Massive biobank aims to unlock Cancer's secrets
NCT ID NCT04314401
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study collects tissue and blood samples from 1,600 people with various advanced cancers, along with their medical information, over the course of their treatment. Researchers will store these samples and data in a biobank for current and future studies. The goal is to better understand how cancer changes and why some treatments stop working, without directly testing a new treatment on participants.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 1,600 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2020
- Expected to finish
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Apr 2027
An estimate. End dates often move.
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients undergoing treatment for cancer types with commercially available therapies.
- Ages
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13 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Is consistent with OR has been diagnosed with one of the following: * Colorectal cancer: stage IV * Non-small cell or small cell lung cancer: stage III/IV * Prostate cancer: metastatic prostate cancer * Gastric cancer, not otherwise specified (NOS): stage IV * Esophageal cancer, NOS: stage IV * Adenocarcinoma of gastroesophageal junction: stage IV * High grade serous ovarian cancer: stage III/IV * Invasive breast carcinoma: stage III/IV * Melanoma: stage III/IV * Acute myeloid leukemia * Multiple myeloma * For the purposes of this study, * Re-staging is allowed * Having more than one primary cancer is allowed, if the patient is being treated solely for one of the eligible cancers listed above * Patient should fit in one of the following four clinical scenarios (a-d) * Undergoing diagnostic workup for one of the diseases listed for which treatment will likely include a new regimen of standard of care therapy OR * Scheduled to begin treatment with a new regimen of standard of care therapy OR * Currently progressing on a regimen of standard of care therapy OR * Currently being treated with a regimen standard of care therapy, without evidence of progression * Requirements for fresh tissue biospecimen collections at enrollment: * For clinical scenarios a, b, and c above, freshly collected tumor tissue or bone marrow (BM) aspirate must be submitted at enrollment * For clinical scenarios a and b, the fresh tissue collection must be prior to starting therapy * For clinical scenario a, the biospecimen collection must be part of a standard of care medical procedure * For clinical scenarios b or c, the biospecimen collection may be part of a standard of care medical procedure OR * The biospecimen collection may be part of a study-specific procedure ("research only biopsy"), when the patient has a tumor amenable to image guided or direct vision biopsy and is willing and able to undergo a tumor biopsy for molecular profiling * Note: For research-only biopsies, the biopsy must not be associated with a significant risk of severe or major complications or death; the procedure cannot be a mediastinal, laparoscopic, open or endoscopic biopsy; nor can the procedure be a brain biopsy; nor can the patient be under the age of majority as determined by each U.S. state * Requirements for archival tissue: * For clinical scenarios a and b above, archival tissue as outlined below must be submitted IF AVAILABLE * For clinical scenarios c and d above, archival tissue as outlined below is REQUIRED * Pre-existing archival material (formalin-fixed, paraffin-embedded \[FFPE\] block, BM aspirate, or unstained slides) that: * Contains the cancer type for which the participant is enrolled, and * Was collected no more than 5 years prior to initiation of therapy, and * Contains at least a surface area of 5 mm\^2 and optimal surface area of 25 mm\^2 or 3-5 mL cryopreserved bone marrow aspirate to yield 200 million bone marrow mononuclear cells, and * Contains at least 10% tumor content. 70% tumor content is optimal, and * No more than 1 line of standard of care systemic therapy was administered from the date of archival material collection to the date of initiation of therapy * Requirements for blood collection: ALL scenarios require fresh blood collection at enrollment * Blood collection for clinical scenarios a, b, and c must take place within 1 week of fresh tumor specimen collection * Blood collection for clinical scenario d must take place within 4 weeks of enrollment, and while patient is on treatment * Age 13 or older * Any sex * Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0, 1, or 2 * Ability to understand and willingness to sign an informed consent document. Consent may be provided by a Legally Authorized Representative (LAR) in accordance with 45 CFR 46.102(i) * NCI PDMR INCLUSION CRITERIA: Patients with CRC with mismatch repair deficient (dMMR) or microsatellite instability-high (MSI-H) status * NCI PDMR INCLUSION CRITERIA: Patients with CRC who are 40 years old or younger at time of collection irrespective of mismatch repair deficient (dMMR) or microsatellite instability-high (MSI-H) status * NCI PDMR INCLUSION CRITERIA: Patients with BRCA that are either * Any race/ethnicity with hormone receptor positive (ER+PR+, ER+PR-, or ER-PR+) * African American with triple negative (ER-PR-HER2-) * NCI PDMR INCLUSION CRITERIA: Patients with lung cancer (LCA), prostate cancer (PCA), gastroesophageal cancer (GEC), ovarian cancer (OV), acute myeloid leukemia (AML), multiple myeloma (MML) Exclusion Criteria: * Treated with or has already begun treatment with a non-standard of care therapeutic agent (investigational) in an interventional clinical trial * For the purposes of this study, past enrollment in clinical trials whereby the patient was randomized and treated with standard-of-care anti-cancer treatment (chemotherapy regimen, surgery and radiation therapy) is allowed * Uncontrolled intercurrent illness that in the physician's assessment would pose undue risk for biopsy * Use of full dose coumarin-derivative anticoagulants such as warfarin are prohibited. Patients may be switched to low molecular weight (LMW) heparin at physician discretion * Low molecular weight (LMW) heparin is permitted for prophylactic or therapeutic use * Factor X inhibitors are permitted * Use of anti-platelet drugs are permitted * Stopping the anticoagulation treatment for biopsy, bone marrow aspirate, or resection should be per site standard operating procedure (SOP) * NCI PDMR EXCLUSION CRITERIA: Patients with complete response * NCI PDMR EXCLUSION CRITERIA: Patients with invasive fungal infections * NCI PDMR EXCLUSION CRITERIA: Patients with active and/or uncontrolled infections or who are still recovering from an infection * Actively febrile patients with uncertain etiology of febrile episode * All antibiotics for non-prophylactic treatment of infection should be completed at least 1 week (7 days) prior to collection * No recurrence of fever or other symptoms related to infection for at least 1 week (7 days) following completion of antibiotics * NCI PDMR EXCLUSION CRITERIA: Patients with human immunodeficiency virus (HIV), active or chronic hepatitis (i.e. quantifiable hepatitis B virus \[HBV\]-deoxyribonucleic acid \[DNA\] and/or positive hepatitis B surface antigen \[HbsAg\], quantifiable hepatitis C virus \[HCV\]-ribonucleic acid \[RNA\]) or known history of HBV/HCV without documented resolution
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AIS Cancer Center at San Joaquin Community Hospital
Bakersfield, California, 93301, United States
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Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada, 89135, United States
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Audie L Murphy VA Hospital
San Antonio, Texas, 78229, United States
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Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, 53215, United States
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Bayhealth Hospital Kent Campus
Dover, Delaware, 19901, United States
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Bayhealth Hospital Sussex Campus
Milford, Delaware, 19963, United States
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Blank Children's Hospital
Des Moines, Iowa, 50309, United States
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Boca Raton Regional Hospital
Boca Raton, Florida, 33486, United States
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Broward Health Medical Center
Fort Lauderdale, Florida, 33316, United States
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Broward Health North
Deerfield Beach, Florida, 33064, United States
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Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, 62526, United States
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Carle Cancer Center
Urbana, Illinois, 61801, United States
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Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938, United States
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Carle at The Riverfront
Danville, Illinois, 61832, United States
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Carson Tahoe Regional Medical Center
Carson City, Nevada, 89703, United States
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Centra Alan B Pearson Regional Cancer Center
Lynchburg, Virginia, 24501, United States
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Centro Comprensivo de Cancer de UPR
San Juan, 00927, Puerto Rico
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Chelsea Hospital
Chelsea, Michigan, 48118, United States
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Children's Hospital New Orleans
New Orleans, Louisiana, 70118, United States
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Children's Hospital at Montefiore
The Bronx, New York, 10467, United States
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Chilton Medical Center
Pompton, New Jersey, 07444, United States
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Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, 89148, United States
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Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, Nevada, 89169, United States
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Comprehensive Cancer Centers of Nevada - Town Center
Las Vegas, Nevada, 89144, United States
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Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan, 49503, United States
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CoxHealth South Hospital
Springfield, Missouri, 65807, United States
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Decatur Memorial Hospital
Decatur, Illinois, 62526, United States
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Dickinson County Healthcare System
Iron Mountain, Michigan, 49801, United States
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ECU Health Medical Center
Greenville, North Carolina, 27834, United States
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ECU Health Oncology Kinston
Kinston, North Carolina, 28501, United States
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East Carolina University
Greenville, North Carolina, 27834, United States
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Edwards Comprehensive Cancer Center
Huntington, West Virginia, 25701, United States
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FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst, North Carolina, 28374, United States
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Freeman Health System
Joplin, Missouri, 64804, United States
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Gibbs Cancer Center-Gaffney
Gaffney, South Carolina, 29341, United States
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Gibbs Cancer Center-Pelham
Greer, South Carolina, 29651, United States
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Good Samaritan Hospital - Cancer Centers of Colorado
Lafayette, Colorado, 80026, United States
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Gulf Health Hospitals Inc/Infirmary Cancer Care - Malbis
Daphne, Alabama, 36526, United States
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Gulf Health Hospitals Inc/Infirmary Cancer Care - Saraland
Saraland, Alabama, 36571, United States
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Harold Alfond Center for Cancer Care
Augusta, Maine, 04330, United States
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Hartford Hospital
Hartford, Connecticut, 06102, United States
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Heartland Regional Medical Center
Saint Joseph, Missouri, 64506, United States
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Hope Cancer Care of Nevada
Las Vegas, Nevada, 89103, United States
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Illinois CancerCare - Washington
Washington, Illinois, 61571, United States
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Illinois CancerCare-Bloomington
Bloomington, Illinois, 61704, United States
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Illinois CancerCare-Galesburg
Galesburg, Illinois, 61401, United States
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Illinois CancerCare-Pekin
Pekin, Illinois, 61554, United States
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Illinois CancerCare-Peoria
Peoria, Illinois, 61615, United States
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Intermountain Health Platte Valley Hospital
Brighton, Colorado, 80601, United States
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Iowa Methodist Medical Center
Des Moines, Iowa, 50309, United States
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John H Stroger Jr Hospital of Cook County
Chicago, Illinois, 60612, United States
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Kingman Regional Medical Center
Kingman, Arizona, 86401, United States
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LSU Health Sciences Center at Shreveport
Shreveport, Louisiana, 71103, United States
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Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia, 31405, United States
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Lutheran Hospital - Cancer Centers of Colorado
Golden, Colorado, 80401, United States
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MMP Surgical Care Casco Bay
Portland, Maine, 04102, United States
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Maine Children's Cancer Program
Scarborough, Maine, 04074, United States
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Maine Medical Partners Surgical Care
Portland, Maine, 04102, United States
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MaineHealth Cancer Care and IV Therapy - Brunswick
Brunswick, Maine, 04011, United States
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MaineHealth Cancer Care and IV Therapy - Sanford
Sanford, Maine, 04073, United States
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MaineHealth Cancer Care and IV Therapy - South Portland
South Portland, Maine, 04106, United States
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MaineHealth Franklin Hospital
Farmington, Maine, 04938, United States
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MaineHealth LincolnHealth Hospital
Damariscotta, Maine, 04543, United States
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MaineHealth Maine Medical Center - Biddeford
Biddeford, Maine, 04005, United States
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MaineHealth Maine Medical Center - Portland
Portland, Maine, 04102, United States
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MaineHealth Maine Medical Center- Scarborough
Scarborough, Maine, 04074, United States
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MaineHealth Stephens Hospital
Norway, Maine, 04268, United States
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MaineHealth Urology - South Portland
South Portland, Maine, 04106, United States
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MaineHealth Waldo Hospital
Belfast, Maine, 04915, United States
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Marion L Shepard Cancer Center - ECU Health Beaufort Hospital
Washington, North Carolina, 27889, United States
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Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids, Wisconsin, 54494, United States
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Marshfield Medical Center - Minocqua
Minocqua, Wisconsin, 54548, United States
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Marshfield Medical Center - Weston
Weston, Wisconsin, 54476, United States
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Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, 54701, United States
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Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449, United States
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Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, 54868, United States
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Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin, 54482, United States
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McFarland Clinic - Ames
Ames, Iowa, 50010, United States
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Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri, 65401, United States
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Mercy Hospital Fort Smith
Fort Smith, Arkansas, 72903, United States
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Mercy Hospital Joplin
Joplin, Missouri, 64804, United States
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Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma, 73120, United States
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Mercy Hospital Saint Louis
St Louis, Missouri, 63141, United States
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Mercy Hospital South
St Louis, Missouri, 63128, United States
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Mercy Hospital Springfield
Springfield, Missouri, 65804, United States
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Mercy Hospital Washington
Washington, Missouri, 63090, United States
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Mercy Infusion Center - Chippewa
St Louis, Missouri, 63109, United States
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Mercy Oncology and Hematology - Clayton-Clarkson
Ballwin, Missouri, 63011, United States
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Mid Coast Hospital
Brunswick, Maine, 04011, United States
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Missouri Baptist Medical Center
St Louis, Missouri, 63131, United States
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Mobile Infirmary Medical Center
Mobile, Alabama, 36607, United States
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Monongalia Hospital
Morgantown, West Virginia, 26505, United States
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Montefiore Medical Center - Moses Campus
The Bronx, New York, 10467, United States
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Montefiore Medical Center-Einstein Campus
The Bronx, New York, 10461, United States
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Montefiore Medical Center-Weiler Hospital
The Bronx, New York, 10461, United States
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Morristown Medical Center
Morristown, New Jersey, 07960, United States
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NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032, United States
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Nebraska Cancer Specialists/Oncology Hematology West PC
Grand Island, Nebraska, 68803, United States
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Newton Medical Center
Newton, New Jersey, 07860, United States
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North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington, 98902, United States
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NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois, 60201, United States
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NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois, 60026, United States
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NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois, 60035, United States
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Northside Hospital
Atlanta, Georgia, 30342, United States
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Novant Health Cancer Institute - Kernersville
Kernersville, North Carolina, 27284, United States
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Novant Health Cancer Institute - Mount Airy
Mount Airy, North Carolina, 27030, United States
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Novant Health Cancer Institute - Thomasville
Thomasville, North Carolina, 27360, United States
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Novant Health Forsyth Medical Center
Winston-Salem, North Carolina, 27103, United States
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Novant Health Presbyterian Medical Center
Charlotte, North Carolina, 28204, United States
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Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa, 52403, United States
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OptumCare Cancer Care at Charleston
Las Vegas, Nevada, 89102, United States
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OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada, 89183, United States
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Our Lady of the Lake Physician Group
Baton Rouge, Louisiana, 70808, United States
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Overlook Hospital
Summit, New Jersey, 07902, United States
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PCR Oncology
Arroyo Grande, California, 93420, United States
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Penobscot Bay Medical Center
Rockport, Maine, 04856, United States
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Phelps Health Delbert Day Cancer Institute
Rolla, Missouri, 65401, United States
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Physicians' Clinic of Iowa PC
Cedar Rapids, Iowa, 52402, United States
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Prisma Health Baptist Hospital
Columbia, South Carolina, 29220, United States
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Prisma Health Greenville Memorial Hospital
Greenville, South Carolina, 29605, United States
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Prisma Health Richland Hospital
Columbia, South Carolina, 29203, United States
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Roger Williams Medical Center
Providence, Rhode Island, 02908, United States
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SMC Center for Hematology Oncology Union
Union, South Carolina, 29379, United States
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SSM Health Good Samaritan
Mount Vernon, Illinois, 62864, United States
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Saint James Community Hospital and Cancer Treatment Center
Butte, Montana, 59701, United States
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Saint Joseph Hospital
Nashua, New Hampshire, 03060, United States
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Saint Joseph Hospital - Cancer Centers of Colorado
Denver, Colorado, 80218, United States
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Saint Mary's Hospital and Regional Medical Center
Grand Junction, Colorado, 81501, United States
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Saint Mary's Regional Medical Center
Lewiston, Maine, 04240, United States
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Saint Vincent Frontier Cancer Center
Billings, Montana, 59102, United States
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Salinas Valley Memorial
Salinas, California, 93901, United States
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San Juan City Hospital
San Juan, 00936, Puerto Rico
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San Juan Community Oncology Group
San Juan, 00917, Puerto Rico
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Spartanburg Medical Center
Spartanburg, South Carolina, 29303, United States
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Swedish Covenant Hospital
Chicago, Illinois, 60625, United States
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Tampa General Hospital
Tampa, Florida, 33606, United States
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Thomas Hospital
Fairhope, Alabama, 36532, United States
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Trinity Health Medical Center - Brighton
Brighton, Michigan, 48114, United States
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Trinity Health Medical Center - Canton
Canton, Michigan, 48188, United States
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Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, 48106, United States
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Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan, 48341, United States
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Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, 48154, United States
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UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa, 50309, United States
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University Medical Center New Orleans
New Orleans, Louisiana, 70112, United States
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University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf, Iowa, 52722, United States
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University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242, United States
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VCU Massey Cancer Center at Stony Point
Richmond, Virginia, 23235, United States
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VCU Massey Comprehensive Cancer Center
Richmond, Virginia, 23298, United States
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Valley Medical Center
Renton, Washington, 98055, United States
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Veterans Affairs Loma Linda Healthcare System
Loma Linda, California, 92357, United States
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