Could a common solvent make your fillings last longer?

NCT ID NCT07196618

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 2 times

Summary

This study tests whether applying dimethyl sulfoxide (DMSO) to aging teeth before placing a filling improves how well the filling bonds and reduces tiny leaks that can cause decay. Thirty adults aged 50-75 with non-cavity tooth lesions will receive either DMSO or chlorhexidine pretreatment. Their fillings will be checked at 2 weeks, 3 months, and 6 months using standard dental criteria.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
dimethyl sulfoxide (DMSO)
What this could lead to
If successful, this could lead to a better way to prepare teeth for fillings, making them last longer and reducing the need for repeat dental work.
What could go wrong
This is a small, early-stage study with only 30 participants, so results may not apply to everyone. DMSO may not outperform existing treatments like chlorhexidine.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Al-Azhar university

    Cairo, Egypt

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