METASTATIC PROSTATE CARCINOMA

This study is testing a drug called talazoparib in people with advanced solid tumors that have specific DNA repair gene mutations. The goal is to see if this PARP inhibitor can shrink tumors or slow their growth, even in patients who have already tried a similar drug. About 36 ad…

This study is for men whose prostate cancer has returned after surgery, shown by a rising PSA level. It tests whether adding a stronger drug combination (apalutamide plus abiraterone and prednisone) to standard radiation and hormone therapy can better control the cancer. For thos…

This early-phase trial tests a new treatment for men with a type of advanced prostate cancer that no longer responds to hormone therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. Some participants will als…

This study tests whether adding radiation therapy guided by a special PET scan to standard hormone therapy can help men with prostate cancer that has spread. About 125 men will be randomly assigned to receive either standard treatment alone or standard treatment plus radiation to…

This early-phase study tests a treatment called bipolar androgen therapy for men with advanced prostate cancer that no longer responds to standard hormone therapy and has spread. The approach rapidly switches testosterone levels from very low to very high to shock cancer cells an…

This study tests whether a 16-week supervised exercise program (combining resistance, functional, and aerobic training) can improve frailty and muscle loss in 80 men with metastatic prostate cancer who are on hormone therapy. Participants must be pre-frail or frail. The goal is t…

This study looks at whether giving cancer therapy at home instead of in a clinic can improve the experience for Black men with advanced prostate cancer. About 38 participants will try both home and clinic treatments to compare safety, side effects, and satisfaction. The goal is t…

This study tests whether using bright white light therapy glasses can reduce fatigue and improve mood in men with advanced prostate cancer who are on hormone therapy. About 210 men will either start light therapy right away or wait a few months. The goal is to help patients feel …

This study tests whether adding cryoablation (freezing cancer cells) to standard radiation therapy provides better pain relief for people with cancer that has spread to the bones. About 40 adults with certain advanced cancers (like prostate, kidney, or colorectal) will be enrolle…

This study looks at whether a network of peer genetic coaches can help African American men with metastatic prostate cancer overcome barriers to genetic testing. The coaches will provide education and support to increase awareness and navigation. The goal is to see if this approa…

This study looks at whether having a trained peer navigator—someone who guides patients through the process—helps African American men with advanced prostate cancer better understand and complete genetic testing. Genetic testing is important for treatment decisions, but many Afri…

This study looks at men with advanced prostate cancer that has spread to the bones. Researchers want to see if certain DNA repair problems make the drug radium-223 work better. About 48 men will take part, and their response will be measured by blood tests. The goal is to help do…

This study looks at why some prostate cancers become resistant to a treatment called 177Lu-PSMA, which delivers radiation directly to cancer cells. Researchers will take small tissue samples (biopsies) from tumors in 30 men with advanced prostate cancer that has spread. The goal …

This study tests whether a computer-generated character can effectively educate cancer patients about genetic testing, compared to a human genetics counselor. The goal is to see if this approach increases testing rates, especially for minority and rural patients who often lack ac…

This study looks at how common low vitamin D levels are in African American men with prostate cancer, and whether correcting those levels can improve immune function. Researchers will measure vitamin D and immune cells in blood samples before and after supplementation. The goal i…