STAGE IVB PROSTATE CANCER AJCC V8

This study is testing whether using genetic information from a patient's tumor can help doctors choose a more effective treatment for advanced prostate cancer that has stopped responding to standard hormone therapy. About 474 men will have their tumor's DNA and RNA analyzed, and …

This study is testing a new cell therapy called STEAP1 CART, given with the hormone drug enzalutamide, for men with advanced prostate cancer that has spread and no longer responds to standard treatments. The trial aims to find a safe dose and see if this combination can shrink tu…

This study is testing if adding the drug carboplatin to the standard chemotherapy cabazitaxel works better than cabazitaxel alone for men with advanced prostate cancer that has spread and no longer responds to hormone therapy. Researchers will enroll about 528 participants and gr…

This study is testing if giving very high doses of testosterone, along with chemotherapy or a targeted radiation drug, can help control advanced prostate cancer that has spread and stopped responding to standard hormone-blocking treatments. The idea is to shock cancer cells that …

This study is for men whose prostate cancer has spread to only a few other places in the body. It compares two approaches: precise radiation alone versus the same radiation plus a daily pill (relugolix) that temporarily lowers testosterone. The goal is to see if adding the pill h…

This study is testing whether patients with advanced prostate cancer that has spread can safely take a break from their targeted radiation treatment. Researchers want to see if stopping treatment after 5 cycles and only resuming if the cancer worsens works as well as getting the …

This study is testing an experimental treatment for men with advanced prostate cancer that has spread and stopped responding to standard hormone therapies. The treatment uses a radioactive drug that specifically seeks out and attaches to prostate cancer cells to damage them from …

This early-stage study is testing the safety and best dose of a personalized immune therapy for men with advanced prostate cancer that has spread and stopped responding to standard hormone treatments. Doctors take a patient's own immune cells, modify them in a lab to better targe…

This study is testing if adding a drug called vorinostat makes a newer radioactive cancer treatment work better for men with advanced prostate cancer. The cancer has spread and stopped responding to standard hormone treatments. Researchers want to see if vorinostat can 'turn on' …

This large study is testing if adding a chemotherapy drug (docetaxel) to the current standard two-drug hormone therapy helps men with prostate cancer that has spread live longer. It will enroll about 1,260 men to compare the three-drug combination against the standard two-drug tr…

This study is testing whether giving a second course of a targeted radiation drug can help men with advanced prostate cancer that has spread and stopped responding to standard hormone therapy. The treatment, called 177Lu-PSMA-617, is given by IV and seeks out and delivers radiati…

This study is testing whether less aggressive treatment works as well as more intensive therapy for prostate cancer that has returned or spread. Researchers are comparing different approaches, including targeted radiation alone versus radiation combined with hormone-blocking drug…

This early-stage study is testing whether adding the drug ruxolitinib to the standard treatment enzalutamide is safe and effective for men with advanced prostate cancer that has stopped responding to hormone-blocking therapy. The goal is to find the best dose and see if this comb…

This early-stage study is testing if combining two different treatments is safe and works better than one alone for advanced prostate cancer. One treatment is a targeted radiation drug that seeks out and kills cancer cells. The other is a personalized vaccine designed to train th…

This large study is testing whether adding surgery to remove the prostate or radiation therapy to standard drug treatments helps men with prostate cancer that has spread to other parts of the body live longer. It will enroll over 1,200 men who have already started standard hormon…

This study is testing whether combining a bone-targeting radiation drug with one or two other medications works better for advanced prostate cancer that has spread to bones and stopped responding to standard hormone therapy. It will compare three approaches: the radiation drug al…

This study aims to understand why some men with advanced prostate cancer that has spread to bones respond better to the drug radium-223 than others. Researchers will test blood samples from 48 patients to look for specific DNA repair defects that might make the cancer more sensit…

This study is testing a combination of three drugs—cabozantinib, nivolumab, and ipilimumab—for patients with rare types of bladder, kidney, penile, and other urinary tract cancers that have spread. The goal is to see if this three-drug approach can shrink tumors and control the d…

This large study is testing if using a PET scan to guide treatment decisions helps control prostate cancer that returns after surgery. For about 800 men, the scan will determine if they receive standard radiation and hormone therapy alone, or if stronger drug therapy and targeted…

This study is testing whether adding targeted radiation to standard drug treatments helps men with advanced prostate cancer that has spread. Doctors use a special PET scan to find active cancer spots, then aim radiation directly at those areas. The goal is to see if this combined…

This early-stage study is testing a counterintuitive approach for men with advanced prostate cancer that has stopped responding to standard hormone-blocking treatments. Researchers are giving patients cycles of testosterone injections to see if rapidly switching between very low …

This study is testing a two-step treatment for advanced prostate cancer that has spread and stopped responding to standard hormone therapies and chemotherapy. First, patients take a pill (abemaciclib) for two weeks, aiming to make cancer cells more visible. Then, they receive a t…

This study is testing whether adding a new targeted drug called talazoparib to standard hormone-blocking treatments can better control advanced prostate cancer that has spread. It aims to see if this combination helps stop cancer growth for longer by preventing cancer cells from …

This study is testing if adding a freezing procedure (cryoablation) to standard radiation therapy works better to relieve pain from cancer that has spread to the bones. Researchers will compare the combination treatment to radiation alone in 40 patients with advanced cancers. The…

This study aims to learn why some advanced prostate cancers become resistant to a targeted radiation treatment called 177Lu-PSMA therapy. Researchers will take small tissue samples (biopsies) from 30 patients before and during their treatment to analyze the cancer cells. The goal…

This study is testing whether a simpler, easier-to-read survivorship care plan helps Black and African American men who have finished treatment for prostate cancer. Researchers want to see if this tailored plan helps patients understand their follow-up care and manage long-term s…

This study is collecting tissue and blood samples from cancer patients over time to create a research resource called a biobank. Researchers will analyze these samples to understand how cancer changes during treatment and why some treatments stop working. The goal is to help scie…