MALIGNANT SOLID NEOPLASM

This study is testing whether the drug copanlisib can help treat advanced cancers that have lost a specific protein called PTEN. The drug aims to block signals that cancer cells need to grow. The trial includes about 22 patients with various solid tumors that have not responded t…

This study is testing whether a combination of two targeted drugs, trastuzumab and pertuzumab, can help control advanced cancers that have a specific genetic change called HER2 amplification. The trial is for patients whose cancers are not breast, stomach, or colorectal cancer, a…

This small pilot study is testing whether a home exercise program, with or without a vitamin B3-like supplement called nicotinamide riboside, is practical and helpful for adult survivors of childhood cancer who have prediabetes. The main goal is to see if survivors can stick to t…

This study is testing a personalized cell therapy called LN-145 for patients with advanced cancers that have stopped responding to standard treatments. Doctors collect a patient's own immune cells from their tumor, grow large numbers of them in a lab, and then infuse them back in…

This study is testing whether two oral drugs, olaparib and ceralasertib, can help control advanced cancers that have a specific genetic change called an IDH mutation. It is for adults whose cancer has grown despite standard treatments. The main goal is to see if the drug combinat…

This study is testing whether adding a third drug, navitoclax, to two existing melanoma drugs (dabrafenib and trametinib) can help shrink tumors more effectively. It involves adults with advanced, BRAF-mutant melanoma or other solid tumors that have spread or cannot be removed by…

This study is testing whether a combination of two oral drugs, talazoparib and temozolomide, can shrink advanced rare cancers that have spread and for which standard treatments have stopped working. The trial aims to see if this drug pair can stop tumor growth by damaging cancer …

This study is testing a drug called tipifarnib in children and young adults whose advanced cancers have a specific genetic change in a gene called HRAS. The goal is to see if the drug can shrink tumors and control the disease. Participants take the drug as a pill or through a fee…

This study is testing different ways to help childhood and young adult cancer survivors become more physically active and improve their diets. Researchers are comparing several approaches including telehealth sessions with clinicians, personalized goal-setting with social media s…

This study compares two smartphone apps designed to help cancer patients quit smoking. Researchers want to see if the new Quit2Heal app works better than the existing QuitGuide app at helping patients stay smoke-free for a full year. The trial involves 427 cancer patients who cur…

This early-stage study is testing a new oral drug called IPdR (ropidoxuridine) in combination with standard whole-brain radiation therapy. The goal is to see if the drug makes cancer cells in the brain more sensitive to radiation, potentially improving treatment for patients whos…

This study is testing whether the drug erdafitinib can help control advanced solid tumors that have specific genetic changes called FGFR mutations or fusions. The drug works by blocking a faulty protein that tells cancer cells to grow. The trial enrolled 35 adults whose cancer ha…

This study compares two drugs, infliximab and vedolizumab, to treat severe colon inflammation and diarrhea caused by cancer immunotherapy drugs. The trial involves 47 patients with melanoma, lung cancer, or urinary cancers who developed these side effects. Researchers aim to find…

This study is testing whether combining a targeted form of radiation therapy with an immunotherapy drug (pembrolizumab) is safe and more effective than the drug alone for patients with advanced non-small cell lung cancer that has spread. The goal is to see if the radiation helps …

This large national trial is testing whether a combination of two immunotherapy drugs (nivolumab and ipilimumab) can help control over 50 different types of rare cancers that have few or no standard treatment options. It enrolled over 800 adults whose rare cancers had progressed …

This early-stage study is testing the safety and best doses of a combination of cancer drugs for people with advanced cancers of the urinary system (like bladder and kidney cancer) that have spread. The trial combines a pill (cabozantinib) that aims to block tumor growth with one…

This early-stage study is testing the safety and best dose of a chemotherapy drug called eribulin when given with radiation therapy before surgery. It involves 15 patients with a rare abdominal cancer called retroperitoneal liposarcoma. The goal is to see if this combined approac…

This study is testing a treatment for a viral infection called CMV that can be dangerous for people who have had a stem cell transplant. It uses special white blood cells from a donor who has fought off CMV before. The goal is to see if these 'borrowed' immune cells can help clea…

This study is testing whether taking two oral drugs together—palbociclib and binimetinib—is better than taking one of them alone for controlling advanced cancers that have specific genetic changes called RAS mutations. It focuses on certain hard-to-treat cancers like low-grade ov…

This study is testing if a drug called pegloticase can quickly lower dangerously high uric acid levels in cancer patients. High uric acid is a side effect of some cancer treatments and can damage the kidneys. The goal is to see if one or two doses of pegloticase can protect kidne…

This study is testing a drug called ensartinib in children and young adults whose advanced cancers have specific genetic changes (ALK or ROS1). The goal is to see if the drug can shrink tumors or stop them from growing in patients whose cancer has come back or hasn't responded to…

This study is testing the safety and effectiveness of avelumab, an immunotherapy drug, when given in combination with other immune-boosting drugs and sometimes radiation. It is for patients with advanced solid tumors that have spread and who have run out of standard treatment opt…

This early-stage study is testing the safety and best dose of a three-drug combination (entinostat, nivolumab, and ipilimumab) for people with advanced solid tumors that have spread and are hard to treat. The goal is to see if boosting the immune system with two drugs while using…

This study is testing a combination of two immunotherapy drugs, tiragolumab and atezolizumab, for children and adults with rare, aggressive cancers that have come back or stopped responding to standard treatments. These cancers are missing specific genes (SMARCB1 or SMARCA4). The…

This study is testing a combination of three immunotherapy drugs—tocilizumab, ipilimumab, and nivolumab—in patients with advanced melanoma, non-small cell lung cancer, or bladder cancer. The main goal is to see if adding tocilizumab can help manage the serious side effects someti…

This study is testing a new way to calculate the dose of the cancer drug vincristine for infants and very young children. The goal is to give them drug levels in their blood that are similar to older children, who use a standard dosing method, while trying to reduce severe side e…

This study is testing whether portable heart monitoring devices can detect early heart problems in childhood cancer survivors as accurately as standard clinic tests. Researchers are comparing two portable devices that can be used at home against traditional echocardiograms and MR…

This study is testing small, wearable sensors that stick to the skin to see if they can detect early signs of arm swelling (lymphedema) in cancer survivors. Researchers want to see if these sensors, which measure tiny changes in tissue, can tell the difference between a healthy a…

This study tests whether taking an over-the-counter probiotic supplement can prevent a serious side effect of cancer immunotherapy. Up to 45% of patients receiving immunotherapy develop severe colon inflammation and diarrhea, which can delay treatment and require hospitalization.…

This study is testing whether a daily broccoli seed and sprout extract can boost the body's natural ability to clear out cancer-causing chemicals that firefighters breathe in during their work. It involves 66 active, non-smoking firefighters who will take either the broccoli extr…

This study looks at whether a light therapy treatment helps reduce painful mouth sores and other oral problems in cancer patients receiving a stem cell transplant. Researchers are observing 6 patients and the nurses who give the treatment to see how well it works. The goal is to …

This study is testing whether fast-acting opioid pain medications (fentanyl or morphine) can help control the distressing shortness of breath that cancer patients often feel during physical activity. About 150 patients will take either one of the opioids or a placebo pill daily f…

This study is testing whether the medication bupropion can help reduce severe fatigue in cancer survivors. Over 400 participants who have finished their main cancer treatments will receive either bupropion or a placebo pill for 13 weeks. Researchers will measure changes in fatigu…

This study is testing a combination of treatments to help cancer patients who are having trouble sleeping. It combines counseling sessions with possible use of a stimulant, melatonin, and light therapy. The goal is to see if this package improves sleep quality, reduces fatigue, a…

This study is testing whether a yoga program can help cancer patients and their partners feel better during radiation treatment. It will enroll 600 couples where one person has lung, head and neck, or esophageal cancer. Researchers want to see if doing yoga together improves phys…

This study is testing if a dietary supplement called PEA can relieve nerve pain, numbness, and tingling caused by chemotherapy in cancer survivors. About 88 participants who have had these symptoms for at least 3 months will take either PEA or a placebo pill for 8 weeks. Research…

This study is testing whether adding a special digital app and web platform can improve depression care for people undergoing cancer treatment. It compares this tech-enhanced approach to the usual collaborative care methods. The goal is to see if the technology helps patients and…

This study aims to find the best way to give intravenous pain medicine to hospitalized cancer patients. Researchers are comparing whether giving the drug hydromorphone quickly over 2 minutes or slowly over 15 minutes provides better pain relief while lowering the risk of patients…

This study is testing a mobile health program designed to help young people who have survived childhood cancer become more physically active. It compares a full program—which includes a Fitbit, personalized goal setting, and a social media support group—against just wearing a Fit…

This study is testing a new mobile phone app designed to help cancer patients during radiation therapy. The app provides education and guidance on managing treatment side effects and logistics. Researchers want to see if patients find the app easy to use and helpful. The study in…

This study is testing if a simple, home-based exercise program can better relieve the nerve pain, numbness, and tingling that often follows chemotherapy. About 133 cancer patients who have this side effect are being assigned to either follow a 6-week walking and resistance progra…

This study is testing whether smelling lavender or similar scents can help reduce pain and anxiety for cancer patients during bone marrow biopsy procedures. Researchers want to see if this simple, drug-free approach can make these uncomfortable tests easier to tolerate. The trial…

This study aims to understand why minority cancer patients often don't join clinical trials and to build a better educational tool to help them. Researchers will survey nearly 600 new cancer patients about their knowledge and attitudes, then test different educational approaches.…

This early-phase study is testing a new imaging agent called 68Ga-FAPI-46 to see where it goes in the body of patients with various cancers. Researchers will give participants the tracer and then perform PET/CT scans to see how it collects in both normal and cancerous tissues. Th…

This study aims to understand the financial stress cancer patients experience and what personal and social factors help them cope. Researchers will survey 625 recently diagnosed patients about their confidence, support networks, and financial knowledge. The goal is to gather info…

This study aims to find the best way to identify malnutrition in older adults with cancer. Researchers are comparing four different short screening tools to see which one best predicts a patient's risk of dying or being hospitalized over the next year. The goal is to help doctors…

This study aims to understand what cancer patients and their radiation doctors think about using video visits (telemedicine) for appointments. Researchers are surveying 200 adults who have had a video visit with their radiation oncology team, as well as the doctors themselves. Th…

This study is testing a web-based education tool called HOPE-Genomics. It aims to help cancer patients better understand their personal genetic test results and general cancer genomics. Researchers are comparing the tool's effectiveness against standard education methods to see i…

This study aims to find a better way to calculate the right dose of the chemotherapy drug carboplatin for cancer patients. Researchers are testing if a special dye (iohexol) can help doctors measure kidney function more accurately than standard blood tests, which is key for safe …

This study is testing if regular online team meetings can help cancer imaging doctors feel less burned out and more connected to their colleagues. Researchers are enrolling 36 doctors to either join weekly virtual meetings for 13 weeks or wait and join later. The main goal is to …

This study uses existing genetic and health data to investigate whether having naturally lower testosterone levels might cause an increased risk of dementia, depression, or anxiety. Researchers are analyzing information from large public health databases, not testing a new treatm…

This study observes how children, teens, and young adults with cancer respond to COVID-19 vaccines. Researchers are tracking immune system reactions over two years to understand how cancer treatments affect vaccine protection. The study involves blood tests and surveys but does n…

This study aims to understand how immunotherapy cancer treatments affect patients' balance and hearing. Researchers will follow 50 adult cancer patients for one year, testing their balance and hearing before they start treatment and again at 3, 6, and 12 months. The goal is to ga…

This study observes cancer patients who get COVID-19 to understand how the virus affects their cancer treatment and recovery. Researchers collect blood samples and medical information from 1,877 participants over two years to learn about immune responses and treatment changes. Th…

This study aims to understand if Black and White cancer patients experience different side effects and treatment results when receiving immunotherapy drugs. Researchers will follow 2,100 patients already scheduled to receive these treatments in community cancer clinics. By collec…

This study aims to understand cancer screening awareness and barriers among incarcerated women. Researchers will survey 1,200 women at a Florida prison to learn about their knowledge, screening history, and challenges. The information will be used to create a digital education pr…

This study is testing a symptom questionnaire designed specifically for teenagers with cancer. Researchers are interviewing 13-17 year old cancer patients to see if the questionnaire accurately captures their experiences with pain, fatigue, and other symptoms. The goal is to crea…

This study aims to understand the worries parents have about giving opioid pain medication to their children with cancer. Researchers are surveying 110 parents to learn why some might hesitate to use these strong pain relievers, even when their child is hurting. The information w…

This study is testing whether people find it acceptable to use a full-body MRI scan and a special blood test (liquid biopsy) to try to detect cancer early. It involves 100 adults with a strong family history of cancer. The main goal is to see if people are comfortable with this a…

This early study is testing a new type of PET-CT scan that uses a special tracer to measure oxygen levels inside solid tumors. The goal is to see if this scan is reliable and safe, and to find the best timing for it. Doctors hope that mapping a tumor's oxygen can help them plan m…

This study aims to understand how the COVID-19 pandemic affected the well-being and quality of life of cancer patients and survivors. Researchers are surveying over 13,000 patients about their pandemic experiences, including health impacts, financial stress, and emotional challen…

This study aims to understand cancer patients' preferences and experiences when using marijuana products (THC or CBD) alongside prescription opioids for pain. Researchers are surveying 200 patients with cancer-related pain in Texas and Arizona to learn which combination they find…

This study aims to understand how patients with cancer or COVID-19 perceive their doctor's empathy. Researchers are comparing two visit types: in-person where the doctor wears full protective equipment (PPE) versus a video call where the doctor does not. The goal is to learn whic…

This study is testing a new type of PET-CT scanner called the RefleXion system. Researchers want to see if its images are as good as standard PET-CT scans at finding cancer spots in patients with various tumors. The goal is to learn if this new system could one day allow doctors …

This study aims to learn how the COVID-19 pandemic affected the quality of life of cancer patients who also have nerve pain (neuropathy). Researchers are surveying 274 patients who were in previous studies to see if their pain, anxiety, and daily life were impacted. They also wan…

This study aims to understand why certain cancers develop at younger ages in people from different racial and ethnic backgrounds. Researchers will collect tumor tissue and blood samples from 2,400 patients during their regular cancer surgeries. By analyzing these samples, they ho…

This study is testing whether providing training and support to cancer clinic staff helps them deliver a special health check-up for older adults starting new cancer treatments. The check-up looks at a patient's overall physical health, support network, and daily life impact, not…

This study aims to understand how the COVID-19 pandemic impacted the well-being and quality of life of cancer patients, regardless of whether they got COVID-19. Over 1,200 former participants from prior behavioral studies completed a 35-45 minute online survey about their pandemi…

This study aimed to gather information to help design future 'hospital at home' programs for cancer patients with fever and low white blood cell counts. Researchers planned to review medical records to see how often these patients had serious complications and what treatments the…