STAGE IV OVARIAN CANCER AJCC V8

This study looks at the safety of giving heated chemotherapy directly into the belly during surgery for advanced ovarian, fallopian tube, or peritoneal cancer. About 45 people will receive either chemotherapy before surgery or heated chemotherapy during surgery. The goal is to se…

This study is testing a drug called talazoparib in people with advanced solid tumors that have specific DNA repair gene mutations. The goal is to see if this PARP inhibitor can shrink tumors or slow their growth, even in patients who have already tried a similar drug. About 36 ad…

This early-stage study tests a drug called talazoparib combined with radiation therapy for people whose gynecologic cancer (like ovarian, uterine, or cervical) has returned. The goal is to find the safest dose and see if the combination can shrink tumors. About 24 participants wi…

This early-phase study tests a new drug called IACS-6274, given alone or with other medicines, in people with advanced solid tumors (like melanoma, ovarian, or head and neck cancers). The main goal is to find the safest dose and understand side effects. About 54 adults will take …

This study tests a drug called PLX038 in people with ovarian, peritoneal, or fallopian tube cancer that has spread and no longer responds to platinum chemotherapy. The goal is to see if PLX038 can shrink tumors by blocking enzymes cancer cells need to grow. About 43 adults with a…

This early-phase trial is testing a procedure called PIPAC, which turns liquid chemotherapy into a fine mist and sprays it directly into the abdomen during a keyhole surgery. It is for people with ovarian, uterine, appendix, colorectal, or stomach cancer that has spread to the li…

This study tests if a less invasive surgery (laparoscopy) works as well as standard open surgery for people with advanced ovarian, fallopian tube, or peritoneal cancer who have already had chemotherapy. About 580 participants will be randomly assigned to one of the two surgeries.…

This early-phase study tests a wearable device that creates low-intensity electric fields to disrupt cancer cell growth, combined with standard drugs (cabozantinib or nab-paclitaxel plus atezolizumab). About 43 adults with advanced solid tumors in the abdomen or chest that have s…

This study is testing a new way to detect ovarian cancer earlier by looking at DNA from a uterine wash and proteins in the blood. Researchers will collect samples from 250 women before surgery for a suspected ovarian mass or as a preventive measure for those with BRCA mutations. …

This study tests whether taking probiotics can improve gut and vaginal health in 161 women with advanced or recurrent ovarian cancer who are receiving platinum chemotherapy. Participants will take either a probiotic or a placebo pill. Researchers will check stool and vaginal samp…

This study tests whether a personalized activity program using a Fitbit can help women with advanced ovarian or endometrial cancer exercise more and improve their quality of life. About 120 participants will either get standard care or the automated program. Researchers will also…