COPD

This study tests whether a home-based breathing exercise program can help people with COPD avoid being readmitted to the hospital or dying after a severe flare-up. About 358 adults who were hospitalized for at least 3 days due to a COPD attack will either receive usual care or ad…

This study is checking the long-term safety of a drug called tozorakimab in people with COPD who have had flare-ups in the past. About 82 adults who finished a previous tozorakimab study will take the drug and be monitored for side effects. The goal is to see if the drug remains …

This study looks at whether finding and treating COPD early can help people who are also being checked for lung cancer. About 280 adults with breathing problems will get either standard care or extra COPD treatment. The goal is to see if this improves symptoms, quality of life, a…

This study is testing a new clinic designed to find and treat muscle loss (sarcopenia) in people with COPD. About 80 adults who have been hospitalized for COPD will join. The clinic uses CT scans to check muscle mass and offers a team approach with a lung doctor, pharmacist, and …

This study looks at whether creating a personalized care plan for people with COPD after they leave the hospital can help them stay healthier and avoid future hospital visits. About 110 adults who smoke or used to smoke will get a thorough check-up and a custom plan that may incl…

This study tests whether adults with sudden illnesses like infections, heart failure, or asthma can be safely treated at home instead of in a hospital. About 3,000 participants will receive hospital-level care in their own homes, with a caregiver present for the first 24 hours. T…

This study tests whether a nebulized drug called ensifentrine can reduce inflammation in the lungs of people with COPD. About 56 adults aged 40-80 who smoke or have smoked will receive both the drug and a placebo at different times to compare results. The main goal is to see chan…

This study tests a new drug, solrikitug, in 171 adults aged 40-75 with moderate-to-severe COPD and high eosinophil levels. The goal is to see if the drug is safe and can improve lung function and reduce inflammation. Participants will receive either the drug or a placebo, and res…

This study tests whether a detailed health assessment can help people with COPD who have frequent flare-ups. Participants get a half-day check-up including lung and heart tests, and a personalized treatment plan. The goal is to reduce the number of flare-ups that require steroid …

This study tests a permanent implant called the Apreo BREATHE Airway Scaffold in up to 250 adults with COPD and emphysema who still feel short of breath despite standard treatments. The implant is placed in the airways to release trapped air and keep them open. Researchers will c…

This study tests a new device called an implantable artificial bronchus (IAB) for people with severe emphysema or COPD. The goal is to see if the device can improve lung function and make breathing easier. About 60 adults will take part, and the main results will be checked 90 da…

This study tests a self-management program for people with COPD to see which parts work best to reduce hospital stays and improve daily life. Researchers will enroll 448 adults aged 40+ who have had a COPD-related hospitalization in the past year. Participants will use a smartpho…

This study tests a one-time treatment called lung denervation for people with COPD. The procedure targets nerves in the lungs to help open airways and improve breathing. Researchers will compare lung function in 200 adults who receive the treatment plus standard care versus those…

This study tests a new device called the IAB 50 Flex, an implant designed to help people with severe emphysema or COPD breathe easier. About 20 adults will receive the implant at two hospitals. The main goal is to check for serious side effects within 90 days.

This study looks at whether people with COPD and chronic bronchitis who switch from regular cigarettes to a tobacco heating system (THS) experience fewer symptoms like coughing and shortness of breath, and see improvements in lung function and walking ability. The study will comp…

This study is testing a new ultrasound measurement called the Lung Sliding Index (LSI) to see if it can help doctors tell apart different lung diseases like COPD, pneumonia, and pneumothorax. Researchers will measure LSI in 700 adults with various lung conditions and healthy volu…

This study will test if a smartphone app called AWARE can accurately detect and monitor lung diseases like asthma, COPD, and cystic fibrosis by analyzing breathing sounds. Researchers will enroll 800 people aged 8-70, including healthy volunteers, to compare the app's results wit…

This study looks at whether two easy breathing tests—oscillometry and FeNO—can help family doctors accurately diagnose asthma and COPD without needing complex spirometry. About 600 adults with symptoms like wheezing or shortness of breath will take these tests at their primary ca…

This early-stage study tests whether a new inhaled drug, HRS-9821, is safe and tolerable. It involves 160 participants: healthy volunteers receiving a single dose and COPD patients receiving multiple doses. Researchers will monitor side effects, drug levels in the blood, and hear…

This study tests whether a community-based exercise program can improve exercise capacity in 200 adults aged 18-85 with reduced heart or lung function. Participants will do 40-60 minutes of exercise (like brisk walking or cycling) five times a week for eight weeks. Researchers wi…

This study tests whether telenursing (nurse support by phone or video) can improve oral health in 80 adults with COPD. Participants will receive remote guidance on mouth care, and their oral health will be measured before and after. The goal is to see if this approach can reduce …

This study compares a new asymmetric nasal high-flow interface to a standard nasal cannula in 50 people with mild-to-moderate COPD flare-ups. The goal is to see if the new device lowers carbon dioxide levels, reduces breathing rate, and improves comfort. Each participant will try…

This study tests whether a device called Airvo 3 in OptiO2 mode can automatically keep oxygen levels in a healthy range for hospitalized COPD patients. About 70 adults with COPD and low oxygen will be enrolled. The goal is to see if the device works better than nurses manually ad…

This study looks at whether interval exercise can improve daily activity, daytime sleepiness, and heart health in veterans who have both COPD and obstructive sleep apnea (called Overlap Syndrome). About 28 veterans will take part in a 12-week exercise program. The goal is to find…

This study tests a device that teaches people with COPD or asthma how to use their inhalers correctly. 140 adults will be trained with either the device or standard brief instruction. After 6 weeks, their inhaler skills and lung function will be checked to see if the device helps…

This study looks at whether adding music to standard rehabilitation helps people with COPD and chronic respiratory failure exercise more easily. About 156 participants will be randomly assigned to rehab with or without music. The goal is to see if music can improve how far they c…

This study tests whether dronabinol, a synthetic THC (the active compound in cannabis), can reduce severe breathlessness in people with advanced COPD. About 30 adults with very severe COPD who still struggle to breathe despite standard treatments will receive either dronabinol or…

This study tests a special 'eccentric' exercise program for people with COPD, a chronic lung disease. The goal is to see if this smart training can improve heart and lung fitness, immune function, and quality of life. About 170 adults who have done pulmonary rehab for at least 3 …

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea—a combination called overlap syndrome. Researchers will measure mem…

This study tests a new 3-month counseling program for people with stable COPD. The program is led by a nurse and focuses on emotional distress caused by the disease. It includes 10 sessions and involves other healthcare professionals. The goal is to see if this approach is practi…

This study looks at whether a 12-week Coping Skills Training program can reduce depression and anxiety in people with COPD, especially those with low income, different racial backgrounds, or living in rural areas. About 750 participants will be randomly assigned to either the Cop…

This study tests if a program combining walking and Tai Chi can help veterans with COPD (a lung disease) and long-term muscle or joint pain move around better. About 136 veterans aged 40 and older will use a FitBit to track their steps and report their pain and breathing. The goa…

This study tests a small, hands-free device called the PEP-buddy that helps people with COPD breathe easier during sudden breathlessness. About 25 adults with moderate to severe COPD will use the device for 4 weeks to see if it reduces shortness of breath. The goal is to find a s…

This study looks at whether using a nasal high-flow device during a 6-minute walk test helps people with COPD walk farther and feel less breathless. About 30 adults with COPD who use little or no extra oxygen will take part. Researchers will compare how far they walk and how hard…

This study looks at how the right side of the heart works in people with COPD, both at rest and during exercise. Researchers want to find different patterns of heart strain to help develop better treatments in the future. The study involves 60 adults aged 40 and older with COPD.

This study looks at how different types of exercise change oxygen levels in the brain and leg muscles of people with COPD. Researchers will compare 60 participants (COPD patients and healthy volunteers) during walking, strength, and breathing exercises. The goal is to find the sa…

This study follows 100 adults with COPD for one year to see how airway inflammation, lung function, and symptoms change over time. Researchers use a simple breath test (FeNO) and a small blood sample to measure inflammation. Participants attend three routine visits (start, 6 mont…

This study is testing a new MRI technique that uses a special gas called hyperpolarized xenon to take detailed pictures of lung function. It will include 260 healthy volunteers and people with various lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if thi…

This study looks at whether fungi moving from the gut into the blood can cause inflammation and worsen lung function in people with HIV. Researchers will measure fungal markers and lung health in 100 participants over time. The goal is to better understand why some people with HI…

This study looks at how a treatment for severe COPD (placing valves in the lungs) changes the amount of oxygen people use during everyday activities like walking or cleaning. Researchers will measure oxygen use before and 6 months after the procedure in 20 patients. The goal is t…

This study looks at two simple methods—measuring thigh size with a tape and using ultrasound to check muscle stiffness—to see if they can help track muscle loss in people with COPD. About 30 adults starting pulmonary rehabilitation will take part. The goal is to find better ways …

This study looks at how an inhaled drug called BGF 160 changes the way people with stable COPD breathe. Researchers want to understand the drug's mechanism by measuring breathing complexity and variability. About 35 adults aged 40-75 with moderate-to-severe COPD will participate.…

This study aims to find people who have asthma or COPD but don't know it yet. Participants will complete an online questionnaire to see if they are at risk. Those at risk will be randomly assigned to receive early diagnosis and treatment from their doctor or usual care. The goal …

This study looks at how well muscles work in people with COPD, those with a condition called PRISm (which can lead to COPD), and healthy adults. Researchers will measure breathing muscle strength, arm and leg strength, and how muscles use oxygen during exercise. The goal is to be…

This study aims to develop a noninvasive way to detect blood vessel changes in the lungs of people with Group 3 pulmonary hypertension (PH) using a special MRI technique. Researchers will compare MRI scans with lung tissue from 30 patients awaiting lung transplants. The goal is t…

This study looks at how well the diaphragm works in 800 people with lung diseases like asthma, COPD, fibrosis, or pulmonary hypertension. Researchers want to understand if diaphragm problems are linked to shortness of breath. No new treatments are being tested—this is an observat…

This study looks at whether people with a genetic mutation that causes alpha-1 antitrypsin deficiency (AATD) also have changes in nearby genes that might weaken their immune system and lead to more lung infections. Researchers will compare immune responses to a pneumonia vaccine …

This study will check how many workers in an industrial zone in Thailand have asthma or COPD. About 310 adults will answer a questionnaire and take a breathing test. The goal is to find out how common these lung problems are in this group, not to test a treatment.

This study looks at why the sympathetic (fight-or-flight) nervous system is overactive in people with COPD. Researchers will measure nerve signals, heart rate, and blood pressure in 135 adults with COPD. The goal is to understand how sleep apnea, lung function, and inflammation c…

This study collects genetic and health information from 3,000 people to help doctors choose the right medications and avoid side effects. Participants include those taking multiple medications or specific drugs for blood pressure or depression. The goal is to learn how genes affe…

This study is creating a Turkish version of a questionnaire that helps find breathing pattern problems in people with COPD. Researchers will test the questionnaire on 90 stable COPD patients to make sure it works well. The goal is to give doctors a better tool to understand and t…

This study looks at 25 people with COPD and high carbon dioxide levels who need a breathing mask (non-invasive ventilation) to help them breathe. Researchers want to see if nighttime breathing problems can predict how well the treatment works over 6 to 12 months. They will also c…

This study is testing a digital tool that includes a smartphone app and a home spirometer to help 50 people with COPD monitor their lung function daily. The goal is to see if the tool is easy to use, safe, and can help patients know when to contact their doctor. Participants will…

This study looks at how air pollution particles get into the bodies of non-smokers who have lung cancer, COPD, or leukemia. Researchers will compare these patients with healthy volunteers to find new markers that show how pollution causes disease. The goal is to better understand…

This study looks at whether an ultrasound measurement of the diaphragm can help predict which patients hospitalized with a COPD flare-up will need breathing support or die. Researchers will measure diaphragm motion during normal and deep breathing in 186 participants. The goal is…

This study looks at how the right side of the heart works in people with COPD, both at rest and during exercise. Researchers want to find different patterns of heart strain to help design better treatments in the future. About 60 adults aged 40 and older with COPD will take part.

This study follows 730 adults with COPD who still have severe shortness of breath even after using standard inhalers. Researchers will track their health over time to find out who gets worse, who needs hospital care, and who may die. The goal is to learn what factors predict poor…

This study is observing 850 people with COPD in China to understand how the disease progresses and what factors affect it. Researchers will collect medical history, lung function tests, and blood samples over 1 to 3 years. The goal is to identify different types of COPD and find …

This study looks at people who are already getting lung cancer screening to find and track those who also have COPD. Researchers will collect information on symptoms, lung function, and CT scans from 420 participants. The goal is to better understand and manage COPD in this group…