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Flavonoid gel boosts bone density around dental implants in small trial

NCT ID NCT07156799

Disease control Sponsor: Al-Azhar University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested a gel made from kaempferol, a natural flavonoid, to see if it helps bone heal better around dental implants. Thirty patients with a missing back tooth received the gel during implant surgery. Those who got the gel showed higher levels of a bone-healing marker and greater bone density after six months compared to those who did not. The results suggest kaempferol may speed up early bone healing and improve implant stability.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
kaempferol gel
What this could lead to
If confirmed, this could lead to a simple gel that helps dental implants heal faster and stronger, possibly allowing earlier use of the implant.
What could go wrong
This was a small, early study with only 30 patients. Larger and longer trials are needed to know if the gel is truly effective and safe for widespread use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Jun 2023

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * At least one missing maxillary posterior tooth with a healed ridge Exclusion Criteria: * Previous bone grafting at the implant site.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Peri-implant bone healing and osseointegration

Contacts and locations

Locations

  • Faculty of Dental Medicine for Girls, Al-Azhar University

    Cairo, Cairo Governorate, Egypt