STAGE IVB PROSTATE CANCER AJCC V8
Clinical trials for STAGE IVB PROSTATE CANCER AJCC V8 explained in plain language.
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Engineered immune cells take on Hard-to-Treat prostate cancer
Disease control Recruiting nowThis early-phase trial tests a new treatment for men with a type of advanced prostate cancer that no longer responds to hormone therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. Some participants will als…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 26, 2026 03:37 UTC
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New combo aims to boost radiation therapy for advanced prostate cancer
Disease control Recruiting nowThis study tests whether giving a drug called abemaciclib before a targeted radiation therapy (177Lu-PSMA-617) can make the radiation work better for men with advanced prostate cancer that has stopped responding to other treatments. About 30 participants will receive the combinat…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Vadim S Koshkin • Aim: Disease control
Last updated May 26, 2026 03:37 UTC
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Triple therapy may extend lives in advanced prostate cancer
Disease control Recruiting nowThis study tests whether adding a chemotherapy drug (docetaxel) to the usual hormone therapy plus apalutamide helps men with prostate cancer that has spread to other parts of the body live longer. About 1,260 participants will receive either the standard two-drug treatment or the…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated May 26, 2026 03:36 UTC
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PET scans guide new combo therapy to fight returning prostate cancer
Disease control Recruiting nowThis study is for men whose prostate cancer has returned after surgery, shown by a rising PSA level. It tests whether adding a stronger drug combination (apalutamide plus abiraterone and prednisone) to standard radiation and hormone therapy can better control the cancer. For thos…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE3 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Disease control
Last updated May 26, 2026 03:32 UTC
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Two-Drug attack on Hard-to-Treat prostate cancer shows promise in early trial
Disease control Recruiting nowThis early-phase study tests whether combining a targeted radiation drug (177Lu-PSMA-617) with an immune cell therapy (Sipuleucel-T) works better than the radiation drug alone for men with advanced prostate cancer that has spread and stopped responding to hormone therapy. About 3…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 26, 2026 03:30 UTC
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New hope for tough prostate cancer: two chemo drugs may work better than one
Disease control Recruiting nowThis study tests whether adding a second chemotherapy drug (carboplatin) to the standard chemo (cabazitaxel) helps men with advanced prostate cancer that has spread and stopped responding to hormone therapy. About 528 participants will be randomly assigned to receive either cabaz…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE3 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated May 26, 2026 03:29 UTC
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Second dose of radioactive drug shows promise for tough prostate cancer
Disease control Recruiting nowThis study looks at whether giving a second course of a radioactive drug called 177Lu-PSMA-617 can help people with advanced prostate cancer that no longer responds to hormone therapy. Participants must have already benefited from an initial round of this treatment. The goal is t…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: Jonsson Comprehensive Cancer Center • Aim: Disease control
Last updated May 26, 2026 03:28 UTC
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New hope for advanced prostate cancer: can surgery or radiation boost survival?
Disease control Recruiting nowThis study is for men with prostate cancer that has spread to other parts of the body. It compares standard drug therapy alone versus standard therapy plus either surgery to remove the prostate or radiation to the prostate. The goal is to see if adding local treatment helps patie…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE3 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated May 26, 2026 03:27 UTC
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Could fewer doses of targeted radiation control prostate cancer just as well?
Disease control Recruiting nowThis study is for people with a type of advanced prostate cancer that has spread and no longer responds to hormone therapy. It compares the standard 6 cycles of a targeted radiation drug (Lu-177 PSMA-617) against stopping after 5 cycles, to see if the shorter course can control t…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 26, 2026 03:26 UTC
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New drug cocktail targets rare cancers that have spread
Disease control Recruiting nowThis study is testing a combination of three drugs (cabozantinib, nivolumab, and ipilimumab) in people with rare cancers of the urinary and reproductive systems that have spread to other parts of the body. The goal is to see if this mix can shrink tumors better than any single dr…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 02:48 UTC
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New targeted radiation trial hopes to slow resistant prostate cancer
Disease control Recruiting nowThis study tests a radioactive drug, 177Lu-PSMA-617, in 51 men with advanced prostate cancer that has spread and stopped responding to hormone therapy. The drug seeks out prostate cancer cells and damages their DNA to slow tumor growth. The goal is to see if this treatment can de…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control
Last updated May 22, 2026 14:02 UTC
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New trial aims to Fine-Tune prostate cancer treatment timing
Disease control Recruiting nowThis study looks at whether giving radiation alone or with hormone therapy works better for men whose prostate cancer has returned and spread. It also tests if adding pelvic radiation helps stop further spread. About 532 men with recurrent, hormone-sensitive prostate cancer will …
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 22, 2026 14:01 UTC
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Could High-Dose testosterone boost prostate cancer treatment?
Disease control Recruiting nowThis study tests whether giving high levels of testosterone alongside chemotherapy or a targeted radiation drug can help men with advanced prostate cancer that has stopped responding to standard hormone therapy. About 69 participants will receive one of three treatment combinatio…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control
Last updated May 22, 2026 13:54 UTC
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New trial aims to boost prostate cancer treatment with targeted radiation
Disease control Recruiting nowThis study tests whether adding radiation therapy guided by a special PET scan to standard hormone therapy can help men with prostate cancer that has spread. About 125 men will be randomly assigned to receive either standard treatment alone or standard treatment plus radiation to…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: Northwestern University • Aim: Disease control
Last updated May 22, 2026 13:53 UTC
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Promising combo targets prostate cancer at early stage
Disease control Recruiting nowThis study tests whether adding the drug talazoparib to standard hormone therapy can better control prostate cancer that still responds to hormone treatment. About 70 men with metastatic prostate cancer will receive the combination. The goal is to see if this approach lowers PSA …
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 22, 2026 13:52 UTC
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Testosterone therapy shows promise for Hard-to-Treat prostate cancer
Disease control Recruiting nowThis early-phase study tests a treatment called bipolar androgen therapy for men with advanced prostate cancer that no longer responds to standard hormone therapy and has spread. The approach rapidly switches testosterone levels from very low to very high to shock cancer cells an…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE1 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated May 20, 2026 11:56 UTC
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New combo drug trial targets tough prostate cancer
Disease control Recruiting nowThis study tests a combination of two drugs, ruxolitinib and enzalutamide, in men with advanced prostate cancer that has spread and no longer responds to hormone therapy. The goal is to find the safest dose and see if the combination can shrink tumors or lower PSA levels. About 2…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: University of Michigan Rogel Cancer Center • Aim: Disease control
Last updated May 20, 2026 11:53 UTC
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Triple-Drug attack aims to halt bone metastases in prostate cancer
Disease control Recruiting nowThis study is for men with advanced prostate cancer that no longer responds to hormone therapy and has spread to bones or lymph nodes. It tests whether adding the experimental drug M3814 and/or the immunotherapy avelumab to the standard radioactive drug radium-223 can better cont…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 20, 2026 11:53 UTC
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Engineered immune cells take on Hard-to-Treat prostate cancer
Disease control Recruiting nowThis study tests whether a new cell therapy (STEAP1 CART) combined with the drug enzalutamide is safe and effective for men with advanced prostate cancer that has spread and stopped responding to standard treatments. About 48 participants will receive their own immune cells, modi…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated May 06, 2026 16:01 UTC
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New combo aims to make resistant prostate cancer cells visible to targeted radiation
Disease control Recruiting nowThis study tests whether the drug vorinostat can help men with a type of advanced prostate cancer that has low levels of a specific marker (PSMA). The marker is needed for a radioactive therapy called 177Lu-PSMA-617 to work. By giving vorinostat first, the hope is to increase PSM…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Apr 30, 2026 15:49 UTC
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Freezing tumors may boost radiation pain relief for bone metastases
Symptom relief Recruiting nowThis study tests whether adding cryoablation (freezing cancer cells) to standard radiation therapy provides better pain relief for people with cancer that has spread to the bones. About 40 adults with certain advanced cancers (like prostate, kidney, or colorectal) will be enrolle…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated May 22, 2026 13:50 UTC
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DNA-Guided prostate cancer trial aims to match patients with targeted drugs
Knowledge-focused Recruiting nowThis study tests whether analyzing the DNA and RNA of a patient's prostate cancer can help doctors pick the most effective treatment. About 474 men with advanced, treatment-resistant prostate cancer will have their tumor tissue tested for specific genetic changes. Based on the re…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Knowledge-focused
Last updated May 26, 2026 03:30 UTC
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Can DNA glitches predict prostate cancer treatment success?
Knowledge-focused Recruiting nowThis study looks at men with advanced prostate cancer that has spread to the bones. Researchers want to see if certain DNA repair problems make the drug radium-223 work better. About 48 men will take part, and their response will be measured by blood tests. The goal is to help do…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Sponsor: University of Washington • Aim: Knowledge-focused
Last updated May 26, 2026 03:28 UTC
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Tailored care plans aim to close health literacy gap for black prostate cancer survivors
Knowledge-focused Recruiting nowThis study compares a standard survivorship care plan to one that is simplified for people with lower health literacy. Researchers want to see if the tailored plan helps African American prostate cancer patients better understand their treatment side effects and follow-up needs. …
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: NA • Sponsor: Emory University • Aim: Knowledge-focused
Last updated May 26, 2026 03:27 UTC
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Biopsies reveal secrets of prostate cancer resistance
Knowledge-focused Recruiting nowThis study looks at why some prostate cancers become resistant to a treatment called 177Lu-PSMA, which delivers radiation directly to cancer cells. Researchers will take small tissue samples (biopsies) from tumors in 30 men with advanced prostate cancer that has spread. The goal …
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE1 • Sponsor: Jonsson Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated May 22, 2026 13:50 UTC