MALIGNANT SOLID NEOPLASM

This study is testing the safety of the immunotherapy drug nivolumab in people who have both advanced cancer and an autoimmune disease like lupus, rheumatoid arthritis, or Crohn's disease. It will enroll 300 adults to see how well they tolerate the treatment and to find the right…

This study is testing whether giving a cancer immunotherapy treatment called nivolumab as an injection at home is a safe and practical alternative to receiving it at a clinic. It aims to see if home treatment reduces the burden of travel and time spent in medical facilities, pote…

This study is testing whether stem cells from a donor's bone marrow can help control heart failure in people whose hearts were weakened by certain chemotherapy drugs. Researchers will compare two different ways of giving the cells (through an IV or directly into the heart) agains…

This study aims to find out if giving a precise, high-dose radiation treatment before surgery works better than giving it after surgery for brain tumors that have spread from other cancers. It will enroll 140 adults with a single brain tumor that surgeons can remove. The main goa…

This study is testing a more precise way to deliver radiation therapy to people whose lung cancer, melanoma, or kidney cancer has spread to a few new spots. It uses PET scans to guide the radiation beams to the most active parts of the tumors. The goal is to see if this targeted …

This study is testing whether stem cells from umbilical cord blood can help control severe COVID-19 pneumonia. The trial will involve 70 hospitalized adults with moderate to critical pneumonia, comparing stem cell infusions against standard care. Researchers want to see if these …

This early-stage trial is testing the safety of combining a wearable device that uses electric fields to disrupt cancer cells with different drug combinations. It is for adults with advanced cancers in the abdomen or chest that have spread and who have run out of standard treatme…

This study is for people with advanced HER2-positive cancers that have come back or spread. It aims to see if taking two targeted drugs together works better than taking one alone to slow or stop cancer growth. About 70 participants will be randomly assigned to one of the two tre…

This early-stage study is testing whether specially modified immune cells can safely help control serious viral infections in cancer patients with weakened immune systems. Researchers are collecting a patient's own T-cells, genetically engineering them to better target specific v…

This study is testing whether a drug called triptorelin can protect the ovaries in young women and adolescents receiving chemotherapy for cancer. Chemotherapy can damage the ovaries, which may make it difficult or impossible to have children later. Researchers want to see if givi…

This study is testing whether adding an experimental cancer vaccine to standard chemotherapy works better than chemotherapy alone for advanced neuroendocrine tumors that have spread and are growing. The vaccine aims to train the immune system to attack cancer cells. Researchers w…

This study is testing if a special oxygen mask, called non-invasive ventilation, is better than standard high-flow oxygen at helping cancer patients with sudden, severe breathing problems. The main goal is to see if the mask can reduce the need for doctors to place a breathing tu…

This study tests a two-step treatment for patients with advanced cancer tumors that block the main breathing tubes in the lungs and cannot be removed by surgery. First, patients receive standard low-dose radiation to shrink the tumor. Then, they receive a special light-sensitive …

This study is testing whether a remote support program can improve care for older adults with cancer. Researchers will use video calls to conduct detailed health assessments and connect patients to a support team. They want to see if this approach helps patients better manage tre…

This study is testing two new blood tests designed to screen for 11 different cancers at the same time. It will enroll 24,000 healthy adults aged 45-75 to see how well these tests work for early detection and to understand how people and their doctors respond to the results. The …

This study aims to establish normal ranges for a new cancer screening test that analyzes DNA in blood and urine. Researchers will collect samples from 10,000 healthy volunteers without known cancer to determine what test results look like in people without the disease. The goal i…

This study aims to collect blood and tissue samples to help develop a single blood test that can detect many different cancers early. Researchers will enroll 2,000 people, including those with cancer and those without, to create a reference set for testing. The goal is to validat…

This study is testing a new approach to detect cancer early using simple blood and urine tests. Researchers want to see if these tests can accurately find cancer and even identify where in the body it started. The study will involve 6150 people, including those with and without c…

This study is testing whether a drug called letermovir can prevent a serious viral infection called cytomegalovirus (CMV) in children and teenagers who have received a stem cell transplant. After a transplant, patients' immune systems are very weak, making them highly vulnerable …

This study is testing if a guided writing exercise can help cancer survivors manage stress and improve their well-being. Researchers will enroll about 414 adults who have been diagnosed with cancer in the last three years. Participants will be randomly assigned to either write ab…

This study is testing a short, virtual talk therapy program designed to help young cancer survivors (ages 15-39) who are struggling with depression, anxiety, and emotional distress. The therapy focuses on building hope and strengths rather than just discussing problems. Researche…

This study is testing whether a 12-week supervised exercise and nutrition education program, held in a community setting, is practical and helpful for people who have finished cancer treatment. Researchers want to see if this program can improve survivors' confidence, physical fi…

This small pilot study is testing whether using virtual reality (VR) is a safe and helpful way to improve the mental well-being of cancer patients during treatment. Participants will use a VR headset to experience relaxing, immersive environments like forests or coral reefs. The …

This early-stage study is testing whether L-theanine, a natural compound found in green tea, can help cancer survivors feel more relaxed and improve their mood. The study will enroll 50 adults who have finished cancer treatment and are now in follow-up care. Participants will tak…

This study is testing whether a spinal cord stimulation device can help reduce pain and improve quality of life for people suffering from nerve damage caused by chemotherapy. Researchers will follow 20 patients who have already had a successful trial with the device to see how mu…

This study is testing whether combining a brain-training therapy called neurofeedback with a medication (duloxetine) works better than either treatment alone for relieving nerve pain caused by chemotherapy. About 380 cancer survivors with this type of pain will be assigned to rec…

This study is testing whether a phone app can effectively teach family caregivers how to perform safe, specialized massage techniques to help cancer survivors manage long-term nerve pain and numbness caused by chemotherapy. The goal is to reduce these symptoms for patients while …

This study is testing whether a 6-week online support group curriculum helps young adult cancer survivors adjust to life after treatment. The program, led by social workers, provides education and peer support about coping with survivorship challenges. Researchers want to see if …

This study is testing a special support program for older adults who have finished cancer treatment. The program includes health education, exercise plans, and consultations to help improve daily physical abilities, mental well-being, and memory. Researchers want to see if this a…

This study is testing an online platform designed to help cancer patients track their experiences and concerns about their medications while at home. The goal is to see if this tool makes it easier for patients to monitor side effects and communicate problems to their doctors, po…

This study is testing a new web-based toolkit called CONNECT, designed to help older cancer survivors living in rural areas manage emotional distress and anxiety. The program offers educational materials, helps set up telehealth visits, and provides personalized mental health res…

This study is testing whether an online mindfulness program can help reduce stress and anxiety in cancer patients who live in rural Minnesota, where mental health services are harder to access. The program teaches techniques to help manage stress from home. Researchers will measu…

This study is testing whether cancer patients prefer to receive their standard drug treatments at home instead of in a clinic. Researchers want to see if home-based care reduces the burden of travel and improves treatment satisfaction and quality of life for patients. A specializ…

This study is testing whether creative arts activities like drawing, painting, and making sculptures can help improve symptoms and quality of life for children with cancer. Researchers will compare children doing art activities with children watching videos to see which approach …

This study tests whether a telehealth program can help reduce stress, depression, and financial strain for people caring for loved ones undergoing a major cancer surgery and heated chemotherapy. Researchers will enroll 50 caregivers and provide half with a one-hour virtual sessio…

This study aims to see if American ginseng can help reduce the severe fatigue that many cancer patients experience, whether they are currently on treatment or not. It will compare ginseng capsules to a placebo (a dummy pill) in 160 adults with solid tumors who report significant …

This study aims to find out which of two non-drug approaches works better to reduce insomnia in cancer patients undergoing treatment. Researchers are comparing a brief behavioral therapy program designed for cancer-related insomnia against a healthy eating education program. The …

This study tests if a financial counseling program helps cancer patients manage treatment costs and reduces stress. It will enroll 760 adults recently diagnosed with solid tumors. Participants will be randomly assigned to receive either standard information or a series of persona…

This study is testing whether acupressure, a technique using finger pressure on specific body points, can help reduce anxiety in people receiving chemotherapy for cancer. Researchers will compare real acupressure to a 'sham' version in 78 adult cancer patients who report signific…

This study is testing whether a daily routine of guided breathing exercises can improve brain health and mental well-being. It is enrolling patients with multiple sclerosis or certain cancers, as well as their caregivers, to see if the practice reduces symptoms like fatigue, anxi…

This study is testing a home-based fitness program designed specifically for Hispanic and Latino young adults who survived childhood cancer. The program uses a Fitbit, a mobile app, and a private social media group to encourage physical activity. Researchers want to see if this c…

This study is testing a new mobile app called PACT that helps people with advanced cancer talk with their loved ones and doctors about the type of medical care they would want if they became too sick to speak for themselves. The trial will enroll 400 patients and their support pe…

This study is testing whether online group therapy sessions can help cancer patients cope with the stress and emotional challenges of their diagnosis and treatment. Researchers want to see if these virtual meetings improve patients' psychological flexibility, reduce distress, and…

This study is testing if a virtual diet coaching program can help reduce nerve pain and numbness caused by chemotherapy. Researchers want to see if a diet low in sugar and high in fiber and healthy fats is practical and acceptable for cancer survivors. The main goal is to check i…

This early study is testing whether alteplase, a drug that dissolves blood clots, can help cancer patients breathe easier. It focuses on patients who have a build-up of fluid around their lungs that won't drain properly through a permanent catheter, causing severe shortness of br…

This study is testing whether a reward-based exercise program can help children and young adults with cancer stay active during a stem cell transplant. Participants earn stickers for walking and other activities, which they can trade for rewards. Researchers want to see if this a…

This study is testing whether a 12-week virtual exercise program, delivered through a partnership with the YMCA, is practical and helpful for underserved cancer survivors. The main goal is to see if this community-based approach is feasible and if it improves participants' qualit…

This study is testing phone-based support programs to help people manage the side effects and emotional distress that often come with taking oral cancer medications at home. Researchers are comparing two approaches: one involves weekly check-in calls that report symptoms to docto…

This study tests a digital coaching program called ASCENT to help cancer survivors manage their pain better. Participants receive personalized guidance from health coaches and learn pain management techniques through phone or video calls. The goal is to improve pain control while…

This study is testing whether different types of massage can help reduce anxiety for cancer patients while they receive chemotherapy. Researchers will enroll 50 patients to try massages on areas like the feet, head, or hands during their infusion sessions. The main goal is to see…

This study is testing whether a virtual art therapy program can help young adult cancer survivors cope with emotional challenges like anxiety and depression. Researchers want to see if this online approach is practical and helpful for participants aged 18-25. The program involves…

This study aims to understand why some cancer patients develop heart problems after chemotherapy while others don't. Researchers will collect blood samples and review medical records from 1,000 adults who either experienced heart issues after cancer treatment, completed treatment…

This study aims to understand the connection between physical activity and memory or thinking skills in young adults who have finished cancer treatment. Researchers will enroll 100 survivors aged 18+ who were diagnosed with cancer between ages 15-39. Participants will wear an act…

This study aims to better understand the side effects that occur in cancer patients receiving anti-VEGF therapies and how these side effects might relate to treatment effectiveness. Researchers will review medical records of 170 patients with blood cancers or solid tumors who are…

This study aims to understand genetic differences in cancers affecting Indigenous American communities, who face worse cancer outcomes than other groups. Researchers will collect tumor samples and genetic data from 300 Indigenous American cancer patients and survivors to identify…

This study aims to learn if offering free genetic testing to the general public is a better way to find people with high inherited cancer risk than only testing those with a known family history. Researchers will enroll up to 27,500 adults, collect saliva samples for DNA testing,…

This study aims to improve how cancer patients learn about and understand clinical trials. Researchers are testing educational materials (written and video) with 50 adult cancer patients from diverse racial and ethnic backgrounds. Participants review the materials and complete su…

This study aims to understand how the body's immune cells respond to an experimental cancer vaccine. Researchers will collect blood samples from 24 participants, including people with solid tumors and healthy individuals, to analyze immune reactions. The goal is to learn how thes…

This study aims to collect genetic samples from cancer patients to build a library of information. Researchers will analyze DNA and tissue samples to identify genetic markers that could help prevent, detect, or treat cancer better in the future. The study is recruiting 350 partic…

This study collects and stores tissue and blood samples from patients with cancer. The goal is to create better laboratory models from these samples to help scientists learn more about cancer and test potential new drugs. Participants are patients being evaluated or treated for c…

This study is testing special hospital rooms equipped with sensors, cameras, and microphones to monitor cancer patients. The goal is to see if this technology can spot early signs of problems like confusion, falls, or sleep issues before they become serious. Researchers hope this…

This study collects detailed information about side effects experienced by cancer patients receiving proton radiation therapy. Researchers will follow 5,000 patients to understand both short-term and long-term effects, aiming to predict risks and improve safety for future patient…

This study aims to understand how personal relationships and physical activity affect the well-being of young adults who have survived cancer. Researchers will follow 250 young adult survivors for one year, having them complete surveys and wear activity trackers. The goal is to l…

This study aims to understand how the COVID-19 pandemic impacted the mental, financial, and social well-being of adolescent and young adult cancer patients and survivors. Researchers will survey about 600 participants to measure their stress, healthcare use, and life disruptions …

This study is testing a new digital tool called SALSA to see if it can spot thinking and memory problems early in cancer patients receiving a powerful immunotherapy called CAR-T. Researchers will compare the tool to standard check-ups in about 38 adults getting CAR-T treatment in…

This study aims to get expert doctors to agree on the most important information that should be consistently recorded in prostate cancer patient charts. A small panel of specialists will complete several rounds of surveys to reach a consensus. The goal is to create a standard rep…

This study is testing whether a virtual community health educator—a photo-realistic digital guide—can help more cancer patients and their caregivers get referred to clinical trials. It focuses on increasing participation from groups that are often underrepresented in research. Th…

This study is testing whether a multilingual AI chatbot named PERLA can help more cancer patients get important genetic testing. It compares patients who learn about testing from the chatbot to those who learn from a human genetics counselor. The goal is to see if this technology…

This study analyzes cancer patients' tumor tissue and blood samples to identify specific genetic changes in their cancer. The goal is to create a detailed database of cancer mutations and use that information to match patients with the most relevant treatment options and clinical…

This study aims to understand if men and women experience the side effects of cancer immunotherapy differently. It will also compare how patients report their symptoms versus how their doctors assess them. Researchers will observe 100 adults with various cancers who are starting …

This study is creating a large registry and tissue bank for children and young adults with cancer. It collects health information and leftover tissue samples from patients up to age 25 to help researchers understand these diseases better. The goal is to use this information to im…

This study tests whether having healthcare providers contact family members directly about inherited cancer risk leads to more genetic testing than when patients share this information themselves. Researchers are comparing two approaches: one where patients share results with rel…

This study aims to learn more about the tiny blood vessels that feed solid tumors. Researchers will use a special microscope during a patient's standard cancer surgery to see these vessels in real time. The goal is to understand how tumor blood flow works and if it relates to how…

This study aims to understand why some cancer patients develop serious side effects from immunotherapy drugs while others don't. Researchers will follow 2,062 patients with solid tumors who are starting standard immunotherapy treatment. By tracking side effects, collecting blood …

This Mayo Clinic study explores how sharing messages of wisdom and hope affects the sense of dignity in cancer patients and their caregivers. Forty participants with cancer and their caregivers will record messages about their experiences and complete surveys about dignity before…

This study aims to predict which cancer patients might experience serious side effects from their treatments. Researchers will take blood samples from 30 adult cancer patients and turn their cells into heart and nerve cells in the lab. By testing these lab-grown cells with cancer…

This study aims to understand how a doctor's behavior and other aspects of care affect emotional distress in cancer patients. Researchers will survey 5,000 adults undergoing or recently finished with radiation therapy at Mayo Clinic. The goal is to identify what specific doctor a…

This study collects blood and tissue samples from people with prostate or bladder cancer to learn why treatments sometimes stop working. Researchers will analyze these samples in a lab to look for genetic patterns and markers related to the cancer. The goal is to discover new tar…

This study is a nationwide survey asking lung doctors how their practices changed during the COVID-19 pandemic. Researchers want to learn how hospitals adapted their staffing, procedures, and outpatient care. The goal is to use this information to guide better responses to future…

This study aims to understand how cancer-related genetic mutations differ among various ethnic populations. Researchers will collect blood or saliva samples from 1,800 cancer patients from diverse backgrounds to identify genetic patterns. The findings could help create more perso…

This study is collecting tissue and blood samples from cancer patients over time to create a research resource called a biobank. Researchers will analyze these samples to understand how cancer changes during treatment and why some treatments stop working. The goal is to help scie…

This study aims to understand why some cancer patients develop severe diarrhea and colon inflammation (colitis) while taking powerful immunotherapy drugs called immune checkpoint inhibitors. Researchers will collect stool, blood, and tissue samples from 800 patients with melanoma…

This study aims to understand how the bacteria in our digestive system (gut microbiome) influence how well cancer treatments work. Researchers will collect stool and blood samples from 3,000 cancer patients undergoing treatment or stem cell transplants. By analyzing these samples…