DIABETES MELLITUS

This early-phase trial tests a new treatment for people with a type of stomach cancer that has spread to the lining of the abdomen. The therapy uses the patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The main goals are to chec…

This study looks at whether an automated insulin delivery system (the Medtronic 780G) can help adults with diabetes and advanced kidney disease better control their blood sugar. Participants will use the system for 8 weeks and then switch to their usual care for another 8 weeks, …

This study compares two diabetes medications, pioglitazone and empagliflozin, to see which better controls blood sugar in people whose diabetes is caused by chronic or recurrent acute pancreatitis. About 40 adults aged 18-80 will take one of the drugs, and researchers will measur…

This study tests a new once-weekly injection called NNC0487-0111 for people who are overweight or have obesity and type 2 diabetes. About 630 adults will receive either the active drug or a placebo for several weeks. The main goal is to see if the drug safely helps reduce body we…

This study tests whether taking algae supplements (spirulina or seaweed) for 20 weeks can improve heart health markers and gut bacteria in 150 adults aged 50+ with conditions like heart disease, diabetes, or kidney disease. Participants are randomly assigned to receive algae or a…

This study tests a new medicine called retatrutide in adults with type 2 diabetes. The goal is to see if it improves how the body makes and uses insulin compared to a placebo or another diabetes drug. About 95 people will take part, and they will continue their usual diabetes med…

This study tests whether an AI-powered health coach can help 300 adults with heart disease, diabetes, or kidney disease better manage their conditions. Participants use a smartphone app and monitoring devices to track health markers and get personalized guidance. The goal is to r…

This study tests a gel called ENERGI-F703 on diabetic foot ulcers that haven't healed for at least 4 weeks. About 230 adults with diabetes will use either the gel or a placebo for 16 weeks. The main goal is to see if the gel helps the wound close completely and stay closed for 2 …

This study tests a new drug called tegoprubart in people with type 1 diabetes who have dangerous low blood sugar episodes and are getting islet cell transplants. The drug aims to prevent the immune system from attacking the transplanted cells without using standard anti-rejection…

This study looks at how well the Omnipod 5 automated insulin delivery system works for people with type 1 diabetes in their daily lives. About 304 participants aged 2 and older will use the system for the first time. Researchers will measure blood sugar control, quality of life, …

This study tests a new digital tool that helps doctors create personalized exercise plans for people with heart disease risk factors like high blood pressure, diabetes, and obesity. About 72 patients and 24 doctors will take part. The goal is to see if the tool is easy to use and…

This study tests if a device called the Gemini System can safely lower blood pressure by disrupting certain nerves in the kidney and liver. It includes 175 adults with uncontrolled high blood pressure, with or without other health risks like heart or kidney disease. The main goal…

This study tests a new medicine called NNC0487-0111 in adults with type 2 diabetes. The goal is to see how it affects the body's use of insulin and how well the pancreas works. About 80 people will take either the study drug or a placebo. This is an early-phase trial to gather sa…

This study tests whether continuous glucose monitors (CGMs) help people with type 2 diabetes who are uninsured or on Medicaid better control their blood sugar. About 50 adults who take daily insulin will be randomly assigned to use a CGM or standard care. The goal is to see if CG…

This study tests a single pill that combines three common diabetes medicines (empagliflozin, linagliptin, and metformin) to see if it helps people with type 2 diabetes control their blood sugar better. About 800 adults aged 18-80 with high blood sugar (HbA1c 8% or above) who alre…

This study tests a program that connects rural diabetes patients with community services to help with food, housing, utilities, transportation, and safety. About 12,000 adults with diabetes in two Kentucky communities will take part. The goal is to see if linking clinics with loc…

This study tests whether extra support from a community pharmacist can help people with type 2 diabetes better manage their blood sugar levels. About 600 adults with uncontrolled diabetes will either receive pharmacist-led care or continue with their usual doctor visits. The goal…

This study tests whether an online training and peer support platform, called Support-t, can help teenagers with type 1 diabetes prepare for the move from pediatric to adult healthcare. About 200 teens aged 14-16 will either receive usual care or also get access to the platform. …

This study looks at whether a spinal cord stimulator can reduce pain and improve blood vessel health in people with type 2 diabetes who have nerve pain in their legs. About 25 adults with diabetes for over a year and poor circulation will get the device. Researchers will check pa…

This study tests whether automated phone reminders about diabetes and eye health, plus free reading glasses, help people in Bangladesh keep their appointments. About 640 adults recently diagnosed with diabetes will take part. The goal is to see if these simple tools improve atten…

This study tests whether giving children (ages 8 to under 18) with newly diagnosed type 1 diabetes repeated doses of the BCG vaccine (normally used for tuberculosis) can improve blood sugar control and reduce insulin needs. The goal is to see if the vaccine can calm the immune at…

This study tests whether giving low-income adults with type 2 diabetes vouchers to buy fruits and vegetables helps them attend diabetes education classes and improves their blood sugar control. About 120 participants will be randomly assigned to receive different levels of suppor…

This study looks at whether using a patient's own continuous glucose monitor (CGM) during a hospital stay can help doctors and nurses give better insulin doses. About 150 adults with diabetes who already use a CGM at home will be enrolled. The goal is to see if this approach redu…

This study is testing whether a smartphone app powered by artificial intelligence can help people who have had heart bypass surgery or a stent procedure better control their blood pressure, diabetes, and cholesterol. About 536 adults who already have these conditions will use the…

This study tests whether sending text messages can help homeless adults with uncontrolled diabetes better manage their blood sugar and stick to medications. About 100 participants will receive SMS reminders and tips. The goal is to see if this simple, low-cost approach improves h…

This study looks at whether using both a drug-coated balloon and a drug-eluting stent together is better than using just one of them to open blocked heart arteries. It involves 120 adults with diabetes and coronary artery disease who have not had a stent before. Participants are …

This study looks at whether continuing GLP-1 agonist drugs (like Ozempic or Wegovy) after weight-loss surgery helps people lose more weight and control blood sugar better than stopping them. About 150 adults with severe obesity will be randomly assigned to either keep taking the …

This study tests a new medication for a rare, inherited form of diabetes caused by a faulty glucokinase gene. About 44 adults with this condition will receive the drug or a placebo in two separate periods to see if it lowers blood sugar levels. The goal is to improve glucose cont…

This study tests a new device called the Eversense Gemini System, which helps people with diabetes check their blood sugar levels without finger sticks. About 80 adults with type 1 or type 2 diabetes will use the system to see how accurate and safe it is compared to standard moni…

This study compares a smart insulin pump called the iLet Bionic Pancreas to usual diabetes care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the pump or continue their routine care for 13 weeks to see if the pump improves blood sugar …

This early-stage trial tests a new treatment called RGB-5088 for people with type 1 diabetes. It involves injecting special islet cells that can produce insulin, aiming to help the body control blood sugar better and prevent dangerous low blood sugar events. The study will includ…

This study tests whether dapagliflozin, a diabetes medication, can reduce the amount of time people with diabetes spend in atrial fibrillation (an irregular heart rhythm). About 28 participants will wear a heart monitor for two weeks at the start and again after three months of t…

This study tests a streamlined version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys to lower blood pressure. The goal is to see if a faster approach works just as well as the standard method. About 130 adults with uncontrolle…

This study looks at whether opening blocked leg arteries within 48 hours (early angioplasty) helps heal foot ulcers faster in people with type 2 diabetes compared to waiting for a scheduled procedure. Researchers will track wound healing with a 3D camera and study how the wound's…

This study tests whether using smart insulin pens along with continuous glucose monitors and telemedicine can help veterans with type 2 diabetes better control their blood sugar compared to traditional insulin pens. About 50 adults on multiple daily insulin injections will take p…

This study looks at how well the Omnipod 5 automated insulin delivery system works in daily life for people with type 1 diabetes. About 152 participants aged 2 and older will use the system for the first time. The goal is to see if it helps keep blood sugar in a healthy range and…

This study is observing how well the drug dapagliflozin works and how safe it is for people with type 2 diabetes who also have high blood pressure. Researchers will track blood sugar and blood pressure control in 9,000 participants over time. The goal is to see if this medication…

This study tests a new way to help people with diabetes and diabetic retinopathy (an eye complication) in Bangladesh. Doctors will receive eye exam results along with specific tips on how to manage the patient's diabetes. The goal is to see if this extra information helps more pa…

This study tests a new blood test called Avantect to see if it can find pancreatic cancer early in people aged 50-84 who were diagnosed with type 2 diabetes in the last 6 months. About 15,000 participants will give blood samples and fill out anxiety questionnaires over a year. Th…

This study looks at whether whole genome sequencing, combined with expert review, can better identify genetic causes of atypical diabetes compared to standard gene panel testing. Researchers will enroll 1020 adults with unusual diabetes forms and follow them for 5 years. The goal…

This study compares a new rapid DNA tool (MinION) with standard lab tests to identify bacteria and fungi in bone samples from people with diabetic foot infections. The goal is to see if the new method can find more germs and provide results faster, helping doctors choose the righ…

This study tests two home-visiting programs for nearly 1,000 pregnant or new mothers who had gestational diabetes. One group gets enhanced lifestyle coaching plus medically tailored meals; the other gets coaching alone. The goal is to see if these programs reduce the risk of deve…

This study tests whether a special discharge program for continuous glucose monitors (CGMs) can improve satisfaction and quality of life in adults with diabetes who use insulin. About 37 participants will complete surveys before and after using the device. The goal is to see if b…

This study tests whether an 8-week program of supervised physical and mental exercises can improve daily function, thinking, and quality of life in adults with Long COVID who also have high blood pressure or diabetes. About 374 participants will be randomly assigned to either the…

This study is testing a special soft cast for diabetic foot ulcers. Researchers want to see if it helps ulcers heal completely, is comfortable, and safe to use. The study will include 100 adults with diabetic foot ulcers. Participants will use the cast until their ulcer heals or …

This study tests whether simple oral care steps, given by diabetes doctors during regular check-ups, can reduce dry mouth and improve quality of life in people with diabetes. About 80 adults with diabetes and dry mouth symptoms will take part. Doctors will be trained to screen fo…

This study looks at why people with indigestion and diabetes have stomach issues, possibly due to sensitivity in the small intestine. Researchers are testing ondansetron, a drug used for nausea, to see if it can reduce symptoms like fullness, discomfort, and nausea. The trial inv…

This study tests two walking training programs to help veterans with leg amputation walk more evenly. It includes 54 veterans who have lost a leg below the knee due to diabetes or artery disease. The goal is to improve walking symmetry, reduce pain, and prevent long-term disabili…

This study looks at whether taking melatonin can improve sleep and daily body rhythms in people with diabetic retinopathy, an eye problem caused by diabetes. Researchers will track sleep patterns and hormone levels in 42 adults aged 40-65. The goal is to see if a simple supplemen…

This study looks at whether adding exercise to standard vitamin D treatment can improve erectile function in men with type 2 diabetes who have low vitamin D levels. Researchers will enroll 40 men and measure changes in erectile function, blood sugar, and body measurements. The go…

This study compares two virtual group programs—one focused on emotions, the other on problem-solving—to help adults with type 1 diabetes reduce diabetes distress. Participants who don't improve may get extra one-on-one sessions. The goal is to find better ways to support emotiona…

This study looks at how high blood pressure, diabetes, and high cholesterol change the tiny blood vessels in the retina (the back of the eye). Researchers will use a special, non-invasive scan called OCTA to measure these changes over five years. The goal is to see if eye vessel …

This study looks at how red blood cells from people with type 2 diabetes can harm the heart and blood vessels. Researchers will collect blood from 500 participants (healthy, with diabetes, or after a heart attack) and test it in the lab. The goal is to understand the damage and f…

This study looks at how many adults with type 2 diabetes experience severe emotional distress related to their condition. Researchers at a French hospital will ask 246 participants to fill out questionnaires about their feelings, quality of life, and diet. The goal is to understa…

This study aims to learn more about insulin resistance and diabetes by collecting blood and skin samples from up to 1,200 participants. Researchers will compare people with these conditions to healthy volunteers to understand how insulin works in the body. No new treatments are t…

This study looks at how rare genetic changes affect beta cells, which control blood sugar. Researchers will compare people with and without these gene variants using blood tests and optional MRI scans. The goal is to find new biomarkers and understand the disease better, but ther…

This study explores whether long-term blood sugar control (measured by HbA1c) is linked to how fast the stomach empties before surgery. About 134 adults having planned surgery will get an ultrasound of their stomach after fasting. The goal is to see if people with higher HbA1c ha…

This study observes 80 adults with and without diabetes to see how long-term blood sugar control (measured by HbA1c) relates to brain oxygen levels during urologic surgery. Researchers will use a special light-based device (NIRS) to monitor brain oxygen and track recovery. The go…

This study looks at 150 people with diabetic macular edema (DME) to see if certain markers in the blood and eye scans can predict how well they respond to two common treatments: anti-VEGF injections or a dexamethasone implant. Participants will be divided into groups based on the…

This study looks at why people with chronic conditions like high blood pressure, diabetes, and high cholesterol often struggle to adopt healthy behaviors, even when they know it's important. Researchers will test a program designed to boost motivation and help patients take charg…

This study is enrolling 8,000 adults who are already getting a routine physical exam. Researchers will look at how a person's environment, genes, and proteins interact to find early clues for diseases like diabetes and high blood pressure. The goal is to create a better early war…

This study builds a worldwide online registry for people with Wolfram syndrome, a rare genetic disorder causing diabetes, vision loss, and hearing problems. Researchers will track how the disease progresses over time and analyze participants' DNA to better understand the conditio…

This study follows 500 American Indian adults with chronic kidney disease to learn what makes the disease worse and how it affects the heart. Participants will have regular check-ups and tests over time. The goal is to find better ways to prevent kidney failure and heart problems…

This study looks at 3,000 people with type 2 diabetes to see if signs of inflammation in the blood are linked to diabetes-related health problems. The goal is to find early clues that could help doctors identify who is at higher risk. No new treatments are being tested—just measu…

This study aims to see if cells from plucked hair follicles can be used to create stem cell lines for studying diseases like diabetes and for developing cell-based treatments. Researchers will collect hair samples from 100 healthy adults and grow the cells in a lab. The goal is t…

This study is enrolling 20,000 adults in Taining County, China, to better understand chronic diseases like high blood pressure, diabetes, and frailty. Researchers will collect health data and samples over three years to find patterns and risk factors. The goal is to create a bett…

This study tests whether a drug called diazoxide can lower the amount of sugar the liver makes by activating control centers in the brain. It includes 100 people—some with type 2 diabetes and some healthy—to see how this affects blood sugar levels. The goal is to better understan…

This study looks at whether giving older adults (65+) with diabetes or high blood pressure written notes from their doctor visits, plus audio recordings, can improve their quality of life. About 1,022 participants will be randomly assigned to receive only written notes through a …

This study looks at whether people with diabetes can collect their own blood at home for key tests (HbA1c, cholesterol, thyroid) as accurately as having blood drawn by a professional in a clinic. 300 adults with type 1 or type 2 diabetes will try either a finger prick or a device…

This study is testing whether showing people with diabetic nerve damage real-time visual and audio feedback while they walk can improve their gait. Researchers will measure foot pressure and forward push during treadmill walking. The goal is to understand how feedback might help …

This study looks at whether the chemicals we breathe out change during the day in people with and without diabetes. Researchers will compare breath samples from 60 adults—some without diabetes, some with type 1, and some with type 2. The goal is to understand normal daily pattern…

This study looks at why adults with diabetes have trouble taking their medicines as prescribed. Researchers will survey 220 patients to understand barriers like cost, family support, and communication with doctors. The goal is to find ways to help patients stick to their treatmen…

This study looks at whether people aged 50+ who recently developed diabetes or whose diabetes got worse might have early signs of pancreatic cancer. Participants will get an MRI scan and give blood samples over time to help create a future blood test. The goal is to catch pancrea…

This study tests whether a machine learning program can detect hidden lumps (lipohypertrophy) under the skin where people with diabetes inject insulin. These lumps can change how insulin is absorbed, but they are hard to feel. The study will use ultrasound images to train the com…

This study looks at why some people newly diagnosed with diabetes in the emergency room don't get the follow-up care they need. Researchers will review medical records, interview patients, and test whether telehealth visits can help connect them to a regular doctor. The goal is t…

This study is testing a smartphone app designed to help older adults (55+) with conditions like heart failure, diabetes, and kidney disease after they leave the hospital. The app provides fall prevention tips, a personalized care plan, and a way to track symptoms and questions fo…

This study checks if a new, over-the-counter continuous glucose monitor (Syai Tag) is accurate and safe for ICU patients. About 100 adults in intensive care who need blood sugar checks will wear two small sensors on their arms. Researchers will compare the sensor readings with st…

This study aims to learn the step-by-step process that leads to type 1 diabetes by studying families where at least one member has the condition. Researchers will collect blood samples, medical history, and measurements from 4,000 participants over 10 years. The goal is to unders…

This study follows 800 adults with type 2 diabetes to see how their lifestyle choices relate to long-term complications like heart or kidney problems. Researchers will track participants over time to find patterns that could help identify high-risk individuals early. The goal is …

This study is following 1,000 people who are having bariatric (weight-loss) surgery to see how their weight, body fat, and blood sugar levels change over two years. Participants will have tests before surgery and at several follow-up visits. The goal is to better understand the h…

This study looks at how fat buildup in the pancreas (pancreatic steatosis) is connected to diabetes and metabolic syndrome. Researchers will use a special ultrasound technique to measure the fat and compare it with blood sugar and other health markers. The goal is to better predi…

This study looks at how certain diabetes medications (semaglutide, liraglutide, tirzepatide) change blood flow and oxygen use in the eyes of people with diabetes. About 20 adults with diabetes will have their eye blood flow and oxygen levels measured before and after starting one…

This early-stage study tests how well different doses of the experimental drug SHR-3167 are absorbed by the body and whether they are safe. It involves 60 healthy adults aged 18 to 55. The goal is to gather information, not to treat any disease.

This study follows over 500 adults with type 2 diabetes who had a heart CT scan years ago. Researchers will repeat the scan to see how plaque builds up in heart arteries over time and identify factors that increase risk. The goal is to better understand heart disease in diabetes,…

This study follows 1,500 pregnant women and their children for up to 18 years to understand how a mother's health, lifestyle, and environment during pregnancy affect her child's growth and risk for conditions like obesity, diabetes, and fatty liver. Participants are American Indi…