The University Of Texas Health Science Center At San Antonio

This study tests whether rapamycin, a drug used for other conditions, is safe and tolerable for older adults with mild cognitive impairment or early Alzheimer's disease. Over 12 months, 40 participants will take oral rapamycin and be monitored for side effects, changes in memory,…

This study is testing a treatment called IR-TMS, which uses magnetic pulses to target specific brain areas, to see if it can help people with alcohol use disorder drink less. About 150 participants will receive several sessions of this treatment, along with brain scans and blood …

This early-stage study tests whether adding the drug avasopasem to standard hormone therapy and a CDK 4/6 inhibitor is safe and can help control metastatic hormone receptor positive breast cancer. About 35 women whose cancer has worsened on current treatments will participate. Th…

This small early study is testing whether drinking a ketone ester supplement for 7 days can improve how well the heart pumps blood in people who have both type 2 diabetes and heart failure with reduced pumping strength. Ten adults aged 18–80 with stable heart medications will tak…

This study tests whether taking amino acid supplements during dialysis can help reduce fatigue, frailty, and improve thinking in people with end-stage kidney disease. About 28 adults on dialysis will take either a single amino acid (valine) or a mix of essential amino acids. The …

This study looks at whether using the Calm meditation app for 10 minutes a day can help people with blood cancer who have trouble sleeping. About 276 patients will be randomly assigned to one of two app-based wellness programs for 8 weeks, then followed for another 12 weeks. The …

This study creates a 'living biobank' of miniature lung tumors (organoids) from 150 patients with early-stage lung cancer. Researchers will test how these lab-grown tumors respond to chemotherapy and targeted drugs, comparing results to what happens in the patient. The goal is to…

This study looks at the genes of people with rare nervous system tumors called pheochromocytoma and paraganglioma. Researchers want to find the genetic causes and link them to specific symptoms. Up to 2,000 participants, including patients and their family members, will provide D…

This study looks at how dupilumab changes the way the nose and blood respond to house dust mites in adults with allergic asthma. Participants will be exposed to dust mites in a special chamber and then receive either dupilumab or a placebo. The goal is to understand the drug's ef…

This study looks at how two types of weight-loss surgery—gastric bypass and sleeve gastrectomy—change the way the body handles sugar after eating. Researchers will measure insulin levels in 200 people, including those who had surgery and healthy volunteers. The goal is to underst…

This study looks at why some people who had gastric bypass surgery develop dangerously low blood sugar years later, while others see their diabetes improve. Researchers will measure gut hormones and nerve signals in 160 volunteers—including those with and without low blood sugar …

This study looks at how a common diabetes medication (SGLT2 inhibitor) changes energy use in the heart and muscles of people with type 2 diabetes and heart failure. Researchers will measure key energy molecules and walking ability in 71 adults aged 18-80. The goal is to understan…

This study looks at how giving DHA and ARA (types of healthy fats) to very premature babies (born between 25 and 29 weeks) affects their body's fat processing and development. Researchers will measure changes in blood fats and related markers to understand how these supplements i…

This study looks at how the liver uses energy in people who have both type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). Researchers will measure liver cell activity before and after 16 weeks of treatment with the diabetes drug pioglitazone. The goal is to understand h…