MALIGNANT SOLID NEOPLASM

This study tests two immunotherapy drugs, nivolumab and ipilimumab, in adults with over 50 types of rare cancers. The goal is to see if this drug combination can shrink tumors or stop them from growing. The trial is no longer enrolling new participants, but results will help guid…

This study compares two medications, infliximab and vedolizumab, for treating colitis (colon inflammation) caused by immune checkpoint inhibitor cancer therapy. About 47 adults with genitourinary cancer, melanoma, or non-small cell lung cancer who develop moderate to severe diarr…

This study tests a treatment made from a patient's own immune cells (called LN-145) for cancers like ovarian, triple-negative breast, anaplastic thyroid, and bone sarcomas that have not responded to standard therapy or have returned. The cells are taken from the tumor, grown in a…

This study tests a drug called erdafitinib in 35 adults whose cancers have certain FGFR gene changes. The drug blocks a faulty protein that helps cancer cells grow. The goal is to see if the drug can shrink or stop the cancer. Participants must have already joined the main MATCH …

This study tests a drug called copanlisib in 22 adults with various cancers that have lost a protein called PTEN. The drug blocks enzymes that help cancer cells grow, aiming to shrink or slow the tumors. While it may help control the disease, it is not expected to be a cure, and …

This early-phase study tests two or three drugs together (cabozantinib, nivolumab, and sometimes ipilimumab) in people with advanced cancers of the urinary and genital systems that have spread. The main goals are to find the safest dose and understand side effects. About 152 adul…

This study tests a combination of three drugs (dabrafenib, trametinib, and navitoclax) in people with BRAF-mutant melanoma or other solid tumors that have spread or cannot be removed by surgery. The goal is to find the best dose and see how well the drugs shrink tumors. About 75 …

This study tests a combination of two targeted drugs, trastuzumab and pertuzumab, in people with cancers that have a specific gene change called HER2 amplification. The cancers treated are not breast, stomach, or colorectal cancers. The goal is to see if the drug pair can shrink …

This study tests two immunotherapy drugs, tiragolumab and atezolizumab, in children and adults whose rare cancers (like certain brain, kidney, and soft tissue tumors) have returned or not responded to treatment. These cancers lack specific genes (SMARCB1 or SMARCA4), making them …

This early-phase trial tests the safety and best dose of the chemotherapy drug eribulin when given with radiation before surgery for a rare cancer called retroperitoneal liposarcoma. About 15 adults with this abdominal fat-cell tumor will receive the combination to see how well i…

This study tests a combination of two drugs, palbociclib and binimetinib, in people with cancers that have a RAS mutation, including certain ovarian and pancreatic cancers. The goal is to see if the combination can slow cancer growth better than one drug alone. About 199 adults w…

This study was designed to test if itacitinib can help cancer patients whose immune system attacks their own body after immunotherapy, causing side effects that steroids can't fix. The drug works by calming the overactive immune response. However, the trial was withdrawn before e…

This study tested the drug ensartinib in 13 children and young adults (ages 1–21) whose cancers had come back or did not respond to treatment and had specific ALK or ROS1 gene changes. The goal was to see if the drug could shrink or stop tumor growth. While the drug targets cance…

This study tests whether a daily broccoli seed and sprout extract (BSSE) can boost firefighters' natural ability to remove cancer-causing chemicals like benzene from their bodies. 72 firefighters who do not smoke will take either the extract or a placebo for 12 weeks. Researchers…

This study tests the drug tipifarnib in children and young adults (ages 1 to 21) whose advanced solid tumors, lymphoma, or related cancers have a specific change in the HRAS gene. The goal is to see if tipifarnib can shrink or stop the growth of these hard-to-treat cancers. Parti…

This study tests whether adding tocilizumab to standard immunotherapy (ipilimumab and nivolumab) can reduce severe side effects in people with advanced melanoma, lung cancer, or bladder cancer. About 35 participants will receive the combination to see if it is safer and still eff…

This study tests the safety and effectiveness of combining the immunotherapy drug avelumab with other drugs and radiation in people with advanced cancers that have not responded to standard treatments. About 173 adults with various solid tumors, including prostate cancer, will re…

This study tests whether specially trained white blood cells from donors can treat a stubborn CMV infection in people who have had a stem cell transplant. About 49 participants will receive these cells to see if the infection clears. The goal is to control the virus when standard…

This study tests whether a combination of two drugs, talazoparib and temozolomide, can shrink advanced rare cancers or stop them from growing. The trial includes 14 adults with rare solid tumors that have not responded to standard treatments. Talazoparib blocks a protein that hel…

This early-phase study tests the safety and best doses of three drugs—entinostat, nivolumab, and ipilimumab—given together to people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if this combination can help the immune system figh…

This study tested two drugs, olaparib and ceralasertib, in 24 people with advanced solid tumors that have an IDH mutation, including a type of bile duct cancer. The goal was to see if the combination could shrink or stop tumor growth. Unfortunately, no patients had their tumors s…

This early-phase trial studies how well a special PET-CT scan using a tracer called [18F]FAZA can measure oxygen levels in solid tumors. About 25 adults with breast, colorectal, pancreatic, or other solid tumors will receive the tracer and undergo imaging to see if the scan is re…

This study looks at whether portable, easy-to-use devices can detect early signs of heart damage in childhood cancer survivors. These devices can be used at home or in a clinic, potentially catching problems sooner than standard tests. The study involves 149 participants and comp…

This study tests whether taking an over-the-counter probiotic (VSL#3®) can prevent colitis (colon inflammation and diarrhea) in cancer patients receiving immunotherapy. Immunotherapy helps the immune system fight tumors but can cause colitis in up to 45% of patients. The trial en…

This study tests whether smelling lavender oil can help cancer patients feel less pain and anxiety during a bone marrow biopsy. About 45 adults with cancer who are nervous about the procedure will try the aromatherapy. The goal is to find a safe, non-drug way to make the experien…

This study tests if fast-acting opioids (fentanyl or morphine) can reduce shortness of breath during or after walking in 150 cancer patients who already take strong painkillers. Participants will take the drug or a placebo before a short walk test, and researchers will measure ch…

This phase 3 trial tests whether bupropion, a drug used for depression and smoking cessation, can reduce fatigue in cancer survivors. About 422 adults who have completed cancer treatment and still have moderate to severe fatigue will receive either bupropion or a placebo. The stu…

This study tests whether combining cognitive behavioral therapy with three medications (methylphenidate, melatonin, and light therapy) can improve sleep in cancer patients. About 68 adults currently on cancer treatment who have poor sleep quality will participate. The goal is to …

This study looks at whether a yoga program can improve physical performance, quality of life, and reduce symptoms like fatigue and distress in cancer patients undergoing radiation therapy, as well as their partners. About 600 patients with lung, head and neck, or esophageal cance…

This study tests whether a natural supplement called PEA can reduce nerve pain, numbness, and tingling caused by chemotherapy in cancer patients. About 88 adults who have had these symptoms for at least 3 months will take PEA or a placebo for 8 weeks. The goal is to see if PEA im…

This study looks at how fast or slow a dose of hydromorphone (a strong painkiller) is given through an IV to cancer patients with pain. The goal is to see if the speed affects how well it controls pain and how likely it is to be misused. About 84 hospitalized cancer patients will…

This study tests different behavioral programs to help childhood and young adult cancer survivors become more physically active and improve their diet. Participants are survivors aged 18-55 who are not very active. The goal is to see if personalized support can help them adopt he…

This study tests whether a brief behavioral therapy (BBT-CI) or healthy eating education (HEAL) better reduces insomnia in 400 cancer patients receiving treatment. Participants have stage I-IV cancer and report sleep disturbances. The goal is to improve sleep and quality of life.

This study looks at whether a special light treatment (photobiomodulation) can help reduce mouth sores, pain, taste changes, and dry mouth in patients getting a stem cell transplant. Six adult patients are being observed, some who received the light therapy and some who did not. …

This study looks at whether exercise can reduce nerve damage symptoms caused by chemotherapy, like pain, numbness, or tingling in hands and feet. About 133 cancer patients who had nerve-damaging chemo in the past 9 months will either exercise or receive standard drug treatment. T…

This study tests whether a smartphone app called Quit2Heal can help cancer patients stop smoking better than another app, QuitGuide. About 427 adults with cancer who smoke will use one of the two apps for support. The main goal is to see how many people can stay smoke-free for at…

This early-phase study tests an oral drug called ropidoxuridine (IPdR) given alongside whole brain radiation for people whose cancer has spread to the brain. The goal is to see if the drug can make radiation work better by sensitizing tumor cells, while checking for side effects.…

This study looks at how cancer patients view using marijuana products (THC or CBD) along with opioids for pain relief. Researchers will survey 200 patients in Texas and Arizona to understand their preferences and symptom control. The goal is to learn if adding marijuana helps pat…

This study looks at whether low testosterone levels increase the risk of dementia, depression, and anxiety. Researchers will analyze genetic data from large biobanks to see if certain gene variants linked to lower testosterone are also tied to these mental health conditions. The …

This study looks at how patients with cancer perceive their doctor's empathy during the COVID-19 pandemic. It compares in-person visits where doctors wear protective equipment (PPE) to video calls where doctors do not wear PPE. About 107 adults from MD Anderson's emergency cancer…

This study looks at whether a dye called iohexol can help doctors more accurately calculate the right dose of the chemotherapy drug carboplatin for cancer patients. Researchers will compare different methods of estimating kidney function to see which one best predicts how the bod…

This research study aims to collect tissue, blood, and other samples from 2,400 people diagnosed with breast, colon, kidney, liver, multiple myeloma, or prostate cancer at a young age. The goal is to identify genetic changes that may explain why these cancers occur early in certa…

This study looks at how immunotherapy drugs affect balance and hearing in people with cancer. Researchers will test 50 patients before, during, and after treatment to see if their balance changes. The goal is to better understand side effects so doctors can help patients manage t…

This study surveyed over 1,200 cancer patients who had taken part in earlier behavioral trials to learn how the COVID-19 pandemic impacted their quality of life, mental health, and daily routines. Participants filled out questionnaires about stress, sleep, diet, exercise, and soc…

This study looks at whether a program of exercise and a dietary supplement called nicotinamide riboside (similar to vitamin B3) can improve muscle health and insulin resistance in adult survivors of childhood cancer who have prediabetes. About 20 participants will follow a 6-week…

This early-phase study tests a new imaging tracer called 68Ga-FAPI-46 in 26 people with various cancers. The tracer targets cells around tumors, helping PET scans show where cancer is located. Researchers want to see how well the tracer works and compare it to standard imaging. T…

This study follows nearly 1,900 cancer patients who tested positive for COVID-19. Researchers collect blood samples, medical records, and images to see how the virus impacts their cancer treatment and overall health. The goal is to learn which factors make COVID-19 more severe in…

This study tracks how the immune systems of children, teens, and young adults with cancer respond to COVID-19 vaccines. Cancer and its treatments can weaken immunity, so researchers want to see if factors like vaccine type, timing, and booster shots affect protection. About 549 p…

This study tests a web-based education tool called HOPE-Genomics that teaches cancer patients about their genetic test results. About 465 adults with lung, breast, colorectal, pancreatic, ovarian, or prostate cancer are taking part. The goal is to see if the tool helps patients r…

This study compares two ways to increase physical activity in teens and young adults who have finished cancer treatment. One group uses a mobile app and social media support, while the other just wears a fitness tracker. The goal is to see which approach helps them stay active an…

This study looks at why minority cancer patients often don't take part in clinical trials. Researchers will survey about 590 patients to understand their challenges and preferences. The goal is to create an educational platform that helps these patients learn about trials and fee…

This study compares how well immune checkpoint inhibitors work in African American/Black and European American/White cancer patients. Researchers will collect blood, saliva, and health information from 2,100 participants to see if there are differences in side effects and treatme…

This study looks at whether whole body MRI scans and liquid biopsies (blood tests) are acceptable to people with a strong family history of cancer. Researchers want to see if these tools can help find early-stage cancers. About 100 participants aged 50 or older (or younger if clo…

This study looks at what parents think about the risks of using opioids to manage pain in children with cancer. Researchers want to understand why some parents give less pain medicine than prescribed or stop it early, even when their child is still in pain. About 110 parents of c…

This study tests a new PET-CT scanner (RefleXion) in 20 cancer patients to see if it can produce images as good as the standard scan. The goal is to use the same scan for both imaging and planning radiation therapy, potentially reducing the number of scans needed. Participants wi…

This study looks at how often cannabis withdrawal happens and what symptoms appear in patients hospitalized for bone marrow transplant or CAR-T therapy. Researchers will track 300 adults at Mayo Clinic using a symptom questionnaire. The goal is to better understand withdrawal in …

This study looks at whether training cancer clinic staff to give a special health check-up (called a geriatric assessment) helps older adults (65+) starting a new cancer therapy. The check-up covers physical health, daily life, and support networks. Researchers want to see if thi…

This study looks at how the COVID-19 pandemic affected the well-being of cancer patients who also have nerve pain (neuropathy). Researchers want to understand how the pandemic changed their quality of life and health outcomes. They will also compare patients who received a brain-…

This study collects tissue and blood samples, along with medical information, from 1,600 people with various advanced cancers. The goal is to track how cancer changes over time and during treatment. Researchers hope this will help them understand why some cancers resist therapy a…

This study looks at whether a special type of online meeting, called ECHO telementoring, can help diagnostic imaging doctors feel more connected and work more efficiently. Researchers at MD Anderson Cancer Center are testing this with 36 doctors. The goal is to see if these meeti…

This study looked at cancer patients who had a fever and low white blood cells (neutropenic fever) to understand how often they had serious complications. The goal was to see if some of these patients could be safely treated at home instead of in the hospital. The study was withd…

This study tests a mobile app called Oncpatient designed to help cancer patients navigate radiation therapy. Radiation treatment involves daily visits and managing side effects, which can be overwhelming. The app aims to provide easy-to-access information and guidance. Twenty adu…

This study looked at how the COVID-19 pandemic impacted the well-being and quality of life of over 13,000 cancer patients and survivors. Researchers used questionnaires to learn about people's experiences, such as exposure to the virus, isolation, financial problems, and emotiona…

This study surveys 1,200 incarcerated women at a Florida prison to learn about their cancer screening history, risk factors, and barriers to care. The goal is to create a digital education module to improve cancer awareness and screening in prisons. Participants fill out a 15-min…

This study surveys 200 patients and healthcare providers to understand their opinions on using telemedicine (video visits) for radiation oncology. Participants must be 18 or older, English-speaking, and have had at least one telemedicine visit. The goal is to measure satisfaction…

This study looks at how well nutritional check-ups can find malnutrition in older adults with cancer. About 180 participants will undergo special assessments to see if their nutrition affects their health and survival. The goal is to help doctors better identify and address malnu…

This study tests a symptom questionnaire designed for teenagers with cancer. Researchers interview teens aged 13-17 to see if the survey is easy to use and accurately captures their symptoms. The goal is to improve the tool so doctors can better understand and manage what teens g…

This study looks at the financial challenges people face after a cancer diagnosis. Researchers are surveying 625 English- or Spanish-speaking adults diagnosed within the past year to understand what factors contribute to financial stress. The goal is to identify targets for futur…

This study compares a new dosing method for the cancer drug vincristine in infants and young children to the standard method used in older children. The goal is to see if the new approach gives similar drug levels in the blood with fewer side effects. About 83 children up to 12 y…