Breast carcinoma

This trial tests whether MR-guided focused ultrasound can safely and effectively treat early breast cancer. The procedure uses MRI images to target and heat tumors with ultrasound waves, destroying them without surgery. Participants are women with a single small breast tumor that…

This trial tests whether applying tranexamic acid directly to the wound during a mastectomy reduces the amount and duration of fluid drainage afterward. Researchers will compare 30 patients who receive the topical drug with 30 who get standard postoperative care. The goal is to s…

This phase II trial tested the drug alisertib, alone or combined with fulvestrant, in 96 postmenopausal women with advanced breast cancer that no longer responds to hormone therapy. Alisertib blocks enzymes that help cancer cells grow, while fulvestrant blocks estrogen. The goal …

This study tests whether giving 6 months of hormone therapy before surgery helps remove all cancer cells in women with early-stage, estrogen-positive breast cancer. It involves 8 postmenopausal women with low-risk, node-negative tumors. The goal is to see if this approach leads t…

This phase III trial asks whether adding bevacizumab to standard hormone therapy (tamoxifen or letrozole) helps women with hormone receptor-positive advanced breast cancer live longer without the disease worsening. Hormone therapy blocks estrogen, which fuels tumor growth, while …

This study looked at whether shutting down the ovaries (ovarian suppression) combined with hormone therapy (tamoxifen or exemestane) could better prevent breast cancer from coming back in premenopausal women with hormone-sensitive breast cancer. Over 3,000 women who had surgery t…

This completed study examined the safety and effectiveness of Ibrance (palbociclib) in women with advanced or metastatic breast cancer using a large real-world database. Researchers looked at side effects and how well the drug worked in everyday practice. The study included adult…

This phase II study tested a combination of two chemotherapy drugs (cyclophosphamide and paclitaxel) plus the targeted drug trastuzumab given after surgery to 20 patients with early-stage HER2-positive breast cancer. The goal was to see if this regimen is safe and can help preven…

This phase 3 trial compares two treatment approaches for women aged 70 and older with estrogen-receptor-positive, HER2-negative breast cancer. Participants receive either hormone therapy alone for five years or chemotherapy followed by hormone therapy. The study aims to see if ad…

This study looked at whether adding focused radiation (SBRT) or surgery to standard treatments like chemo or hormone therapy helps people with breast cancer that has spread to just one or two places. 129 participants were randomly assigned to get standard care alone or standard c…

This phase 2 trial tests a new drug called TVB-2640 (denifanstat) combined with trastuzumab and either chemotherapy (paclitaxel) or hormone therapy in 17 people with HER2+ metastatic breast cancer that no longer responds to trastuzumab. TVB-2640 blocks an enzyme cancer cells need…

This Phase 2 trial tested whether disulfiram (Antabuse), a drug used for alcoholism, combined with copper supplements could help people with metastatic breast cancer who had run out of standard options. Only 9 patients took part, and researchers measured tumor response and surviv…

This phase II trial studied 92 women with early-stage breast cancer to see how well chemotherapy (paclitaxel and cyclophosphamide) with or without trastuzumab works before surgery. The main goals were to check side effects and see if the tumor disappears completely by the time of…

This large phase III trial tests which of three chemotherapy drugs—paclitaxel, nab-paclitaxel, or ixabepilone—works best, with or without the targeted drug bevacizumab, for people with stage IIIC or IV breast cancer that has returned or spread. The study aims to find the most eff…

This phase II trial tested whether combining the immunotherapy drug pembrolizumab (Keytruda) with the chemotherapy carboplatin could help people with HER2-negative metastatic breast cancer that has spread. The 12 participants had cancer cells in their blood and had already tried …

This study compares a new formulation of the chemotherapy drug doxorubicin (Doxopeg) to the standard version (Caelyx) in people with advanced ovarian cancer or metastatic breast cancer. The goal is to see if the two drugs are absorbed and processed by the body in the same way. Pa…

This phase II trial tested a combination of two targeted antibodies (pertuzumab and trastuzumab) plus a chemotherapy drug (nab-paclitaxel) in 63 patients with HER2-positive advanced breast cancer. The goal was to see how well the drugs work together to stop tumor growth and impro…

This study tested a new oral drug called BGB-43395 in 33 Chinese patients with advanced or metastatic HR+/HER2- breast cancer and other solid tumors. The drug blocks a protein (CDK4) that helps cancer cells grow. The goal was to find a safe dose and see if it can shrink tumors wh…

This early-phase trial tested whether using mathematical models to schedule chemotherapy drugs docetaxel and epirubicin could reduce severe side effects in 17 patients with metastatic breast cancer. The goal was to find the safest dose and schedule while still giving six cycles o…

This early-phase study tested a new drug called ONO-4578 combined with standard hormone therapy and targeted drugs (letrozole plus palbociclib or abemaciclib) in 46 postmenopausal women with advanced or recurrent hormone receptor-positive, HER2-negative breast cancer. The main go…

This early-phase trial tested a new drug called SRG-514 in 25 people undergoing breast-conserving surgery for breast cancer. The drug was given directly into the area where the tumor was removed. The main goal was to find a safe dose and check for side effects. This is a first st…

This phase 2 study tested a drug called patritumab deruxtecan in 121 people with advanced or metastatic breast cancer. The drug is an antibody-drug conjugate designed to deliver chemotherapy directly to cancer cells. The main goal was to see how many patients had their tumors shr…

This early-phase trial tested a combination of four therapies to see if they could safely boost the immune system to fight cancer. 17 adults with non-Hodgkin's lymphoma, metastatic breast cancer, or head & neck cancer received low-dose radiation and two immune-boosting drugs inje…

This study tested a combination of enzalutamide (a hormone blocker) and paclitaxel (chemotherapy) given before surgery to 24 people with a specific type of triple-negative breast cancer that has androgen receptors. The goal was to see if this treatment could shrink tumors and red…

This phase 2 trial tested a drug called patritumab deruxtecan (HER3-DXd) in 63 patients with breast cancer, lung cancer, or other solid tumors that had spread to the brain or the lining of the brain and spinal cord. The drug is designed to seek out and destroy cancer cells carryi…

This study tested a new way to give radiation to people with early-stage breast cancer. Instead of many sessions, patients received just three doses aimed only at the tumor area. The goal was to see if this shorter treatment is safe and works well. 77 patients took part, and the …

This early-phase trial tested a new drug called AZD8186 combined with the chemotherapy docetaxel in 23 patients with advanced solid tumors that have PTEN or PIK3CB gene mutations. The main goal was to find the safest dose and understand side effects. The study is complete, but re…

This study tested a type of breast cancer surgery called nipple-sparing mastectomy, where the breast tissue is removed but the nipple and skin are kept. It involved 450 women with early-stage breast cancer who needed a full mastectomy. The goal was to see if this surgery keeps th…

This early-phase study tested a new daily pill called TQB3616 in 40 adults with advanced breast cancer that had stopped responding to standard hormone therapy. The pill works by blocking a protein that helps cancer cells multiply. The main goals were to find a safe dose and under…

This phase 2 trial tested whether adding the drug veliparib to standard chemotherapy (cisplatin) helps people with metastatic triple-negative or BRCA-related breast cancer, including those with brain metastases. The study enrolled 344 participants to see if the combination slows …

This study tested a drug called hetrombopag in 60 advanced breast cancer patients whose platelets dropped too low from chemotherapy. The goal was to see if the drug could safely raise platelet counts and prevent treatment delays or dose reductions. Patients took the pill daily wh…

This early-phase trial tested a personalized cancer vaccine (SV-BR-1-GM) combined with an immunotherapy drug (retifanlimab) in 36 people with advanced breast cancer that had stopped responding to standard treatments. The vaccine is made from the patient's own tumor cells and aims…

This study tested a special collagen scaffold placed during breast cancer surgery to help the breast keep its shape after tumor removal. Forty women with early-stage breast cancer took part. The goal was to see if the scaffold safely helps the breast heal and look better, improvi…

This study tested a new two-drug combination (samuraciclib and elacestrant) in 49 adults with a common type of advanced breast cancer (HR+/HER2-). The goal was to find a safe dose and see if it can slow the cancer's growth. Participants had already tried other treatments and thei…

This early-phase trial tested a new drug, ipatasertib, added to two existing breast cancer medicines (trastuzumab and pertuzumab) in 17 people with advanced HER2-positive breast cancer that has a specific genetic change (PIK3CA mutation). The main goal was to find the safest dose…

This study looked at whether a test called RAD51-foci can predict how well the drug olaparib works in people with advanced HER2-negative breast cancer who have certain gene mutations (BRCA1, BRCA2, PALB2, RAD51C, or RAD51D). About 65 participants received olaparib, and researcher…

This early-phase trial tested a new drug called ALRN-6924 combined with the chemotherapy paclitaxel in 28 adults with advanced solid tumors that had spread or couldn't be removed by surgery, including a type of breast cancer. The main goal was to find the safest dose and check fo…

This early-stage trial tested whether adding pulsed electromagnetic fields (PEMFs) to standard chemotherapy is safe for people with breast cancer. Fourteen participants received the combination before surgery. The main goal was to check for side effects, not to cure the disease. …

This study looked at whether adding focused radiation to the cancer spots (metastases) can help people with breast cancer that has spread to a few places (up to 5 spots). 87 participants received either standard drug therapy alone or standard therapy plus radiation. The goal was …

This early-phase trial tested a new experimental drug called AZD2014 combined with the standard hormone therapy fulvestrant in 99 people with advanced ER+ breast cancer. The main goals were to check the safety of the combination and find the right dose. Researchers also looked fo…

This Phase 3 trial compared the pill olaparib to standard chemotherapy in 302 people with metastatic breast cancer who have inherited BRCA1 or BRCA2 mutations. The goal was to see if olaparib could slow cancer growth better than chemo. Participants took olaparib twice daily or re…

This study tested giving focused radiation before breast cancer surgery instead of the usual 5-6 weeks after surgery. 139 women with early-stage breast cancer received either one or three doses of radiation before their lumpectomy. The goal was to see if this approach can prevent…

This early-phase study tested two drugs, abemaciclib and niraparib, given together before surgery in 8 people with hormone receptor-positive, HER2-negative breast cancer. The goal was to find the best dose and see if the combination could shrink tumors safely. The study focused o…

This study tested a combination of two drugs, palbociclib and tamoxifen, as the first treatment for people with a certain type of advanced breast cancer (HR-positive, HER2-negative). The goal was to see how long the cancer could be kept from growing. 49 participants took both pil…

This study tested a new bone graft material, ZetaMet, in 10 women with breast cancer that spread to their spine, causing bone defects. The graft was implanted into the damaged vertebra to see if it could safely stabilize the spine and reduce pain. The main goals were to track com…

This early-phase trial tested a combination of three drugs—olaparib, palbociclib, and fulvestrant—in 9 people with BRCA-mutated, hormone-positive, HER2-negative metastatic breast cancer. The main goal was to see if the combination is safe. Researchers also looked at how long the …

This study tested whether adding the experimental drug samuraciclib to standard hormone therapy (fulvestrant) works better than fulvestrant alone for people with advanced HR+/HER2- breast cancer. The trial enrolled 60 adults whose cancer had worsened despite prior treatment. Rese…

This phase II trial tested a combination of hormone therapy drugs (fulvestrant or an aromatase inhibitor) plus palbociclib in 14 elderly patients with hormone-responsive breast cancer who either had inoperable tumors or were too frail for surgery. The goal was to see if this drug…

This early-phase study tested whether combining stereotactic radiosurgery (precise radiation) with the immunotherapy drug nivolumab (Opdivo) is safe and can shrink tumors in people with breast cancer that has spread to the brain. Fourteen participants received the combination. Th…

This early-phase trial tested a new way to treat advanced cancers that have spread. It combined a special type of radiation with two immunotherapy drugs (MEDI4736 and tremelimumab) to see if the combination is safe and tolerable. The study included 53 adults with advanced melanom…

This study looked at 155 people with metastatic breast cancer whose original tumors were HER2-negative. Researchers checked their blood for HER2-positive cancer cells. Those who had them received the drug T-DM1, which delivers chemotherapy directly to HER2-positive cells. The goa…

This study tested a new way to give the drug trastuzumab (Herceptin) to women with HER2-positive breast cancer that had spread to the lining of the brain. Instead of through a vein, the drug was injected directly into the spinal fluid via a lumbar puncture or a special reservoir.…

This study tested a new strategy for people with a common type of advanced breast cancer (ER+, HER2-). It used a blood test to look for a gene change (ESR1 mutation) that can make cancer stop responding to the first hormone therapy. When the mutation appeared, some patients switc…

This phase II trial tested a combination of panitumumab (a targeted therapy) plus two chemotherapy drugs (carboplatin and paclitaxel) given before surgery to women with triple-negative breast cancer that didn't respond to standard chemo. The goal was to shrink tumors and reduce t…

This study looked at combining the drug abemaciclib with standard hormone therapy as a first treatment for women with metastatic breast cancer that has spread to organs or has a high tumor burden. The goal was to see how many patients' tumors shrank or disappeared. The study enro…

This completed Phase 2 trial tested whether adding atorvastatin (a cholesterol-lowering drug) to standard hormone therapy (letrozole or fulvestrant) could improve outcomes in 126 women with advanced, hormone-receptor-positive breast cancer. The main goal was to see if the combina…

This Phase 2 trial tested whether adding enzalutamide (a drug that blocks male hormones) to the standard hormone therapy exemestane could help slow advanced breast cancer in postmenopausal women. The study enrolled 247 participants with hormone receptor-positive, HER2-normal brea…

This trial tests whether indocyanine green, a dye injected before surgery, can find sentinel lymph nodes as reliably as the standard technetium-99 radioactive tracer. About 744 adults with various cancers will receive both agents, and surgeons will compare detection rates using a…

This study tested a new 3D ultrasound called quantitative transmission imaging (QTI) against standard MRI for breast cancer screening in 26 women at high risk. The goal was to see if QTI could effectively detect suspicious findings. If it works, QTI might offer a faster, less exp…

This study tested whether contrast-enhanced ultrasound (CEUS) can estimate the pressure inside breast tumors without using a needle. Twenty-five women scheduled for breast biopsy received an IV contrast agent and underwent ultrasound imaging. The goal was to see if the ultrasound…

This study looked at over 3,000 women with dense breast tissue to see if adding molecular breast imaging (MBI) to standard digital breast tomosynthesis (DBT) finds more invasive cancers. MBI uses a small amount of radioactive material to highlight active cells, like cancer. The g…

This study tested whether contrast-enhanced mammography (CEM) can find more breast cancers than standard mammography in women already diagnosed with breast cancer. 89 women received CEM, which uses an iodine dye to highlight suspicious areas. The goal was to see if CEM detects ad…

This study follows up on women who took a low dose of tamoxifen (5 mg daily) for three years to see if it continues to prevent breast cancer over the long term. The original trial found a 42% reduction in breast cancer events. Researchers will also combine data from three similar…

This study tested whether bupropion, a medication that affects brain chemicals, can improve low sexual desire in women who have had breast or gynecologic cancer. About 230 women took either bupropion or a placebo pill for 9 weeks. The main goal was to see if their self-reported s…

This study tests whether a 12-week community program combining supervised physical exercise (Nordic walking and Tai Chi) with health education workshops can improve quality of life and reduce fatigue in women with metastatic breast cancer who are receiving active treatment. Parti…

This study tested a simple questionnaire called the Values Assessment Tool to help women with metastatic breast cancer and their caregivers talk about what matters most to them with their doctors. The goal was to see if using the tool reduces confusion about treatment choices and…

This study tested whether professional socio-aesthetics (specialized beauty and well-being care) can improve quality of life, reduce pain, and ease anxiety in adults undergoing chemotherapy for lung, breast, colon, or prostate cancer. 400 participants were randomly assigned to re…

This study looked at 157 women with breast cancer who had a mastectomy. It compared two ways to drain fluid after surgery: active drainage (using suction) and passive drainage (gravity). The goal was to see which method led to less fluid buildup (seroma), shorter drain time, and …

This study compared two ways to manage pain after a mastectomy: a nerve block (pectoral block) using bupivacaine, and standard IV painkillers (ketorolac). Sixty women undergoing mastectomy for breast cancer took part. The goal was to see which method provides better pain relief i…

This study looked at 8 adults with metastatic breast cancer who were starting the drug alpelisib. Alpelisib often causes high blood sugar, so researchers used a continuous glucose monitor (a small sensor worn on the arm) to track glucose levels day and night for at least 3 months…

This study looked at whether a 6-month physical activity program using a fitness tracker could help women with metastatic breast cancer feel better and less tired. 124 women with hormone receptor-positive, HER2-negative metastatic breast cancer who were starting chemotherapy took…

This study tested whether an online exercise and education program could help cancer patients and survivors feel better during the COVID-19 pandemic. Thirty adults with metastatic breast or gynecological cancer, or breast cancer survivors, took part. The program aimed to reduce f…

This pilot study tested whether acupuncture could reduce tingling, numbness, and pain in the hands and feet caused by chemotherapy in breast cancer survivors. Fifty-seven women who had completed taxane-based chemotherapy were randomly assigned to receive acupuncture immediately o…

This study tested whether a program that combines behavioral activation (a type of counseling that helps people engage in meaningful activities) with medication optimization (reviewing and adjusting current medications) can reduce anxiety and depression in adults aged 60 and olde…

This pilot study tested a smartphone app that lets breast cancer patients on oral chemotherapy report side effects and get basic advice. Hospital pharmacists were alerted when needed. The goal was to see if the app could improve monitoring and reduce phone calls. Only 28 patients…

This study tested whether group-based cancer rehabilitation could work when done virtually instead of in person for people with advanced breast or colorectal cancer. 111 participants were offered either in-person or online sessions to see which was more practical and acceptable. …

This study tested whether using telehealth visits and smart pill bottles can help breast cancer patients take their hormone therapy as prescribed. 305 women and men with early-stage hormone receptor-positive breast cancer participated. They either had regular in-person checkups o…

This completed trial tested a web-based remote monitoring platform called CONTINUUM+ CONNECT in 411 adults with metastatic breast, lung, colorectal, or prostate cancer. Patients used the platform to report symptoms and receive alerts, aiming to improve their physical health and q…

This study looked at whether using a special numbing technique (tumescent local anesthesia) during breast cancer surgery leads to less pain afterward compared to standard general anesthesia. 349 women who had breast cancer surgery took part. The goal was to see if this approach c…

This study tested a program that teaches couples communication skills when one partner has advanced cancer. About 440 patients and their partners took part, with half receiving the training and half getting general healthy living information. The goal was to see if the training c…

This study tested an online nurse-led program to help young women who had breast cancer improve their sexual health, body image, and menopausal symptoms. 43 women who finished treatment within the last five years took part in eight weekly sessions. The program aimed to see if it …

This study tested whether telemedicine and connected watches can help monitor symptoms and improve quality of life for women with advanced breast cancer who live far from their cancer center. Fifteen patients reported symptoms weekly on a tablet, while a smartwatch tracked their …

This pilot study tested whether a mindfulness program could help prevent chemo-brain in women about to start chemotherapy for breast cancer. Fifteen women participated in mindfulness sessions and underwent brain scans and blood tests. The main goal was to see if women would stick…

This study tested a personalized home exercise program for women with metastatic breast cancer who were not very active. The program was designed by a cancer exercise specialist to fit each patient's needs and abilities. The goal was to see if it could help them become more physi…

This study tested a program called CONTINUUM, where advanced cancer patients had a video visit with an oncology nurse within three days of leaving the hospital. The goal was to help patients feel more confident managing their health and improve communication with their care team.…

This phase 3 trial tested whether adding prochlorperazine or olanzapine to standard anti-nausea medication (netupitant/palonosetron and dexamethasone) better controls nausea and vomiting caused by chemotherapy in breast cancer patients. Over 1,300 women receiving common chemo dru…

This study tested whether group dance classes can improve balance and motivation in breast cancer survivors who have nerve damage from chemotherapy. Fifty-two survivors participated in either dance-based exercise or standard exercise for several weeks. The goal was to see if danc…

This study tested whether interpersonal psychotherapy (a type of talk therapy) could help breast cancer patients who are at risk for depression. Forty-two patients with stage II or III breast cancer took part. The therapy aimed to lower depression scores and improve how patients …

This study tests a new way to find the first lymph node (sentinel node) during breast cancer surgery. Instead of using the usual armpit hairline as a guide, doctors will use ultrasound to mark the exact spot. The goal is to see if this leads to a smaller cut, less tissue damage, …

This completed study looked at blood and tumor samples from 66 women with breast cancer who were about to receive chemotherapy before surgery. Researchers searched for unique protein patterns that might show whether the tumor would shrink with treatment. The goal was to find a wa…

Researchers at Centre Oscar Lambret are studying how immune cells get inside breast and colon tumors. They will analyze stored tumor samples from about 70 patients treated between 2005 and 2007, looking at genes and proteins on blood vessel cells that may control this process. Th…

This study looks at how the adrenal glands work in people who are critically ill, such as those with sepsis. Adrenal insufficiency may affect up to 77% of ICU patients, but current tests are not reliable. Researchers will measure hormone levels in 225 participants, including heal…

This completed study observed 22 adults with HER2-positive or HER2-low metastatic breast cancer who were taking trastuzumab deruxtecan (Enhertu) as part of routine care. Researchers tracked how many patients stopped treatment early or needed dose changes, and why. The goal is to …

This study looks at medical records from across Europe to see how well a drug combination (palbociclib plus an aromatase inhibitor) works as a first treatment for people with a common type of advanced breast cancer (HR+/HER2-). Researchers want to understand how long the treatmen…

This early-phase trial tested a precise, high-dose radiation technique called stereotactic body radiotherapy (SBRT) in 42 patients with breast, lung, or prostate cancer that had spread to several places in the body. The main goal was to find the safest dose and check for side eff…

This study explored whether a simple blood test measuring the neutrophil-to-lymphocyte ratio (NLR) can help predict how well women with advanced breast cancer respond to a common treatment (CDK4/6 inhibitors plus hormone therapy). Researchers followed 165 patients starting this t…

This completed study looked at 121 women in Brazil with a certain type of advanced breast cancer (HR+/HER2-). Researchers tracked how doctors prescribed palbociclib combined with other drugs in everyday practice, not in a strict trial setting. The goal was to describe patient bac…

This study examined blood samples from 49 women with metastatic breast cancer to find genetic markers that predict side effects from trastuzumab (Herceptin). The goal was to understand why some patients experience heart or allergic reactions. It did not test a new treatment, but …

This study looked at whether information from routine medical records (real-world data) can produce the same results as a carefully controlled clinical trial called MONALEESA-2 for advanced breast cancer. Researchers analyzed data from over 2,400 patients to see if they could rel…

This completed study looked at whether information from routine medical records can produce the same results as a gold-standard clinical trial. Researchers analyzed data from 3,883 women with advanced breast cancer to see if real-world analyses could match the findings of the MON…

This study examined whether specific gene variations influence how well metastatic breast cancer patients respond to chemotherapy with or without the drug bevacizumab. Researchers enrolled 307 women from Italy to compare outcomes and analyze genetic interactions. The goal was to …

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This completed study looked at whether a deficiency in the DPD enzyme can predict severe side effects from the chemotherapy drug capecitabine in women with metastatic breast cancer. Researchers analyzed blood samples from 303 participants to see if genetic differences could help …

This completed study analyzed medical records of 1,170 advanced breast cancer patients in Japan to see how they used the drug palbociclib (Ibrance). Researchers looked at blood test frequency and how long patients stayed on treatment. The goal was to describe real-world treatment…

This study aims to develop and validate a scoring system to identify which patients with metastatic breast cancer are likely to live longer with third-line chemotherapy. Researchers will collect clinical, histological, and biological data from 267 women starting a third line of t…

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This completed study involved 775 women who had breast-conserving surgery and radiation for breast cancer. Researchers compared different surgery and radiation techniques to see which ones led to less breast hardening (fibrosis) and better cosmetic results. The goal was to find w…

This study looked at whether cancer survivors living in rural areas can create their own survivorship care plans and learn from telehealth education. 261 survivors of breast, colorectal, lung, lymphoma, or prostate cancer took part. The goal was to see if this approach improves t…

This study tested a mobile-friendly app called HERCaRE, designed to help Black women who have finished breast cancer treatment. The app provides culturally tailored education and resources to support survivorship. Researchers measured how often participants used the app and wheth…

This study looked at how closely 200 adults with advanced breast or prostate cancer follow their prescribed oral cancer treatments. Participants filled out questionnaires about their medication use and gave blood samples to check certain health markers. The goal was to understand…

This study analyzed blood samples from breast cancer patients to find genetic factors that might predict how well they respond to chemotherapy. Researchers looked at patients who had already received standard chemo drugs. The goal was to identify biomarkers that could guide futur…

This study looked at how well women of color understand their personal risk of developing breast cancer. Researchers surveyed 324 women aged 18 to 50 who had never had breast cancer. The goal was to see if their perceived risk matched actual risk, which can help improve education…

This study tested whether breathing in humidified wood or fragrant oils could mimic the immune-boosting effects of a forest walk. 28 adults who finished chemotherapy or radiation for early-stage breast or prostate cancer took part. The goal was to see if this approach is practica…

This observational study enrolled 94 women with breast cancer to see if it's possible to collect blood, stool, and survey data from older patients taking aromatase inhibitors (a type of hormone therapy). The main goal was to test the feasibility of gathering this information for …

This completed study from the University of Alabama at Birmingham involved 200 women with metastatic or early-stage breast cancer. Researchers conducted interviews and focus groups with patients, nurses, and doctors to understand how treatment decisions are made, including the op…

This study looked at how well anti-HER2 drugs work in Egyptian women with HER2-positive breast cancer. Researchers followed 80 patients who received either one drug (trastuzumab) or a combination (trastuzumab plus pertuzumab or lapatinib) as part of their regular care. The goal w…

This study looked at whether using a CPAP machine (commonly used for sleep apnea) during radiation therapy can reduce the amount of radiation reaching the lungs. Eight people with left-sided breast cancer or lung cancer took part. Researchers compared lung radiation doses with an…

This early-phase study tested whether two anti-inflammatory drugs—fish oil (omega-3 fatty acid) and celecoxib (Celebrex)—could reduce inflammation and slow cancer growth in women aged 18-50 with pregnancy-associated breast cancer. The 42 participants took one of the drugs for at …

This study looked at 120 women with early-stage breast cancer to see if having low muscle mass (sarcopenia) before treatment raises the risk of nerve damage from the chemotherapy drug paclitaxel. Researchers measured muscle mass on CT scans and checked for nerve symptoms using qu…

This study looked at how breast cancer treatments affect sexual health in 25 women. Participants filled out anonymous questionnaires about their sexual function, quality of life, and emotional well-being before and after chemotherapy. The goal was to understand how these factors …

This completed study looked at 559 adults in Israel with metastatic breast cancer who were prescribed palbociclib (Ibrance) as part of their treatment. Researchers tracked how the drug was used in everyday practice, including doses, combinations with other treatments, and how lon…

This completed study looked at records from over 20,000 women with metastatic breast cancer in France. Researchers wanted to see if earlier measures of treatment success, like progression-free survival, could reliably predict overall survival. By comparing real-world data to clin…

This study looked at whether measuring circulating tumor cells (CTCs) in the blood can help doctors decide when to switch chemotherapy for women with metastatic breast cancer that has worsened after two prior treatments. The trial involved 265 women and compared standard care wit…

This study looked at 60 people with metastatic breast cancer to find out whether certain cells in their blood (called DP-circulating cells) come from the tumor. Researchers took a blood sample before starting treatment and checked tumor samples. The goal was to better understand …

This study looked at whether giving cancer patients a decision aid before their doctor visit (on a smartphone) or during the visit (on paper) helps them feel more involved in treatment decisions. 274 adults with breast or colorectal cancer took part. The goal was to see which for…

This study looked at whether a blood test called DiviTum-TKa can help doctors check if patients with metastatic breast cancer are taking their CDK4/6 inhibitor medication correctly and if other drugs are interfering. The test measures a marker of cell growth to see if the treatme…

This study worked with American Indian communities in New Mexico to find better ways to encourage screening for breast, colon, and cervical cancers. Over 500 adults took part in focus groups, surveys, and pilot programs. The goal was to understand barriers and test simple educati…

This study looked back at medical records of 517 women in Gulf countries with advanced breast cancer that was previously labeled HER2-negative. Researchers re-tested old tumor samples to find out how many actually have HER2-low breast cancer, a newer subtype. The goal is to bette…

This completed study looked at 312 patients with advanced breast cancer who received either trastuzumab deruxtecan or sacituzumab govitecan. Researchers collected real-world information on side effects and how long the cancer was kept under control. The goal was to see how these …

This study tested whether a special MRI sequence called ZTE can show breast biopsy markers made of bone cement more clearly than standard metal markers. Twenty adults with breast cancer had MRI scans, and two radiologists rated how well the markers were seen. The goal is to impro…

This study looked at how the way blood samples are collected and processed affects the ability to detect tumor DNA in women with early-stage breast cancer. Researchers tested different collection tubes, processing speeds, and storage conditions to see which methods preserve tumor…