Cancer Patients' samples fuel future drug discovery

NCT ID NCT02474160

Knowledge-focused Sponsor: National Cancer Institute LAO Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study collects tissue and blood samples from up to 5,000 cancer patients of all ages. The samples are used to create lab models, such as cell lines and animal models, to help scientists better understand cancer and test new treatments. Participants do not receive direct treatment from this study.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 5,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2015

Expected to finish

May 2026

An estimate. End dates often move.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients undergoing evaluation and/or treatment for cancer

Ages

2 months and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients older than 2 months of age who are being evaluated, treated, or enrolled in a clinical trial for cancer at participating sites * Patients with a histologically or cytologically confirmed diagnosis of cancer * Patients without histologically or cytologically confirmed diagnosis of cancer, but for whom approval has been requested and received from the coordinating site study coordinator * Requests for coordinating site approval should only be made if the patient's existing work-up at the time of the request demonstrates a combination of two or more of the following indicating the greater likelihood of a cancerous process in the assessment of the treating physician: * Radiographic imaging (computed tomography \[CT\], magnetic resonance imaging \[MRI\], etc.) * Elevated tumor markers * Clinical symptoms * Documented risk factors, known genetic changes (mutation, deletion, fusion, etc.), and/or known familial cancer history or syndrome * Complete blood count (CBC) w/differential indicative of a probable hematologic malignancy * If the patient will be undergoing surgical resection at a later time and will be accessible to approach for study participation at that time, resected material following cancer diagnosis confirmation is preferred * Important: Additional medical, genetic and/or demographic work-up should not be obtained solely for determination of eligibility for protocol 9846 by these criteria. Once available, final histology must be confirmed to the coordinating site detailing the cancer diagnosis for patients enrolled based on the above criteria * Patients with a newly diagnosed primary and/or metastatic solid tumor or hematologic malignancy for which they have not yet received treatment * Patients with a solid tumor or hematologic malignancy that is recurrent, newly metastasized, or progressing while on treatment indicated by: * Radiographic evidence of tumor growth, re-growth, and/or new metastases, OR * Documentation by the treating physician of clinical disease progression, OR * CBC w/differential and/or flow cytometry for hematologic malignancies * Patients currently undergoing treatment (adjuvant, neoadjuvant, etc.) * Specimen collection should occur as distant in time from the most recent drug administration as possible (e.g., after completion of a treatment cycle and immediately prior to initiation of the next cycle) * Specimens should not be collected from patients between doses within a single treatment cycle * Confirmation of viable residual malignancy and/or \< 90% tumor necrosis, fibrosis, or hemorrhage must be confirmed to the National Cancer Institute (NCI) coordinating site, as indicated in the final post-operative/post-procedure pathology and/or flow cytometry report * Patients with ongoing partial response (PR) or stable disease (SD) are eligible * Confirmation of viable malignancy and/or \< 90% tumor necrosis, fibrosis, or hemorrhage must be confirmed to the NCI coordinating site, as indicated in the final post-operative/post-procedure pathology and/or flow cytometry report * Ability to understand and willingness to sign a written informed consent document indicating their willingness to have their tissue or biologic fluid specimens used for research as outlined in this protocol * For pediatric patients, ability and willingness to assent to participation, using an explanation that is understandable/age appropriate, as well as receiving parental permission. Signature requirements for pediatric patients can be adjusted based on local guidelines Exclusion Criteria: * Patients with cancer-like syndromes and/or blood disorders such as systemic mastocytosis, Langerhans cell histiocytosis, chronic eosinophilic leukemia/hypereosinophilic syndrome, lymphomatoid granulomatosis, or monoclonal gammopathy of undetermined significance (MGUS) * Patients with invasive fungal infections * Patients with active and/or uncontrolled bacterial, fungal, or viral infections or who are still recovering from an infection * Actively febrile patients with uncertain etiology of febrile episode * All antibiotics prescribed for the treatment of a bacterial infection should be completed at least 1 week (7 days) prior to collection * Patients with a hematologic malignancy who are treated with an antibiotic, anti-fungal, and/or anti-viral medication for an active infection who then remain on the treatment for prophylaxis following resolution of the infection as assessed by the treating physician are not excluded * No recurrence of fever or other symptoms related to infection for at least 1 week (7 days) following completion of antibiotics * Patients receiving antibiotics, antifungals, and/or antivirals for prophylaxis are permissible * Antibiotics being administered topically at a location distant from the planned tissue collection site or eye drops for a localized infection are permissible * Patients with human immunodeficiency virus (HIV), active or chronic hepatitis (i.e., quantifiable hepatitis B virus \[HBV\]-deoxyribonucleic acid \[DNA\] and/or positive hepatitis B surface antigen \[HbsAg\], quantifiable hepatitis C virus \[HCV\]-ribonucleic acid \[RNA\]) or known history of HCV, HBV, or HIV; testing for HBV, HCV, HIV or other infections for eligibility will be performed only if clinically indicated * Patients with hepatitis A as indicated by anti-hepatitis A virus (HAV) IgM reactivity * Patients that are anti-HAV IgG reactive only are eligible * Specimen collections from patients with benign tumors including but not limited to desmoid tumors, carcinoma in situ, or ongoing evidence of complete disease response (CR)

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Conditions

The condition(s) this trial relates to.

cancer hematopoietic and lymphoid system neoplasm metastatic malignant neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hematopoietic and lymphatic system neoplasm Malignant solid neoplasm Metastatic malignant solid neoplasm Recurrent malignant solid neoplasm

How to take part

Only the study team decides who joins. These are the ways to reach them.

The study's own enquiry address

This study publishes an address for enquiries. See it below .
The places running it

90 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Show contact details

Locations

Ascension Borgess Hospital
SUSPENDED

Kalamazoo, Michigan, 49048, United States
Ascension Via Christi Hospitals Wichita
RECRUITING

Wichita, Kansas, 67214, United States

Contact Email: •••••@•••••
Aspirus Cancer Care - Stevens Point
ACTIVE_NOT_RECRUITING

Stevens Point, Wisconsin, 54481, United States
Associates In Womens Health
SUSPENDED

Wichita, Kansas, 67208, United States
Augusta University Medical Center
RECRUITING

Augusta, Georgia, 30912, United States
BJC Outpatient Center at Sunset Hills
SUSPENDED

Sunset Hills, Missouri, 63127, United States
Baptist Memorial Hospital and Cancer Center-Memphis
RECRUITING

Memphis, Tennessee, 38120, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Oxford
RECRUITING

Oxford, Mississippi, 38655, United States

Contact Email: •••••@•••••
Bronson Battle Creek
SUSPENDED

Battle Creek, Michigan, 49017, United States
Cancer Care Center of O'Fallon
SUSPENDED

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States
Cancer Center of Kansas - Chanute
SUSPENDED

Chanute, Kansas, 66720, United States
Cancer Center of Kansas - Dodge City
SUSPENDED

Dodge City, Kansas, 67801, United States
Cancer Center of Kansas - El Dorado
SUSPENDED

El Dorado, Kansas, 67042, United States
Cancer Center of Kansas - Fort Scott
SUSPENDED

Fort Scott, Kansas, 66701, United States
Cancer Center of Kansas - Newton
SUSPENDED

Newton, Kansas, 67114, United States
Cancer Center of Kansas - Parsons
SUSPENDED

Parsons, Kansas, 67357, United States
Cancer Center of Kansas - Pratt
SUSPENDED

Pratt, Kansas, 67124, United States
Cancer Center of Kansas - Salina
SUSPENDED

Salina, Kansas, 67401, United States
Cancer Center of Kansas - Wellington
SUSPENDED

Wellington, Kansas, 67152, United States
Cancer Center of Kansas - Wichita
RECRUITING

Wichita, Kansas, 67214, United States

Contact Email: •••••@•••••
Cancer Center of Kansas - Winfield
SUSPENDED

Winfield, Kansas, 67156, United States
Cancer Center of Kansas-Independence
SUSPENDED

Independence, Kansas, 67301, United States
Cancer Center of Kansas-Kingman
SUSPENDED

Kingman, Kansas, 67068, United States
Cancer Center of Kansas-Liberal
SUSPENDED

Liberal, Kansas, 67905, United States
Cancer Center of Kansas-Manhattan
SUSPENDED

Manhattan, Kansas, 66502, United States
Cancer Center of Kansas-Wichita Medical Arts Tower
SUSPENDED

Wichita, Kansas, 67208, United States
Cancer Therapy and Integrative Medicine
ACTIVE_NOT_RECRUITING

Las Vegas, Nevada, 89121, United States
Cancer and Blood Specialists-Henderson
ACTIVE_NOT_RECRUITING

Henderson, Nevada, 89052, United States
Cancer and Blood Specialists-Shadow
ACTIVE_NOT_RECRUITING

Las Vegas, Nevada, 89106, United States
Cancer and Blood Specialists-Tenaya
ACTIVE_NOT_RECRUITING

Las Vegas, Nevada, 89128, United States
Central Care Cancer Center - Bolivar
SUSPENDED

Bolivar, Missouri, 65613, United States
Central Illinois Hematology Oncology Center
ACTIVE_NOT_RECRUITING

Springfield, Illinois, 62702, United States
Centralia Oncology Clinic
SUSPENDED

Centralia, Illinois, 62801, United States
Christiana Care Health System-Christiana Hospital
ACTIVE_NOT_RECRUITING

Newark, Delaware, 19718, United States
Christiana Care Health System-Wilmington Hospital
ACTIVE_NOT_RECRUITING

Wilmington, Delaware, 19801, United States
City of Hope Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING

Duarte, California, 91010, United States
Comprehensive Cancer Centers of Nevada
ACTIVE_NOT_RECRUITING

Las Vegas, Nevada, 89148, United States
Comprehensive Cancer Centers of Nevada - Central Valley
ACTIVE_NOT_RECRUITING

Las Vegas, Nevada, 89169, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
SUSPENDED

Saint Joseph, Michigan, 49085, United States
Corewell Health Lakeland Hospitals - Niles Hospital
SUSPENDED

Niles, Michigan, 49120, United States
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
SUSPENDED

Saint Joseph, Michigan, 49085, United States
Corewell Health Reed City Hospital
SUSPENDED

Reed City, Michigan, 49677, United States
Cox Cancer Center Branson
SUSPENDED

Branson, Missouri, 65616, United States
CoxHealth South Hospital
RECRUITING

Springfield, Missouri, 65807, United States
Crossroads Cancer Center
SUSPENDED

Effingham, Illinois, 62401, United States
Dana-Farber Cancer Institute
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02215, United States
Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States
Delaware Clinical and Laboratory Physicians PA
ACTIVE_NOT_RECRUITING

Newark, Delaware, 19713, United States
Delbert Day Cancer Institute at PCRMC
RECRUITING

Rolla, Missouri, 65401, United States

Contact Email: •••••@•••••
Duke University Medical Center
ACTIVE_NOT_RECRUITING

Durham, North Carolina, 27710, United States
Freeman Health System
RECRUITING

Joplin, Missouri, 64804, United States
Gundersen Lutheran Medical Center
SUSPENDED

La Crosse, Wisconsin, 54601, United States
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
ACTIVE_NOT_RECRUITING

Las Vegas, Nevada, 89149, United States
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
ACTIVE_NOT_RECRUITING

Las Vegas, Nevada, 89109, United States
HealthCare Partners Medical Group Oncology/Hematology-San Martin
ACTIVE_NOT_RECRUITING

Las Vegas, Nevada, 89113, United States
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
ACTIVE_NOT_RECRUITING

Las Vegas, Nevada, 89128, United States
Heartland Regional Medical Center
RECRUITING

Saint Joseph, Missouri, 64506, United States
Helen F Graham Cancer Center
ACTIVE_NOT_RECRUITING

Newark, Delaware, 19713, United States
Illinois CancerCare-Bloomington
SUSPENDED

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton
SUSPENDED

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage
SUSPENDED

Carthage, Illinois, 62321, United States
Illinois CancerCare-Eureka
SUSPENDED

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg
SUSPENDED

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic
SUSPENDED

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb
SUSPENDED

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic
SUSPENDED

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin
SUSPENDED

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria
SUSPENDED

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru
SUSPENDED

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton
SUSPENDED

Princeton, Illinois, 61356, United States
John H Stroger Jr Hospital of Cook County
RECRUITING

Chicago, Illinois, 60612, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
ACTIVE_NOT_RECRUITING

Baltimore, Maryland, 21287, United States
Lawrence Memorial Hospital
SUSPENDED

Lawrence, Kansas, 66044, United States
M D Anderson Cancer Center
ACTIVE_NOT_RECRUITING

Houston, Texas, 77030, United States
MU Health Care Goldschmidt Cancer Center
SUSPENDED

Jefferson City, Missouri, 65109, United States
Marshfield Clinic Cancer Center at Sacred Heart
ACTIVE_NOT_RECRUITING

Eau Claire, Wisconsin, 54701, United States
Marshfield Clinic-Chippewa Center
ACTIVE_NOT_RECRUITING

Chippewa Falls, Wisconsin, 54729, United States
Marshfield Clinic-Wausau Center
ACTIVE_NOT_RECRUITING

Wausau, Wisconsin, 54401, United States
Marshfield Medical Center - Minocqua
ACTIVE_NOT_RECRUITING

Minocqua, Wisconsin, 54548, United States
Marshfield Medical Center - Weston
ACTIVE_NOT_RECRUITING

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-Marshfield
ACTIVE_NOT_RECRUITING

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake
ACTIVE_NOT_RECRUITING

Rice Lake, Wisconsin, 54868, United States
Mayo Clinic in Rochester
ACTIVE_NOT_RECRUITING

Rochester, Minnesota, 55905, United States
Medical Oncology Hematology Consultants PA
ACTIVE_NOT_RECRUITING

Newark, Delaware, 19713, United States
Memorial Hospital of Carbondale
SUSPENDED

Carbondale, Illinois, 62902, United States
Mercy Clinic-Rolla-Cancer and Hematology
SUSPENDED

Rolla, Missouri, 65401, United States
Mercy Hospital Fort Smith
RECRUITING

Fort Smith, Arkansas, 72903, United States
Mercy Hospital Joplin
RECRUITING

Joplin, Missouri, 64804, United States
Mercy Hospital Oklahoma City
RECRUITING

Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital Saint Louis
RECRUITING

St Louis, Missouri, 63141, United States
Mercy Hospital South
RECRUITING

St Louis, Missouri, 63128, United States
Mercy Hospital Springfield
RECRUITING

Springfield, Missouri, 65804, United States
Methodist Medical Center of Illinois
SUSPENDED

Peoria, Illinois, 61636, United States
Missouri Baptist Medical Center
RECRUITING

St Louis, Missouri, 63131, United States
Missouri Baptist Sullivan Hospital
SUSPENDED

Sullivan, Missouri, 63080, United States
Montefiore Medical Center - Moses Campus
ACTIVE_NOT_RECRUITING

The Bronx, New York, 10467, United States
Montefiore Medical Center-Einstein Campus
ACTIVE_NOT_RECRUITING

The Bronx, New York, 10461, United States
Montefiore Medical Center-Weiler Hospital
ACTIVE_NOT_RECRUITING

The Bronx, New York, 10461, United States
MultiCare Auburn Medical Center
ACTIVE_NOT_RECRUITING

Auburn, Washington, 98001, United States
MultiCare Gig Harbor Medical Park
ACTIVE_NOT_RECRUITING

Gig Harbor, Washington, 98335, United States
MultiCare Good Samaritan Hospital
ACTIVE_NOT_RECRUITING

Puyallup, Washington, 98372, United States
Munson Medical Center
SUSPENDED

Traverse City, Michigan, 49684, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
RECRUITING

New York, New York, 10032, United States

Contact Email: •••••@•••••
OSF Saint Francis Medical Center
SUSPENDED

Peoria, Illinois, 61637, United States
OSF Saint Francis Radiation Oncology at Pekin
SUSPENDED

Pekin, Illinois, 61554, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
SUSPENDED

Peoria, Illinois, 61615, United States
OSF Saint Joseph Medical Center
ACTIVE_NOT_RECRUITING

Bloomington, Illinois, 61701, United States
OptumCare Cancer Care at Fort Apache
ACTIVE_NOT_RECRUITING

Las Vegas, Nevada, 89148, United States
PCR Oncology
ACTIVE_NOT_RECRUITING

Arroyo Grande, California, 93420, United States
Parkland Health Center-Bonne Terre
SUSPENDED

Bonne Terre, Missouri, 63628, United States
Radiation Oncology of Northern Illinois
SUSPENDED

Ottawa, Illinois, 61350, United States
SSM Health Good Samaritan
RECRUITING

Mount Vernon, Illinois, 62864, United States
Saint Francis Medical Center
SUSPENDED

Cape Girardeau, Missouri, 63703, United States
Saint Louis Cancer and Breast Institute-South City
SUSPENDED

St Louis, Missouri, 63109, United States
Sainte Genevieve County Memorial Hospital
SUSPENDED

Sainte Genevieve, Missouri, 63670, United States
Smilow Cancer Center/Yale-New Haven Hospital
ACTIVE_NOT_RECRUITING

New Haven, Connecticut, 06510, United States
Southeast Cancer Center
SUSPENDED

Cape Girardeau, Missouri, 63703, United States
Southern Illinois University School of Medicine
SUSPENDED

Springfield, Illinois, 62702, United States
Springfield Clinic
SUSPENDED

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital
SUSPENDED

Springfield, Illinois, 62781, United States
Trinity Health Grand Rapids Hospital
SUSPENDED

Grand Rapids, Michigan, 49503, United States
Trinity Health Muskegon Hospital
SUSPENDED

Muskegon, Michigan, 49444, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
ACTIVE_NOT_RECRUITING

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Mary Mercy Livonia Hospital
ACTIVE_NOT_RECRUITING

Livonia, Michigan, 48154, United States
UCHealth University of Colorado Hospital
ACTIVE_NOT_RECRUITING

Aurora, Colorado, 80045, United States
UNC Lineberger Comprehensive Cancer Center
SUSPENDED

Chapel Hill, North Carolina, 27599, United States
USC / Norris Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING

Los Angeles, California, 90033, United States
University of Alabama at Birmingham Cancer Center
SUSPENDED

Birmingham, Alabama, 35233, United States
Valley Radiation Oncology
SUSPENDED

Peru, Illinois, 61354, United States
Virginia Mason Bainbridge Island Medical Center
ACTIVE_NOT_RECRUITING

Bainbridge Island, Washington, 98110, United States
Virginia Mason Federal Way Medical Center
ACTIVE_NOT_RECRUITING

Federal Way, Washington, 98002, United States
Virginia Mason Lynnwood Medical Center
ACTIVE_NOT_RECRUITING

Lynnwood, Washington, 98036, United States
Virginia Mason Medical Center
ACTIVE_NOT_RECRUITING

Seattle, Washington, 98101, United States
Washington University School of Medicine
ACTIVE_NOT_RECRUITING

St Louis, Missouri, 63110, United States
Wesley Medical Center
SUSPENDED

Wichita, Kansas, 67214, United States
West Michigan Cancer Center
SUSPENDED

Kalamazoo, Michigan, 49007, United States
Western Illinois Cancer Treatment Center
SUSPENDED

Galesburg, Illinois, 61401, United States
Yale University
ACTIVE_NOT_RECRUITING

New Haven, Connecticut, 06520, United States

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