Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Smoking may slow gum healing after deep cleaning, study finds

NCT ID NCT07339670

Knowledge-focused Sponsor: Al-Azhar University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how smoking affects gum healing after non-surgical treatment for stage II gum disease. Researchers measured two proteins (PLAP-1 and Sclerostin) in the gum fluid of 36 patients—both smokers and non-smokers—before and after deep cleaning. The goal was to see if smoking changes the body's healing response at a molecular level.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Non-surgical periodontal treatment (scaling, root planing, and Listerine mouthwash)
What this could lead to
If successful, this study could reveal how smoking interferes with gum healing, potentially leading to better treatment approaches for smokers with gum disease.
What could go wrong
This is a small, completed observational study with only 36 participants. It measures protein levels rather than long-term health outcomes, so results may not directly change treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Nov 2024

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female aged from 25 - 40 years old. * Patients diagnosed as having Stage II periodontitis. * Group of current smoker's patients, more than 10 cigarettes per day. * Group of non-smoker's patients. * Maximum probing depth ≤ 5 mm, mostly horizontal bone loss. * Clinical Attachment loss from 3-4 mm. * Radiographic bone loss about 15% to 33%, mostly horizontal. Exclusion Criteria: * Pregnant or lactating women. * Any known systemic disease. * Patients who received periodontal treatment in last 6 months.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Periodontitis stage II are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Cigarette Smoking periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis stage II Smoking ( cigarette)

Contacts and locations

Locations

  • Faculty of Dental Medicine for Girls, Al-Azhar University

    Cairo, Nasr City, 4450113, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.