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Nerve block or IV drugs? study seeks best pain relief after mastectomy

NCT ID NCT07257874

Symptom relief Sponsor: Islamabad Medical and Dental College Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared two ways to manage pain after a mastectomy: a nerve block (pectoral block) using bupivacaine, and standard IV painkillers (ketorolac). Sixty women undergoing mastectomy for breast cancer took part. The goal was to see which method provides better pain relief in the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine (nerve block) and ketorolac (IV painkiller)
What this could lead to
If the nerve block works better, it could become a standard way to manage pain after mastectomy, reducing the need for strong IV painkillers.
What could go wrong
This is a small, single-center study with only 60 participants. The results may not apply to all patients, and nerve blocks carry risks like infection or allergic reaction.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

60 people

The number who actually took part.

Started

Jul 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female Patients undergoing Modified Radical Mastectomy for biopsy proven Carcinoma Breast * Patient with age 18-65 years * Patients with ASA Grade 2 * BMI less than 40 kg/meter square Exclusion Criteria: * Block site infection * Coagulopathies (INR \> 1.6 and Platelets \< 100000) * Any Organ dysfunction such as severe cardiac, pulmonary, renal or liver dysfunction * Systemic infection * Dementia * Known hypersensitivity to local anesthetic agents

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Conditions

The condition(s) this trial relates to.

breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mastectomy, modified radical

Contacts and locations

Locations

  • Akbar Niazi Teaching Hospital

    Islamabad, 44000, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.