MALIGNANT SOLID NEOPLASM

This study tests whether using a PET scan to guide radiation therapy can better control lung cancer, melanoma, or kidney cancer that has started growing again in up to 5 spots. About 32 adults will receive either standard radiation or a PET-adapted version that delivers a higher …

This study looks at whether using a mask to deliver air pressure (non-invasive ventilation) can help cancer patients with breathing failure avoid needing a breathing tube. About 256 adults with cancer and low oxygen levels will be randomly assigned to get either the mask or stand…

This study tests whether giving triptorelin before chemotherapy can protect the ovaries of young women (under 40) with cancer. Chemotherapy drugs called alkylating agents can harm the ovaries, making it hard to get pregnant later. Triptorelin temporarily pauses ovary activity to …

This study tests whether adding a cancer vaccine (SurVaxM) to standard chemotherapy (temozolomide) helps control advanced neuroendocrine tumors that are growing. About 60 adults with metastatic disease will receive either the combination or chemo alone. The goal is to see if the …

This study compares the drug neratinib alone versus neratinib plus palbociclib in people with HER2-positive gynecologic and other solid tumors (excluding breast cancer). Both drugs block signals that make cancer cells grow. The goal is to see if the combination shrinks tumors or …

This early-stage trial tests whether specially designed immune cells (T-cells) can safely control serious viral infections in cancer patients whose immune systems are weakened by treatment. The cells are modified to target specific viruses like CMV, BK virus, or COVID-19. The stu…

This study looks at whether adding a procedure called vertebroplasty (which strengthens broken spine bones) to radiation therapy can help prevent further spine fractures and improve outcomes in people whose cancer has spread to the spine. About 200 adults with spine metastases wi…

This early-phase study tests a wearable device that creates low-intensity electric fields to disrupt cancer cell growth, combined with standard drugs (cabozantinib or nab-paclitaxel plus atezolizumab). About 43 adults with advanced solid tumors in the abdomen or chest that have s…

This study tests whether the antiviral drug letermovir can prevent cytomegalovirus (CMV) infection in children and teens after a stem cell transplant. About 105 participants aged 2 to 17 who are CMV-positive will receive letermovir to see if it lowers infection rates compared to …

This early-stage trial tests whether donor bone marrow stem cells can help control heart failure in people whose hearts were weakened by a type of chemotherapy called anthracyclines. About 72 adults with reduced heart function will receive either standard care alone or standard c…

This study looks at whether giving focused radiation before or after surgery works better for people with cancer that has spread to the brain. About 140 adults who need surgery for a brain tumor will be randomly assigned to receive stereotactic radiosurgery either before or after…

This study tests whether infusions of stem cells from donated umbilical cord blood can help people with moderate to critical COVID-19 pneumonia. The stem cells are grown in a lab and given to reduce lung inflammation and improve breathing. About 70 adults with COVID-19 and relate…

This study is for people who have both an autoimmune disorder (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer that has spread or cannot be removed. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with othe…

This study tests a two-step treatment for people with advanced cancer that blocks their main breathing passages. First, they get low-dose radiation to shrink the tumor. Then, they receive a light-sensitive drug and a laser treatment to destroy remaining tumor tissue. The goal is …

This study is testing a new blood and urine test that looks for DNA markers to detect cancer early and identify where it started. Researchers at Mayo Clinic will collect samples from 6,150 people, including those with and without cancer, to see how accurate the test is. The goal …

This study tests three ways to prevent nerve damage (numbness, tingling, pain) caused by taxane chemotherapy. About 777 cancer patients will wear special wraps that cool and/or compress their arms and legs during treatment. The goal is to see which method best stops peripheral ne…

This study looks at whether a spinal cord stimulation device can reduce pain and improve daily life for people with nerve damage caused by chemotherapy. About 20 adults who have had chemo-related nerve pain for over six months will receive the treatment. Researchers will track pa…

This study tests a telehealth program designed to help caregivers of patients undergoing a major cancer surgery (cytoreductive surgery with heated chemotherapy). The goal is to reduce caregivers' stress, depression, and financial worries by connecting them with helpful resources.…

This study tests whether a 12-week community-based exercise and nutrition program is practical and helpful for cancer survivors. Researchers want to see if it improves survivors' confidence, physical fitness, and quality of life. About 150 cancer survivors or their caregivers wil…

This study tests a web-based toolkit called CONNECT designed to help rural older cancer survivors manage cancer-related emotional distress and anxiety. The toolkit includes interactive activities for setting up telehealth visits, educational materials, and personalized mental hea…

This study tests whether a virtual stress reduction program using mindfulness techniques can improve mental health for cancer patients living in underserved or rural areas of Minnesota. About 30 adults with a history of cancer who report high stress will take part. The program is…

This study tests if alteplase, a drug that dissolves blood clots, can help drain fluid from around the lungs and improve breathing in people with cancer. Participants have a tube in their chest that is not draining well. The study will compare alteplase to a placebo to see if it …

This study tests whether using virtual reality (VR) can improve symptoms like pain, anxiety, and fatigue in patients receiving a bone marrow transplant. About 28 adult patients will either use VR or receive standard care while in the hospital. The goal is to see if VR helps them …

This study tests whether L-theanine, a natural substance found in green tea, can help cancer patients who have finished treatment feel more relaxed and improve their mood. About 50 adults who are at least 6 months past cancer treatment will take L-theanine and report their stress…

This study tests a community-based exercise program for cancer survivors who have finished active treatment. Researchers partner with the YMCA to offer tailored home workouts. The goal is to see if this program is practical and helps improve quality of life. About 200 participant…

This study tests whether acupressure—a gentle finger-pressure technique—can reduce anxiety in cancer patients receiving chemotherapy. About 78 adults with cancer will either receive real acupressure or a sham (placebo) version. Researchers will measure anxiety levels before and a…

This study tests whether giving cancer treatment at home is preferred over going to a clinic. It involves 27 adults with various cancers in the Florida Panhandle. The goal is to see if home care improves patient satisfaction and is safe.

This study tests if a home-based exercise program designed for Hispanic and Latino/Latina teens and young adults who survived childhood cancer can help them be more active. Participants will use a Fitbit and get support through social media. The goal is to improve physical fitnes…

This study tests a short, virtual therapy called solution-focused brief therapy (SFBT-C) to see if it reduces anxiety and depression in teens and young adults who have had cancer. About 60 participants aged 15-39 who are currently distressed will receive either SFBT-C or standard…

This study tests whether Wisconsin ginseng can reduce fatigue in people with solid-tumor cancers. Fatigue is a common and troubling side effect of cancer and its treatment. Researchers will compare ginseng to a placebo in 160 adults to see if it truly helps.

This study tests if different types of massage can help lower anxiety in cancer patients during chemotherapy. About 50 adults who have already had at least one chemo session and feel anxious will receive massage during their infusions. Researchers will check if patients can compl…

This study tests whether giving the cancer drug nivolumab as a shot at home is as safe and effective as getting it in a clinic. About 50 adults with various cancers will try both settings to see which they prefer and how it affects their quality of life. The goal is to reduce the…

This study tests two phone-based programs to help cancer patients manage symptoms and emotional distress while taking oral anti-cancer drugs. One program uses automated calls to track symptoms and share them with the care team. The other adds a self-help handbook and counseling f…

This study looks at whether expressive writing can help cancer survivors cope with stress, especially during challenging events like the COVID-19 pandemic. About 414 adults diagnosed with cancer in the past 3 years will participate online from home. They will write about their th…

This study tests a program called TRACT that helps cancer patients find transportation to their radiation treatments. Many patients miss or delay care due to travel problems, which can affect their health. The program will be offered to 76 adults with solid tumors who are getting…

This study tests whether a virtual diet program focused on lowering added sugar, increasing fiber, and eating more omega-3s can help cancer survivors manage nerve pain, numbness, and tingling caused by chemotherapy. About 50 adults who finished chemo at least three months ago and…

This study looks at whether a special exercise program called TEAM Me can help children, teens, and young adults with cancer stay active while they are in the hospital for a stem cell transplant. The program uses tokens like stickers that can be traded for rewards to encourage wa…

This study tests a program called GEM-S, which combines a geriatric check-up with health education, to see if it helps older cancer survivors improve their physical abilities, thinking, and memory. About 668 survivors of lymphoma or solid tumors will be assigned to either GEM-S o…

This study tests whether a short guided meditation session before cancer surgery can lower patients' anxiety more than sitting in silence. About 300 adults scheduled for cancer surgery will take part. Researchers will measure anxiety levels and also track pain medicine use after …

This study tests whether using virtual reality (VR) headsets is safe and helpful for cancer patients who feel anxious, depressed, or stressed during treatment. About 24 patients will use VR to explore calming scenes like forests or oceans. The goal is to see if this can improve t…

This study tests whether a mobile app can teach family caregivers safe massage techniques to help cancer survivors with long-term nerve pain from chemotherapy. About 300 participants (patients and their caregivers) will use the app at home. The goal is to reduce nerve symptoms li…

This study tests a program called ASCENT that helps cancer survivors manage pain using an educational guide and coaching from community health workers and pain care managers. The goal is to improve pain and reduce the risk of opioid misuse. The study will include 660 adults with …

This study looks at whether creative arts like drawing, painting, and sculpting can help children with cancer feel better and improve their quality of life. Researchers will compare art activities to watching videos in 72 children aged 8 to 13 who were diagnosed with cancer in th…

This study tests a program called CostCOM that provides financial counseling and resources to cancer patients. The goal is to see if it helps them stick with their treatments and reduces the financial burden of medical costs. About 760 patients will take part.

This study tests a virtual art therapy program for teens and young adults who have had cancer. The goal is to see if it can help with anxiety, depression, stress, and thinking skills. About 30 people aged 10 to 25 who were diagnosed in the past year or finished treatment within 5…

This study tests whether combining a nerve pain drug (duloxetine) with neurofeedback—a therapy that teaches you to change your own brain waves—can better relieve chemotherapy-induced nerve damage than either treatment alone. About 380 adults with nerve pain from past chemo will b…

This study tests if a virtual group therapy program, combining Acceptance and Commitment Therapy (ACT) and compassion-based techniques, can improve psychological well-being in cancer patients. Researchers will enroll 200 adults at Mayo Clinic Arizona who have a cancer diagnosis o…

This study looks at how the COVID-19 pandemic affected the emotional, financial, physical, and social well-being of adolescent and young adult (AYA) cancer patients and survivors. Researchers will survey 600 participants to understand their stress and challenges during the pandem…

This study tests whether a telemedicine program can help older adults (65+) with cancer get care that matches their needs and goals. Researchers will use a special health assessment to find areas of weakness and connect patients with a team of experts. The goal is to see if this …

This study is gathering information on side effects from proton therapy in 5,000 adults with various cancers. Researchers will collect detailed treatment and toxicity data to better understand and predict short- and long-term side effects. The goal is to improve future patient ca…

This study enrolls 50 adults with any type of cancer to see if watching videos and reading materials improves their understanding of clinical trials. Participants complete a survey before and after the educational content. The goal is to learn which approaches work best for diffe…

This study looks at how cancer patients and their doctors discuss immunotherapy. Researchers want to understand where patients get information, what they know, and how doctors explain the treatment. They will also test if educational videos can improve patient understanding. The …

This study looks at whether recording messages of wisdom and hope can help patients with serious illnesses and their caregivers feel more dignity and support. About 40 adults with chronic or progressive illness will make recordings and answer surveys. The goal is to find where pa…

This study looks at a new way to help family members of people with inherited cancer get tested for the same gene changes. About 15% of cancers are inherited, but many people don't know they carry a risky gene. The study will test if having a doctor reach out to at-risk relatives…

This study tests a tool kit called SALSA that tracks stress, mood, and speech to spot thinking problems early in people receiving CAR-T therapy for cancer. About 38 adults will use the tool during their hospital stay. The goal is to see if it's practical and better than current m…

This study aims to see if blood samples from cancer patients can be turned into stem cells that mimic how each person reacts to cancer treatments. Researchers will compare cells from patients who had severe side effects to those who did not. The goal is to better understand and e…

This study collects tissue and blood samples from up to 5,000 cancer patients. The samples are used to create lab models, like cell lines and tumor grafts, to help scientists study cancer and test new drugs. It does not offer direct treatment but supports future research.

This study collects and analyzes genetic material (DNA, RNA) and tissue samples from 500 adults with cancer to identify markers and causes of the disease. Researchers will build a biobank to explore better ways to prevent, detect, and treat cancer. Participants must have a confir…

This study looks at whether a 6-week group program can help young adults (ages 18-39) who have finished cancer treatment feel more prepared for daily life. Participants will attend group meetings led by social workers and complete surveys about their quality of life and mental we…

This study tests whether a virtual community health educator (vCHE) can increase referrals to cancer clinical trials for patients and their caregivers. The vCHE is a computer-generated guide that offers personalized, culturally tailored information in English or Spanish. Research…

This study is testing whether step counts from a wearable device can help predict when cancer patients undergoing radiation therapy might need to go to the emergency room or be hospitalized. Researchers will collect activity data from 260 adults with cancer to see if changes in w…

This study collects blood and tissue samples from 2000 people—some with cancer, some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of mu…

This study explores whether specific breathing exercises can boost brain and mental health in people with multiple sclerosis or certain cancers, as well as their caregivers. Researchers will use brain scans to measure oxygen delivery and fluid flow in the brain. The goal is to un…

This study offers free genetic testing to the general public to find people with inherited cancer syndromes like hereditary breast and ovarian cancer or Lynch syndrome. Researchers want to see if broad testing is better than only testing those with a family history. Up to 27,500 …

This study aims to create better tools to measure quality of life in adolescents and young adults (ages 15-39) with cancer. Researchers will ask 3,000 participants—including patients, survivors, and their caregivers—about body image, fertility concerns, and financial stress. The …

This study collects health information and leftover tumor or blood samples from children and young adults with cancer. The goal is to learn more about these diseases and find better ways to treat and care for patients over time. Up to 75,000 people will take part, and no experime…

This study aims to understand why some cancer patients develop heart issues after chemotherapy while others do not. Researchers will collect blood samples from 1,000 adults who have had chemotherapy for any type of cancer, especially those who developed heart problems or are at h…

This study looks at how the body's immune cells react to a new type of cancer vaccine called a neoantigen vaccine. Researchers will collect blood samples from 24 people with solid tumors or healthy volunteers to study immune responses. The goal is to learn how to better grow and …

This study is testing new blood tests that look for signs of many different cancers at the same time. The goal is to see if these tests can find cancer early, when treatment works best. About 24,000 adults aged 45 to 75 who do not have cancer will take part. They will be placed i…

This study surveys 250 lung specialists across the U.S. to learn how the COVID-19 pandemic changed the way they perform procedures, staff their teams, and run their clinics. The goal is to understand what worked and where to focus future research so hospitals can better handle th…

This study brings together a panel of prostate cancer experts to agree on the most important information to include in medical reports. The goal is to create a standard way of reporting key data in electronic health records, helping doctors better manage patients from diagnosis t…

This study looks at how the gut microbiome (the bacteria living in your digestive system) might influence how well cancer treatments work. Researchers at Mayo Clinic will collect samples from 3000 cancer patients undergoing therapy or stem cell transplants. The goal is to find li…

This study looks at genetic changes in cancer cells from Indigenous American people in the Southwest. The goal is to learn more about these cancers to improve screening and treatment. Researchers will enroll 300 adults who have or had cancer and identify as Indigenous American. P…

This study looks at how the way doctors act and talk to cancer patients during radiation treatment affects their distress levels. Researchers will ask 5,000 patients about which physician behaviors help or hurt their emotional well-being. The goal is to learn how to improve patie…

This study uses virtual reality to show people two versions of the same neighborhood—one clean and well-kept, the other with litter and graffiti. Researchers measure heart rate, sweat, and mood to see how these environments affect stress. The goal is to understand how neighborhoo…

This study is developing and testing a patient navigation program designed specifically for American Indian and Alaska Native cancer patients in rural California. The program helps guide patients through the healthcare system to reduce delays between diagnosis and treatment. Rese…

This study collects tissue and blood samples from 1,500 people with prostate or bladder cancer that has returned or spread. Researchers will analyze the samples to find genetic changes and other markers that explain why some cancers stop responding to treatment. The goal is to di…

This study uses a special microscope called intravital microscopy (IVM) to watch blood vessels inside solid tumors in real time during surgery. Researchers want to see how these vessels work, which could help decide if a patient's tumor is likely to respond to certain treatments.…

This study follows over 2,000 cancer patients receiving immunotherapy to see why some develop mild or serious side effects. Researchers will look at factors like age, gender, and other health conditions. The goal is to help doctors choose safer treatments in the future.

This study looks at whether men and women have different symptoms while receiving immunotherapy for cancer. Researchers will track patient-reported symptoms and quality of life, as well as clinician assessments. The goal is to better understand how sex and gender affect treatment…

This study is testing a mobile app called PACT that helps people with advanced cancer talk about and plan the care they would want if they couldn't speak for themselves. The app involves both the patient and a loved one (support person) to make planning easier. Researchers want t…

This study tests whether a computer-generated character can effectively educate cancer patients about genetic testing, compared to a human genetics counselor. The goal is to see if this approach increases testing rates, especially for minority and rural patients who often lack ac…

This study asks cancer patients at USC Norris about their interest in integrative oncology services like acupuncture, nutrition counseling, and mind-body therapies. Researchers will survey 10 adults with solid or blood cancers to find out what patients know, what they want, and w…

This study tests whether an online platform helps cancer patients track medication safety events and concerns while taking oral anticancer drugs at home. About 80 adults with lung, colorectal, breast, or prostate cancer will use the system to log symptoms and issues. Researchers …

This study aims to find normal levels for a new blood and urine test that looks for DNA markers of cancer. Researchers will collect samples from 10,000 adults without known cancer to establish a baseline. The goal is to improve future cancer screening methods.

This study analyzes tumor tissue from up to 12,000 cancer patients to identify gene mutations. The goal is to match each patient with a clinical trial or therapy that targets their specific cancer type. Researchers will also build a database of mutations to improve future cancer …

This study looks at how the bacteria in your gut might influence stomach issues like diarrhea and colitis caused by certain cancer drugs (immune checkpoint inhibitors). Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung cancer, or genito…

This study tracks side effects and treatment results in 170 advanced cancer patients receiving anti-VEGF therapy. Researchers want to see if certain side effects are linked to how well the cancer responds. The goal is to help doctors better predict outcomes and manage treatment.

This study places cancer patients in special hospital rooms equipped with cameras, microphones, and temperature sensors. The goal is to see if these tools can help nurses and doctors detect early signs of confusion, falls, sleep trouble, or mood changes. About 134 patients and th…

This study aims to learn more about cancer genes in people from different ethnic backgrounds. Researchers will test 1,800 adults with various solid tumors to see how common certain gene changes are. The goal is to improve cancer risk assessment and tailor screening for these popu…

This study explores the link between physical activity and thinking skills (like memory and attention) in people who survived cancer as teens or young adults. Researchers will use computer-based brain games to measure cognitive performance. The goal is to understand how exercise …

This study follows 250 young adults (ages 18-39) recently diagnosed with cancer to see how their social relationships and physical activity change over time and affect their quality of life. Researchers will track hospitalizations, treatment details, exercise habits, and well-bei…