New combo therapy targets rare childhood and adult cancers
NCT ID NCT05286801
First seen Sep 30, 2025 · Last updated Jun 22, 2026 · Updated 45 times
Summary
This study tests two immunotherapy drugs, tiragolumab and atezolizumab, in children and adults with rare cancers that have come back or not responded to treatment. These cancers lack certain genes (SMARCB1 or SMARCA4), making them hard to treat. The goal is to see if the drug combination can shrink tumors or stop them from growing.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77030, United States
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C S Mott Children's Hospital
Ann Arbor, Michigan, 48109, United States
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Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, H3T 1C5, Canada
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Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta, Georgia, 30329, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
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Children's Hospital of Alabama
Birmingham, Alabama, 35233, United States
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Children's Hospital of Orange County
Orange, California, 92868, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, 15224, United States
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Children's Hospital of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Children's Mercy Hospitals and Clinics
Kansas City, Missouri, 64108, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Cook Children's Medical Center
Fort Worth, Texas, 76104, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287, United States
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Lucile Packard Children's Hospital Stanford University
Palo Alto, California, 94304, United States
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Lurie Children's Hospital-Chicago
Chicago, Illinois, 60611, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032, United States
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
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Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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New York Medical College
Valhalla, New York, 10595, United States
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Oregon Health and Science University
Portland, Oregon, 97239, United States
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Primary Children's Hospital
Salt Lake City, Utah, 84113, United States
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Queensland Children's Hospital
South Brisbane, Queensland, 4101, Australia
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Riley Hospital for Children
Indianapolis, Indiana, 46202, United States
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Royal Children's Hospital
Parkville, Victoria, 3052, Australia
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Saint Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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Sydney Children's Hospital
Randwick, New South Wales, 2031, Australia
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UCSF Medical Center-Mission Bay
San Francisco, California, 94158, United States
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UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390, United States
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University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637, United States
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University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, 55455, United States
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Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tiragolumab and atezolizumab (immunotherapy drugs)
What this could lead to
If successful, this could offer a new treatment option for people with rare, aggressive cancers that have not responded to standard therapy.
What could go wrong
This is an early-phase trial with a small number of participants, so the drugs may not work or could cause significant side effects. Results may not apply to all patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.