METASTATIC PROSTATE CARCINOMA

This study is testing whether the drug talazoparib can help control advanced cancers in patients whose tumors have specific genetic mutations that affect DNA repair. The trial is for adults with various advanced solid tumors (like breast, ovarian, prostate, pancreatic, or gastric…

This early-stage study is testing the safety and best dose of a personalized immune therapy for men with advanced prostate cancer that has spread and stopped responding to standard hormone treatments. Doctors take a patient's own immune cells, modify them in a lab to better targe…

This study aims to understand why some men with advanced prostate cancer that has spread to bones respond better to the drug radium-223 than others. Researchers will test blood samples from 48 patients to look for specific DNA repair defects that might make the cancer more sensit…

This study is testing whether giving prostate cancer treatment at home is as safe and effective as receiving it in a clinic. Black men with advanced prostate cancer will receive part of their standard treatment at home with remote monitoring. Researchers want to see if home treat…

This large study is testing if using a PET scan to guide treatment decisions helps control prostate cancer that returns after surgery. For about 800 men, the scan will determine if they receive standard radiation and hormone therapy alone, or if stronger drug therapy and targeted…

This study is testing whether adding targeted radiation to standard drug treatments helps men with advanced prostate cancer that has spread. Doctors use a special PET scan to find active cancer spots, then aim radiation directly at those areas. The goal is to see if this combined…

This early-stage study is testing a counterintuitive approach for men with advanced prostate cancer that has stopped responding to standard hormone-blocking treatments. Researchers are giving patients cycles of testosterone injections to see if rapidly switching between very low …

This study is testing whether wearing special bright white light glasses can help reduce severe fatigue and depression in men with advanced prostate cancer who are receiving hormone-blocking combination therapy. The light therapy aims to regulate sleep-wake cycles and boost mood …

This study is testing whether a 16-week supervised exercise program can help men with advanced prostate cancer who are on hormone therapy. The goal is to see if exercise can reduce frailty and muscle loss, which are common side effects of the treatment. About 80 participants will…

This study is testing if adding a freezing procedure (cryoablation) to standard radiation therapy works better to relieve pain from cancer that has spread to the bones. Researchers will compare the combination treatment to radiation alone in 40 patients with advanced cancers. The…

This study is testing whether having a trained peer navigator helps African American men with advanced prostate cancer better understand and go through the process of genetic testing. Genetic test results can be important for choosing treatments, but the process can be confusing.…

This study aims to understand how common low vitamin D levels are in Black men with prostate cancer and whether taking vitamin D supplements can improve their immune system function. Researchers will enroll 220 participants with either localized or metastatic prostate cancer who …

This study aims to learn why some advanced prostate cancers become resistant to a targeted radiation treatment called 177Lu-PSMA therapy. Researchers will take small tissue samples (biopsies) from 30 patients before and during their treatment to analyze the cancer cells. The goal…

This study is testing whether a multilingual AI chatbot named PERLA can help more cancer patients get important genetic testing. It compares patients who learn about testing from the chatbot to those who learn from a human genetics counselor. The goal is to see if this technology…

This study is collecting tissue and blood samples from cancer patients over time to create a research resource called a biobank. Researchers will analyze these samples to understand how cancer changes during treatment and why some treatments stop working. The goal is to help scie…