DIABETES MELLITUS

This study looks at whether people with type 2 diabetes can safely keep taking their usual diabetes pills while in the hospital, instead of switching to insulin. About 255 adults aged 18-80 who are admitted to general medical or surgical units will take part. The goal is to see i…

This study compares two diabetes medications, semaglutide and sitagliptin, in 58 adults who have received a liver transplant and have poorly controlled diabetes. The goal is to see which drug better improves blood sugar control and reduces body weight. Participants will take one …

This study tests a 10-week program called HomeStyles, adapted for Chinese Americans, to help them eat more fiber, be more active, and lower their risk for heart disease and diabetes. About 400 adults of Chinese heritage who have or live with someone with a cardiometabolic conditi…

This study looks at whether sending text message reminders and education can help pregnant women with diabetes follow their care plan better. About 185 pregnant women with diabetes will be split into two groups: one gets text reminders, the other gets standard care. The goal is t…

This pilot study tests whether adding a community health worker to the care team helps children newly diagnosed with type 1 diabetes improve blood sugar control. About 28 children under 17 with government insurance and living near Philadelphia will take part. The study tracks blo…

This study looks at whether having a cancer survivor's regular doctor work closely with their cancer team can better manage heart-related conditions like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers (like breast, prostate, or lung) an…

This study tests a new automated insulin delivery system in 48 adults with type 2 diabetes aged 16–70. The system uses a smart algorithm to adjust insulin automatically, aiming to keep blood sugar in a safe range and reduce dangerous highs and lows. Participants use a study-provi…

This study is testing a special snack bar made from red beans and tomatoes, called GlycoBite, to see if it helps people with type 2 diabetes control their blood sugar. About 100 adults with diabetes will eat the bar as part of their diet. Researchers will measure changes in fasti…

This study looks at whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have had a kidney transplant. About 25 participants, at least 3 months post-transplant, will follow a plant-based diet for 16 weeks. Researchers will track c…

This study is testing a new continuous glucose monitor (CGM) called iCan O3 in 70 adults with type 1 or type 2 diabetes. Participants will wear the device for 60 days to see if it helps them keep their blood sugar in a healthy range more often. The goal is to improve diabetes con…

This study looks at a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys, to help lower blood pressure in people whose hypertension is not controlled by medication. About 1,900 adults with high blood pressure are taking part. The goal i…

This study aimed to test whether a combination of four drugs (anti-thymocyte globulin, low-dose interleukin-2, adalimumab, and exenatide) could help people newly diagnosed with type 1 diabetes keep making their own insulin. The trial planned to enroll adults aged 18-35 within 120…

This study looks at whether a natural substance called fisetin can reduce inflammation and improve stem cell function in people with advanced chronic kidney disease, including those with diabetes. About 30 adults aged 40-80 will take fisetin or a placebo for 14 days. Researchers …

This large study tests whether lowering blood pressure more than usual can prevent major heart problems, strokes, and memory loss in people with type 2 diabetes. About 9,500 participants with high blood pressure and diabetes are being followed to compare intensive versus standard…

This study tests whether adding short educational videos to standard care helps pregnant women with diabetes manage their blood sugar and improve their baby's birthweight. About 500 women participated, receiving either usual face-to-face education or extra virtual lessons on diet…

This study compares two ways of peeling a thin layer inside the eye during surgery for diabetic patients with severe eye disease. The goal is to see which method better protects vision and eye structure after surgery. About 48 adults with diabetes and certain eye problems will ta…

This study tests whether transplanting insulin-making cells (islets) can help people with type 1 diabetes who struggle with dangerous blood sugar swings. About 17 participants will receive the transplant along with immune-suppressing drugs to prevent rejection. The goal is to red…

This study tests a targeted screening approach to detect undiagnosed heart failure in 706 adults aged 40+ with type 1 or type 2 diabetes who also have additional heart risk factors. Participants are randomly assigned to receive the screening or usual care, and researchers track h…

This study checks if a new device can screen for type 2 diabetes by measuring sugar levels in fingernails instead of using a blood test. About 100 adults with and without diabetes will have their fingernails scanned and compare results to a standard finger-prick blood test. The g…

This study tests a free, culturally tailored program called Eat, Move, Live (EML) to help reduce the risk of cancer and chronic diseases like diabetes in underserved communities. About 347 adults will attend 12 weeks of nutrition and physical activity sessions. The program teache…

This study tests a program for Black 9th and 10th grade girls and their mothers to prevent obesity. The program focuses on increasing physical activity and improving diet. About 120 daughter-mother pairs will participate, and researchers will measure changes in steps, activity le…

This study in Guinea-Bissau tests whether the BCG vaccine (normally used for tuberculosis) can prevent or delay type 2 diabetes in 200 adults with pre-diabetes. Researchers believe the vaccine may reduce inflammation and insulin resistance. The goal is to find a low-cost way to c…

This study tests a culturally-appropriate education program called Indigenous SIPin for Native American men who are part of athletic communities. The goal is to help them drink fewer sugary beverages like soda and juice, which can lead to obesity, diabetes, heart disease, and som…

This study tests a program called REST that helps older adults (65+) with type 1 or type 2 diabetes learn to use continuous glucose monitors (CGMs). The goal is to reduce dangerous low blood sugar episodes and improve time in a healthy blood sugar range. Participants receive remo…

This study tests whether an 8-session nutrition education program is practical and well-liked by patients in a general medicine clinic. The program focuses on eating more fiber-rich foods like fruits, vegetables, and whole grains. It includes 42 adults with prediabetes, diabetes,…

This long-term study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related disabilities. Researchers used medical records and exams to identify risks and triggers. The goal was to better understand how to prevent these con…

This study looks at whether a special algorithm can help find pancreatic cancer earlier in people aged 50-85 who have recently developed high blood sugar or diabetes. About 8,869 participants are being followed to see if the screening method can detect cancer before symptoms appe…

This study watches glucose levels in 40 adults with diabetes who are on dialysis for kidney failure. Using a continuous glucose monitor, researchers will see how glucose changes during and between dialysis sessions over two weeks. They will also check if these patterns relate to …

This study aimed to understand how often people with diabetes have high calcium buildup in their heart arteries, and how doctors currently manage this finding. It planned to enroll adults with type 1 or type 2 diabetes who had no heart symptoms. The study was withdrawn before any…

This study aims to understand why some people with diabetes develop kidney disease, especially in Ecuador. Researchers will look at social, environmental, and biological factors in over 10,000 adults, including those with and without diabetes or kidney problems. The goal is to fi…

This study aims to better understand the pancreas in people with type 1 diabetes by using advanced MRI scans. Researchers will measure pancreas size and texture in 250 participants, including those recently diagnosed. The goal is to develop standard methods for assessing the panc…

This study collects blood, urine, and tissue samples from 500 adults with obesity to help researchers learn why people gain or lose weight, and why some regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up t…

This study is creating a large biobank of 48,000 people with diabetes in Hong Kong. Researchers will collect blood samples and health data to find genetic markers that predict serious complications like kidney failure, heart disease, and stroke. The goal is to improve early detec…

This study follows over 5,000 Black and White adults from age 18-30 for decades to see how their lifestyle and health changes affect heart disease risk later in life. Researchers measure things like blood pressure, weight, and cholesterol over time. The goal is to understand what…

This study uses advanced MRI scans to learn how pancreatitis affects the pancreas over time and to predict complications like diabetes. About 195 children and young adults will have MRI exams, blood and stool tests, and genetic testing. The goal is to find imaging markers that ca…

This study follows people who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring, cancer, or liver failure. About 121 adults will be monitored for up to 10 years with regular tests, scans, and questionnaires. The goal is …

This study looks at how a measure called the Hemoglobin Glycation Index (HGI) changes over time in 750 adults with diabetes who use continuous glucose monitors. HGI helps doctors understand how well blood sugar is controlled. The goal is to see if HGI stays stable or varies, whic…

This study looks at whether a telehealth program called ECHO can help healthcare teams better manage patients with diabetes and multiple chronic conditions. About 20 clinic sites in New Mexico will take part, with some teams receiving the training and others not. Researchers will…

This study looked at medical records from 22,000 adults with diabetes who had major surgery in Danish hospitals between 2017 and 2023. The goal was to see if doctors and nurses followed official guidelines for giving insulin when patients' blood sugar was too high. The findings w…

This study measures how well nerves in the leg send signals in 50 adults aged 45-76 with diabetic peripheral neuropathy. Researchers will compare nerve speed with blood sugar levels, diabetes duration, and neuropathy screening scores. The goal is to find better ways to detect ner…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. It involves 20 VA sites across 4 regions, testing two different support strategies. The goal is to see which approach gets more women …

This study looks at the DNA of over 9,000 people with diabetes and kidney disease, along with their family members, to find genes that increase the risk of diabetic kidney disease. Researchers are collecting blood samples and health information to identify genetic markers. The go…

This long-term study followed over 6,400 adults from different racial and ethnic backgrounds to learn how early signs of heart disease develop and lead to serious events like heart attacks or strokes. Participants were healthy at the start and were monitored for years through exa…

This study looks at why Black people with HIV are more likely to develop kidney disease, diabetes, and heart problems. Researchers are analyzing genetic and health data from over 3,000 participants to find risk factors. The goal is to better understand these diseases and improve …

This study is collecting health and genetic information from 120,000 people with chronic diseases like pancreatitis, inflammatory bowel disease, diabetes, and arthritis. Researchers want to understand how genes, lifestyle, and other factors affect disease progression and quality …

This study planned to see if training residents of Boston housing developments as Community Health Ambassadors could help more people get regular doctor visits and screenings for high blood pressure and diabetes. The ambassadors would lead workshops and connect neighbors to clini…