) and a magnetic hammer (Magnetic Mallet)—to see which better prepares a narrow jawbone for dental implants. Only 5 people took part, all with partial tooth loss and enough bone height but not enough width. The ma…