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Could a common solvent make your fillings last longer?

NCT ID NCT07196618

Disease control Sponsor: Al-Azhar University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 2 times

Summary

This study tests whether applying dimethyl sulfoxide (DMSO) to aging teeth before placing a filling improves how well the filling bonds and reduces tiny leaks that can cause decay. Thirty adults aged 50-75 with non-cavity tooth lesions will receive either DMSO or chlorhexidine pretreatment. Their fillings will be checked at 2 weeks, 3 months, and 6 months using standard dental criteria.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dimethyl sulfoxide (DMSO)
What this could lead to
If successful, this could lead to a better way to prepare teeth for fillings, making them last longer and reducing the need for repeat dental work.
What could go wrong
This is a small, early-stage study with only 30 participants, so results may not apply to everyone. DMSO may not outperform existing treatments like chlorhexidine.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Nov 2025

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients included in the study will be required to present at least one of non caries cervical lesion with sclerotic dentin without pulpal involvement. * Age of patient: 50 - 75 years * Patients with non caries cervical lesion will be standardized by clinical performance (FDI world dental federation). Exclusion Criteria: * Teeth with deep dentinal lesions with pulpal involvement, abscess, pain or swelling * Developmental disorders and adjacent soft tissue lesions * Patients with systemic illness will be excluded.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bonding

Contacts and locations

Locations

  • Al-Azhar university

    Cairo, Egypt

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